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All Journal Medula Jurnal Biologi Tropis Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) Poltekita: Jurnal Pengabdian Masyarakat JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Karima, Nisa
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : medula

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Obstructive Sleep Apnea (OSA) pada Usia Produktif Annisarahma, Lyvia; Karima, Nisa; Sangging, Putu Ristyaning Ayu; Rudiyanto, Waluyo
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.951

Abstract

Obstructive sleep apnea (OSA) is a sleep disorder which characterized by cessation of breathing for more than 10 seconds. A blockage in the upper respiratory tract may be the cause of OSA. One known risk factor for OSA is smoking. Moreover, the degree of physical activity might also influence OSA risk. This article is a literature review with a variety of the latest sources that are relevant to the topic. The sources used were obtained from the search engine for health journals. The prevalence of OSA in the productive age community in Asia is 4.1 - 7.5%. Some factors that affect the symptoms of OSA, especially in productive age, namely obesity, male sex, old age, genetic, smoking habits, and small upper airway diameter. OSA is characterized by snoring, periodic apnea, hypoxemia during sleep and hypersomnolence during the day. Some symptoms of OSA are snoring hard and annoying, stopping repeated breathing during sleep at night, insomnia, fatigue, and drowsiness during the day. Death from OSA in productive age is usually caused by complications after having OSA in the long period ahead.
MIGRAIN DENGAN AURA: TINJAUAN PUSTAKA Oktarlina, Rasmi Zakiah; Setiawan, Muhamad Rizky; Karima, Nisa; Sutarto, Sutarto
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1451

Abstract

Migraine is a neurovascular disorder characterized by recurrent headaches with symptoms such as nausea, phonophobia and photophobia. Factors related to migraine include food, psychosocial and environmental factors. The purpose of this article is to identify migraine trigger factors. The type of research is a literature review. Migraines can occur due to trigger factors including foods with certain ingredients (such as tyramine, chocolate), menstrual cycle, weather, sleep patterns, bright light, and screen time. The prevalence of migraine in the world reaches 10-14% with the highest incidence in North America, Central America and South America. In Indonesia alone, the prevalence of migraine has reached 3.5 million people with the highest coming from individuals aged 15-24 years. Until now, the exact cause of migraines is not known. However, there are many risk factors that can influence the occurrence of migraines. The diagnosis of migraine can be made through the results of the history and physical examination, and if necessary, supporting examinations can also be carried out to rule out other secondary causes that may influence migraine. Efforts to prevent migraines from occurring by controlling and avoiding trigger factors and living a healthy lifestyle. Migraine prevention can be done by avoiding trigger factors and adopting a healthy lifestyle, such as maintaining a regular sleep pattern, managing stress, and consuming a balanced nutritious diet.
Faktor Gangguan Ginjal dan Diabetes Melitus yang Mempengaruhi Mortalitas Penderita Sindrom Koroner Akut di RSUD Dr. H. Abdul Moeloek Tahun 2020–2021 Fadhlurrahman, Fadhlurrahman; Yonata, Ade; Karima, Nisa; Kurniati, Intanri
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1676

Abstract

Acute Coronary Syndrome (ACS) is one of the leading causes of cardiovascular mortality worldwide and in Indonesia. Various risk factors have been investigated, yet two important comorbidities that frequently worsen the prognosis are diabetes mellitus and kidney disorders. Diabetes mellitus accelerates atherosclerosis and promotes plaque instability, whereas kidney disorders exacerbate cardiovascular metabolism and restrict therapeutic options due to impaired drug elimination. This study aimed to analyze the influence of diabetes mellitus and kidney disorders on the mortality of ACS patients at Dr. H. Abdul Moeloek General Hospital. An analytic observational study with a cross-sectional design was conducted involving 71 patients diagnosed with ACS during the 2020–2021 period. The main independent variables were diabetes mellitus and kidney disorders, while mortality served as the dependent variable. Data were analyzed using the Chi-Square test, Fisher’s Exact Test, and Odds Ratio (OR) calculations, with a significance level of p < 0.05. The study found an overall mortality rate of 25.3% among ACS patients. A significant relationship was observed between diabetes mellitus and mortality (p = 0.012; OR = 3.1) as well as between kidney disorders and mortality (p = 0.019; OR = 4.0). This indicates that ACS patients with diabetes mellitus have approximately three times higher risk of death, and those with kidney disorders have about four times higher risk compared to those without these comorbidities. In conclusion, diabetes mellitus and kidney disorders are significant predictors of mortality among ACS patients, highlighting the importance of comprehensive management for patients with these conditions in clinical cardiovascular care.
Perbandingan, Monoterapi, Double Terapi, Triple Kombinasi Terapi Pada Pasien Glaukoma Primer Sudut Terbuka Di Rumah Sakit Mata Lampung Eye Center Zaiva, Syalsa; Karima, Nisa
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1764

