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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Althea Medical Journal Indonesian Journal of Tropical and Infectious Disease Biomedika Herb-Medicine Journal Indonesian Journal of Medicine MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan JURNAL PENDIDIKAN TAMBUSAI JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmiah Kesehatan Indonesian Journal for Health Sciences (IJHS) Jurnal Kesehatan Jurnal Biomedika dan Kesehatan Health Information : Jurnal Penelitian Solo Journal of Anesthesi, Pain and Critical Care KESANS : International Journal of Health and Science Journal of Innovation Research and Knowledge Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Medika International Journal of Health Science and Technology JHeS (Journal of Health Studies) Jurnal Keperawatan Biomedika Cermin Dunia Kedokteran Proceeding Book Call for Papers Fakultas Kedokteran Universitas Muhammadiyah Surakarta
Iin Novita Nurhidayati Mahmuda
Universitas Muhammadiyah Surakarta
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Concurrent Dengue and Malaria Infection : A Case Series Iin Novita Nurhidayati Mahmuda; Dhani Redhono Harioputro; R. Satriyo Budhi Susilo; Arifin Arifin; Tatar Sumandjar
Biomedika Vol 17, No 1 (2025): Biomedika Februari 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i1.7898

Abstract

Introduction: Malaria and dengue are endemic in Indonesia, and therefore, may result in the possibility of co-infection. Urban demographic expansion, deforestation, and agricultural settlements in peri-urban areas are known causes of the increase in the probability of concurrent infection of these two diseases. It is reasonable to envisage that the occurrence of concurrent infections would not be rare, mainly during outbreaks of dengue in the rainy season. However, due to non-systematic investigation of both diseases, only a few cases of malaria and dengue co-infection have been reported. These three patients demonstrated co-infection manifestations with good outcomes and prognoses. Case Illustrations: Two cases of co-infection of malaria vivax and dengue fever in male patients aged 35 and 43 years. The difference between these two cases is that one patient had experienced a previous episode of malaria with a fever lasting less than 5 days. Meanwhile, one patient who had never suffered from malaria experienced a relatively longer fever episode, up to 14 days. Thrombocytopenia in these two patients was still above 50,000/µL and rose quickly after anti-malarial administration. The third case was a 47-year-old woman with co-infection of malaria falciparum and dengue. This woman lived in Papua and had been infected with malaria before. This third case showed platelet numbers reaching levels as low as 38,000/µL and hypotension without signs of shock in the critical phase of dengue. The three patients did not show complications from other organs due to malaria or dengue and responded well to antimalarials with good outcomes. These patients were treated with a combination of DHP and primaquine, along with supportive care for fever and fluid management. Conclusion: Whenever co-infection is confirmed, we recommend careful monitoring for bleeding and hepatic complications, which may result in a higher chance of severity. Careful and intense monitoring of fluid requirements is necessary to avoid complications of fluid overload.
Hubungan Interleukin-6 dan Malondialdehyde terhadap Skor Kerusakan Multiorgan pada Sepsis Tikus Jantan Induksi Escherichia coli Muhammad Adnan; Nor Hilyati; Iin Novita Nurhidayati Mahmuda; Roro Flaviana Bayu Adistyani; Olivia Bunga Putri; Denny Bimatama Pradita
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.151-161

