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All Journal Biospecies Jurnal Anestesiologi Indonesia Majalah Kedokteran Bandung Biology, Medicine, & Natural Product Chemistry JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) The Indonesian Biomedical Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kesehatan Vokasional JURNAL PENELITIAN PENDIDIKAN MIPA GHIDZA: Jurnal Gizi dan Kesehatan Jambura Journal of Health Sciences and Research Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Maternitas Kebidanan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Journal of Telenursing (JOTING) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Pancasakti Journal Of Public Health Science And Research Ahmar Metastasis Health Journal (AMHJ) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Journal of Pharmaceutical and Sciences.
Mutia, Maya Sari
Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Prima Indonesia, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Ekstrak Granul Nanopartikel Kulit Jeruk Sunkist (Citrus Sinensis (L.) Osbeck) Dan Ekstrak Kulit Jeruk Nipis (Citrus Aurantifolia) Terhadap Gambaran Perlemakan Hati Pada Tikus (Rattus Norvegicus) Model Diabetes) Mutia, Maya Sari; Nabila, Putri; Hamsi, Ulpah Zahara; Lubis, Yolanda Eliza Putri
Jurnal Maternitas Kebidanan Vol. 9 No. 2 (2024): Jurnal Maternitas Kebidanan
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jumkep.v9i2.5623

Abstract

Sunkist oranges (Citrus sinensis (L.) Osbeck have a high content of anthocyanins (95% of which are cyanidin-3-glucoside and cyanidine-3-6"-malonyl-glucoside), flavanone (hesperidin and narirutin), as well as hydroxynamic acid (caffeic acid, cumaric acid, cinnamic acid, and ferulic acid), carotenoids, sugars, minerals, and fiber, considered a good food source of bioactive substances with beneficial effects on health. This study aims to examine the potential for liver improvement in mice with a diabetes model after the administration of nanoparticle granules combining sunkist orange peel and lime peel. The design of this experimental research is Post Test Only Control Group Design. Twenty-five male rats of the wistar strain were used which were divided into 5 groups at random, namely the negative control group (aloxan), the positive control group (aquadest), Treatment 1 (aloxan + nanoparticle granules 50mg/kgBB), Treatment 2 (aloxan + nanoparticle granules 100mg/kgBB) Treatment 3 (aloxan + nanoparticle granules 200mg/kgBB). The liver organ was prepared for observation with 10x ocular magnification and 40x objective lens magnification. Liver improvement had an effect on the decrease of SGPT, SGOT, and Histopathological picture of the liver in diabetic model mice after the administration of nanoparticle granules combined with sunkist orange peel and lime peel at concentrations of 50 mg/KgBB, 100 mg/KgBB and 200 mg/KgBB showed significant differences. The best liver improvement is by administering nanoparticle granules a combination of sunkist orange peel and lime peel at a concentration of 200 mg/KgBB. Keyword: Diabetes Mellitus, Sunkist orange and lime peel extracts, fatty live.  
UJI EFEKTIVITAS ANTIHIPERGLIKEMIA FRAKSI AKTIF EKSTRAK ETANOL DAUN SALAM (Syzygium polyanthum) DAN EKSTRAK IKAN GABUS (Channa striata) PADA TIKUS Salsabila, Dinda Ayu; Razoki, Razoki; Mutia, Maya Sari
Jambura Journal of Health Sciences and Research Vol 6, No 3 (2024): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v6i3.25985

Abstract

Senyawa flavonoid dan tanin pada daun salam serta protein pada ikan gabus dapat membantu menurunkan kadar gula darah. Kebaruan  penelitian ini adalah kombinasi komponen alami dari tumbuhan (daun salam) dan hewan (gabus) sebagai agen antihiperglikemik. Tujuan penelitian ini adalah untuk mengetahui efektivitas fraksi aktif ekstrak etanol daun salam (FAEEDS) dan ekstrak ikan gabus (EIG) dalam menurunkan KGD pada tikus yang diberi glukosa 40% secara oral. Penelitian menggunakan 30 ekor tikus yang dibagi menjadi enam kelompok perlakuan. Kelompok 1 mendapat akuades, kelompok 2 mendapat FAEEDS 250 mg/kg bb, kelompok 3 mendapat EIG 250 mg/kg bb, dan kelompok 4 mendapat FAEEDS 250 mg/kg bb dan EIG 250 mg/kg bb, kelompok 5 mendapat FAEEDS 500 mg/kg dan EIG 250 mg/kg bb, kelompok 6 mendapat FAEEDS 750 mg/kg bb dan EIG 250 mg/kg bb. Sebelum pengobatan, tikus diberi dosis oral glukosa 40%. Hasil penelitian yang dilakukan menunjukkan bahwa FAEEDS dan EIG mampu menurunkan kadar gula darah pada tikus. Tingkat persentase pengurangan setelah 120 menit adalah ↑18,81%, ↓68,18%, ↓57,00%, ↓71,07%, ↓71,33%, dan ↓70,14% pada kelompok perlakuan. Dari persentase tersebut dapat disimpulkan bahwa kelompok 5 merupakan dosis optimal untuk menurunkan KGD pada tikus. 
B Nasution, Ali Napiah; Fitrisia, Rina; Tio, Susanthy; Girsang, Ermi; Mutia, Maya Sari
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.5773

