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All Journal Biospecies Jurnal Anestesiologi Indonesia Majalah Kedokteran Bandung Biology, Medicine, & Natural Product Chemistry JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) The Indonesian Biomedical Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kesehatan Vokasional JURNAL PENELITIAN PENDIDIKAN MIPA GHIDZA: Jurnal Gizi dan Kesehatan Jambura Journal of Health Sciences and Research Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Maternitas Kebidanan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Journal of Telenursing (JOTING) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Pancasakti Journal Of Public Health Science And Research Ahmar Metastasis Health Journal (AMHJ) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Journal of Pharmaceutical and Sciences.
Mutia, Maya Sari
Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Prima Indonesia, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Effect of sunkist orange peel nanoparticle granules on cardiac and aorta histopathology in diabetic rats Sihotang, Widya Yanti; Putri, Indah Juwita Dwi; Henny, Henny; Suandy, Suandy; Mutia, Maya Sari
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4426

Abstract

Sunkist oranges (Citrus sinensis (L.) Osbeck) is rich in anthocyanins (95% of which are represented by cyanidin-3-glucoside and cyanidin-3-6"-malonyl-glucoside), flavanones (hesperidin and narirutin), hydroxycinnamic acid, carotenoids, sugars, minerals, and fiber, which offer health benefits. This study aimed to evaluate the efficacy of sunkist orange peel nanoparticle granules on the histopathological appearance of the cardiac and aorta in alloxan-induced diabetic rats. This study used a post-test experimental design, with a control group. Twenty-five male Wistar rats were randomly divided into five groups: negative control (alloxan+distilled water), positive control (alloxan+metformin), treatment 1 (alloxan+granular nanoparticles 50 mg/kg BW), treatment 2 (alloxan+granular nanoparticles 70 mg/kg BW), and treatment 3 (alloxan+granular nanoparticles 100 mg/kg BW). The heart and aorta were prepared for observation using 10x ocular magnification and 40x objective lens magnification. Kruskal-Wallis statistical test results revealed a significant difference in the average cardiac histopathological score between the treatment groups (p = 0.011). The amount of aortic endothelial cell damage can be seen from the presence of foam cells in the K(-) treatment group, while the K(+), P1, P2, and P3 groups did not have foam cells in the aortic endothelium. The findings of this study indicate that sunkist orange peel extract nanoparticles in granular form improve cardiac and aortic histopathology, with a dose of 100 mg/kg BB being the best dose for improving cardiac and aortic histopathology.
Effect of sunkist orange peel extract nanoparticle granules on the lipid profile levels in diabetic wistar rat Mutia, Maya Sari; Harahap, Safriani; Nurhady, Fahira Zahra; Gunawan, Robby; Dewani, Yunita; Chairul, Muhammad; Fadillah, Qori
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4439

Abstract

The research was conducted to determine the effect of Sunkist orange (Citrus sinensis (L.) Osbeck) peel extract nanoparticles in granular form on lipid profile levels in alloxan-induced Wistar rats (Rattus norvegicus). The study employed an experimental method with a posttest-only control group design. The population for this research was Wistar rats. The study used five treatment groups, resulting in a total of 25 rats, with five rats in each treatment group, as determined using the Federer formula. After the administration of sunkist orange peel extract nanoparticles at different doses for 14 days, the results showed a decrease in total cholesterol, LDL, triglycerides, and HDL levels. The research findings demonstrated the influence of reducing lipid profile levels in diabetic rats. The effective dose for reducing the lipid profile in this study was found to be 100 mg for total cholesterol, 70 mg for triglyceride, and 70 mg for both HDL and LDL when using the ethanol extract of sunkist orange peel.
Liver Protection Effect of Red Rose Petal Methanol Extract in Copper-Induced Liver Injury in Male Wistar Rats Hutagalung, Caroline Febrina; Girsang, Ermi; Mutia, Maya Sari; Suhartina, Suhartina; Natali, Oliviti
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.507-513

