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All Journal Biospecies Jurnal Anestesiologi Indonesia Majalah Kedokteran Bandung Biology, Medicine, & Natural Product Chemistry JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Kesehatan Vokasional JURNAL PENELITIAN PENDIDIKAN MIPA Jambura Journal of Health Sciences and Research Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Maternitas Kebidanan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Journal of Telenursing (JOTING) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Journal of Pharmaceutical and Sciences.
Mutia, Maya Sari
Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Prima Indonesia, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences

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The Effect of Sunkist Orange (Citrus Sinensis (L.) Osbeck) Granule Extract on Ovarian Follicle Histomorphology in Female Rats (Rattus Norvegicus) with Obesity Mutia, Maya Sari; Faridahanum, Faridahanum; Silitonga, Impola Dinita Felicia; Ramadhini, Amelya Putri; Sari, Ajeng Mestika; Lubis, Yolanda Eliza Putri; Sihotang, Widya Yanti
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Obesity is a medical condition in which a person experiences abnormal fat accumulation that exceeds normal limits, which can have a negative impact on health. Obesity sufferers are increasing, especially in developed and developing countries. The prevalence of obesity is estimated to be 42% in 2030. Risk factors that can cause obesity include unhealthy lifestyles and lack of physical activity. When there is excess fat accumulation in the body, there will be an increase in leptin levels in the body resulting in oxidative stress that triggers the emergence of free radicals that can inhibit the growth of follicles in the ovaries. To neutralize free radicals in the body, antioxidants are needed. One type of fruit that is rich in antioxidants is sunkist oranges (Citrus sinensis (L) Osbeck), this study discusses the effect of giving sunkist orange granule extract (Citrus sinensis (L) Osbeck) on the morphology of ovarian follicles in obese female wistar rats (Ratus norvegicus). Using a laboratory experimental research design with a post-test only control group design, using 25 female rats divided into 5 groups, namely the Negative Control Group, the Positive Control Group (Alloxan and High Fat), and the Treatment Group given alloxan and Sunkist orange granule extract at a dose of 50 mg / kgBW / day, 100 mg / kgBW / day, 150 mg / kgBW / day. Results: Sunkist Orange Granule Extract (Citrus sinensis (L.) Osbeck) has a significant effect on the histomorphology of ovarian follicles with obesity induction in female rats (Rattus norvegicus).
The Effect of Sunkist Orange (Citrus Sinensis (L.) Osbeck) Peel Granule Extract on Testicular Histophatology in Male Rats (Rattus Norvegicus) with Obesity Mutia, Maya Sari; Br Sitepu, Rachel Maria Cruz Jovanca; Putri, Shafyra Mahdyah; Gurusinga, Fransisco Bastanta; Lubis, Yolanda Eliza Putri
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

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Abstract

Obesity is a body condition where there is excessive weight gain due to an imbalance between calories consumed and energy expended so that calories accumulate in fat tissue. In Indonesia, there are 14.8% of the population aged > 18 years who are obese. The basic principle of obesity is that there is an imbalance between three aspects, namely food intake (intake), energy expenditure (output), and energy storage. The result of the imbalance in energy intake and output, where energy intake is greater than energy expenditure, will cause the accumulation of fat tissue in the body and will be stored as energy reserves. Obesity is a predisposing factor for various health problems. One of them is the quality of a person's reproduction which results in infertility. To find out that the extract of sunkist orange peel granules can affect the histopathology of testis in male mice with obesity, this study used an in vivo laboratory experimental method with a research design of Post Test Only Control Group Design. In this study, there were 25 male rats divided into 5 groups, with a negative control group (normal rats without treatment), a positive control group (rats induced with high-fat feed), a treatment group of rats induced with high-fat feed with Sunkist orange peel extract granules (Citrus Sinensis (L.) Osbeck) at a dose of 50 mg/KgBW, 100 mg/KgBW, and 150 mg/KgBW. Conclusion: Sunkist orange peel granule extract (Citrus Sinensis (L.) Osbeck) had an effect on blood glucose levels, total cholesterol, and body weight, but did not show a significant effect on the histopathological results of the testes in male rats.
Unmet need for family planning among women visiting community health Nathasia, Ingee; Rusip, Gusbakti; Mutia, Maya Sari
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5569