Abstract

Natural treatment is plant extract nanoemulsion. Forming nanoemulsions with a specific method may help skin wound healing. Fruit cardamom (Amomum compactum Sol. Ex Maton) was used as an antimicrobial, but its wound-healing activity was unstudied. This study compares nanoemulsion from cardamom seed ethanol extract to cardamom extract in suppressing bacterial growth, wound healing, and determining component makeup. Research methods with Lab experiments involve sampling, processing, extracting, and UV-VIS spectrophotometer testing secondary metabolite chemicals, creating nanoemulsions, and characterizing them with HPLC, FTIR, UV-VIS, and PSA. TPC and disc diffusion for antibacterial and wound healing characterization and SPSS analysis. The research results found high quantities of gallic acid, catechin, and epigallocatechin were found in 20% (v/v) cardamom extract nanoemulsion, with HPLC analysis showing levels of 4590.10 µg/mL, 2128.95µg/mL, and 755.42µg/mL, respectively. FTIR and UV-Vis tests indicate a single peak around the phenol compound's absorption area and describe its group by absorbing functional groups in the IR spectrum. Nanoemulsion suppressed E. coli and S. aureus better than cardamom extract. At 1% (v/v), nanoemulsion heals wounds faster than cardamom extract and gentamicin sulfate. The particle size of 53.13 ± 1.25 nm and particle size distribution of 0.56 ± 0.02 nm contribute to the stability and high activity of the nanoemulsion.
Determination of Patient Satisfaction with Dental and Oral Care Services for Clinical Students at Dental and Oral Hospital Prima Medan Dewi, Silvi Tiara; Ginting, Chrismis Novalinda; Mutia, Maya Sari
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6459

Abstract

The aim of this research is to determine the determinants of patient satisfaction with dental and oral care services for clinical students at Dental and Oral Hospital Prima Medan. This type of research is quantitative research with a cross-sectional design. The sample in this study was 200 patients. Data analysis in this study used univariate, bivariate and multivariate analysis. The results of the study showed that there was a correlation between patient satisfaction with dental and oral care services among clinical students at Dental and Oral Hospital Prima Medan based on time, procedure, attitude, level of knowledge, p < 0.05 (0.000 < 0.05) with a very high correlation level strong. There is a correlation between patient satisfaction with dental and oral care services among clinical students at Dental and Oral Hospital Prima Medan based on communication and spatial comfort, p < 0.05 (0.000 < 0.05) with a strong correlation level. The influence of service time, procedures, attitudes, level of knowledge, communication and spatial comfort on dental and oral care patient satisfaction among clinical students at Dental and Oral Hospital Prima Medan was 83.7%. The variable that most influences patient satisfaction with dental and oral care services for clinical students at Dental and Oral Hospital Prima Medan is the procedure variable
- Uji Efektivitas Ekstrak Bunga Pepaya (Carrica papaya L.) Terhadap Kadar Gula Darah Mencit (Mus musculus L.) Jantan Yang Diinduksi Sukrosa: Uji Efetivitas Ekstrak Bunga Pepaya (Carrica Papaya L.) Terhadap Kadar Gula Darah Mencit (Mus Musculus L.) Jantan Yang Diinduksi Sukrosa Marpaung, Febri Sri; Tampubolon, Ester Juanita br.; Andika, Muhammad Insan; Lubis, Yolanda Eliza Putri; Mutia, Maya Sari
Biospecies Vol. 14 No. 1 (2021): Januari 2021
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/biospecies.v14i1.11175