Abstract

The eye is an essential sensory organ that delivers visual information to the brain. Glaucoma is a progressive optic neuropathy that can disrupt this process and lead to irreversible blindness. Primary open angle glaucoma is the most common type and is characterized by a gradual increase in intraocular pressure with minimal early symptoms. Glaucoma treatment is usually initiated with single drug therapy or monotherapy. If monotherapy is insufficient to control intraocular pressure, combination therapy using two or more medications is required, including double therapy and triple combination therapy. This study aimed to compare the effectiveness of monotherapy, double therapy, and triple combination therapy in reducing intraocular pressure in patients with primary open angle glaucoma at Lampung Eye Center Eye Hospital. An observational analytic method with a cross sectional design was used. Data on intraocular pressure and treatment regimens were obtained from medical records. Bivariate analysis was performed using the Kruskal Wallis test. The results showed that most subjects were male, with 23 patients or 53.5%, and the most common age group was 40 to 60 years, accounting for 41.9% of participants. Of the 43 patients included, 20.9% (9 patients) received monotherapy, 60.5% (26 patients) received double therapy, and 8 patients or 18.6% received triple combination therapy. Bivariate analysis demonstrated a statistically significant reduction in intraocular pressure in patients receiving triple combination therapy, with a p value less than 0.05. These findings indicate that triple combination therapy provides the most significant intraocular pressure reduction in patients with primary open angle glaucoma.
Co-Authors Ade Yonata, Ade Adnan, Ayu Zahera Agustyas Tjiptaningrum Andriani, Silvia Annisarahma, Lyvia Ari Wahyuni AS, Putu Ristyaning Asep Sukohar Audah, Kholis A. Ayu, Putu Ristyaning Christy, Angelica Philia Dian Isti Angraini Dwi Indria Anggraini eko efendi Esti Harpeni Ety Apriliana Fadhlurrahman, Fadhlurrahman Fadli, Muhammad Yogie Ferdiansyah, Ahmad Irzal Fitria Saftarina Giska Tri Putri Hendra Tarigan Sibero Intanri Kurniati Irawati, Nur Ayu Virginia Irawati, Nur Bebi Ulfah Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Khairun Nisa Kurniawaty, Evi Muamar, Aslam Muhartono Muhartono Murfi, Syahrani Alya Nirwana HR, Herlingga Nurhaliza, Suci Padmadisastra, Jauzaa Faishal Ahmad Purnomo, Rizki Agung Rahmah, Azizah Nur Rasmi Zakiah Oktarlina Ratna, Maya Ganda Rudiyanto, Waluyo Safira, Ditya Ananda Sangging, Putu Ristyaning Ayu Sari, Mahala Ramah Setiawan, Muhamad Rizky Setiorini, Anggi Shiddiq, Haikal Shinta Nareswari, Shinta Sidik, Faizah Zahrah Siregar, Maulana Irfan Hazairin Sukarti Sukarti Susanti, Oktora Sutarto Sutarto Syazili Mustofa TA Larasati TP, Giska Utari Gita Mutiara Vi, Nur Ayu Virginia, Nur Ayu Zahra, Tsurayya Fathma Zaiva, Syalsa