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Journal : JURNAL PHARMASCIENCE

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PENGEMBANGAN FORMULASI DAN EVALUASI GUMMY CANDIES PARASETAMOL UNTUK ANAK-ANAK Chabib, Lutfi; Rizki, Muhammad Ikhwan; Aprianto, Aprianto; Zahrah, Aghna Mafruha
JURNAL PHARMASCIENCE Vol 1, No 1 (2014): JURNAL PHARMASCIENCE
Publisher : JURNAL PHARMASCIENCE

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Abstract

INTISARIGummy candy parasetamol adalah sediaan permen kenyal mengandung parasetamol yang ditujukan untuk hancur dan larut di dalam mulut. Tujuan penelitian untuk mengetahui pengaruh variasi campuran pemanis sorbitol dan glukosa cair terhadap sifat fisik sediaan gummy candy parasetamol. Pembuatan sediaan menggunakan metode cetak tuang. Perbandingan konsentrasi sukralos dengan sorbitol, manitol, stevia, serta xylitol masing masing 25:75%. Data yang diperoleh dianalisis dengan deskriptif non analitik. Hasil uji sifat fisik dan uji stabilitas fisik sediaan dengan parameter bentuk, rasa, aroma, tekstur, pengamatan kekakuan, pengamatan kristal, dan pH sediaan. Formula 4 (25:75%) memiliki rasa yang sedikit manis dan stabil dalam penyimpanan selama sebulan di climatic chamber suhu 25º dibandingkan formula yang lain. Hasil persentase uji hedonik (bentuk, rasa dan aroma) pada 28 responden memilih formula 4. Kombinasi pemanis sukralose dan stevia (25:75%) dapat menutupi rasa pahit dari parasetamol.Kata kunci : parasetamol, gummy candy,pemanis, sukralos.ABSTRACTGummy candy paracetamol is candy containing paracetamol that to disintegrate and dissolve in the mouth. The aim of research to determine influence of variation mixed sorbitol and liquid glucose on the physical properties of paracetamol dosage form gummy candy. Preparations used molding method. Concentration ratio sukralose with sorbitol, manitol, and xylitol 25:75%. Data were analyzed descriptive non analytic. Test results of physical properties and physical stability dosage form with parameter shape, taste, odor, texture, stiffness, crystal, and pH of dosage form. Formula 4 (25:75%) had a sweet taste and stable in storage for a month in the climatic chamber temperature of 25ºC compared to other formula. Concentration ratio sukralos and stevia (25:75%) could mask the bitterness of paracetamol.Key word: paracetamol, gummy candy, sweetener, sukralos.
Co-Authors Aan Hendry Afrida, Anggrelia Aghna Mafruha Zahrah, Aghna Mafruha Ahmad Faisal Aisyah Aisyah Alam, Hafidz Al Alfan, Alfan Anggorowati, M.Sc, Ir. Dini Ardhana, Praditya Aryanti Baehaqi Berliani, Teti Chairil, Muhammad Dewi, Novi Ayu Kristiana Dita Pratiwi Kusuma Wardani Dwi Septiani Eduard Asna Padagi, Eduard Asna Eka Priadi Eka, Priadi Ernawatie, Ernawatie Esdarwati, Susila Eshariyani, Eshariyani Febrianti, Mariska Ferdi Prima Nurhasan Firayanti, Yuni Ghazi Mauer Idroes Grossbia, Danny Harlen Sutandra, Harlen Helmi ., Helmi Hendrawan Hetty Nursawemi, Hetty Hikmah Hikmah Hud, Ibnu muhammad yusuf I Ketut Suada Ibnuwati, Sri Indra Kanedi Irvanizam, Irvanizam Istiqomah Nur Rahmawati Jamaluddin Jamaluddin Karolina, Puspa Erika Kiki Rezvianti Ladewi , Yuhanis Ladewi, Yuhanis Lala, Andi Lilik Warsito Limin, Dagai L Lutfi Chabib, Lutfi M. Ervan Dwi Setiaji M. Rezky Septiyadi M. Septianto M.Imamuddin, M.Imamuddin Magati, Hefinto Maithy, Sifera Patricia Marhamah Marhamah Marsudi . Marwan Marwan Maryono Maulana, Aga Muhammad Ikhwan Rizki Muhammad Yusuf Musram Abadi Nasution, Awal Kurnia Putra Nizamuddin Nizamuddin Novita Sari, Muthiah Nusril Nusril Perdana, Aryadika Putra Piter Joko Nugroho Prahasti, Prahasti Purnomo, Widiharto Qo’imah, Alamanda Nurul R M Rustamaji Radiafilsan, Christian Rahaju, Minto Rahmadona, Cahaya Raldo Andika Mandasia Rata, Fildayanti Razief Perucha Fauzie Afidh Rifaldi, Muhammad Arif Riski, Moh Rustamaji, R.M. Sarah, Muthia Sari, Yona Satrio, Yoga Sedek, Melky Shofia Nurun Alanur S Simamora, Roberton Siregar, Novita Januarti Siregar Siregar, Yustika Handayani Siti Haryani Sriyoto Sriyoto, Sriyoto Sudarkam R Mertosono Sudarsono, Tantri Analisawati Sukmawati Sukmawati Sumarnie, Sumarnie Sunardi Suri, Atika Surya Kusuma Wardana Susana M.Sc, Ir. Rini Syarif Razhik Ghazali TAKDIR SAILI Tarsono, Edi Teuku Rizky Noviandy Tiara Fatrin Tongenge, Miranda Utami?, Bernadhita Herindri Samodera Vivi Bachtiar Wahyu Adi Tama A Wahyudin Wahyudin Winaryo, Slamet Wingki Sapta Dewa Yuningtyastuti Yuningtyastuti Zulkipli ., Zulkipli