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ANALISIS POTENSI INTERAKSI OBAT PADA PASIEN GAGAL GINJAL KRONIK (GGK) STADIUM AKHIR DI RUMAH SAKIT AULIA PEKANBARU Primadhini, Tessa Amanda; Almasdy, Dedy; A, Almahdy
Jurnal Kesehatan Medika Saintika Vol 14, No 2 (2023): Desember 2023
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v14i2.2173

Abstract

Setiap tahun terjadi peningkatan prevalensi penyakit gagal ginjal kronik (GGK) stadium akhir atau End Stage Renal Disease (ESRD) di Indonesia, seiring dengan meningkatnya jumlah penduduk usia lanjut dan angka kejadian penyakit diabetes melitus dan hipertensi yang juga berpotensi terjadinya komplikasi penyakit lain dalam jangka panjang seperti anemia, kelainan mineral dan tulang, sehingga membutuhkan penggunaan berbagai macam obat (polifarmasi). Penggunaan obat dalam jumlah banyak dan dalam waktu yang lama akan meningkatkan kemungkinan terjadinya interaksi obat yang berisiko menurunkan efektivitas terapi dan memperburuk kondisi pasien. Penelitain ini bertujuan untuk mengetahui karakteristik pasien, jenis obat yang digunakan, potensi interaksi obat, tingkat keparahan dan mekanisme interaksi obat pada pasien GGK stadium akhir. Penelitian ini menggunakan teknik purposive sampling dengan total 112 sampel yang memenuhi kriteria inklusi periode Januari dan Desember 2022. Penelitian ini merupakan penelitian observasional, dan data dikumpulkan secara retrospektif. Analisis interaksi obat dilakukan berdasarkan software Drugs.com dan Drugbank.com dengan pengelompokan berdasarkan tingkat keparahan minor, sedang dan mayor. Hasil yang didapatkan, pasien dengan GGK sebagian besar berjenis kelamin laki-laki (55,36%), rentang usia ≥65 tahun (48,21%), lama perawatan ≤7 hari (60.71%), hipertensi (51,79%), jumlah penggunaan obat 6-10 jenis ( 56.25%) dan obat yang paling banyak digunakan adalah Furosemid (6,54%). Proporsi pasien yang mengalami kejadian interaksi obat sebesar 95% dengan kejadian interaksi terbanyak 1-3 kali (56,60%) dalam waktu penggunaan obat yang bersamaan. Interaksi obat yang paling sering terjadi adalah kombinasi Furosemide dan Omeprazole (8,73%). Proporsi tingkat keparahan kelompokkan dengan kategori minor (13,32%), moderat (13,32%) dan mayor (2,4%)
Isolation and Structural Analysis of Active Antioxidant Phenolic Compounds from Elephantopus mollis Kunth Verawati, Verawati; Almahdy, Almahdy; Febriyenti, Febriyenti; Prima Putra, Deddi
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/a2hcyr24

Abstract

Elephantopus mollis is a common weed found in West Sumatra, known for its diverse traditional uses and rich phytochemical content. This study aimed to isolate phenolic compounds and evaluate the antioxidant activity of the polar extract of E. mollis herb. The polar extract was obtained through successive extraction using solvents of increasing polarity. Separation of the polar extract was carried out using Amberlite XAD-4 resin chromatography with methanol and water eluents, followed by isolation through silica gel column chromatography using a step-gradient polarity elution system. The separation and isolation processes were monitored by thin-layer chromatography (TLC). Total phenolic content was determined by the Folin–Ciocalteu method, while antioxidant activity was assessed using the DPPH radical scavenging assay. Structural identification of the isolated compound was performed using UV-Vis, IR, NMR, and LC-MS spectroscopic techniques. Subfraction D of the polar extract exhibited a high phenolic content of 618.06 ± 3.38 mg GAE /g. From subfraction D, a phenolic compound designated D3a was isolated as a yellowish-white powder (95.30 mg) with an Rf value of 0.64, producing a dark blue color upon reaction with 10% FeCl₃. The antioxidant activity of compound D3a was classified as very strong, with an IC₅₀ value of 12.42 ppm. Based on physicochemical characterization, compound D3a was identified as caffeic acid with a molecular formula of C₉H₈O₄ and a molecular weight of 180.049.
EDUKASI PEMANFAATAN TANAMAN SUNGKAI SEBAGAI TANAMAN OBAT KELUARGA DI NAGARI PADANG LAWEH KECAMATAN SUNGAI PUAR KABUPATEN AGAM Dillasamola, Dwisari; Nasif, Hansen; Alen, Yohannes; Almahdy, Almahdy; Oktomalioputri, Biomechy; Sari, Azzahra Ayu
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 7 No. 3 (2024)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v7i3.633

