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All Journal Biospecies Jurnal Anestesiologi Indonesia Majalah Kedokteran Bandung Biology, Medicine, & Natural Product Chemistry JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) The Indonesian Biomedical Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kesehatan Vokasional JURNAL PENELITIAN PENDIDIKAN MIPA GHIDZA: Jurnal Gizi dan Kesehatan Jambura Journal of Health Sciences and Research Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Maternitas Kebidanan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Journal of Telenursing (JOTING) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Pancasakti Journal Of Public Health Science And Research Ahmar Metastasis Health Journal (AMHJ) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Journal of Pharmaceutical and Sciences.
Mutia, Maya Sari
Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Prima Indonesia, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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The Antiacne Activity of Sunkist Peels Methanol Extract in Propionibacterium Acne-Induced Acne Vulgaris Mutia, Maya Sari; Damayanti, Etha Wilda Hasiani; Suyono, Tan; Sihotang, Widya Yanti
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol.9 No.2 November 2023
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v9i2.12320

Abstract

Treatment with acne vulgaris is a challenge because the complex pathophysiology of acne vulgaris. One of the natural products that potentially use as a herbal medicine is Sunkist peel. The peel of Sunkist is more inclined to end up as waste from domestic industries. The aim of this study was to investigate the antiacne activity of the Sunkist peel methanol extract gel in vivo study. The experimental study used by applied Sunkist peel extract gel to rats injected intradermally with Propionibacterium acne suspension. One hour before the injection of Propionibacterium acnes suspension, all rats were applied to a topical gel based on the group. Control, standard, Sunkist Peel Extract Gel-I, II, and III groups received gel base, clindamycin, 5%, 10%, and 15% of Sunkist peel extract gel, respectively. This study indicates the methanol extract of Sunkist orange peel with a yield of 8.73% revealed the presence of some phytochemicals, including alkaloids, flavonoids, tannins, and saponins. Sunkist orange peel methanol extract gel significantly reduced the size of acne vulgaris lesions after 7-14 days of extract application (p-value <0.05). It is in line with the histological study that the gel concentration increased, followed by the growth of the epidermal layer. This study sstrongly indicates that Sunkist orange peel methanol extract has an antiacne effect in a physically stable gel form.
The Effect of Sunkist Orange (Citrus Sinensis (L.) Osbeck) Granule Extract on Ovarian Follicle Histomorphology in Female Rats (Rattus Norvegicus) with Obesity Mutia, Maya Sari; Faridahanum, Faridahanum; Silitonga, Impola Dinita Felicia; Ramadhini, Amelya Putri; Sari, Ajeng Mestika; Lubis, Yolanda Eliza Putri; Sihotang, Widya Yanti
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Obesity is a medical condition in which a person experiences abnormal fat accumulation that exceeds normal limits, which can have a negative impact on health. Obesity sufferers are increasing, especially in developed and developing countries. The prevalence of obesity is estimated to be 42% in 2030. Risk factors that can cause obesity include unhealthy lifestyles and lack of physical activity. When there is excess fat accumulation in the body, there will be an increase in leptin levels in the body resulting in oxidative stress that triggers the emergence of free radicals that can inhibit the growth of follicles in the ovaries. To neutralize free radicals in the body, antioxidants are needed. One type of fruit that is rich in antioxidants is sunkist oranges (Citrus sinensis (L) Osbeck), this study discusses the effect of giving sunkist orange granule extract (Citrus sinensis (L) Osbeck) on the morphology of ovarian follicles in obese female wistar rats (Ratus norvegicus). Using a laboratory experimental research design with a post-test only control group design, using 25 female rats divided into 5 groups, namely the Negative Control Group, the Positive Control Group (Alloxan and High Fat), and the Treatment Group given alloxan and Sunkist orange granule extract at a dose of 50 mg / kgBW / day, 100 mg / kgBW / day, 150 mg / kgBW / day. Results: Sunkist Orange Granule Extract (Citrus sinensis (L.) Osbeck) has a significant effect on the histomorphology of ovarian follicles with obesity induction in female rats (Rattus norvegicus).
The Effect of Sunkist Orange (Citrus Sinensis (L.) Osbeck) Peel Granule Extract on Testicular Histophatology in Male Rats (Rattus Norvegicus) with Obesity Mutia, Maya Sari; Br Sitepu, Rachel Maria Cruz Jovanca; Putri, Shafyra Mahdyah; Gurusinga, Fransisco Bastanta; Lubis, Yolanda Eliza Putri
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Volume 11 No.1 Mei 2025
Publisher : Fakultas Kedokteran Universitas Malikussaleh

