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All Journal JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) The Indonesian Biomedical Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Poltekita : Jurnal Ilmu Kesehatan Jurnal Kesmas Prima Indonesia Jurnal Prima Medika Sains Science Midwifery Jurnal Promotif Preventif Jurnal Kesehatan Tambusai Jurnal Penelitian Inovatif Action Research Literate (ARL) Jurnal Impresi Indonesia Journal of Social Research Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Buletin Kedokteran dan Kesehatan Prima Jurnal Pendidikan Indonesia (Japendi) Eduvest - Journal of Universal Studies
Lina, Juliana
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Histopathological characteristics of soft tissue tumors at Madani General Hospital Nasution, Prenan Dito Perdana; Lina, Juliana; Wardhani, Fiska Maya; Loren, Jeff; Muchtar, Muhammad Arafat; Iskandar, Ari Rahman
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.5677

Abstract

Benign tumors were more common than malignant tumors, with a ratio of 1:100. However, in 2019, approximately 13,000 cases of malignant tumors were reported in the United States. Based on data from Cancer Referral Hospitals in Indonesia, soft tissue sarcomas were among the ten most common cancers in 2013, with approximately 75% of cases occurring in the extremity region. This study aimed to describe the histopathological examination results of patients with soft tissue tumors at the Madani General Hospital, Medan City. This study used a retrospective descriptive design by collecting data from the medical records of patients who underwent histopathological examination at the Anatomical Pathology Laboratory of Madani General Hospital (period 2018-2022). Data were analyzed based on the distribution of cases according to age, sex, and tumor type. The results showed that soft tissue tumors were most prevalent in the 41-50 age group with 30 patients (20.3%), the majority were female with 85 patients (57.4%), and based on histopathological diagnosis, lipoma was the most common type of tumor found in 70 patients (47.3%). All cases studied were benign tumors, with a total of 148 patients (100%).
Genetic factor, short-distance activity, and myopia among medical students Tiswan, Jiad Hanan; Pratama, Irza Haicha; Lina, Juliana; Ivonne, Ivonne; Purwoko, Heri; Yumardika, Deza
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.6160

Abstract

Myopia, a common refractive error, has seen a significant global increase, particularly among young adults. This study aims to investigate the association between genetic factors, short-distance activity, and the incidence of myopia among medical students. A cross-sectional survey design was employed to collect data from medical students in batches 2022 and 2023. Chi-square tests were used to analyze the relationship between the variables. Demographic data revealed a predominantly young female population, with a high proportion of students enrolled in the 2023 academic year. A significant number of students were diagnosed with myopia, ranging from low to high degrees. Risk factor analysis indicated a strong association between reduced short-distance activity and increased myopia risk. Additionally, a family history of myopia emerged as a significant genetic predisposition to the condition. These findings highlight the importance of addressing both environmental and genetic factors to prevent and manage myopia among medical students. Future longitudinal studies with larger sample sizes are needed to further explore the temporal relationship between risk factors and myopia progression.
Squamous cell carcinoma of the kidney: A case report Lina, Juliana; Karo, Reh Malem br; Theresia, Yohani; Fadillah, Qori
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6544

Abstract

Primary renal squamous cell carcinoma (SCC) is a rare neoplasm strongly associated with a history of nephrolithiasis. Renal SCC is reported to have high morbidity and mortality rates, especially in the elderly population. Clinical manifestations of renal SCC are generally characterized by hematuria, flank pain, and a palpable mass in the retroperitoneal area. Histopathological examination reveals the infiltration of squamous cell nests that destroy the stroma. These cells show nuclear pleomorphism, an increased nuclear/cytoplasmic ratio, irregular nuclear membranes, coarse chromatin, prominent and dense basophilic nucleoli, and eosinophilic cytoplasm. These histopathological findings confirm the diagnosis of squamous cell carcinoma. The uniqueness of this case lies in the diagnosis of renal SCC in a relatively young age group, making it a distinct clinical concern. Further immunohistochemical examination, including CK5/6, p63, p40, and CK14 panels, is needed to determine the prognosis and appropriate treatment strategy. This case report emphasizes the importance of understanding kidney stone disease as a preventive measure against the development of renal SCC.
Gambaran Karakteristik Sitologi Dan Histopatologi Nodul Tiroid Di Laboratorium Patologi Anatomi RSU Madani Medan Periode Tahun 2022-2024 Br Manihuruk, Deselomita Hagarma; Lina, Juliana; Lister, Clarissa
Jurnal Impresi Indonesia Vol. 4 No. 10 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i10.7066

