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Habibi
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Journal : International Journal of Cell and Biomedical Science

 1 
Secretome-Based Therapy Promotes Epidermal Thickness Recovery and Follicular Regrowth in Fluconazole-Induced Alopecia in Rats Ametati, Holy; Prawitasari, Salindri; Habibi
International Journal of Cell and Biomedical Science Vol 4 No 11 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i11.72

Abstract

Background: Alopecia involves hair loss characterized by decreased follicle density and epidermal thinning, which may be exacerbated by prolonged fluconazole exposure. The secretome derived from human umbilical cord mesenchymal stem cells (hUC-MSCs) possesses anti-inflammatory and regenerative properties that could aid follicular repair. Methods: Twenty-four male Wistar rats were randomly assigned to four groups: control, 5% minoxidil, hUC-MSC secretome, and secretome–minoxidil combination. Alopecia was induced by fluconazole administration for seven days, followed by a seven-day treatment period. Histological evaluation using hematoxylin and eosin staining assessed hair follicle count and epidermal thickness. Results: The hUC-MSC secretome group exhibited a significant increase in follicle count (mean 39.2; p < 0.001) compared with the control and minoxidil groups. However, changes in epidermal thickness were not statistically significant (p = 0.133). Conclusion: hUC-MSC secretome effectively enhances follicular regeneration in fluconazole-induced alopecia and represents a promising biotherapeutic approach for hair restoration.
Co-Authors Ady Purwoto Ameer, Khairul Andi Bukti Djufri Andi Tenriola Fitri Kessi Andi Tenriola Fittri Kessi Andini Putri, Natasha Anna Veronica Pont Arni Julian Azahra, Devani Baiq Azmi Sukroyanti Dadang Muhammad Hasyim Daryani Darwis Desty Endrawati Subroto Dwi Pangga Dwi Sabda Budi Prasetya Elvina Triana Putri Ety Lisma, Ni Putu Fitri Yulia Gani, Helmy Hafiz, Akbar Maulana Haidir Harfiansyah, Sri Hasbi Ibrahim, Hasbi Hasibuan, Arfin Holy Ametati Ibnu Hajar Irawan Karim, Qadri Kusumastuti Legowo, Mig Irianto Listriorini Lali Pora Madinah Mokobombang Mahendra, Rudi Makki, Muhammad Maulidza, Noor Maysarah, Delvi Mesiono, Mesiono Muhammad Amri Muhammad Azrul Syamsul Munawir Amansyah Musabikha Nikitasari, Arini Nildawati Pamungkas, Lalu Johandi Saufa Prawitasari, Salindri Prifiharni Priyotomo Radjali Amin Rasyidin, Gunawan Reza Lestari Riastuti Rindu Syamsuddin Riswadani, Krisna Rizky Maharja Rose Sihombing, Okto Fernando Saifudin Setiady, Nova Teguh sipahutar, nurkhalizah Sitti Fatimah Rahmansyah Sri Wulandari Sulaeman Syahrul Basri Syaiful Bastari Syamsul Alam, Syamsul T. Iskandar, Seriel Taufiq Hidayat Ulasaswini, Andi Ade Wulandari, Febriana Tri Yasir