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All Journal Majalah Kedokteran Bandung Jurnal Online Mahasiswa (JOM) Bidang Keguruan dan Ilmu Pendidikan Lisanuna: Jurnal Ilmu Bahasa Arab dan Pembelajarannya Sari Pediatri JCES (Journal of Character Education Society) Journal of Epidemiology and Public Health Current : Jurnal Kajian Akuntansi dan Bisnis Terkini COURT REVIEW: Jurnal Penelitian Hukum Narra J ALEXANDRIA: Journal of Economics, Business, and Entrepreneurship Jurnal Pijar MIPA Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Journal of Education, Cultural, and Politics AHKAM : Jurnal Hukum Islam dan Humaniora Jurnal Pengabdian Masyarakat Bangsa Buletin Pengabdian PORTAL ABDIMAS Grimsa Journal of Science Engineering and Technology Syiah Kuala Psychology Journal The Indonesian Journal of Computer Science Bakoba: Journal of Social Science Education Journal of Ethics and Character Education Jurnal Wicara Desa Al-Irfan: Journal Of Arabic Literature and Islamic Studies Scientific Journal for Nation Building
Aini, Zahratul
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Journal : Grimsa Journal of Science Engineering and Technology

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Rational Use of Proton Pump Inhibitors Among the Early Aging Population: Evidence from a Community Health Center in Indonesia Suryawati, Suryawati; Animalika, Lulu; Narisa, Maghyan; Suardi, Hijra Novia; Aini, Zahratul; Mulia, Vera Dewi; Maghfirah, Desi
Grimsa Journal of Science Engineering and Technology Vol. 4 No. 1 (2026): April 2026
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v4i1.116

Abstract

Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide and are widely used for the management of acid-related disorders, particularly among adults in their early ageing period, where concerns about inappropriate prescribing remain prevalent. This study aimed to evaluate the rational use of PPIs among adults aged ≥46 years at a primary healthcare centre in Banda Aceh, Indonesia. This study focuses on the appropriateness of indications, dosages, and durations, as well as potential drug–drug interactions. Dose appropriateness was assessed using Lexicomp standard adult dosing. Duration and appropriateness of indications were assessed according to the Indonesian Gastroenterology Consensus. A retrospective cross-sectional study was conducted, comprising 1,997 records. A sample of 107 patients who met the predefined inclusion and exclusion criteria was analysed. Most patients were aged 56–65 years and predominantly female, with dyspepsia as the main indication. Omeprazole was prescribed in all cases, commonly at 20 mg twice daily. Nearly half of prescriptions were inappropriate, and appropriate dosing was limited. While treatment duration was generally adequate, some cases were shorter than recommended. Potential drug–drug interactions were identified but were mostly of low clinical significance. Overall, the rational use of PPIs among the patients in this primary healthcare setting remains suboptimal, particularly in terms of indication and dosing. These findings highlight the need to strengthen adherence to clinical guidelines and to implement regular medication reviews to promote safer, more rational PPI use in this population.
Co-Authors Abidin, Awwalul Adista, Muhammad Ansari Afifi, Muhammad Ridho Aida, Welven Aini, Dinatul Aini, Niza Husnul Aini, Zalfa Zahya Al Rafni Aminarti, Dini Animalika, Lulu Apriani , Nurul Aulia Aprilia, Dwi Ayu Ari Natalia Probandari Azkia, Tina Imro’atun Buan Anshari Buhori Muslim Cantika, Mira Dewi, Fitria Meutia Elfirza, Elfirza Eti Poncorini Pamungkasari Fatmariza Fatmariza Fazliah, Nurul Fuada, Nurul Geumpana, Teuku A. Gunawan Santoso Hafiz, Lalu Muhamad Fajri Hakim, Hamdi HARDIANTO - Hariadi Yasni, Hariadi Henny Purwaningsih Herlina Dimiati, Herlina Hermawan, Cecep Maman Hijra Novia Suardi I Made Suartika Ibrahim, Tilaili Indrianti, Cahaya Lalu Hamdani Husnan, Lalu Hamdani Husnan Maghfirah, Desi Maharani, Cut Rika Maharani, Disa Belvia Maly, Solhana Arwin MARDIANA Mira Delima Moneta, Lily Rezky Muffidah, Muhammad Asrarul Muhamad Irham, Muhamad Muhammad Reza Mulia, Vera Dewi Nadhirah, Cut Narisa, Maghyan Nestita, Nesa Ningsih, Ayu Cahya Nurin Rochayati Nurul Indriani Nurwijayanti Nuwansa, Riski OKTA ROSFIANI Pratama, Angga Bagus Rachmad Suhanda Raden Mohamad Herdian Bhakti Rizaldy Khair Rizki, Beni Rovy Pratama, Rovy Safariah, Safariah Safitri, Alia Safitri, Auliya Salsabila, Nisa Saputra, Irwan Sehatta Saragih Sitti Wajizah Suhermi, Suhermi Sujudin, Sujudin Sukma D Suryanef Suryanef Suryawati Suryawati Syahrizal Syahrizal Tun Tedja Irawadi Ulfayati, Sri Utami, Nadia Fitri Waraztuty, Ika Yodita, Zahrawana Putri Yurliasni Yurliasni Zahra, Misfhilatud Zainuddin, Zainuddin Zaujatul Amna, Zaujatul Zuraida Hanum