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Journal : Global Medical and Health Communication

Screening for Latent Tuberculosis Infection using Interferon-Gamma Release Assay Test among Healthcare Workers Rosamarlina, Rosamarlina; Mariana, Nina; Sundari, Titi; Setianingsih, Tri Yuli; Jahiroh, Jahiroh; Pertiwi, Intan; Widiantari, Aninda Dinar; Setiawaty, Vivi; Murtiani, Farida
Global Medical & Health Communication (GMHC) Vol 11, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i2.10927

Abstract

Healthcare workers (HCWs) represent a significant demographic for screening latent tuberculosis infection (LTBI) due to their potential exposure to infectious patients. Tests based on immunology detection, such as the tuberculin skin test (TST) and the interferon-gamma release assay (IGRA), have been pivotal in diagnosing LTBI. The objective of this study was to evaluate the efficacy of the IGRA test in detecting LTBI compared to the TST among HCWs in an infectious disease hospital. In a cross-sectional study conducted in August 2019 at the Sulianti Saroso Infectious Disease Hospital, we examined 84 HCWs selected through consecutive sampling. Participants were assessed using questionnaires, and the IGRA and TST tests were performed. The findings revealed that 42 (50%) HCWs tested positive for LTBI based on the IGRA test. Most were female, aged 36–45 years, had direct exposure to TB patients, and had been in the healthcare profession for over a decade. The concordance between the TST and IGRA test, as indicated by a κ value, was 0.234. Furthermore, a significant correlation was observed between the incidence of LTBI and the duration of the healthcare profession (p=0.016). In conclusion, our research suggests that both TST and IGRA tests can effectively detect LTBI. The IGRA test had a higher positivity rate among HCWs with over ten years of service. 
Diphtheria Outbreak among Children in 2017–2018: a Single Centre Study in Indonesia Aliza, Nur; Maemun, Siti; Yoenoes, Dedet Hidayati; Syafendra, Mega Oktariena; Amin, Desrinawati Muhammad; Afrina, Yeni; Rahmawani, Atika; Aryanto, Dara Tyas Putri; Murtiani, Farida
Global Medical & Health Communication (GMHC) Vol 11, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i2.10951

Abstract

Diphtheria is an acute infectious disease caused by the bacterium Corynebacterium diphtheriae. Accurate and prompt diagnosis is essential for effective case management, predicting disease prognosis, preventing complications, and ensuring cost-effective medical intervention. This study aimed to assess the variety of clinical symptoms exhibited by pediatric diphtheria cases during an outbreak. An observational cross-sectional study was conducted using data from the medical records of pediatric diphtheria cases at Sulianti Saroso Infectious Disease Hospital from November 1, 2017, to February 28, 2018. The study involved 202 cases, and statistical analysis was performed using the chi-square test. Out of the 202 cases, 58.4% were male. Age distribution was <1 year: 7.4%, 1–2 years: 3.5%, >2–5 years: 24.8%, >5–12 years: 45.5%, and >12 years: 18.8%. Anamnestic findings revealed the presence of fever in 88.1% of patients, pain upon swallowing in 73.3%, and cough in 55.4%. Clinically, every patient exhibited pseudomembrane formations. Other findings included bilateral tonsillar involvement in 53%, lymphadenopathy in 40.1%, bullneck in 17.8%, and snoring in 7.9%. Four significant variables were associated with the diphtheria diagnosis: fever, snoring, bullneck, and snoring (p<0.05) respectively. Clinical signs and symptoms are pivotal in establishing a diphtheria diagnosis in pediatric cases.
Co-Authors Abdul Khamid, Abdul Achmad Shidiq, Achmad Adria Rusli, Adria Afrina, Yeni Agustin Agustin Agustin, Heidy Aliza, Nur Ambarwati, Desi Amin, Desrinawati Muhammad Apriliani, Isnawati Armedy Ronny Hasugian Aryanto, Dara Tyas Putri Asep Purnama, Asep Asri C. Adisasmita Ciuputri, Pauline Dadang Darmawan Darmawan, Flora Honey Dinar Widiantari, Aninda Djajaningrat, Husjain Dyna Apriany Endang Sri Roostini Hardjolukito Fajrunni’mah, Rizana Fitri Nurhayati Fitri, Desi Yulia Fitrianur Laili, Fitrianur Hadayna, Saila Hana Yuliana Hanum, Sitti Fatimah Harimat Hendarwan Hendrawati, Nunung Herawati, Ita Herlina Herlina Heryandi, Dadang Hutabarat, Veronika Ika WAHYUNI Indawati, Eli Jahiroh, Jahiroh Kunti Wijiarti, Kunti Kusmardi Kusmardi Lisna Anisa Fitriana, Lisna Anisa Maemun, Siti Maryani Maryani Matondang, Faisal Mauliku, Novie Mieska Despitasari Mochammad Hatta Mochartini, Tri Muhammad Atoillah Isfandiari Nina Mariana, Nina Norma Norma Novi Malisa, Novi Nugroho, Anita Puspitasari Dyah Nur Farhanah, Nur Nuraidah Nuraidah, Nuraidah Nurhayati Nurhayati PERTIWI, INTAN Pratiwi, Tiara Z. Pujiantana, Artetha Mutiara Purnama, Tri B. Rahmawani, Atika Rakhmawati, Arifah Rivaldiansyah, Rivaldiansyah rosamarlina, rosamarlina Sahrudi, Sahrudi Saputra, Mohamad Hendra Sarif, Armaji Kamaludi Septian Andriyani, Septian Setianingsih, Tri Yuli Setiawan, Guling Suci Tuty Putri, Suci Tuty Sudarto Ronoatmodjo Suliati Suliati Sumaryati Sumaryati Syafendra, Mega Oktariena Tampubolon, Maria L. Tanjungsari, Dian W. Tanjungsari, Dian Wahyu Titi Sundari Upik Rahmi, Upik Utama, Made Susila Vivi Setiawaty Wahyuning, Indah Wasilah Wasilah Widiantari, Aninda D. Widiantari, Aninda Dinar Wirasmi, Sundari Yoenoes, Dedet Hidayati Yogasara, Yoseph Yulianto, Aris