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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Jurnal Farmasi Sains dan Komunitas Jurnal Pengabdian UntukMu NegeRI Jurnal Penelitian Pendidikan IPA (JPPIPA) ALCHEMY Jurnal Penelitian Kimia Jurnal Pengabdian Pada Masyarakat Majalah Farmaseutik JCES (Journal of Character Education Society) JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) Bubungan Tinggi: Jurnal Pengabdian Masyarakat Madaniya Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian Kepada Masyarakat Itekes Bali Journal of Food and Pharmaceutical Sciences Journal of Applied Agriculture, Health and Technology

ERMAWATI, DIAN EKA

Sekolah Vokasi, Universitas Sebelas Maret, Surakarta

Author-ID : 1304732

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OPTIMATION OF COMPOSTION OF SPAN 80-CRODURET 50-PROPYLENE GLYCOL AS EMULSIFIER OF STRAWBERRY JUICE (Fragaria vesca L.) EMULGEL AND TRANSPORT TEST THROUGH SHED SNAKE SKIN MEMBRANE ERMAWATI, DIAN EKA
Journal of Food and Pharmaceutical Sciences Vol 4, No 3 (2016): J. Food Pharm. Sci (September-December)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Strawberry (Fragaria vesca L.) contains many nutrients that are beneficial to health because rich of antioxidant such as ascorbic acid, quercetin-3-Î²-Dâ€“glucoside, anthocyanin pelargonidin-3-O-glucoside and cyanidin-3-glucoside. Amount of anthocyanins and flavonoids in strawberry during process will decline respectively 53% for pelargonidin-3-O-glucoside and 40% for flavonoid quercetin. Using water-oil emulsion (w/o) topically less convenient, so it needs to be dispersed in the matrix gel to help sustain the permeation of the active components of strawberry juice into the stratum corneum. Emulsion consisting of water and oil components are not mixed with each other, thus requiring additional emulsifier to create a system that is homogeneous and stable.The proportion of combination of emulsifier as span 80, croduret 50, propylene glycol are optimized, to produce an optimum formula with good physical stability. The optimization method was Simplex Lattice Design by using Design ExpertÂ® software 7.1.5. The results of the response of the assessed physical parameter were viscosity, separation ratio (F), and diameter of emulsion globule. The optimum formula have measured physical stability test, active ingredient of flavonoid and anthocyanins, whichÂ then was conductedÂ transportÂ testÂ through the membrane of shed snake skin by Franzâ€™s model diffusion cells with the flavonoid concentration parameters that were able to pass through the membrane.Emulsion w/o that use combination of 2,00% Span 80; 4,00% croduret 50, and 2,00% of propylene glycol which produce a physically stable emulsion base on Simplex Lattice Design [p-value> 0.05]. Strawberry juice contains 23,3 % of flavonoid, 13,23% of anthocyanin, and IC50 331 Âµg/mL. The optimum formula of emulgel contains 20% of flavonoids and 11.67% of anthocyanin. The cumulative amount of flavonoid which was transported through the shed snake skin membrane was 117,14 Âµg/cm2Â during five hours. The permeability of membrane shed snake skins is 2,84x10-5 Âµg/cm2and flux value is 6,6x10-5 Âµg/secon.Â Keywords : strawberry juice, emulsifier, Simplex Lattice Design, emulgel, flavonoid