Abstract

The human body requires low amounts of copper to maintain homeostasis, but high copper intake can cause various health problems. Many previous studies have been performed to look for natural products that can neutralize the excessive copper effect; one such natural product is a rose petal. Therefore, this study aims to investigate the liver protection effect of rose petals in copper-induced liver injury in male Wistar rats. This experimental study used thirty male Wistar rats that were grouped into five groups, including control, standard (quercetin), Rose Petal Methanol Extract-1 (400 mg/kg BW), 2 (800 mg/kg BW), and 3 (1,200 mg/kg BW). All groups were treated for 14 days, and all rats were given copper (II) sulfate suspension for the last three days. On the fifteenth day, all rats were sacrificed to obtain blood and liver tissue SGOT, SGPT, and liver histology study. The results showed that rose petal methanol extract significantly decreased SGOT and SGPT levels compared to the control group (P-value <0.05). The reduced area of ballooning degeneration and necrosis were in line with the increased dose of rose petal extract supported the liver protection effect of rose petal extract. Therefore, it can be concluded that rose petal methanol extract protects the liver against copper impacts.
Nephroprotective Effects of Sunkist Peel Ethanol Extract on Diabetic Nephropathy Mutia, Maya Sari; Ginting, Chrismis Novalinda; Yulizal, OK; Suhartomi, Suhartomi; Sihotang, Widya Yanti
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3496

Abstract

The most common long-term diabetic complication is diabetic nephropathy which, in most cases, falls into the End-Stage Kidney Disease. Numerous studies on the nephroprotective effects of citrus fruit have been conducted recently. This study was performed to investigate the phytochemical properties of Sunkist peel ethanol extract and their possible effects on improving diabetic nephropathy. To get the extract, the Sunkist peels were macerated and the extract was analyzed by GC-MS. An in vivo assay of five different groups of 25 male Wistar rats was then performed using the extracts. The groups included control, standard, 500 mg/kg extract, 750 mg/kg extract, and 1,500 mg/kg BW extract. All rats were sacrificed after 28 days of treatment and VEGF level serum and kidney histology analysis were performed. The VEGF data were first analyzed descriptively, followed by one-way ANOVA or Kruskal-Wallis test based on the data distribution. Meanwhile, the kidney histology was observed and narratively described. Results showed that the Sunkist peel ethanol extract has a potential effect to suppress the VEGF level (p-value < 0.05). The extract at the highest dose revealed the mildest pathology damage in the form of tubular structure degeneration without any glomerular damage. This study indicates that Sunkist peel extract has nephroprotective effects from its various phytochemical compounds that work as antioxidants and anti-inflammation.
Effects Of Combination Sunkist and Lime Peel Nanoparticle Granules on Oxidative Stress and Heart Histopathology in Diabetes Rats Sihotang, Widya Yanti; Mutia, Maya Sari; Chairul, Muhammad; Irwanda, Desi Danilah; Nabila, Putri; Hamsi, Ulpah Zahara
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 10 No.2 November 2024
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v10i2.18973

Abstract

Diabetes mellitus and its consequences are significantly influenced by oxidative stress. Sunkist and lime oranges are a nutritional powerhouse, offering a range of health benefits due to their high content of antioxidants, vitamins, minerals, and fiber. Key compounds like anthocyanins, flavanones, and hydroxycinnamic acid contribute to their potential positive impact to reduce oxidative stress. Therefore, the effect of nanoparticle granules combination of sunkist orange peel and lime peel was investigated on diabetic rats. Twenty male Wistar rats were randomly distributed:  Group 1 as control group given distilled water, Group 2 as DM group with alloxan, Group 3 with DM + NGSLP 100mg / kgBW, Group 4 with DM + NGSLP 200mg / kgBW. Rats with diabetes were treated by intraperitoneal injection with 100 mg/kg alloxan. NGSLP treatment was given for 14 days to each treatment group. At the end, the blood and heart tissue were collected and used to determine the GPx enzyme, SOD, MDA, CAT and histological evaluation. Diabetes induction increased the level of MDA and decreased after treated with NGSLP. In diabetic rats treated with NGSLP showed an increase in SOD, GPX and CAT in blood. Histopathological findings of heart tissue showed the protective effect of NGSLP in rats with diabetic. This study revealed that NGSLP has antioxidant effects in the blood and heart of alloxan-induced diabetic rats.
UJI EFEKTIVITAS EKSTRAK ETANOL PAKKAT (CALAMUS CAESIUS BLUME) DAN BIJI PALA (MYRISTICA FRAGRANS HOUTT) TERHADAP BAKTERI PADA IKAN SALAI DI DAERAH ROKAN HULU Sitepu, Bintang Darma M; Lubis, Yolanda Eliza Putri; Mutia, Maya Sari
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.34457