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Abstract

Obesity is a body condition where there is excessive weight gain due to an imbalance between calories consumed and energy expended so that calories accumulate in fat tissue. In Indonesia, there are 14.8% of the population aged > 18 years who are obese. The basic principle of obesity is that there is an imbalance between three aspects, namely food intake (intake), energy expenditure (output), and energy storage. The result of the imbalance in energy intake and output, where energy intake is greater than energy expenditure, will cause the accumulation of fat tissue in the body and will be stored as energy reserves. Obesity is a predisposing factor for various health problems. One of them is the quality of a person's reproduction which results in infertility. To find out that the extract of sunkist orange peel granules can affect the histopathology of testis in male mice with obesity, this study used an in vivo laboratory experimental method with a research design of Post Test Only Control Group Design. In this study, there were 25 male rats divided into 5 groups, with a negative control group (normal rats without treatment), a positive control group (rats induced with high-fat feed), a treatment group of rats induced with high-fat feed with Sunkist orange peel extract granules (Citrus Sinensis (L.) Osbeck) at a dose of 50 mg/KgBW, 100 mg/KgBW, and 150 mg/KgBW. Conclusion: Sunkist orange peel granule extract (Citrus Sinensis (L.) Osbeck) had an effect on blood glucose levels, total cholesterol, and body weight, but did not show a significant effect on the histopathological results of the testes in male rats.
Unmet need for family planning among women visiting community health Nathasia, Ingee; Rusip, Gusbakti; Mutia, Maya Sari
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5569

Abstract

The unmet need for family planning is a significant reproductive health issue, particularly in developing countries. This study aimed to identify the factors associated with the unmet need for family planning among women visiting puskesmas in Medan City. This study used a cross-sectional design and included 186 participants. Data were collected using questionnaires. Data were analyzed using the chi-squared test and logistic regression. The results showed that age, education, knowledge, and perception of family planning were significantly associated with an unmet need for contraception (p<0.05). The younger the age, the lower the level of education, the lower the knowledge and perception of family planning, and the higher the likelihood of an unmet need for contraception. In contrast, family income and parity were not significantly associated with the unmet need for family planning. Satisfaction with family planning services was also not significantly associated with unmet need for contraception. The results highlight the importance of comprehensive interventions to address the unmet need for family planning. Educational programs targeting younger age groups, especially those with low educational levels, need to be improved. Additionally, efforts to improve knowledge and change community perceptions of family planning are crucial.
Peran Selenium dan Vitamin C sebagai Antioksidan dalam Mengatasi Sepsis Akibat Infeksi Bakteri Escherichia Coli : Systematic Literature Review Napitupulu, Olivia Des Vinca Albahana; Rusip, Gusbakti; Mutia, Maya Sari
Ghidza: Jurnal Gizi dan Kesehatan Vol. 9 No. 1 (2025): June
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/ghidza.v9i1.2034