Optimum Dose and Formulation of Centella asiatica L. Urban Extract Against IgG of Wistar Strain Male Mices which Induced by BCG Vaccine Ermawati, Dian Eka; Sasmito, Ediati; Mufrod, Mufrod; ND., Pramitha Esha; UA., Ni Putu; KD, Anggi; H., Muchammad; S., Aini
Journal of Food and Pharmaceutical Sciences Vol 4, No 3 (2016): J. Food Pharm. Sci (September-December)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Objective: Centella asiatica L.Urban contains triterphenoid saphonin, flavonoid, and pectin that believed to have an immunomodulatory effect toward the Immunoglobulin-G in Wistar strain male mices which Induced by BCG vaccine. A study was conducted to find out the optimum dose and formulation of in enhancing on the level of IgG. Itâ€™s therefore expected that Cantella asiatica L.Urban can be used as an immunomodulatory suplement in both animals and human.Methods: Centella asiatica L.Urban were macerated with ethanol 50%. This was an experimental study with the post-test control group design. The samples in this study were 35 Wistar strain male mices which divided into 7 groups: negative control [Aquadest 0,5mL/20g BW]; control immunosupresant [PrednisonÂ® 0,06mg/20g BW]; control immunostimulant [LevamisolÂ® 0,445mg/20g BW]; ethanolic extract of Cantella asiatica L.Urban with a dose of 50mg; 100mg; 150mg; 200mg/Kg B.W were administered orally fo 10 day, after the treatments implemented, BCG [Bacillus Calmette Guerin] vaccine was infected intraperitoneally on day 10th, 14th, 21st, and 28th. The most effective doses of ethanolic extract of Cantella asiatica L.Urban was further studied for its effect on hormonal assay using ELISA reader which compared with the effects of PrednisonÂ® and LevamisolÂ®. Based on simplex lattice design to find the optimum proportion of coefficients a, b, and ab of the equation Y = a (A) + b (B) + ab (A) (B), where A is lactose and B is amylum.Results : Oral administration of ethanolic extract of Cantella asiatica L.Urban at dose of 50mg and 100mg/Kg B.W increased the immunity which showed elevated levels of IgG in the blood serum in Wistar strain male mices that had been induced by BCG vaccine. The optimum formula capsul of Centella asiatica L.Urban extract that use combination of 80% Amylum and 20% Lactose which produce the optimum parameters of disintegration time (â‰¤15minutes) and CV of weight uniformity (â‰¤5%)with the test results had no significant difference to the prediction results of Simplex Lattice Design [p>0.05].Keywords: Â Centella asiatica L.Urban extract, Immunomodulator, simplex lattice design

Optimum Dose and Formulation of Centella asiatica L. Urban Extract Against IgG of Wistar Strain Male Mices which Induced by BCG Vaccine Ermawati, Dian Eka; Sasmito, Ediati; Mufrod, Mufrod; Esha ND., Pramitha; Putu UA., Ni; KD, Anggi; Muchammad H., Muchammad; Aini S., Aini
Journal of Food and Pharmaceutical Sciences Vol 4, No 3 (2016): J. Food Pharm. Sci (September-December)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Objective: Centella asiatica L.Urban contains triterphenoid saphonin, flavonoid, and pectin that believed to have an immunomodulatory effect toward the Immunoglobulin-G in Wistar strain male mices which Induced by BCG vaccine. A study was conducted to find out the optimum dose and formulation of in enhancing on the level of IgG. Itâ€™s therefore expected that Cantella asiatica L.Urban can be used as an immunomodulatory suplement in both animals and human.Methods: Centella asiatica L.Urban were macerated with ethanol 50%. This was an experimental study with the post-test control group design. The samples in this study were 35 Wistar strain male mices which divided into 7 groups: negative control [Aquadest 0,5mL/20g BW]; control immunosupresant [PrednisonÂ® 0,06mg/20g BW]; control immunostimulant [LevamisolÂ® 0,445mg/20g BW]; ethanolic extract of Cantella asiatica L.Urban with a dose of 50mg; 100mg; 150mg; 200mg/Kg B.W were administered orally fo 10 day, after the treatments implemented, BCG [Bacillus Calmette Guerin] vaccine was infected intraperitoneally on day 10th, 14th, 21st, and 28th. The most effective doses of ethanolic extract of Cantella asiatica L.Urban was further studied for its effect on hormonal assay using ELISA reader which compared with the effects of PrednisonÂ® and LevamisolÂ®. Based on simplex lattice design to find the optimum proportion of coefficients a, b, and ab of the equation Y = a (A) + b (B) + ab (A) (B), where A is lactose and B is amylum.Results : Oral administration of ethanolic extract of Cantella asiatica L.Urban at dose of 50mg and 100mg/Kg B.W increased the immunity which showed elevated levels of IgG in the blood serum in Wistar strain male mices that had been induced by BCG vaccine. The optimum formula capsul of Centella asiatica L.Urban extract that use combination of 80% Amylum and 20% Lactose which produce the optimum parameters of disintegration time (â‰¤15minutes) and CV of weight uniformity (â‰¤5%)with the test results had no significant difference to the prediction results of Simplex Lattice Design [p>0.05].Â Keywords: Â Centella asiatica L.Urban extract, Immunomodulator, simplex lattice design