Abstract

Background Sepsis remains a leading cause of intensive-care mortality, primarily through multiple organ dysfunction syndrome (MODS) driven by overlapping pro-inflammatory and oxidative-stress pathways. Interleukin-6 (IL-6) and malondialdehyde (MDA) represent these two pathways, yet few studies have correlated both biomarkers with histopathological damage across five vital organs simultaneously. Therefore, this study aimed to analyze the association of serum IL-6 and MDA levels with multiorgan tissue-damage scores in an Escherichia coli-induced rat sepsis model. Methods This true-experimental, post-test-only control group study used nine male Wistar rats (Rattus norvegicus) allocated to three groups (n=3 each): an uninduced control and two groups given intraperitoneal Escherichia coli at 1 × 10⁶ and 1.5 × 10⁶ CFU/kgBW. Serum IL-6 (ELISA) and MDA (TBARS) levels, alongside semi-quantitative histopathology scores of five organs (liver, spleen, heart, kidney, and lung), were assessed 72 hours post-induction. Associations were analyzed using the Spearman correlation test. Results IL-6 correlated significantly with damage scores of the liver (r=0.828; p=0.006), spleen (r=0.887; p=0.001), heart (r=0.917; p<0.001), total lung score (r=0.874; p=0.002), and kidney (r=0.678; p=0.045), but not with alveolar dilatation (r=0.390; p=0.300). MDA correlated very strongly with the liver (r=0.931), spleen (r=0.965), heart (r=0.952), and total lung score (r=0.952; all p<0.001), but not significantly with the kidney (r=0.574; p=0.106). Furthermore, IL-6 and MDA were strongly inter-correlated (r=0.879; p=0.002). Conclusions In this Escherichia coli-induced rat sepsis model, serum IL-6 and MDA were both associated with the degree of multiorgan tissue damage and were strongly correlated with each other, a pattern compatible with coupling between inflammatory and oxidative pathways. Renal damage showed the weakest associations of the organs examined, suggesting organ-specific differences that warrant targeted investigation.
Malaria Knowlesi pada Manusia Dahlia Winda Nurarifah; Iin Novita Nurhidayati Mahmuda
Proceeding Book Call for Papers Fakultas Kedokteran Universitas Muhammadiyah Surakarta 2024: Proceeding Book Call for Papers Fakultas Kedokteran Universitas Muhammadiyah Surakarta (Apgar)
Publisher : Universitas Muhammadiyah Surakarta

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Abstract

Malaria adalah masalah kesehatan masyarakat yang serius yang terus menyebabkan penyakit dan kematian. Plasmodium knowlesi merupakan parasit malaria yang ditemukan di alam pada kera ekor panjang dan ekor babi. Plasmodium knowlesi, yang awalnya diketahui menyebabkan malaria simian, kini diakui sebagai parasit malaria kelima pada manusia.Infeksi pengetahuan pada manusia telah dilaporkan di hampir semua negara di Asia Tenggara dan pada wisatawan yang kembali dari negara-negara tersebut.Kasus kumulatif malaria pengetahuan di wilayah Asia Tenggara pada tahun 2004 hingga 2015 adalah 3413 kasus dengan 91,47% diantaranya terdapat di Kalimantan Malaysia. Spektrum penyakit klinis akibat infeksi Plasmodium knowlesi berkisar dari infeksi tanpa gejala, hingga malaria berat dan kematian.Kematian akibat malaria Knowlesi telah terdokumentasi dengan baik, dan P. Knowlesi kini menjadi penyebab kematian terbanyak akibat malaria di Malaysia. Tujuan penulisan agar semua orang mengetahui bahwa terdapat jenis malaria lain yang tersebar di wilayah tertentu yang sama membahayakan dengan jenis lain dan segera mendapat terapi.
Tetanus pada Pasien Usia Lanjut di RS PKU Muhammadiyah Surakarta: Sebuah Laporan Kasus Desty Triza Pratiwi; Iin Novita Nurhidayati Mahmuda
Proceeding Book Call for Papers Fakultas Kedokteran Universitas Muhammadiyah Surakarta 2024: Proceeding Book Call for Papers Fakultas Kedokteran Universitas Muhammadiyah Surakarta (Apgar)
Publisher : Universitas Muhammadiyah Surakarta

