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Journal : Pharma Xplore : Jurnal Sains dan Ilmu Farmasi

STUDI IN SILICO SENYAWA TUMBUHAN FAMILI ASTERACEAE SEBAGAI PENGHAMBAT ENZIM XANTIN OXIDASE Oky Hermansyah; Fadila Jeni Salsabila; Reza Pertiwi; Riana Versita; Ikhsan Ikhsan
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2942

Abstract

Asteraceae family plants contain flavonoid and phenolic compounds which have many benefits including inhibiting the xanthine oxidase enzyme, this enzyme plays a role in the conversion of purines into uric acid. Excessive production of uric acid in the body can cause deposition in the joints which causes pain and stiffness and swelling of the joints. Inhibition of this enzyme can normalize the amount of uric acid in the body and reduce its effects. This study aims to determine the potential of Asteraceae family plants with the best inhibition of the xanthine oxidase enzyme using the in silico method with molecular docking. The potential of the compound was assessed based on the parameters of bond energy values, inhibition constants, hydrogen bonds and amino acid residues. The size of the molecular docking center in this study x= 95,226; y= 47,251; z = 112,78 with volume x, y, and z = 40. The simulation results show that the test compound that has the best bond energy value (ΔG) is myrisetin of -10.58 kCal/mol. In general, from the research results, myrisetin compounds contained in the asteraceae family of chrysanthemum plants are compounds that have the potential to be further tested in vitro or in vivo as inhibitors of the xanthine oxidase enzyme.
Co-Authors Aanisah Hanuun Agung Giri Samudra Agus Martono Agustianto, Sandy Alawiya Simanullang, Khairatul Alfarizi, Aziz Aniza, Mifta Violina Asdim Az Zahra, Farah Azhar, Afra Wafiqah Bekti Widiansyah, Alif Desi Novita Reviana, Desi Novita Dhea Ananda Dian Fita Lestari Dian Handayani Dian Handayani Dominica, Dwi Dyah Fitriani Eni Kurniati, Eni Ernis, Gustria Fadhila, Muhammad Adeng Fadila Jeni Salsabila Fadila, Muhammad Adeng Feby R.A Putri Fitri Ramadhanti Hanuun, Aanisah Hari Marta Saputra Hari Marta Saputra Harianti Putri, Yona Hendri Saputra Hizkia Puspa Pertiwi Ikhsan Ikhsan Ilfanisari, Vinolla Indah Sari, Puput Tri Iwan Mahmud, Iwan Kamilla Putri, Dwi Khaliq, Iyas Nur Khodijah, Petri Siti Komala Sari, Delia Kurnia, Ridho Kurniawati, Noval Lestari, Dian Fita Lestari, Mustika Dewi Mutyarini, Afiska Nasution, Riski Padilah Nesbah, Nesbah Nofa Risma Azis, Nofa Risma Notriawan, Doni Noval Kurniawati Nurjali, Zavira Oky Hermansyah Petri Siti Khodijah Prameswari, Florencaya Prameswari Prima Yudha, Sal Putri Nurlita, Septia Putri, Fadilla Aliyah Putri, Khoirunnisa Awaliyah Putri, Yona Harianti Radestian, Juwita Triananda Rahmawati, Reza Ramadhani, Nasywa Fathia Reni Susanti Riana Versita Risky Hadi Wibowo Rochmah Supriati SALPRIMA YUDHA S Salsabila, Adinda Okta Sani K, Fathnur Santi Nurul Kamilah Sari, Rose Intan Perma SEPTI WULANDARI Sihombing, Imelda Simatupang, Muhaida Ramzany Sipriyadi Syahidah, Aminah Syalfinaf Manaf Triawan, Deni Agus Tya Chalifatul Welly Darwis Wibowo, Aprillia Devi Wibowo, Risky Wibowo, Risky Hadi Yona Harianti Putri