Abstract

Sepsis merupakan respons sistemik yang berbahaya akibat infeksi bakteri, termasuk Escherichia coli, yang dapat menyebabkan kegagalan organ dan kematian. Stres oksidatif dan inflamasi merupakan dua faktor kunci dalam patogenesis sepsis. Penelitian ini bertujuan untuk mengevaluasi peran selenium dan vitamin C sebagai antioksidan dalam menangani sepsis akibat infeksi E. coli. Studi ini merupakan tinjauan literatur sistematis terhadap 10 artikel yang dipublikasikan antara tahun 2015–2024, dengan pendekatan eksperimen hewan, eksperimental klinis, dan kajian literatur. Data dianalisis berdasarkan tahun, metode penelitian, serta efek biologis yang dilaporkan. Selenium berkontribusi dalam meningkatkan aktivitas enzim glutathione peroxidase, menurunkan stres oksidatif, serta melindungi ginjal dari kerusakan. Vitamin C meningkatkan mikrosirkulasi, memperbaiki fungsi imun, dan berperan sebagai antioksidan protektif selama sepsis. Selenium dan vitamin C menunjukkan potensi besar sebagai terapi adjuvan dalam mengatasi sepsis akibat infeksi E. coli. Hasil kajian ini dapat menjadi dasar untuk pengembangan strategi terapi suportif berbasis antioksidan dalam praktik klinis.
The Effect of Botox on Women of Productive Age at Evoluskin Batam Clinic Mangkuanom, Adrian Saleh; Rusip, Gusbakti; Mutia, Maya Sari; Putra, Ananda Rahmat; Tambunan, Adrian Nurrachman
Pancasakti Journal Of Public Health Science And Research Vol 5 No 2 (2025): PJPHSR
Publisher : Fakultas Kesehatan Masyarakat, Universitas Pancasakti, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47650/pjphsr.v5i2.1893

Abstract

Botox (botulinum toxin) is a commonly used aesthetic procedure to reduce facial wrinkles, especially in women of reproductive age. Although its physical benefits have been widely recognized, the effect of Botox on the psychological aspects and quality of life of patients still needs to be studied further. This study aims to analyze the impact of Botox use on the patient's skin condition, self-esteem, self-confidence, and quality of life psychologically, socially, and physically. This quantitative study involved 30 respondents selected by purposive sampling. Data were collected through a questionnaire measuring the frequency of Botox use, dosage, and using the Rosenberg Self-Esteem Scale and WHOQOL-BREF to measure quality of life. Data were analyzed using paired t-test and Pearson correlation at 0.05 level of significance. The results showed a significant reduction in wrinkles and skin problems after Botox treatment (mean from 49% to 34%, p=0.003). There was a significant positive relationship between Botox use and self-esteem (r=0.45, p=0.012), self-confidence (r=0.38, p=0.025), and quality of life (r=0.62, p<0.001). These findings indicate that Botox has a positive effect not only on physical appearance, but also on the psychological aspects and overall quality of life of patients.
Combination of Vitamin D and Vitamin E Against Bacterial Infections Bangun, Primta; Rusip, Gusbakti; Mutia, Maya Sari
JAI (Jurnal Anestesiologi Indonesia) Vol 17, No 2 (2025): JAI (Jurnal Anestesiologi Indonesia)
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v0i0.69122

Abstract

Bacterial infections are a significant health problem worldwide, caused by various microorganisms that can infect different parts of the human body. Bacteria are single-celled microorganisms that can be found in various environments, including in the human body, and most of them are harmless. However, some species of bacteria can cause serious infections and inflammation that require proper medical attention. Some examples of bacteria that cause infections include Streptococcus pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Vibrio cholerae, Mycobacterium tuberculosis, Escherichia coli, and Staphylococcus aureus. A sufficient vitamin D level in the body can enhance antimicrobial activity against various pathogens, including bacteria, viruses, and fungi. Vitamin E is known to be a powerful antioxidant and has a positive effect on the immune system. It plays a role in protecting immune cells from oxidative damage and enhancing the immune response to infection. The combination of vitamins D and E offers significant potential in the prevention and management of bacterial infections, as both contribute to improved immunological function through different and complementary mechanisms.
Review Article: Pharmacological Activities and Bioactive Potential of Chinese Betel Leaf (Peperomia pellucida L. (Kunth.)) Razoki, Razoki; Lister, INE; Mutia, Maya Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1000