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Abstract

Tetanus merupakan suatu keadaan toksemia akut yang disebabkan oleh neurotoksin yang dihasilkan Clostridium tetani. Neurotoksin ini akan menghambat pelepasan neurotransmiter di sistem saraf pusat, menyebabkan spasme otot. Sehingga gejala tetanus ditandai dengan adanya spasme otot yang periodik dan progresif. Tetanus diklasifikasikan berdasarkan lokasi menjadi empat jenis meliputi tetanus lokal, sefalik, generalisata (umum) dan neonatorum. Tetanus generalisata merupakan jenis yang paling sering ditemui di lapangan. Prevalensi tetanus tinggi di negara dengan sumber daya rendah, dengan mortalitas mencapai 20-45%. Diagnosis tetanus dapat ditegakkan berdasarkan temuan klinis, riwayat luka terbuka dan riwayat imunisasi. Staging dan prognosis tetanus dilihat berdasarkan kriteria Pattel Joag atau Klasifikasi Albleets. Laporan kasus ini menyampaikan seorang pria berusia 60 tahun dan 78 tahun yang dirawat di RS PKU Solo Provinsi Jawa Tengah dengan keluhan kaku pada seluruh tubuh. Perbedaan antara kedua kasus di mana pada kasus 1 terdapat fokus infeksi tetanus, grade 2 tetanus generalisata. Kasus 2 tidak terdapat focus infeksi, Riwayat imunisasi tidak diketahui, kejang general, suara tambahan paru, dan grade 3 tetanus.
Tetanus Generalisata pada Pria Usia 57 Tahun: Sebuah Laporan Kasus Anis Nuristiqomah; Iin Novita Nurhidayati Mahmuda
Proceeding Book Call for Papers Fakultas Kedokteran Universitas Muhammadiyah Surakarta 2026: Proceeding Book Call for Papers Fakultas Kedokteran Universitas Muhammadiyah Surakarta (Gastro
Publisher : Universitas Muhammadiyah Surakarta

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Abstract

Latar Belakang: Tetanus adalah penyakit infeksi akut yang disebabkan oleh Clostridium tetani, bakteri anaerob yang menghasilkan toksin tetanospasmin, yang menyerang sistem saraf pusat dan menyebabkan spasme otot yang menyakitkan serta gangguan fungsi otonom. Penyakit ini masih menjadi masalah kesehatan di negara berkembang, terutama pada individu yang tidak memiliki riwayat vaksinasi lengkap.Metode: Laporan kasus ini membahas seorang pria berusia 57 tahun yang datang ke IGD dengan keluhan perut kaku dan nyeri sejak empat hari sebelumnya.Hasil: Pasien disertai kesulitan membuka mulut (trismus), risus sardonikus, dan spasme otot generalisata. Pemeriksaan fisik menunjukkan hipertonus otot, opistotonus, dan tanda-tanda disfungsi otonom. Pasien didiagnosis dengan tetanus generalisata dan mendapat terapi suportif berupa pemberian imunoglobulin tetanus (TIG), antibiotik metronidazol, serta benzodiazepin untuk mengontrol spasme otot.Kesimpulan: Penatalaksanaan tetanus memerlukan pendekatan multidisiplin yang mencakup netralisasi toksin, pemberantasan sumber infeksi, serta dukungan pernapasan dan kardiovaskular. Studi kasus ini menyoroti pentingnya deteksi dini, vaksinasi lengkap, serta penanganan segera untuk mengurangi mortalitas dan morbiditas akibat tetanus.
Correlation of Neutrophil and Procalcitonin Levels with Multiorgan Damage Scores in an Escherichia coli-Induced Male Rat Sepsis Model Nor Hilyati; Muhammad Adnan; Iin Novita Nurhidayati Mahmuda; Roro Flaviana Bayu Astiyani; Olivia Bunga Putri; Denny Bimatama Pradita
Jurnal Kesehatan Vol 17 No 2 (2026): Jurnal Kesehatan (In Progress)
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v17i2.5802