Abstract

Pakkat atau juga dapat di sebut Rotan Muda merupakan makanan khas suku maindailing. Hasil skrining fitokimia dari tumbuhan pakkat ini menunjukan bahwa terdapat golongan senyawa trepenoid, saponin, flavonoida dan tannin yang termasuk golongan metabolik sekunder. Tanaman pala pada bagian biji, daging, buah dan kulit telah banyak dimanfaatkan sebagai antibakteri, Biji buah pala (Myristica Fragrans Houtt) mengandung minyak atsiri, saponin, terpenoid, flavonoid, yang diketahui berpotensi sebagai antibakteri. Tujuan penelitian ini adalah mengetahui efektivitas ekstrak pakkat dan biji pala terhadap Bakteri yang terdapat pada ikan salai. Jenis Jenis penelitian yang di gunakan adalah eksperimen. Penelitian ini dilakukan di Laboraterium Basic Science Universitas Prima Indonesia pada bulan Maret 2024 sampai bulan Juni 2024. Populasi ikan salai dengan berat 10-30 gram. Ekstrak Pakkat ada 5 kelompok yaitu K-, K+ amoxixilin dan ciprofloxacin, ekstrak pakkat 12,5%, 25% dan 50% dan ekstrak biji pala 12,5%, 25% dan 50%. Analisa data menggunakan uji kruskall-wallis. Hasil uji statistik Kruskal Wallis menunjukkan zona hambat pada ekstrak biji pala dengan nilai rata rata paling tinggi di konsentrasi 50% yaitu 8,05 mm dalam kategori sedang, tetapi tidak efektif untuk di jadikan sebagai antibakteri karena belum masuk kategori zona hambat kuat atau sangat kuat. tidak terdapat zona hambat ekstrak pakkat dan biji pala terhadap Shigella dan S-Aureus (p>0,05), tidak terdapat efektivitas ekstrak pakkat dan biji pala terhadap bakteri pada ikan salai dan tidak ditemukan dosis yang efektif terhadap pemberian ekstrak pakkat pada ikan salai.
Pemanfaatan Ekstrak Biji Labu Kuning (Cucurbita moschata) sebagai Sediaan Krim Anti-Aging Mutia, Maya Sari; Rusip, Gusbakti; Kurniawan, Gracella Verren; Sartika, Dewi; Nadia, Felanda Ahsan; Henny, Henny
Jurnal Kesehatan Vokasional Vol 9, No 4 (2024): November
Publisher : Sekolah Vokasi Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkesvo.99524

Abstract

Latar Belakang: Meningkatnya kesadaran akan pentingnya perawatan kulit berbahan alami mendorong permintaan produk anti-aging. Biji labu kuning (Cucurbita moschata) yang mengandung antioksidan seperti vitamin E, karotenoid, dan asam lemak esensial, efektif melawan radikal bebas dan memperlambat penuaan kulit, menjadikan pilihan tepat untuk krim anti-aging ramah lingkungan.Tujuan: Penelitian ini  bertujuan untuk mengetahui manfaat dari ekstrak biji Cucurbita Moschata sebagai krim anti-penuaan.Metode: Penelitian ini menggunakan metode eksperimen dengan desain Pretest-Posttest Control Group. Penelitian dilakukan di Laboratorium Farmakologi Fakultas Farmasi Universitas Sumatera Utara (Mei-Juli 2024). Sampel berupa krim anti-aging dengan ekstrak biji labu kuning, yang diuji pada lima kelompok tikus: kontrol negatif, kontrol positif, dan tiga kelompok dengan konsentrasi 4%, 8%, dan 12%. Data dianalisis menggunakan uji Wilcoxon pada SPSS untuk menilai efektivitas dosis krim terhadap tanda penuaan.Hasil: Ekstrak biji labu kuning dengan konsentrasi 4%, 8%, dan 12% terbukti efektif meningkatkan kelembapan kulit. Analisis histopatologi menunjukkan bahwa konsentrasi 12% secara signifikan meningkatkan kepadatan serat kolagen, mendukung efektivitas krim dalam mengatasi tanda-tanda penuaan.Kesimpulan: Ekstrak biji labu kuning dengan konsentrasi 4%, 8%, dan 12% efektif meningkatkan kelembapan, aktivitas antioksidan, dan densitas kolagen. Konsentrasi 12% sebagai dosis optimal yang memberikan hasil terbaik dibandingkan konsentrasi 4% dan 8%.
Uji Efektivitas Antibakteri Ekstrak Etanol Pakkat (Callamus Caesius Blume) dan Ekstrak Jeruk Nipis (Citrus Aurantifolia) terhadap Bakteri Escherichia Coli ATCC 25922 Monica, Veny; Lubis, Yolanda Eliza Putri; Mutia, Maya Sari
Journal of Telenursing (JOTING) Vol 6 No 2 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i2.13225