Abstract

Nodul tiroid merupakan salah satu kelainan endokrin yang sering dijumpai, dengan insidensi yang terus meningkat. Evaluasi sitologi dan histopatologi sangat penting untuk menentukan sifat jinak atau ganas dari nodul tiroid, serta menentukan tatalaksana yang tepat. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik sitologi dan histopatologi nodul tiroid di Laboratrium Patologi Anatomi RSU Madani pada periode tahun 2022-2024. Jenis penelitian adalah studi deskriptif dengan pendekatan retrospektif. Data diambil dari rekam medis pasien yang menjalani pemeriksaan sitologi dan histopatologi nodul tiroid di Laboratorium Patologi Anatomu RSU Madani selama periode 2022-2024. Hasil pemeriksaan sitologi dan histopatologi menunjukkan bahwa nodul tiroid ditemukan paling banyak pada rentang usia 20-29 dan 50-59 tahun, yang masing masing sebanyak 9 pasien. Mayoritas pasien berjenis kelamin perempuan (85%). Pada pemeriksaan sitologi paling banyakmenunjukkan hasil benign follicular thyroid, sedangkan hasil histopatologi terbanyak adalah adenoma follicular thyroid. Pada kelompok usia 50-59 tahun, diagnosis terbanyak melalui sitologi adalah benign follicular thyroid, sedangkan pada kelompok usia 20-29 tahun, diagnosis terbanyak melalui pemeriksaan histopatologi adalah adenoma follicular thyroid. Pasien yang berjenis kelamin perempuan mendominasi pasien yang menjalani pemeriksaan sitologi (50%) dan histopatologi (37,5%). Nodul tiroid lebih sering terjadi pada perempuan, terutama pada rentang usia 20-29 dan 50-59 tahun. Seluruh nodul tiroid yang diperiksa secara sitologi maupun histopatologi di Laboratrium Patologi Anatomi RSU Madani pada periode tahun 2022-2024 seluruhnya bersifat jinak, dengan diagnosis terbanyak adalah benign follicular thyroid dan adenoma follicular thyroid.
The Relationship Between the Use of Short Form Vidoes on Social Media and the Attention Span of Students in the Class of 2022, Faculty of Medicine, Universitas Prima Indonesia Dhillon, Siena Sanjana; Lister, Clarissa; Lina, Juliana
Journal of Social Research Vol. 4 No. 11 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i10.2859

Abstract

The rise of social media has popularized short-form videos (SFVs) like TikTok, Instagram Reels, and YouTube Shorts among university students. Excessive exposure to SFV content may affect behavioral patterns, particularly attention span, which plays a vital role in academic performance. This study aimed to examine the patterns of SFV usage, assess students’ attention spans, and determine the relationship between SFV use and attention span among 2022 medical students at Universitas Prima Indonesia. Using a quantitative analytical design with a cross-sectional approach, data were collected through questionnaires from 200 respondents and analyzed using univariate and bivariate methods with the Chi-Square test. Statistical analysis was performed at a significance level of ? = 0.05, with the Chi-Square test yielding p < 0.05 as the criterion for significant associations. Results revealed that 85.5% of students had high SFV usage, primarily through TikTok (56.5%), with daily viewing exceeding 3 hours (65%) and weekly viewing exceeding 14 hours (53%). Lifestyle (62.5%) and entertainment (59%) were the most-watched content types. Attention span levels were classified as good (48%) and poor (52%), and statistical analysis showed a significant correlation between SFV usage and attention span (p = 0.000). The study recommends promoting digital literacy, time management, and responsible media consumption among students, alongside further research on SFV impacts on cognition and mental health.
Karakteristik Penderita Kanker Sistem Reproduksi Dan Payudara Di Laboratorium Rumah Sakit Umum Madani Periode 2019-2024 Sintya, Inda Dhea; Lina, Juliana; Lister , Clarissa
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62380

