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All Journal Jurnal Biologi Tropis Jambura Journal of Health Sciences and Research Jurnal Prima Medika Sains Buletin Kedokteran dan Kesehatan Prima Ranah Research : Journal of Multidisciplinary Research and Development Journal of Pharmaceutical and Sciences.
Neswita, Elfia
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POTENSI INTERAKSI OBAT METILPREDNOSOLON INJEKSI DI INTENSIVE CARE UNIT SALAH SATU RUMAH SAKIT KOTA MEDAN PERIODE NOVEMBER 2023-APRIL 2024 Neswita, Elfia; Nurasni, Nurasni
Jambura Journal of Health Sciences and Research Vol 7, No 1 (2025): JANUARI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v7i1.29325

Abstract

Ruang ICU (Intensive Care Unit) rumah sakit berfungsi sebagai unit yang menangani pasien dengan kebutuhan pengawasan ketat dan intervensi medis selama 24 jam. Peran farmasi sangat penting, terutama dalam memantau potensi interaksi obat yang membahayakan pasien. Kebaharuan penelitian ini adalah identifikasi potensi interaksi obat injeksi metilprednisolon dengan obat lain di ruang ICU salah satu rumah sakit di Kota Medan. Penelitian ini bertujuan untuk mengidentifikasi potensi interaksi obat yang melibatkan injeksi metilprednisolon dengan obat lain di ICU salah satu rumah sakit swasta di Kota Medan selama November 2023 hingga April 2024. Data mengenai penggunaan obat di ICU diperoleh dari rekam medis dan potensi interaksi metilprednisolon dengan obat lain menggunakan instrumen Micromedex. Hasil analisis menunjukkan adanya 10 interaksi kategori mayor antara injeksi metilprednisolon dan obat lain, yang didokumentasikan dengan berbagai tingkat validitas. Interaksi dengan dokumentasi excellent ditemukan pada 3 kombinasi obat. Pada dokumentasi good, terdapat 3 interaksi. Sementara itu, dokumentasi fair mencatat 4 interaksi. Dampak interaksi meliputi peningkatan risiko ruptur tendon, pengurangan efektivitas warfarin, pengurangan kadar fentanyl di tubuh, peningkatan efek samping metilprednisolon, serta penurunan kadar. Interaksi juga mencatat risiko salisilisime setelah penghentian metilprednisolon, penurunan efektivitas kodein dan tramadol, serta gejala putus opioid. Tingginya potensi interaksi obat metilprednisolon dengan obat lain di ICU menuntut perhatian khusus dari pihak rumah sakit dalam mengawasi penggunaan obat, meminimalkan interaksi yang terjadi, serta mencegah dampak negatif terhadap pasien. Kesimpulannya ditemukan 10 obat yang berinteraksi dengan injeksi metilprednisolon dalam kategori mayor.
Uji efektivitas antidiare ekstrak etanol biji asam Jawa (Tamarindus indica L.) terhadap mencit jantan dengan metode transit intestinal Simanjuntak, Nerly Juli Pranita; Neswita, Elfia; Lubis, Asyrun Alkhairi; Yunus, Muhammad
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.458

Abstract

Tamarindus indica is a member of the Fabaceae plant family, often used as a food source and traditional medicine. For generations, tamarind has often been used in medicine. One part of this plant that is often used is the seeds, which treat various conditions such as asthma, bronchitis, leprosy, tuberculosis, wounds, stomach problems, diarrhea, dysentery, vertigo, and diabetes. The active components of tamarind seeds include tannin compounds, fatty acids, flavonoids, saponins, alkaloids, and glycosides. This study used the intestinal transit method to examine the antidiarrheal effect of ethanol extract from tamarind seeds on male mice. This research method uses the intestinal transit method, namely comparing the length of the intestine through which the marker passes. The results of the observation of the antidiarrheal effect of the ethanol extract of tamarind seeds at a dose of 50 mg/kg bw gave the weakest antidiarrheal effect. The 450 mg/kg bw dose gave the most substantial antidiarrheal effect. Increasing the tamarind seed ethanol extract dose increased the antidiarrheal effect. The results of statistical analysis showed that administration of 2% tamarind seed ethanol extract suspension at a dose of 150 mg/kg bw and 450 mg/kg bw to male mice showed a practical antidiarrheal effect because it was not significantly different from loperamide 0.52 mg/kg bw which showed an impact. Antidiarrheal in Duncan's mean difference test (P > 0.05). The conclusion is that the ethanol extract of tamarind seeds has an antidiarrheal effect when given to male mice induced with oleum ricini using the small intestine passage method.
Pengaruh konseling obat terhadap pengetahuan dan tingkat kepatuhan pasien hipertensi Tahun 2023 Nainggolan , Intan; Nurasni, Nurasni; Simanjuntak, Nerly Juli Pranita; Novriani , Erida; Piska , Finna; Meutia , Rena; Neswita, Elfia
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.507

Abstract

Hypertension is when blood pressure exceeds normal limits, and it is generally a lifelong condition that requires maintaining stable blood pressure. Every year, the relationship between hypertension and death from heart and blood vessel disease stabilizes. Every year, the link between hypertension and death from heart and blood vessel disease is proven. This research took place from July to September 2023 at H. Adam Malik Hospital, Medan, with 53 patients who met the inclusion criteria. The study aims to assess the level of adherence of hypertensive patients to the use of their medication using the Morisky Medication Adherence Scale questionnaire and to see whether counseling can increase the level of patient compliance. The results of the analysis show that providing counseling has a significant impact on increasing compliance in hypertensive patients at H.Adam Malik General Hospital, Medan, as demonstrated by the Wilcoxon test with p-value < 0.05.
Co-Authors Amanda, Asri Andri Hidayat, Andri Ari Anti Br Bangun, Putri br. Sembiring, Novitaria br. Silalahi, Aancel Christine, Yesina DAMERIA DAMERIA Edy Fachrial Febriyanti Gulo, Putri Fitri, Khairani Halimatussa’diyah Pakpahan, Enni Hanjaya, Hanjaya Khairani, Tetty Noverita Lubis, Asyrun Alkhairi Malem Br Karo, Reh Meutia , Rena Muhammad Yunus Nainggolan , Intan Niranti, Tasya Putri Novita, Cut Elvira Novriani , Erida Novriani, Erida nurasni, nurasni Ongko, Nicolas Xavier Piska , Finna Razoki, Razoki Reh Malem br Karo Samin, Buter Simanjuntak, Nerly Juli Pranita Sinaga, Ade Putra Fratama Suandy, Suandy Tanamal, Claudia Tanjung, Fahrul Azmi