Abstract

The purpose of this study was to determine the comparison of the antibacterial effectiveness test of packet extract (calamus caesius Blume) with lime extract (citrus aurantifolia) against Escherichia coli ATCC 25922 bacteria—experimental research method with in vitro design. The results showed that the inhibition zone in lime extract with the highest average value at a concentration of 100% was 9.23 mm in the moderate category. Still, it was not effective as an antibacterial because it had not entered the category of strong or very strong inhibition zones. The conclusion is that there is no inhibition zone of pakkat extract against the growth of Escherichia coli ATCC 25922 bacteria (p>0.05) and there is an inhibition zone of lime extract but it is not significant against the growth of Escherichia coli ATCC 25922 bacteria (p>0.05). Keywords: Pakkat Extract, Lime Extract, Bacteria Escherichia Coli Bacter
Efficacy of Ginger (Zingiber officinale) and Celery (Apium graveolens L.) Extracts on Hair Growth in Wistar Rats (Rattus norvegicus) Lie, Maylia; Nasution, Ali Napiah; Mutia, Maya Sari; Arviandi, Rizki; Sulistijanto, Eddy
Ahmar Metastasis Health Journal Vol. 4 No. 2 (2024): Ahmar Metastasis Health Journal
Publisher : Yayasan Ahmad Mansyur Nasirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/amhj.v4i2.353

Abstract

Ginger (Zingiber officinale) and celery (Apium graveolens L.) are well-known for their anti-inflammatory and antioxidant properties, and they have been traditionally used to treat hair loss. However, scientific evidence regarding their effectiveness in stimulating hair growth is still limited. This study aims to evaluate the effects of ginger and celery extracts on hair growth in Wistar rats, focusing on growth onset, duration, regrowth, and potential inflammatory effects on the skin. The research method used a total of 25 Wistar rats randomly divided into five groups: control (paraffin), standard (minoxidil), ginger extract, celery extract, and a combination of ginger and celery extracts. Each extract was administered at a dosage of 20 mg/ml. The study monitored the onset, duration, and regrowth scores of hair growth. Histological examinations were performed to assess hair follicle density and inflammation levels. Phytochemical analyses of the extracts were conducted to identify the presence of flavonoids, alkaloids, glycosides, saponins, tannins, and steroids/triterpenoids. The research results show that phytochemical analysis revealed that ginger contains flavonoids, alkaloids, glycosides, and steroids/triterpenoids, while celery contains flavonoids, alkaloids, saponins, tannins, glycosides, and steroids/triterpenoids. The analysis showed no significant differences in hair growth onset, duration, or regrowth scores between the treatment groups and the control group. Histological analysis indicated that the average number of hairs ranged from 4 to 10 per field of view, with the highest count observed in the ginger extract group and the lowest in the celery extract group. Most slides showed light or no inflammation. The conclusion that the tested dosage, ginger and celery extracts did not have a significant impact on the onset, duration, or regrowth of hair in Wistar rats and showed minimal inflammatory responses. Although these extracts contain phytochemicals with known biological activity, they did not demonstrate significant effects on hair growth at the given dosage. Further research with different dosages and compounds is necessary to explore their full potential for hair growth and skin health.
PERANAN ZINC DAN VITAMIN E SEBAGAI ANTIOKSIDAN TERHADAP SEPSIS AKIBAT INFEKSI BAKTERI STAPHYLOCOCCUS AUREUS: SYSTEMATIC LITERATURE REVIEW Napitupulu, Olivia Des Vinca Albahana; Rusip, Gusbakti; Mutia, Maya Sari
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 1 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i1.2797