Abstract

The unmet need for family planning is a significant reproductive health issue, particularly in developing countries. This study aimed to identify the factors associated with the unmet need for family planning among women visiting puskesmas in Medan City. This study used a cross-sectional design and included 186 participants. Data were collected using questionnaires. Data were analyzed using the chi-squared test and logistic regression. The results showed that age, education, knowledge, and perception of family planning were significantly associated with an unmet need for contraception (p<0.05). The younger the age, the lower the level of education, the lower the knowledge and perception of family planning, and the higher the likelihood of an unmet need for contraception. In contrast, family income and parity were not significantly associated with the unmet need for family planning. Satisfaction with family planning services was also not significantly associated with unmet need for contraception. The results highlight the importance of comprehensive interventions to address the unmet need for family planning. Educational programs targeting younger age groups, especially those with low educational levels, need to be improved. Additionally, efforts to improve knowledge and change community perceptions of family planning are crucial.
Combination of Vitamin D and Vitamin E Against Bacterial Infections Bangun, Primta; Rusip, Gusbakti; Mutia, Maya Sari
JAI (Jurnal Anestesiologi Indonesia) Vol 17, No 2 (2025): JAI (Jurnal Anestesiologi Indonesia)
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v0i0.69122

Abstract

Bacterial infections are a significant health problem worldwide, caused by various microorganisms that can infect different parts of the human body. Bacteria are single-celled microorganisms that can be found in various environments, including in the human body, and most of them are harmless. However, some species of bacteria can cause serious infections and inflammation that require proper medical attention. Some examples of bacteria that cause infections include Streptococcus pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Vibrio cholerae, Mycobacterium tuberculosis, Escherichia coli, and Staphylococcus aureus. A sufficient vitamin D level in the body can enhance antimicrobial activity against various pathogens, including bacteria, viruses, and fungi. Vitamin E is known to be a powerful antioxidant and has a positive effect on the immune system. It plays a role in protecting immune cells from oxidative damage and enhancing the immune response to infection. The combination of vitamins D and E offers significant potential in the prevention and management of bacterial infections, as both contribute to improved immunological function through different and complementary mechanisms.
Review Article: Pharmacological Activities and Bioactive Potential of Chinese Betel Leaf (Peperomia pellucida L. (Kunth.)) Razoki, Razoki; Lister, INE; Mutia, Maya Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1000

Abstract

Background: Peperomia pellucida L. Kunth (sirih cina) is a traditional medicinal plant used to treat various ailments. Its broad pharmacological potential needs to be consolidated from various publications to provide a comprehensive overview. Objective: This review aims to analyze and synthesize recent scientific evidence on the pharmacological activities, bioactive compounds, and potential applications of Pperomia pellucida. Methods: This systematic review was conducted by searching electronic databases (Google Scholar, PubMed, ScienceDirect, Scopus) using relevant keywords. From the search results, 21 original research articles published between 2015-2025 that met the inclusion criteria were analyzed descriptively and qualitatively. Results: The analysis revealed that Peperomia pellucida possesses diverse pharmacological activities, including anti-inflammatory, antibacterial, antifungal, antioxidant, anticancer, antidiabetic, antihypercholesterolemic, and osteogenic effects. These activities are supported by bioactive compounds such as flavonoids, tannins, alkaloids, and saponins. Its ethanolic extract has proven effective in in vitro and in vivo tests, including in topical formulations like creams and acne serums. Preliminary safety profiles indicate non-toxic properties. Conclusion: Peperomia pellucida shows great potential as a natural raw material for developing herbal medicines and cosmetics. Further research, such as human clinical trials and the development of technology-based formulations, is necessary to ensure its long-term safety and efficacy.
FORMULASI DAN AKTIVITAS GEL EKSTRAK DAUN PEGAGAN (CENTELLA ASIATICA (L) URBAN) TERHADAP PERTUMBUHAN BAKTERI PENYEBAB JERAWAT Ritonga, Lapita Sarkiah; Meutia, Rena; Mutia, Maya Sari
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.30520