Abstract

Objective: To determine the general characteristics of reproductive and breast cancer patients at the Madani General Hospital Laboratory from 2019 to 2024. Method: This study used a descriptive correlational approach. The research began in December 2024 with proposal writing, followed by research in February 2025 until data collection, which was then followed by a results seminar. The accessible population consisted of all medical records of reproductive and breast cancer patients at the Madani General Hospital Laboratory, a sample size of 32, using a purposive sampling technique. Univariate data analysis was presented in the form of frequency distributions, while bivariate analysis used the chi-square test. Data processing was performed using the computerized IBM SPSS version 25.0. Results: The highest number was in the age group of 52-56 years, totaling 8 people (25%), almost half of the respondents had an origin organ of endometrium and breast, totaling 12 people (41.4%), and almost half of the respondents had of the respodents had a diagnosis of endometrial adenocarcinoma. There was a correlation between organ origin and diagnosis in patients with reproductive system and breast cancer at the Madani General Hospital Laboratory during the 2019-2024 period (p=0.000). There was no correlation between age and diagnosis in patients with reproductive system and breast cancer at the Madani General Hospital Laboratory during the 2019-2024 period (p=0.097). Conclusion: There was a correlation between origin organ and diagnosis, but no correlation between age and diagnosis in patients with reproductive system and breast cancer at the Madani General Hospital Laboratory during the 2019-2024 period.
Examining the Impact of Candlenut Fruit Extract Cream on Hair Growth in Male Wistar Rats (Rattus norvegicus) Fitriani, Anche Pratiwi; Wijaya, Johana Fransiska; Lina, Juliana; Fibrini, Dewi
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3613

Abstract

Hair loss can affect mental health. Natural compound-based hair treatments like candlenut fruit are becoming more popular due to their low side effects and growing scientific research on hair loss. This study aims to prove the effectiveness of candlenut fruit extract cream on the hair growth of male Wistar strain rats (Rattus norvegicus). Research method Laboratory experiment, Principle 3R (Replacement, Reduction, and Refinement): Reducing Rattus norvegicus Wistar male strain samples The 20 male rats in this study will be divided into four groups. Hair growth is examined with 5%, 10%, and 15% candlenut fruit extract cream. Research data was analyzed using SPSS. The results of testing hair growth in rats with 5%, 10%, and 15% doses of candlenut fruit extract cream were normally distributed. The control group had a significant value of 0.928 > 0.05, treatment group 1 had a value of 0.579 > 0.05, treatment group 2 of 0.829 > 0.05, and treatment group 3 of 0.451 > 0.05. Candlenut fruit extract cream is effective for increasing hair growth in Rattus norvegicus. This study concludes that candlenut fruit extract cream can accelerate the development of hair follicles in Wistar strain male white rats. Due to the heated manufacturing process, candlenut extract is safe to use.
Hypoglycemic Activity and Safety Assessment of Pediococcus acidilactici Strain DNH16 in Experimental Type 2 Diabetes Mellitus Rats Induced with Streptozotocin Fachrial, Edy; Lina, Juliana; Harmileni, Harmileni; Anggraini, Sari; Sihotang, Widya Yanti
The Indonesian Biomedical Journal Vol 16, No 1 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i1.2781