Abstract

Background: Peperomia pellucida L. Kunth (sirih cina) is a traditional medicinal plant used to treat various ailments. Its broad pharmacological potential needs to be consolidated from various publications to provide a comprehensive overview. Objective: This review aims to analyze and synthesize recent scientific evidence on the pharmacological activities, bioactive compounds, and potential applications of Pperomia pellucida. Methods: This systematic review was conducted by searching electronic databases (Google Scholar, PubMed, ScienceDirect, Scopus) using relevant keywords. From the search results, 21 original research articles published between 2015-2025 that met the inclusion criteria were analyzed descriptively and qualitatively. Results: The analysis revealed that Peperomia pellucida possesses diverse pharmacological activities, including anti-inflammatory, antibacterial, antifungal, antioxidant, anticancer, antidiabetic, antihypercholesterolemic, and osteogenic effects. These activities are supported by bioactive compounds such as flavonoids, tannins, alkaloids, and saponins. Its ethanolic extract has proven effective in in vitro and in vivo tests, including in topical formulations like creams and acne serums. Preliminary safety profiles indicate non-toxic properties. Conclusion: Peperomia pellucida shows great potential as a natural raw material for developing herbal medicines and cosmetics. Further research, such as human clinical trials and the development of technology-based formulations, is necessary to ensure its long-term safety and efficacy.
FORMULASI DAN AKTIVITAS GEL EKSTRAK DAUN PEGAGAN (CENTELLA ASIATICA (L) URBAN) TERHADAP PERTUMBUHAN BAKTERI PENYEBAB JERAWAT Ritonga, Lapita Sarkiah; Meutia, Rena; Mutia, Maya Sari
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.30520

Abstract

Tanaman pegagan (Centella Asiatica (L) Urb) memiliki banyak kandungan bahan aktif seperti saponin, triterpenoid serta kandungan kimia yang terbagi menjadi beberapa golongan seperti flavonoid, minyak atsiri, asam amino dan triterpenoid. Jerawat merupakan penyakit multifactorial yang berkembang didalam folikel sebaseus yang ditandai dengan adanya erupsi komedo, popul, pustule, nodus dan kista pada tempat seperti muka, leher lengan atas, dada dan punggung. Bentuk sediaan gel lebih baik digunakan pada pengobatan jerawat karena sediaan gel dengan pelarut yang polar lebih mudah dibersihkan dari permukaan kulit. Penelitian ini bertujuan untuk mngetahui bahwa tanaman daun pegagan (Centella Asiatica (L) Urban) dapat diformulasikan dalam bentuk sediaan gel sebagai antibakteri. Metode Penelitian yang digunakan adalah metode eksperimental dengan meliputi pembuatan simplisia, pembuatan ekstrak dan melakukan pembuatan sediaan gel dari ekstrak etanol daun pegagan (Centella Asiatica (L) Urban) serta melakukan uji aktivitas antibakteri terhadap pertumbuhan bakteri Staphylococcus epidermidis. Hasil penelitian menunjukkan bahwa formulasi yang memiliki daya hambat tertinggi terhadap bakteri Staphylococcus epidermis yaitu konsentrasi 15 mg/ml dimana zona hambat yang dihasilkan sebesar 22,68 mm dan Ekstrak daun pegagan (Centella Asiatica (L) Urban) dapat diformulasikan menjadi sediaan gel antibakteri terhadap pertumbuhan penyebab jerawat.
Granule Nanoparticle Citrus sinensis (L.) Osbeck Peel Lowers Blood Glucose Levels and HbA1C in Alloxan-induced Diabetes Rats Mutia, Maya Sari; Sipayung, Yelvreza Rastiani; Elmiam, Dwi; Sihotang, Widya Yanti; Lina, Juliana
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3334