Abstract

The papaya (Carica papaya L) flower contain flavonoids, tannins, and triterpenoid steroids which function as antidiabetic. This study was conducted to determine the antidiabetic effect of papaya (Carica papaya L) flower extract on sucrose-induced male mice. In this study, mice were made diabetic by inducing them with sucrose at a dose of 160 mg/kg BW. A total of 25 mice were grouped homogeneously into 5 groups, consisting of a negative control group (CMC 0.5%), a positive control group (no administration), a group with a dose of 200 mg/kg BW, a group with a dose of 400 mg/Kg. BW, and the group with a dose of 500 mg/Kg BW. Measurement of blood sugar levels of mice was carried out before administration of sucrose, after administration of sucrose and after administration of papaya flower extract. The results showed that the three doses had an antidiabetic effect, and the administration of papaya flower extract at a dose of 200 mg/Kg BW showed a better effect than the negative control.
- Uji Efektivitas Ekstrak Etanol Kulit Jeruk Sunkist (Citrus sinensis (L.) Osbeck) Terhadap Kadar Gula Darah Tikus Wistar (Rattus norvegicus) dengan Hiperkolesterolemia yang di Induksi Streptozotocin. : UJI EFEKTIVITAS EKSTRAK ETANOL KULIT JERUK SUNKIST (Citrus sinensis (L.) Osbeck) TERHADAP KADAR GULA DARAH TIKUS WISTAR (Rattus norvegicus) DENGAN HIPERKOLESTEROLEMIA YANG DI INDUKSI STREPTOZOTOCIN Depari, Sania Angelisa F; Rambe, Daffa Jihan Azmi; Meilando, Rifki; Lisya, Cut; Mutia, Maya Sari; Lubis, Yolanda Eliza Putri
Biospecies Vol. 14 No. 1 (2021): Januari 2021
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/biospecies.v14i1.11250

Abstract

The Condition of high blood sugar levels in people with diabetets appears to trigger an increase in LDL and decrease HDL level where in people with diabetes the energy obtained by the body comes from the decomposition of fat and protein metabolism.”Sunkist orange peel (Citrus sinensis (L.) Osbeck) is reported to have antidiabetic, anti-hypercholesterolemia, anti-inflammatory and antioxidant activities. This study aims to find out the effectiveness of Sunkist orange peel ethanol extract (Citrus sinensis (L.) Osbeck) on blood sugar levels at doses of 500, 750 and 1000 mg/kgBB. This study used the True Experimental Pre-Test and Post-Test Control Group as research design where sunkist orange peel was extracted by maceration method and was given orally for 14 days to streptozotocin induced wistar rat with hypercholesterolemia. Statistical test results showed that ethanol extract of Sunkist orange peel was able to lower blood sugar levels and cholesterol levels of h streptozotocin induced wistar rat with hypercholesterolemia (p<0.05). The most effective dose of Sunkist orange peel ethanol extract in lowering blood sugar levels and cholesterol levels of streptozotocin induced wistar rat with hypercholesterolemia is 1000mg/kgBB.
Co-Authors Andika, Muhammad Insan Annisa, Elvia Arviandi, Rizki Bangun, Primta Br Sitepu, Rachel Maria Cruz Jovanca Chairul, Muhammad Damayanti, Etha Wilda Hasiani Depari, Sania Angelisa F Dewani, Yunita DEWI SARTIKA Dewi, Silvi Tiara Diana S, M Putri Elmiam, Dwi Fadillah, Qori Faridahanum, Faridahanum Fau, Solinia Kifami Yohana Maria Vianne Fitrisia, Rina Ginting, Chrismis Novalinda Girsang, Ermi Gunawan, Robby Gurusinga, Fransisco Bastanta Gusbakti Rusip Hamsi, Ulpah Zahara Harahap, Safriani Hasibuan, Patimah Fitriansyari Henny Henny, Henny Hutagalung, Caroline Febrina Irwanda, Desi Danilah Kurniawan, Gracella Verren Lie, Maylia Lina, Juliana Lister, INE Lisya, Cut Manalu, Cici Valentina Mangkuanom, Adrian Saleh Marpaung, Febri Sri Marpaung, Febri Sri Astuti Meilando, Rifki Meutia, Rena Michiko, Michiko Monica, Veny Nabila, Putri Nadia, Felanda Ahsan Napitupulu, Olivia Des Vinca Albahana Nasution, Ali Napiah Nasution, Tamimi Badzlina Natali, Oliviti Nathasia, Ingee Nurhady, Fahira Zahra Putra, Ananda Rahmat Putri, Indah Juwita Dwi Putri, Shafyra Mahdyah Ramadhini, Amelya Putri Rambe, Daffa Jihan Azmi Razoki, Razoki Ritonga, Lapita Sarkiah Salsabila, Dinda Ayu Sanjaya, Erfan Sari, Ajeng Mestika Silitonga, Impola Dinita Felicia Sipayung, Yelvreza Rastiani Siregar, Lisdawaty Sitepu, Bintang Darma M Suandy, Suandy Suhartina Suhartina, Suhartina SUHARTOMI . Sulistijanto, Eddy Suyono, Tan Tambunan, Adrian Nurrachman Tambunan, Andika Zayani Tampubolon, Ester Juanita Tampubolon, Ester Juanita br. Tio, Susanthy Widya Yanti Sihotang Winato, Brigad Mahardika Yolanda Eliza Putri Lubis Yulizal, Ok