Abstract

BACKGROUND: Type 2 diabetes mellitus (T2DM) cases tend to rise throughout the year in all parts of the world. The α-glucosidase inhibitors are frequently used to both prevent and treat T2DM. This α-glucosidase inhibitor activity is seen in some probiotic species, and a certain strain of Pediococcus acidilactici exhibits promising characteristics as an α-glucosidase inhibitor. This study was conducted to assess the hypoglycemic activity and safety of P. acidilactici strain DNH16 (PADNH16) in experimental rats with T2DM induced by streptozotocin.METHODS: The experiment was conducted in vivo using Wistar rats. Acarbose was employed as a positive control, and Lactobacillus casei was used as a comparative. For 24 days, post-prandial blood glucose levels were assessed every 3 days, followed by serum biochemical levels measurement of liver, kidney, and lipid profiles. The pancreas was histopathologically examined utilizing the Hematoxyline-Eosin staining procedure.RESULTS: Administration of PADNH16 to T2DM rats lowered post-prandial blood glucose levels and gave hypoglycemic benefits comparable to acarbose and commercial probiotics. PADNH16 dosing did not affect serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), urea, or creatinine levels, showing that PADNH16 was not hazardous to liver or kidney function. The lipid profile assessment revealed that the values, including high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides, were comparable to the control group. The pancreatic histopathology revealed that injection of PADNH16 caused no alterations to pancreatic β cells.CONCLUSION: P. acidilactici isolate DNH16 has a hypoglycemic effect on T2DM rats, but does not affect liver function enzymes, kidneys, lipid profiles and does not provide significant changes in pancreatic β cells.KEYWORDS: diabetes mellitus, inhibitor α-glucosidase, Pediococcus acidilactici strain DNH16
Granule Nanoparticle Citrus sinensis (L.) Osbeck Peel Lowers Blood Glucose Levels and HbA1C in Alloxan-induced Diabetes Rats Mutia, Maya Sari; Sipayung, Yelvreza Rastiani; Elmiam, Dwi; Sihotang, Widya Yanti; Lina, Juliana
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3334

Abstract

BACKGROUND: The peel of Citrus sinensis (L.) Osbeck (sunkist orange) peels, which are often seen as waste, actually contains valuable properties such as antioxidants, hypoglycemic, nephroprotective, and anti-inflammatories. The potential effects of C. sinensis peel on diabetes have been discussed but not clear yet. Therefore, this study was performed to evaluate the effects of Granule Nanoparticle Sunkist Peel (GNSP) extracts as an antidiabetic agent in alloxan-induced diabetic rats.METHODS: The nanoparticle suspension was prepared by mixing a formulation of 0.2% chitosan and 0.1% sodium tripolyphosphate. The characteristics of nanoparticles were measured by flow time, tap index and angle of repose. Rats were induced with alloxan injection to create diabetes rat models. Rats were divided into five groups; normal control group, diabetic controls, and diabetic rats receiving either 50, 100, or 200 mg/kg/day GNSP. After 28 days of diabetes induction, rats were euthanized, and blood as well as tissue samples were collected. Blood glucose levels, HbA1c, and histopathology of the liver, kidneys, and pancreas were then assessed.RESULTS: The particle size of the synthesized material was 92.3 nm, which confirmed the nature of nanoparticle. The characteristics of the granule nanoparticle were also in accordance with the standards for drugs suitable for consumption. The administration of GNSP in dose dependent manner significantly decrease blood glucose levels and HbA1C to normal levels compared to control group (p<0.05). Histopathological analysis indicated recovery in pancreas, liver, and kidney tissues following GNSP administration.CONCLUSION: GNSP administration lowers blood glucose levels and HbA1C, as well as improved histopathological condition of pancreas, liver, and kidney in diabetic rats. These findings suggest the potential of utilizing GNSP as a potent antidiabetic agent.KEYWORDS: Citrus Sinensis (L.) Osbeck, histopathology, hyperglycemia, nano medicine, and type 2 diabetes mellitus
KARAKTERISTIK PENDERITA TUMOR SISTEM REPRODUKSI WANITA DENGAN PEMERIKSAAN HISTOPATOLOGI DI RUMAH SAKIT UMUM MADANI MEDAN PERIODE TAHUN 2018 – 2022 Amanda, Carissa; Lina, Juliana; Wardhani, Fiska Maya
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.32745