Abstract

BACKGROUND: The peel of Citrus sinensis (L.) Osbeck (sunkist orange) peels, which are often seen as waste, actually contains valuable properties such as antioxidants, hypoglycemic, nephroprotective, and anti-inflammatories. The potential effects of C. sinensis peel on diabetes have been discussed but not clear yet. Therefore, this study was performed to evaluate the effects of Granule Nanoparticle Sunkist Peel (GNSP) extracts as an antidiabetic agent in alloxan-induced diabetic rats.METHODS: The nanoparticle suspension was prepared by mixing a formulation of 0.2% chitosan and 0.1% sodium tripolyphosphate. The characteristics of nanoparticles were measured by flow time, tap index and angle of repose. Rats were induced with alloxan injection to create diabetes rat models. Rats were divided into five groups; normal control group, diabetic controls, and diabetic rats receiving either 50, 100, or 200 mg/kg/day GNSP. After 28 days of diabetes induction, rats were euthanized, and blood as well as tissue samples were collected. Blood glucose levels, HbA1c, and histopathology of the liver, kidneys, and pancreas were then assessed.RESULTS: The particle size of the synthesized material was 92.3 nm, which confirmed the nature of nanoparticle. The characteristics of the granule nanoparticle were also in accordance with the standards for drugs suitable for consumption. The administration of GNSP in dose dependent manner significantly decrease blood glucose levels and HbA1C to normal levels compared to control group (p<0.05). Histopathological analysis indicated recovery in pancreas, liver, and kidney tissues following GNSP administration.CONCLUSION: GNSP administration lowers blood glucose levels and HbA1C, as well as improved histopathological condition of pancreas, liver, and kidney in diabetic rats. These findings suggest the potential of utilizing GNSP as a potent antidiabetic agent.KEYWORDS: Citrus Sinensis (L.) Osbeck, histopathology, hyperglycemia, nano medicine, and type 2 diabetes mellitus
Co-Authors Andika, Muhammad Insan Annisa, Elvia Arviandi, Rizki Bangun, Primta Br Sitepu, Rachel Maria Cruz Jovanca Chairul, Muhammad Damayanti, Etha Wilda Hasiani Depari, Sania Angelisa F Dewani, Yunita DEWI SARTIKA Dewi, Silvi Tiara Diana S, M Putri Elmiam, Dwi Fadillah, Qori Faridahanum, Faridahanum Fau, Solinia Kifami Yohana Maria Vianne Fitrisia, Rina Ginting, Chrismis Novalinda Girsang, Ermi Gunawan, Robby Gurusinga, Fransisco Bastanta Gusbakti Rusip Hamsi, Ulpah Zahara Harahap, Safriani Hasibuan, Patimah Fitriansyari Henny Henny, Henny Hutagalung, Caroline Febrina Irwanda, Desi Danilah Kurniawan, Gracella Verren Lie, Maylia Lina, Juliana Lister, INE Lisya, Cut Manalu, Cici Valentina Mangkuanom, Adrian Saleh Marpaung, Febri Sri Marpaung, Febri Sri Astuti Meilando, Rifki Meutia, Rena Michiko, Michiko Monica, Veny Nabila, Putri Nadia, Felanda Ahsan Napitupulu, Olivia Des Vinca Albahana Nasution, Ali Napiah Nasution, Tamimi Badzlina Natali, Oliviti Nathasia, Ingee Nurhady, Fahira Zahra Putra, Ananda Rahmat Putri, Indah Juwita Dwi Putri, Shafyra Mahdyah Ramadhini, Amelya Putri Rambe, Daffa Jihan Azmi Razoki, Razoki Ritonga, Lapita Sarkiah Salsabila, Dinda Ayu Sanjaya, Erfan Sari, Ajeng Mestika Silitonga, Impola Dinita Felicia Sipayung, Yelvreza Rastiani Siregar, Lisdawaty Sitepu, Bintang Darma M Suandy, Suandy Suhartina Suhartina, Suhartina SUHARTOMI . Sulistijanto, Eddy Suyono, Tan Tambunan, Adrian Nurrachman Tambunan, Andika Zayani Tampubolon, Ester Juanita Tampubolon, Ester Juanita br. Tio, Susanthy Widya Yanti Sihotang Winato, Brigad Mahardika Yolanda Eliza Putri Lubis Yulizal, Ok