Formulation of Anti-Acne Gel of Moringa oleifera, L. Ethanolic Extract and Antibacterial Test on Staphylococcus epidermidis Ermawati, Dian Eka; Ramadhani, Cahyarani Intan
Journal of Food and Pharmaceutical Sciences Vol 7, No 1-3 (2019): J. Food Pharm. Sci (January-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/jfps

Moringa oleifera L. leaves contain flavonoid, alkaloid, and phenolic compounds which have antibacterial activity. Staphylococcus epidermidis is one of the bacteria that causes acne. The purpose of this study is to compare bacteriostatic ability of the extracts and gel for S. epidermidis bacteria and to get gel formula that can fulfills the physical properties of a good gel.Moringa leaves were extracted with maceration method using ethanol 70% in three days. HPMC 4000 was used as the polymer. Extract was added with variation concentrations of 5, 10, and 15%. Physical evaluation of gel was organoleptic, homogeneity, pH, viscosity, adhesion, and spread tests for 4 weeks. In vitro bacteriostatic activity test with 1% clindamycin gel as positive control and polymer gel as negative control.The result showed that variations concentrations of ethanolic extract of Moringa leaves affected the physical properties of gel including viscosity, pH, adhesion and spreadability. Bacteriostatic activity test of ethanolic extract of Moringa leaf was classified as strong activity, while 15% Moringa leaf ethanol extract gel was classified as moderate activity with average diameter was 9.14 mm

Formulation of Anti-Acne Gel of Moringa oleifera L Ethanolic Extract and Antibacterial Test on Staphylococcus epidermidis Dian Eka Ermawati; Cahyarani Intan Ramadhani
Journal of Food and Pharmaceutical Sciences Vol 7, No 1 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.707

Moringa oleifera L. leaves contain flavonoid, alkaloid, and phenolic compounds which haveantibacterial activity. Staphylococcus epidermidis is one of the bacteria that causes acne. The purpose of this studyis to compare bacteriostatic ability of the extracts and gel for S. epidermidis bacteria and to get gel formula thatcan fulfills the physical properties of a good gel. Moringa leaves were extracted with maceration method usingethanol 70% in three days. HPMC 4000 was used as the polymer. Extract was added with variationconcentrations of 5, 10, and 15%. Physical evaluation of gel was organoleptic, homogeneity, pH, viscosity,adhesion, and spread tests for 4 weeks. In vitro bacteriostatic activity test with 1% clindamycin gel as positivecontrol and polymer gel as negative control. The result showed that variations concentrations of ethanolicextract of Moringa leaves affected the physical properties of gel including viscosity, pH, adhesion andspreadability. Bacteriostatic activity test of ethanolic extract of Moringa leaf was classified as strong activity,while 15% Moringa leaf ethanol extract gel was classified as moderate activity with average diameter was 9.14mm.

The Characteristic and Antibacterial Activity of Nanosilver Biosynthetic using Sweet Orange Ermawati, Dian Eka; Putro, David Sarono; Amaris Susanto, Nindita Clourisa
Journal of Food and Pharmaceutical Sciences Vol 11, No 1 (2023): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5760

Sweet orange contains citric acid and ascorbic acid that act as a silver ion bioreducer to form nanosilver (AgNPs). Silver ion green synthesis using sweet orange peel resulted in smaller particle sizes than C. lemon and C. limeta. Therofore, this study aims to determine the characteristic of nanosilver biosynthetic using sweet orange bioreductor and antibacterial activity. Silver nitrate solution of 1.0 mM was mixed with sweet orange juice - peel infusion in ratio of 3.0: 0.0; 1.5: 1.5; and 0.0: 3.0 mL. The process was conducted using a water bath at 60 ˚C for 45 minutes. The formation of AgNPs is indicated by a color change from colorless to yellowish-brown using UV/Vis spectrophotometer and PSA. The stability test of AgNPs is determined for 30 days storage at room temprature and their antibacterial activity against S. aureus and S. epidermidis. The results showed that sweet orange juice accelerated the color change at the SPR range of AgNPs at 438-459 nm, but it is less stable. The mix solution of sweet orange juice and sweet orange peel infusion of 1.5: 1.5 mL are stable and promising as an antibacterial agent. Futhermore, the AgNPs produced had a particle size of 41±10 nm and a spherical shape.