Abstract

Tanaman pegagan (Centella Asiatica (L) Urb) memiliki banyak kandungan bahan aktif seperti saponin, triterpenoid serta kandungan kimia yang terbagi menjadi beberapa golongan seperti flavonoid, minyak atsiri, asam amino dan triterpenoid. Jerawat merupakan penyakit multifactorial yang berkembang didalam folikel sebaseus yang ditandai dengan adanya erupsi komedo, popul, pustule, nodus dan kista pada tempat seperti muka, leher lengan atas, dada dan punggung. Bentuk sediaan gel lebih baik digunakan pada pengobatan jerawat karena sediaan gel dengan pelarut yang polar lebih mudah dibersihkan dari permukaan kulit. Penelitian ini bertujuan untuk mngetahui bahwa tanaman daun pegagan (Centella Asiatica (L) Urban) dapat diformulasikan dalam bentuk sediaan gel sebagai antibakteri. Metode Penelitian yang digunakan adalah metode eksperimental dengan meliputi pembuatan simplisia, pembuatan ekstrak dan melakukan pembuatan sediaan gel dari ekstrak etanol daun pegagan (Centella Asiatica (L) Urban) serta melakukan uji aktivitas antibakteri terhadap pertumbuhan bakteri Staphylococcus epidermidis. Hasil penelitian menunjukkan bahwa formulasi yang memiliki daya hambat tertinggi terhadap bakteri Staphylococcus epidermis yaitu konsentrasi 15 mg/ml dimana zona hambat yang dihasilkan sebesar 22,68 mm dan Ekstrak daun pegagan (Centella Asiatica (L) Urban) dapat diformulasikan menjadi sediaan gel antibakteri terhadap pertumbuhan penyebab jerawat.
Ekstrak Granul Nanopartikel Kulit Jeruk Sunkist (Citrus Sinensis (L.) Osbeck) Dan Ekstrak Kulit Jeruk Nipis (Citrus Aurantifolia) Terhadap Gambaran Perlemakan Hati Pada Tikus (Rattus Norvegicus) Model Diabetes) Mutia, Maya Sari; Nabila, Putri; Hamsi, Ulpah Zahara; Lubis, Yolanda Eliza Putri
Jurnal Maternitas Kebidanan Vol. 9 No. 2 (2024): Jurnal Maternitas Kebidanan
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jumkep.v9i2.5623

Abstract

Sunkist oranges (Citrus sinensis (L.) Osbeck have a high content of anthocyanins (95% of which are cyanidin-3-glucoside and cyanidine-3-6"-malonyl-glucoside), flavanone (hesperidin and narirutin), as well as hydroxynamic acid (caffeic acid, cumaric acid, cinnamic acid, and ferulic acid), carotenoids, sugars, minerals, and fiber, considered a good food source of bioactive substances with beneficial effects on health. This study aims to examine the potential for liver improvement in mice with a diabetes model after the administration of nanoparticle granules combining sunkist orange peel and lime peel. The design of this experimental research is Post Test Only Control Group Design. Twenty-five male rats of the wistar strain were used which were divided into 5 groups at random, namely the negative control group (aloxan), the positive control group (aquadest), Treatment 1 (aloxan + nanoparticle granules 50mg/kgBB), Treatment 2 (aloxan + nanoparticle granules 100mg/kgBB) Treatment 3 (aloxan + nanoparticle granules 200mg/kgBB). The liver organ was prepared for observation with 10x ocular magnification and 40x objective lens magnification. Liver improvement had an effect on the decrease of SGPT, SGOT, and Histopathological picture of the liver in diabetic model mice after the administration of nanoparticle granules combined with sunkist orange peel and lime peel at concentrations of 50 mg/KgBB, 100 mg/KgBB and 200 mg/KgBB showed significant differences. The best liver improvement is by administering nanoparticle granules a combination of sunkist orange peel and lime peel at a concentration of 200 mg/KgBB. Keyword: Diabetes Mellitus, Sunkist orange and lime peel extracts, fatty live.  
UJI EFEKTIVITAS ANTIHIPERGLIKEMIA FRAKSI AKTIF EKSTRAK ETANOL DAUN SALAM (Syzygium polyanthum) DAN EKSTRAK IKAN GABUS (Channa striata) PADA TIKUS Salsabila, Dinda Ayu; Razoki, Razoki; Mutia, Maya Sari
Jambura Journal of Health Sciences and Research Vol 6, No 3 (2024): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v6i3.25985