Abstract

Sepsis caused by S. aureus infection is a serious condition requiring effective interventions to improve clinical prognosis. This study aimed to review the role of zinc and vitamin E as antioxidants in sepsis management through a systematic literature review (SLR) following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The research procedure consists of four main stages: identification, screening, eligibility, and inclusion, followed by qualitative data analysis. The review results showed that zinc and vitamin E significantly contribute to reducing NF-κB activation and inflammation, playing a crucial role in enhancing bacterial clearance and patient survival, particularly in neonates. Vitamin E functions as an antioxidant by preventing lipid peroxidation and increasing endogenous antioxidant levels such as glutathione and superoxide dismutase (SOD). Furthermore, vitamin E exhibits anti-inflammatory effects, as evidenced by the reduction of inflammatory biomarkers, including TNF-α and IL-6, which help protect vital organs such as the lungs and liver from inflammatory damage. Zinc, on the other hand, improves immune responses and reduces excessive inflammation, indicating that these two compounds can synergistically improve clinical outcomes in sepsis patients. This finding confirms that zinc and vitamin E supplementation has the potential to serve as an effective supportive strategy in reducing oxidative stress, modulating inflammation, and improving the prognosis of sepsis caused by Staphylococcus aureus.
Co-Authors Andika, Muhammad Insan Annisa, Elvia Arviandi, Rizki Bangun, Primta Br Sitepu, Rachel Maria Cruz Jovanca Chairul, Muhammad Damayanti, Etha Wilda Hasiani Depari, Sania Angelisa F Dewani, Yunita DEWI SARTIKA Dewi, Silvi Tiara Diana S, M Putri Elmiam, Dwi Fadillah, Qori Faridahanum, Faridahanum Fau, Solinia Kifami Yohana Maria Vianne Fitrisia, Rina Ginting, Chrismis Novalinda Girsang, Ermi Gunawan, Robby Gurusinga, Fransisco Bastanta Gusbakti Rusip Hamsi, Ulpah Zahara Harahap, Safriani Hasibuan, Patimah Fitriansyari Henny Henny, Henny Hutagalung, Caroline Febrina Irwanda, Desi Danilah Kurniawan, Gracella Verren Lie, Maylia Lina, Juliana Lister, INE Lisya, Cut Manalu, Cici Valentina Mangkuanom, Adrian Saleh Marpaung, Febri Sri Marpaung, Febri Sri Astuti Meilando, Rifki Meutia, Rena Michiko, Michiko Monica, Veny Nabila, Putri Nadia, Felanda Ahsan Napitupulu, Olivia Des Vinca Albahana Nasution, Ali Napiah Nasution, Tamimi Badzlina Natali, Oliviti Nathasia, Ingee Nurhady, Fahira Zahra Putra, Ananda Rahmat Putri, Indah Juwita Dwi Putri, Shafyra Mahdyah Ramadhini, Amelya Putri Rambe, Daffa Jihan Azmi Razoki, Razoki Ritonga, Lapita Sarkiah Salsabila, Dinda Ayu Sanjaya, Erfan Sari, Ajeng Mestika Silitonga, Impola Dinita Felicia Sipayung, Yelvreza Rastiani Siregar, Lisdawaty Sitepu, Bintang Darma M Suandy, Suandy Suhartina Suhartina, Suhartina SUHARTOMI . Sulistijanto, Eddy Suyono, Tan Tambunan, Adrian Nurrachman Tambunan, Andika Zayani Tampubolon, Ester Juanita Tampubolon, Ester Juanita br. Tio, Susanthy Widya Yanti Sihotang Winato, Brigad Mahardika Yolanda Eliza Putri Lubis Yulizal, Ok