Abstract

Tumor sistem reproduksi wanita merupakan jenis sel tumor yang dapat tumbuh di berbagai organ sistem reproduksi wanita. Berdasarkan data Rikesdas, pravelensi tumor di Indonesia tahun 2018 terdapat 1.017.290 (1,79%) dari 278,8 juta penduduk. Tujuan penelitian untuk mengetahui karakteristik penderita tumor sistem reproduksi wanita dengan pemeriksaan histopatologi di Rumah Sakit Umum Madani Medan Periode Tahun 2018–2022. Jenis penelitian menggunakan pendekatan deskriptif retrospektif, sumber data yang diambil data sekunder yaitu rekam medik dengan metode total sampling sebanyak 234 orang. Analisis hasil penelitian dilakukan dengan analisis statistik frekuensi menggunakan SPSS. Berdasarkan kelompok usia terbanyak yang mengalami tumor sistem reproduksi wanita adalah usia 36-45 tahun sebanyak 103 orang (44,0%), berdasarkan diagnosa histopatologi terbanyak adalah Leiomyoma Uteri sebanyak 129 orang (55,1%), berdasarkan jenis tumor terbanyak adalah tumor jinak sebanyak 234 orang (100%), berdasarkan lokasi tumor terbanyak adalah tumor uterus sebanyak 131 orang (56,0%). Penderita Endometriosis mayoritas berada pada kelompok usia 26–35 tahun sebanyak 16 orang (14,6%), penderita Leiomyoma Uteri mayoritas berusia 36-45 tahun sebanyak 64 orang (62,1%), penderita Mucinous Cystadenoma Ovarii mayoritas berusia 36–45 tahun sebanyak 13 orang (12,6%), penderita Serous Cystadenoma Ovarii mayoritas berusia 36–45 tahun sebanyak 8 orang (7,8%), dan penderita Mature Teratoma mayoritas berusia 26–35 tahun sebanyak 9 orang (2,9%). Mayoritas penderita yang mengalami tumor jinak berada pada kelompok usia 36–45 tahun sebanyak 103 orang (100%). Mayoritas penderita yang mengalami tumor jinak adalah tumor Leiomyoma Uteri sebanyak 129 orang (100%).
Co-Authors Adek Amansyah Aipin, Anggi Sri Ananda Amanda, Carissa Anggraini, Sari Aryana Angkat, Nazwa Nola Ayub, Edwar Barus, Deo Jordy Br Manihuruk, Deselomita Hagarma Br Sembiring, Emelia Putri Bukit, Rosmeri Br Dewi, Tani Sindy Safira Dhillon, Siena Sanjana Dwi Putri, Nabila Edlin, Edlin Edy Fachrial Elmiam, Dwi Fadillah, Qori Fernando Fernando, Fernando Fibrini, Dewi Fiska Maya Wardhani Fitriani, Anche Pratiwi Fritz, Regina Hanjaya Harmileni Hartono Hasibuan, Ahmad Hasanuddin Hasibuan, Selly Rahmadiah Hutapea, Jhonson Hutapea, Risma Ronauli Hyachinta, Izdihar Putri irza Haicha Pratama Iskandar, Ari Rahman Ivonne, Ivonne Johnson Hutapea lister , Clarissa Lister, Clarissa Loren, Jeff Masdalena, Masdalena Muchtar, Muhammad Arafat Muharraran, Firdha Mukti, Ade Indra Mutia, Maya Sari Nadapdap, Marshall Jeremia Nasution, Masdalena Nasution, Prenan Dito Perdana Nasution, Tamimi Badzlina Nazara, Novita Mirna Sari Novita, Cut Elvira Pasaribu, Rigal Arizki Praysela, Praysela Purwoko, Heri Putri Hyachinta, Izdihar Putri, Nabila Dwi Rahmadiah Hasibuan, Selly Reh Malem br Karo Rosari, Carolina Yosita Cahya Saragih, Ayu Theresia Simatupang, Mega Riama Sawitri Br Simbolon, Boyke Marthin Sintya, Inda Dhea Sipayung, Yelvreza Rastiani Sitorus, Teresya Nova Stefenie, Stefenie Suhartomi Surbakti, Betharia Lorenza Br Theresia, Yohani Thirza, Repi Ivena Tiswan, Jiad Hanan Wardhani, Fiska Maya Widya Yanti Sihotang Wijaya, Johana Fransiska Yolanda Eliza Putri Lubis Yumardika, Deza Yunata, Kianie Engaline Zahira, Niza Zaluchu, Sarah Oculi