Abstract

Senyawa flavonoid dan tanin pada daun salam serta protein pada ikan gabus dapat membantu menurunkan kadar gula darah. Kebaruan  penelitian ini adalah kombinasi komponen alami dari tumbuhan (daun salam) dan hewan (gabus) sebagai agen antihiperglikemik. Tujuan penelitian ini adalah untuk mengetahui efektivitas fraksi aktif ekstrak etanol daun salam (FAEEDS) dan ekstrak ikan gabus (EIG) dalam menurunkan KGD pada tikus yang diberi glukosa 40% secara oral. Penelitian menggunakan 30 ekor tikus yang dibagi menjadi enam kelompok perlakuan. Kelompok 1 mendapat akuades, kelompok 2 mendapat FAEEDS 250 mg/kg bb, kelompok 3 mendapat EIG 250 mg/kg bb, dan kelompok 4 mendapat FAEEDS 250 mg/kg bb dan EIG 250 mg/kg bb, kelompok 5 mendapat FAEEDS 500 mg/kg dan EIG 250 mg/kg bb, kelompok 6 mendapat FAEEDS 750 mg/kg bb dan EIG 250 mg/kg bb. Sebelum pengobatan, tikus diberi dosis oral glukosa 40%. Hasil penelitian yang dilakukan menunjukkan bahwa FAEEDS dan EIG mampu menurunkan kadar gula darah pada tikus. Tingkat persentase pengurangan setelah 120 menit adalah ↑18,81%, ↓68,18%, ↓57,00%, ↓71,07%, ↓71,33%, dan ↓70,14% pada kelompok perlakuan. Dari persentase tersebut dapat disimpulkan bahwa kelompok 5 merupakan dosis optimal untuk menurunkan KGD pada tikus. 
- Uji Efektivitas Ekstrak Bunga Pepaya (Carrica papaya L.) Terhadap Kadar Gula Darah Mencit (Mus musculus L.) Jantan Yang Diinduksi Sukrosa: Uji Efetivitas Ekstrak Bunga Pepaya (Carrica Papaya L.) Terhadap Kadar Gula Darah Mencit (Mus Musculus L.) Jantan Yang Diinduksi Sukrosa Marpaung, Febri Sri; Tampubolon, Ester Juanita br.; Andika, Muhammad Insan; Lubis, Yolanda Eliza Putri; Mutia, Maya Sari
Biospecies Vol. 14 No. 1 (2021): Januari 2021
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/biospecies.v14i1.11175

Abstract

The papaya (Carica papaya L) flower contain flavonoids, tannins, and triterpenoid steroids which function as antidiabetic. This study was conducted to determine the antidiabetic effect of papaya (Carica papaya L) flower extract on sucrose-induced male mice. In this study, mice were made diabetic by inducing them with sucrose at a dose of 160 mg/kg BW. A total of 25 mice were grouped homogeneously into 5 groups, consisting of a negative control group (CMC 0.5%), a positive control group (no administration), a group with a dose of 200 mg/kg BW, a group with a dose of 400 mg/Kg. BW, and the group with a dose of 500 mg/Kg BW. Measurement of blood sugar levels of mice was carried out before administration of sucrose, after administration of sucrose and after administration of papaya flower extract. The results showed that the three doses had an antidiabetic effect, and the administration of papaya flower extract at a dose of 200 mg/Kg BW showed a better effect than the negative control.
- Uji Efektivitas Ekstrak Etanol Kulit Jeruk Sunkist (Citrus sinensis (L.) Osbeck) Terhadap Kadar Gula Darah Tikus Wistar (Rattus norvegicus) dengan Hiperkolesterolemia yang di Induksi Streptozotocin. : UJI EFEKTIVITAS EKSTRAK ETANOL KULIT JERUK SUNKIST (Citrus sinensis (L.) Osbeck) TERHADAP KADAR GULA DARAH TIKUS WISTAR (Rattus norvegicus) DENGAN HIPERKOLESTEROLEMIA YANG DI INDUKSI STREPTOZOTOCIN Depari, Sania Angelisa F; Rambe, Daffa Jihan Azmi; Meilando, Rifki; Lisya, Cut; Mutia, Maya Sari; Lubis, Yolanda Eliza Putri
Biospecies Vol. 14 No. 1 (2021): Januari 2021
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/biospecies.v14i1.11250