Formulation of Salam (Syzygium polyanthum (wight) walp) Leaves Ethanolic Extract Matrix Patch and Its Evaluation Ermawati, Dian Eka; Andriani, Novi; Darojati, Ulfa Afrinurfadhilah
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.9011

The total flavonoid content in salam leaves has an anti-inflammatory activity at a dose of 2.1% w/w. For topical anti-inflammatory, a matrix patch has a delivery mechanism that drugs pass through in the skin in a controlled for an extended period. Polymers were the patch's main component to control the drug release. Polyvinyl alcohol (PVA) and alpha-cellulose (AC) were polymers that can increase the rate of drug diffusion and form a strong film layer. Salam leaves were extracted by maceration using ethanol 96%. Matrix patches were made with a combination of PVA and AC in ratios 1:1; 3:1; 1:3. The patches were tested for physicochemical properties. The stability test was conducted at 4, 25, and 40 temperatures for 8 h, respectively. Statistical analysis of the test data used One Way ANOVA with a confidence level of 95%. The results showed that the high concentration of PVA significantly affected the weight and moisture content but did not affect the organoleptic thickness, folding endurance, and pH of the matrix patch. The best matrix patch of salam leaves ethanolic extract was PVA and AC of 3:1 because it met the requirements for the matrix patch, including the weight of 1.96-2.06 grams, thickness of 1.15-1.18 mm, folding endurance >300 times, humidity 25.75 – 30.17% and pH 6.3 – 7.1. The patch contains flavonoids with Rf values for extract and patch of 0.95 and 0.96, respectively. Further study, in vivo anti-inflammatory test is necessary.

The Effect of Temperature on Physicochemical Properties of Moringa Leaf Ethanolic Extract (Moringa oleifera L.) Patch and Anti-Inflamatory Test Ermawati, Dian Eka; Hidayati, Astri; Untari, Meta Kartika
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.13527

Moringa leaf extract contains flavonoids confirmed as anti-inflammatory at 200 mg/Kg b.w. The patch was chosen for topical anti-inflammatory preparation because it is continuous for an extended treatment period. Previous research has developed a patch formula using a polymer combination of polyvinyl alcohol (PVA) and alpha-cellulose (1: 2) that meets the requirements for good patch preparation. However, the effect of temperature resistance on physicochemical properties and anti-inflammatory activity needs to be confirmed. Moringa leaves were macerated in 96% ethanol and dispersed into a patch matrix of PVA and alpha-cellulose. Patches were treated at various storage temperatures, namely 4°C, 25°C, and 40°C each for 8 hours for six cycles. Mice were divided into three groups: blank patch, brand patch product, and moringa leaf patch. Mice were given 0.05 mL of carrageenan suspension intraplanar on the sole of the left foot, and the edema volume was measured using a plethysmometer. Statistical analysis uses One-Way ANOVA and T-test. The results showed that temperature affected the pH, thickness, and weight properties but did not affect the moisture, folding endurance, and organoleptic properties. The average edema volume of mice in the brand product group was not significantly different from the moringa leaf patch group, with a significance value of 0.066 (p > 0.05). The Moringa leaf ethanolic extract patch confirmed it can reduce the volume of mouse foot edema by 5 hours.

The Evaluation of Clove oil Concentration on Physicochemical and Antimicrobial Activity in the Laponite Gel Delivery System Ermawati, Dian Eka; Putriana, Susanti; Setyowati, Tri; Kuntari, Tabita Putri; Salsabila, Fitri; Kartikasari, M. Nur Dewi
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.15875

