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All Journal Medula Indonesian Journal of Urology JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) Indonesian Journal of Nursing and Health Sciences (IJNHS) Jurnal Ilmiah STIKES Yarsi Mataram JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Hadibrata, Exsa
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Agriculture, Biological Sciences & Forestry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Medula

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Systematic Review: Hubungan Obesitas dengan Risiko Benign Prostat Hiperplasia Armadani, Melni; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.978

Abstract

Benign prostatic hyperplasia (BPH) is a non-malignant growth of prostate tissue. The incidence of BPH is influenced by various risk factors such as metabolic syndrome, obesity, and genetic predisposition. The prevalence of obesity in Indonesia with a male population over 18 years old was recorded at 26.60%. The research used a systematic review method. The databases used are NCBI and PUBMED with bulletions namely Benign prostate hyperplasia AND obesity, Benign prostate hyperplasia AND cholesterol, or Benign prostate hyperplasia AND body mass index. Obesity can trigger pro-inflammatory conditions, one of which is micro vascular disease which results in inflammation triggering ischemia and oxidative stress. Obesity can involve changes in the expression of genes such as A2M in the stroma and TFFB3 in the prostate gland and induce sIL-1ra levels.Obesity is associated with the risk of BPH through inflammatory response mechanisms from cellular and humoral microvascular inflammation, programmed cell death, gene expression and sIL-1ra levels.
Nutrional Management in Chronic Kidney Disease Patients: Manajemen Gizi pada Pasien Chronic Kidney Disease (CKD) Al Farisi, Ahmad Fathin; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.982

Abstract

Chronic Kidney Disease (CKD) is kidney function disorder for >3 months. CKD is also a concern because of its relatively high prevalence and is one of the most common causes of death in Indonesia. A number of treatments that can be carried out in CKD patients depend on the symptoms, comorbidities, and complications in the patient. Management of CKD patients can be medical, operative, to conservative. Assessment of nutritional status is also a concern in patients with CKD because it is not uncommon for a decrease in nutritional status to occur. CKD patients undergoing dialysis treatment are more prone to experience protein-energy wasting (PEW). There are a number of nutritional therapies that can be performed on CKD patients, namely a low-protein diet, regulation of energy intake, oral supplementation, and IPPN/IPAA
Manajemen Terapi Acute Kidney Injury (AKI) Suherman, Auriva Renasha; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.983

Abstract

Acute Kidney Injury (AKI) is a syndrome characterized by decreased urine production and increased serum creatinine. AKI is a complication in 10 to 15% of patients in hospital and the incidence of AKI in the Intensive Care Unit (ICU) is 20 to 50%. AKI has 3 stages and based on etiology it is divided into 3, namely pre-renal, renal, and post-renal. AKI can be a complication of disease and can cause complications up to end-stage kidney disease. Biomarkers of AKI are not only a guide in diagnosis, but also a guide in the management of AKI. Prevention and management of AKI needs to be carried out in patients. Several AKI treatments that can be carried out include the administration of isotonic crystalloid, Hydroxerthylstarch, vasopressors, diuretics, vasodilators, GF intervention, glycemic control, and nutritional support.
Diagnosis And Treatment of Testicular Torsion Hilmi, Tamadar; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.987

Abstract

Testicular torsion is an urgent medical condition that occurs when one or both testicles experience rotation or reversal in the scrotum, thereby disrupting blood flow to the testicles. Testicular torsion usually occurs in young male patients (<25 years). If this occurs it can cause rapid testicular ischemia. Furthermore, if ischemia is not treated immediately, it can threaten the safety of the testicles and affect men's reproduction and quality of life. This disease causes 10% to 15% of acute scrotal disease in children, and causes an orchiectomy rate of 42% in boys undergoing testicular torsion surgery. This article discusses testicular torsion, including definition, symptoms, diagnosis, and management. Testicular torsion is characterized by complaints of pain, swelling and/or tenderness in the scrotum, loss of cremaster reflex, Deming's sign and Angell's sign. Apart from that, we will also discuss early detection techniques for testicular torsion, such as physical examination and ultrasound, which are very important for diagnosing this condition quickly. Testicular viability decreases significantly 6 hours after the onset of symptoms therefore early diagnosis is key. Immediate treatment with manual detorsion or surgery is necessary to restore blood flow to the testicle affected by torsion. Delay in action can cause permanent damage to the testicular tissue. Since testicular torsion is a very time-sensitive diagnosis, it may also be subject to many medicolegal challenges.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEJADIAN DISFUNGSI EREKSI PADA PASIEN BENIGN PROSTAT HIPERPLASIA DI RS YUKUM MEDICAL CENTRE Kamalia, Avissa Medina; Hadibrata, Exsa; Susianti, Susianti; Sutyarso, Sutyarso
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1116