Abstract

The Condition of high blood sugar levels in people with diabetets appears to trigger an increase in LDL and decrease HDL level where in people with diabetes the energy obtained by the body comes from the decomposition of fat and protein metabolism.”Sunkist orange peel (Citrus sinensis (L.) Osbeck) is reported to have antidiabetic, anti-hypercholesterolemia, anti-inflammatory and antioxidant activities. This study aims to find out the effectiveness of Sunkist orange peel ethanol extract (Citrus sinensis (L.) Osbeck) on blood sugar levels at doses of 500, 750 and 1000 mg/kgBB. This study used the True Experimental Pre-Test and Post-Test Control Group as research design where sunkist orange peel was extracted by maceration method and was given orally for 14 days to streptozotocin induced wistar rat with hypercholesterolemia. Statistical test results showed that ethanol extract of Sunkist orange peel was able to lower blood sugar levels and cholesterol levels of h streptozotocin induced wistar rat with hypercholesterolemia (p<0.05). The most effective dose of Sunkist orange peel ethanol extract in lowering blood sugar levels and cholesterol levels of streptozotocin induced wistar rat with hypercholesterolemia is 1000mg/kgBB.
Co-Authors Andika Zayani Tambunan Andika, Muhammad Insan Annisa, Elvia Bangun, Primta Br Sitepu, Rachel Maria Cruz Jovanca Chairul, Muhammad Damayanti, Etha Wilda Hasiani Depari, Sania Angelisa F Dewani, Yunita DEWI SARTIKA Diana S, M Putri Fadillah, Qori Faridahanum, Faridahanum Fau, Solinia Kifami Yohana Maria Vianne Ginting, Chrismis Novalinda Girsang, Ermi Gunawan, Robby Gurusinga, Fransisco Bastanta Gusbakti Rusip Hamsi, Ulpah Zahara Harahap, Safriani Hasibuan, Patimah Fitriansyari Henny Henny, Henny Hutagalung, Caroline Febrina Irwanda, Desi Danilah Kurniawan, Gracella Verren Lina, Juliana Lister, INE Lisya, Cut Manalu, Cici Valentina Marpaung, Febri Sri Marpaung, Febri Sri Astuti Meilando, Rifki Meutia, Rena Michiko, Michiko Monica, Veny Nabila, Putri Nadia, Felanda Ahsan Napitupulu, Olivia Des Vinca Albahana Nasution, Tamimi Badzlina Natali, Oliviti Nathasia, Ingee Nurhady, Fahira Zahra Putri, Indah Juwita Dwi Putri, Shafyra Mahdyah Ramadhini, Amelya Putri Rambe, Daffa Jihan Azmi Razoki, Razoki Ritonga, Lapita Sarkiah Salsabila, Dinda Ayu Sanjaya, Erfan Sari, Ajeng Mestika Silitonga, Impola Dinita Felicia Siregar, Lisdawaty Sitepu, Bintang Darma M Suandy, Suandy Suhartina Suhartina, Suhartina Suhartomi Suyono, Tan Tampubolon, Ester Juanita Tampubolon, Ester Juanita br. Widya Yanti Sihotang Winato, Brigad Mahardika Yolanda Eliza Putri Lubis Yulizal, Ok