Recurrent Aphthous Stomatitis (SAR) is inflammation in the oral mucosa. One of the factors that can cause SAR is bacterial and fungal infections of the oral mucosa. Clove oil is an essential oil that contains eugenol and has antimicrobial, analgesic, anti-inflammatory, and antioxidant activities. Clove oil in this study resulted from steam distillation with an eugenol content of 71.06%. Clove oil as an antimicrobial topical requires a drug delivery system that is easy and comfortable to apply. Laponite is a synthetic hydrophilic layered silicate that can hydrate and expand when water is added, is compatible with the properties of active ingredients, and is without an emulsifier. Please state the objective of this research. This research aims to determine the effect of variations in the concentration of clove oil incorporated in laponite on the gel's physicochemical properties and antimicrobial activity. Laponite with a concentration of 2.5% was developed in water and then added to clove oil with a concentration of 2%, 4% and 6%. Physicochemical properties test of oral gel preparations includes organoleptic tests, homogeneity, pH, adhesion, and spreadability tests. Antimicrobial activity test to Streptococcus mutans bacteria and Candida albicans fungi. The research showed that a gel preparation using laponite with a concentration of 2.5% was semi-solid with a clove oil odor. Clove oil, with an eugenol content of 71.06%, has potent antimicrobial activity. The higher concentration of clove oil increases the viscosity and sticky time but decreases the pH and spreadability. The adhesive time and pH of the gel are suitable for application to the oral mucosa with mouth ulcers, and 2.5% laponite can form a gel preparation that meets the gel's physicochemical properties and antimicrobial activity.

Co-Authors Adi, Lutfan Prastyo Aditya, Shafira Nur Agung P. Surya Agung Putu S.P.Kristyawan Aini S., Aini Alfia Andhika Putri Amaris Susanto, Nindita Clourisa Andini, Bimar Putri Anggraini Febriyanty Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti, Anif Nur Anjani, Niki Putri Aprilia Saefanan Shofa Cahyarani Intan Ramadhani Cahyarani Intan Ramadhani Damayanti, Avina Kusuma Darojati, Ulfa Afrinurfadhilah Daswati Rofiatun Sahifah David Sarono Putro Dewi, Aptika Oktaviana Trisna Dita Yuli Budiasih Diyah Tri Utami Dyah Ayu Ambarwati Ediati Sasmito Esha ND., Pramitha Farida, Yeni Fea Prihapsara Fea Prihapsara Fea Prihapsara Fridha Angelina Pamuji Galuh Kartikasari H., Muchammad Hanifah, Fitria Lidini Hanuriansyah, Yavi Hayunda I'zaaz Fajrin Heni Utami Prilantari Heru Sasongko Heru Sasongko Heru Sasongko Heru Sasongko Heru Sasongko Hidayati, Astri Husna, Hanna Miftahul Indah Purwantini Indrajati, Dyah Yekti KD, Anggi Kuntari, Tabita Putri M Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulphadly M. Nur Dewi Kartikasari M. Nur Dewi Kartikasari Megasari, Anis Laela Meitasari, Annisa Diyah Meitasari, Annisa Diyan Muchammad H., Muchammad mufrod mufrod Muhammad Fiqri Zulpadly Nafisa, Fadhila Dian Nailul Maghfiroh ND., Pramitha Esha Niken Rosyana Dewi Septini Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nining Sugihartini Noveri, Priscilla Novi Andriani Novi Andriani Novi Andriani, Novi Nugraha Mas'ud Nuraini, Putri Indah Nurul Rochmawati Prastia, Echa Hana Putriana, Susanti Putro, David Sarono Putu UA., Ni Rahmat S, Anang Kuncoro Raka Sukmabayu W.S Ramadhani, Cahyarani Intan Rido Rohana Tambunan Rochmani, Sholichah Rohmani, Sholicha S., Aini Saifullah Sulaiman Salsabila, Fitri Samrotul Jannah Setyowati, Tri Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani, Sholichah siti nurkhasanah Susanto, Nindita Clourisa Amaris Sutarno Sutarno Suwaldi Martodiharjo T.N Saifullah Sulaiman UA., Ni Putu Ul Millah, Nida Ulfa Afrinurfadhilah Darojati Ulfa Afrinurfadhilah Darojati untari, meta kartika Utami, Diyah Tri Villian Septiana Waliyyin Razan Qanit Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Wulandari, Wening Yeni Farida Zulpadly, M. Fiqri Zulpadly, M.Fiqri Zulpadly, Muhammad Fiqri

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