Abstract

Indonesia is known for its abundant natural resources. Indonesian people have traditionally used herbal plants to maintain and overcome health problems. Traditional medicine is one of the alternative methods used to cure certain diseases. One of the plants that is often used as traditional medicine in Indonesia is Sungkai (Peronema canescens Jack.). The purpose of this activity is to provide education to the community about family medicinal plants (TOGA) which play an important role in maintaining health. With the survey conducted, it is hoped that this activity can have a good impact on the community. This activity was carried out in Padang Laweh, Sungai Pua District, Agam Regency, West Sumatra. Community service in the form of location surveys, education in raising awareness of the benefits of local herbal plants as the development of family medicinal plants (TOGA). Activities were carried out in August-September which were attended by 60 local people. The results of the education programme showed an increase in community understanding about the use of family medicinal plants (TOGA). The results obtained from the questionnaire data filled in by the community show that only 55% of the total respondents know the use of family medicinal plants (TOGA) can be used to improve body health. After education, the questionnaire data increased to 70%. So that the implementation of this education is considered to be able to increase community knowledge about plants that can be used as a medicine. With the implementation of this service, it can be concluded that this survey and education activity has succeeded in increasing the knowledge and utilisation of Sungkai Plants as medicinal plants by the community in Kenagarian Padang Laweh, Sungai Puar District, Agam Regency.
EDUKASI DAN PROMOSI KESEHATAN: PENGGUNAAN OBAT HERBAL YANG AMAN DAN EFEKTIF BAGI MASYARAKAT KECAMATAN PADANG UTARA KOTA PADANG Dillasamola, Dwisari; Nasif, Hansen; Alen, Yohannes; Almahdy, Almahdy; Andini, Airiza Fitri; Al-Khansaa, Syawwal
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 7 No. 3 (2024)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v7i3.642

Abstract

Herbal medicine is an alternative treatment made from natural materials such as plants, animals, or minerals and is often used by the community in addition to modern medicine. The use of traditional medicine in Indonesia is still believed by some people to treat various diseases. Herbal medicine has become an important part of traditional medicine in various parts of the world. Despite its potential, public knowledge regarding the safe and effective use of herbal medicines is still relatively low. For this reason, health promotion and education activities were carried out in the community to increase public understanding and knowledge about the use and benefits of herbal medicines. This activity was attended by 27 participants, mainly from mothers around the implementation location. Prior to the education, a questionnaire survey was conducted, which showed that 51.80% of the respondents had basic knowledge about herbal medicines. The enthusiasm of the participants was very high during the presentation of the material, indicating a great interest in understanding herbal medicine more deeply. The results of this activity showed a significant increase in knowledge among participants regarding the use of herbal medicine, especially in choosing cough medicines safely and effectively. It is hoped that this activity will not only have a positive impact on improving public health, but also equip them with a better understanding of using herbal medicines wisely and appropriately. With the high interest of the community in participating in this activity, it is concluded that this activity has a very positive impact on the community and fosters knowledge and awareness of the community to live a healthy life.
Hubungan Penggunaan Obat Golongan Statin terhadap GDS pada Pasien Diabetes Melitus Tipe 2 di Instalasi Rawat Inap Rsup Dr. M. Djamil Padang Primadhini, Tessa Amanda; A, Almahdy; Arriva, Dzaskia
Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta Vol 5 No 1 (2026): Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE
Publisher : LPPM Universitas Dharma Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jppie.v5i1.2437

Abstract

Dyslipidemia is one of the risk factors for cardiovascular disease in patients with type 2 diabetes mellitus, so statin therapy is often used to lower lipid levels and prevent cardiovascular complications. Although statins have clear benefits in the management of dyslipidemia, their effect on fasting blood glucose (FBG) levels still needs to be studied. This study aimed to determine the relationship between statin use and FBG levels in patients with type 2 diabetes mellitus. This study used a quantitative descriptive design with a retrospective approach. Data were obtained from the medical records of 82 patients with type 2 diabetes mellitus and dyslipidemia who were treated at the inpatient facility of Dr. M. Djamil Hospital in Padang. All patients in this study received statin therapy. The most commonly used statin was atorvastatin, which was used by 96.3% of patients, while simvastatin was used by 3.7% of patients. The results showed that the average decrease in random blood sugar levels in patients using atorvastatin was 55.65 mg/dL, while in patients using simvastatin it was 84.75 mg/dL. Although there was a numerical difference in the reduction of fasting blood glucose levels between the two statin groups, the difference found was not clinically significant. Thus, this study indicates that the use of statin drugs does not have a significant association with changes in fasting blood glucose levels in patients with type 2 diabetes mellitus.
Impact of self-care training on prediabetes prevention among UIN Jakarta employees: The Role of Public Health Pharmacy in Education and Monitoring Siregar, Barita Juliano; A, Almahdy; Almasdy, Dedy; A, Syamsudin; Betha, Ofa Suzanti; Rohaedi, Edi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.206-216.2025

Abstract

Prediabetes is a preclinical condition with a high risk of progressing to type 2 diabetes. This study evaluated an eight-week self-care training program among UIN Jakarta employees, facilitated by Public Health Pharmacy and integrating Avicenna’s classical health principles with WhatsApp-based digital education. A quasi-experimental pre–post design without a control group was applied to 39 participants meeting prediabetes criteria. Clinical parameters assessed included random blood glucose (RBG), systolic blood pressure (SBP), body mass index (BMI), and waist circumference (WC), along with self-care practices using the Indonesian version of the Diabetes Self-Management Questionnaire (DSMQ). Data were analyzed using Wilcoxon signed-rank test and Cohen’s dz effect size. Significant improvements were observed in SBP (dz = -0.530), BMI (dz = -0.253), WC (dz = -0.320), and DSMQ score (dz = +0.793), while RBG showed no significant change. These findings support a culturally relevant, cost-effective model for workplace-based prediabetes prevention. In line with American Diabetes Association (ADA) 2025 Standards of Care, the approach emphasizes person-centered Diabetes Self-Management Education and Support (DSMES) and team-based support; European Society of Cardiology (ESC) 2024 guidelines align the observed SBP reduction with recommended targets after lifestyle intervention. Future programs should extend duration and adopt hybrid delivery for optimal glycemic control.