Abstract

infection, which may lead to multiple-organ damage. Neutrophils and procalcitonin (PCT) are inflammatory biomarkers known to increase during sepsis and are suspected to be associated with the severity of organ injury. This study aimed to analyze the relationship between neutrophil and procalcitonin levels and multiple-organ tissue damage scores in a male rat sepsis model induced by intraperitoneal administration of Escherichia coli. This was a true experimental laboratory study using a post-test-only control group design involving nine male Rattus norvegicus rats divided into a control group, an E. coli-induced group receiving 1 × 10⁶ CFU/kg body weight, and an E. coli-induced group receiving 1.5 × 10⁶ CFU/kg body weight. Neutrophil levels were measured using a hematology analyzer, while PCT levels were determined using an Enzyme-Linked Immunosorbent Assay (ELISA). Multiple-organ damage was assessed through histopathological examination of the liver, kidney, spleen, heart, and lungs. Data were analyzed using Spearman’s correlation test. The results showed that neutrophil levels were significantly and positively correlated with damage scores of the liver (rs = 0.88; p = 0.002), spleen (rs = 0.90; p < 0.001), heart (rs = 0.92; p < 0.001), and lungs (rs = 0.91; p < 0.001). Procalcitonin levels were also significantly and positively correlated with damage scores of the liver (rs = 0.90; p < 0.001), spleen (rs = 0.87; p = 0.002), heart (rs = 0.85; p = 0.004), and lungs (rs = 0.88; p = 0.002). In conclusion, higher neutrophil and procalcitonin levels were associated with greater multiple-organ tissue damage in a male rat sepsis model induced by Escherichia coli.
Co-Authors Adhalia, Lian Aditya Putra Perdana Affifah, Fathiyya Noor Akbar Wardhana Andri Sugeng Prasetyo Angiesta Pinakesty Anis Nuristiqomah Aqmarina, Nadia Wdihi Arifin Arifin Arum Dyah Ripdianti Aulida Azkia Kamila Azahra Khansa Muza Azarine Marwah Bahrodin, Bahrodin Busyra, Busyra Cahyo, Febrian Dwi Citra Saputra, Rada Dahlia Winda Nurarifah Denny Bimatama Pradita Dessy Dessy Desty Triza Pratiwi Devi Usdiana Rosyidah Devi Usdiana Rosyidah Doni Priambodo Dwi, Raafika Studiviani Em Sutrisna Erika Diana Risanti Fairuz Ulfah Faizah, Ishmah Nur Fakhri Nofaldi Fathiyya Noor Afifah Fauziah, Nida Faradisa Febrian, Rizky Ferika Dian Syafitri Flora Ramona Sigit Prakoeswa Fuad Gandhi Torizal Harioputro, Dhani Redhono Herdiana, Nandya Ilhami, Afiq Zakie Indriyati Oktoviano R Ishmah Nur Faizah Iwan Setiawan Izzati, Sofi Filda Jati, Izzah Tsaqoofah Juwita, Triana Rahma Kania, Yulia Intan Khairunnisa, Reza Khotik, Laisa Kurnia Retnowati Kurnia Retnowati, Kurnia Lian Adhalia Listiana Masyita Dewi Maharotullaili Nur Azizah Marhamah, Nisrinah Maryati Maslahah, Syah Fillia Nurul Maulana, Yudrik Maya Monica Manurung Metana Puspitasari Mubaraq, Syahrun El Muhammad Adnan Nadia Wdihi Aqmarina Nanda Dhea Ayu Sawitri Nanda Dhea Ayu Sawitri Nanda Nurkusumasari Nandya Herdiana Naruma, Anteng Nining Lestari Nisa, Faridita Khoirun Nor Hilyati Nugrahaeni, Sarwasri Fajra Nugraheni, Frida Asfarina Oktafiani, Niken Sari Oktoviano R, Indriyati Olivia Bunga Putri Pinakesty, Angiesta Poetrie Wulandari Ruswandi Prasetyo, Andri Sugeng Prihatin Puji Astuti Priscillah, Wildan Putra, Catur Permana Putriyantiwi, Idoviari R. Satriyo Budhi Susilo Raafika Studiviani Dwi Binuko Rada Citra Saputra Rajendra, Hafish Harfian Raniah, Siti Fairuz Ratnasari Bondan Wijayanti Rezki, Yuniana Nur Riandini Aisyah Rochmadina Suci Bestari Roro Flaviana Bayu Adistyani Roro Flaviana Bayu Astiyani Ruswandi, Poetrie Wulandari Safari Wahyu Jatmiko Sahilah Ermawati Sahilah Ernawati Santi, Tika Melandya Sifak, Sheila Faadhila Siti Soekiswati Sri Wahyu Basuki Sri Wahyuni Srirojanakul, Sirada Subekti, Tyas Hanurita Sulistyani Sulistyani , Sulistyani Sulistyani Sulistyani Sulistyani Sulistyani Sutanto, Bambang Syah, Devan Adil Taroeno, Suryo Aribowo Tatar Sumandjar Tri Agustina, Tri Triana Rahma Juwita Tyas Hanurita Subekti Utami, Musrifah Budi Vitania Marsya Wibowo, Muhammad Irfan Sulystyo Wildan Priscillah Wulan Kadarsih Yaasiin, Putri Isa Maharani Yamsun, Rahmat Dani Yudrik Maulana Yulia Intan Kania Yuniana Nur Rezki Zelindrah, Virgil