Abstract

Benign Prostate Hyperplasia (BPH) is the second most common urology’s disease in Indonesia. This disease occurs due to hyperplasia of stromal cells and epithelial cells of the prostate. The clinical manifestations of this disease consist of obstruction symptoms, irritation symptoms, and post void symptoms. People with BPH often complain about the decrease of their quality of life. One of the factor that Impaired to their quality of life is erectile dysfunction. This study aims to identify the factors that impact the incidence of erectile dysfunction in BPH patients at Yukum Medical Centre Hospital. There were 67 men with bph was obtained from Yukum Medical Centre Hospital in January-September 2021. Data were collected with International Index of Erectile Function-5 questionnaire and medical records. Data were analysis with chi-square test using SPSS and a p-value (<0,05 was considered significant). The result showed that 39 BPH patients had erectile dysfunction. Mean age of BPH patiens with erectile dysfunction was 66,74 (SD±6,51) and mean IIEF-5 scores of the BPH patients was 19,41 (SD±4,23). Age and prostate volume had significant impact with p-value 0,004 and 0,002 respectively. Treatment and medication didn’t have significant impact with p-value 0,193, and 0,856 respectively. Age and prostate volume have a significant impact on the incidence of erectile dysfunction in BPH patients. However, treatment and the type of medication doesn’t impact the risk of incident erectile dysfunction in BPH patients.
PENGARUH PEMBERIAN EKSTRAK LADA HITAM (Piper nigrum L) TERHADAP LIBIDO (PERILAKU SEKSUAL) MODEL TIKUS PUTIH JANTAN (RATTUS NORVEGICUS) DIABETES MELITUS Isvari, Gusti Ayu Made Prathita; Hadibrata, Exsa; Yunianto, Andi Eka; Susianti
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1284

Abstract

Abstract Diabetes Mellitus causes complications in the form of sexual libido dysfunction. Some of the treatment for libido dysfunction was aphrodisiac (piperin) which consist in black pepper. This study aimed to determine the effect of black pepper (piper nigrum l) extract on male white rat (Rattus norvegicus) libido (sexual behavior) with diabetes mellitus. The study was an experimental laboratory with a post-test only control group design using 30 samples of male white rats (Rattus norvegicus) which divided into 5 groups. Each divided into, control group 1 (K1) consist of normal rats; control group 2 (K2), diabetic rats induced by alloxan 150 mg/kg; treatment group 1 (P1), diabetic rats induced by alloxan 150 mg/kg and given black pepper extract 122.5 mg/kg; treatment group 2 (P2), diabetic rats induced by alloxan 150 mg/kg and given black pepper extract 245 mg/kg; treatment group 3 (P3), diabetic rats induced by alloxan 150mg/kg and given sildenafil 1mg/kg. Libido’s measurement was done by observing intromission latency in second, mount latency in second, mount frequency by its quantity. Kruskal-Wallis test was used to analyzed introducing  latency, whereas mounting latency and mounting frequency was analyzed with One Way ANOVA.  The results showed that introducing latency of group P1 and P2 significantly different compared to group K2 (p=0,003, p=0,003), Mounting latency of group P1 significantly different compared to group K2 (p=0,000) and mounting frequency of group P1 and P2 significantly different compared to group K2 (p=0,000,p=0,006). Black pepper extract enhances male white rat (Rattus norvegicus) libido with diabetes mellitus.
Potensi Lada Hitam Sebagai Obat Herbal Terstandar Untuk Disfungsi Ereksi: Literature Review Hasbullah, Faza; Hadibrata, Exsa; Mayasari, Diana
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1390

Abstract

Erectile dysfunction (ED) is a condition that affects men of all ages and backgrounds, characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. First-line treatments for ED, such as Phosphodiesterase-5 Inhibitors (PDE5i), often cause side effects and pose contraindications, especially for patients with cardiovascular diseases. Consequently, various studies have been conducted to explore safer natural remedies. One natural substance proven to enhance erectile function is black pepper. This study implement a literature review approach, examining articles from scientific databases published between 2011 and 2025. Piperine, the active compound in black pepper, exhibits significant antioxidant and anti-inflammatory effects, reduces TNF-α levels, and protects nitric oxide (NO) from free radicals. Piperine also enhances testosterone levels by stimulating Leydig cells, contributing to improved erectile function. Moreover, piperine has been shown to increase the expression of the StAR gene, which plays a critical role in testosterone biosynthesis, essential for the erection process. Studies on animal models demonstrated improvements in sexual behavior, testosterone levels, and total penile reflex following black pepper extract administration. Black pepper holds potential as a natural therapy for ED through mechanisms involving increased NO activity, modulation of testosterone hormones, and protection of Leydig cells. While results from animal studies are promising, further research on humans is required to confirm its efficacy and safety.
Pengaruh Pemberian Ekstrak Etanol Lada Hitam (Piper nigrum L) Terhadap Kadar Gula Darah dan Jumlah Spermatogonia Model Diabetes Tikus Putih Jantan (Rattus norvegicus) Galur Sprague dawley Talin, Jinan Naura; Hadibrata, Exsa; Rudiyanto, Waluyo; Windarti, Indri
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1431

Abstract

Diabetes mellitus that is not treated properly can result in infertility. The piperine content in black pepper can help in the quality of spermatogenesis process and blood sugar levels. This study aims to determine the effect of black pepper (P. nigrum L) ethanol extract on blood sugar levels and the number of spermatogonia in a diabetes model of male white rats (R. norvegicus) Sprague dawley strain. The study used a Posttest-only Randomized Control Group on 24 rats divided into 4 groups. All groups were induced with alloxan 150 mg/kgBW except for KN. P1 and P2 were given 122.5 mg/kgBW and 245 mg/kgBW black pepper ethanol extract. Blood sugar levels were checked using Easy Touch GCU with a normal limit of 50-135 mg/dL. The number of spermatogonia was calculated using a tool, namely ImageJ. The data were analyzed using the Shapiro- Wilk normality test and homogeneity test, followed by the Kruskal Wallis non-parametric test and the Post Hoc test. The statistical results of blood sugar levels obtained normally distributed data p>0.05, non-homogeneous data p<0.05, significant Kruskal-Wallis test results and continued Post Hoc test obtained significant results at P2 and K-. The number of spermatogonia obtained normally distributed data p>0.05, non-homogeneous data p<0.05. The results of the Kruskal-Wallis test were significant p<0.05 and continued Post Hoc test obtained significant results at P2 and P1. There was a decrease in blood sugar levels in the administration of black pepper ethanol extract (P. nigrum L) in the diabetes model of male white rats (R. norvegicus) Sprague dawley strain. However, there was no effect of administering black pepper ethanol extract (P. nigrum L) on the number of spermatogonia in the diabetes model of male white rats (R. norvegicus) Sprague dawley strain.
Co-Authors Ade Yonata, Ade Al Farisi, Ahmad Fathin Alfahri, Farhan Dzaki Armadani, Melni Atri Sri Ulandari Bayu Anggileo Pramesona Betta Kurniawan, Betta Daulay, Suryani A. Dwiputri, Maliya Finda Endah Setyaningrum, Endah Fadli, Muhammada Yogi FAUZAN ABDILLAH Fauzi Ahmad Muda Febrianta, Muhammad Kaisar Firdaus, Purna Fredison, Fredison H R Danarto Happy, Terza A Hasbullah, Faza Hendri Busman Hilmi, Tamadar Ikhsan, Muhammad Al Indri Windarti Intanri Kurniati Isvari, Gusti Ayu Made Prathita Iswandi Darwis Jausal, Anisa Nuraisa Kamalia, Avissa Medina Larasati, Ratri M. Lusina, Septia Eva M. Ridho Ulya Mayasari, Diana Muhammad Maulana Nadifa, Shallu Afdha Oktadoni Saputra, Oktadoni Priyono, Angga Hendro Rahmayani, Fidha Ramdini, Dwi Aulia Rasyid, M. Fauzan Abdillah Risal Wintoko Risti Graharti Rizki Hanriko Rudiyanto, Waluyo Siregar, Bintang Abdi Suharmanto Suherman, Auriva Renasha Susianti Susianti Susianti Sutyarso Sutyarso Sutyarso Talin, Jinan Naura Tjahjo, Mars Dwi Trisula Utomo Untung Tranggono, Untung War, Muhammad Fitra Wardhana, Muhammad Fitra Widia, Chyci Wiwi Febriani Yunianto, Andi Eka Yuningrum, Hesti Yusmaidi, Yusmaidi