Article Per Year (5 Year)
p-Index From 2021 - 2026
2.832
P-Index
This Author published in this journals
All Journal International Journal of Public Health Science (IJPHS) Farmasains : Jurnal Farmasi dan Ilmu Kesehatan BALI MEDICAL JOURNAL (BMJ) Media Penelitian dan Pengembangan Kesehatan Jurnal Tumbuhan Obat Indonesia Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Majalah Obat Tradisional JURNAL PENGABDIAN KEPADA MASYARAKAT UNEJ e-Proceeding Journal of Islamic Pharmacy The Indonesian Biomedical Journal Jurnal Farmasi Sains dan Komunitas Journal Of Vocational Health Studies FITOFARMAKA: Jurnal Ilmiah Farmasi PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Madaniya Humanism : Jurnal Pengabdian Masyarakat Farmasis: Jurnal Sains Farmasi Pharmaceutical Sciences and Research (PSR) Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Mangestuti Agil
Faculty Of Pharmacy, Universitas Airlangga
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Public Health Social Sciences

Published : 33 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Journal of Islamic Pharmacy

 1 
Analisis in Silico Senyawa Fitokimia dari Fraksi n-Heksana Daun Semanggi (Marsilea crenata Presl.) sebagai Agen Neuroprotektif Ma'arif, Burhan; Jatmiko, Ricky Arie; Megawati, Dewi Sinta; Annisa, Rahmi; Sugihantoro, Hajar; Muchlisin, Muhammad Artabah; Laswati, Hening; Agil, Mangestuti
Journal of Islamic Pharmacy Vol 5, No 1 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i1.9180

Abstract

Estrogen deficiency causes various health problems in postmenopausal women, including neurodegenerative disease. Phytoestrogens emerged as a group of compounds that can replace the estrogen function in the body, and prevent the neurodegenerative disease to occur. Semanggi (Marsilea crenata Presl.) is a typical plant in Surabaya, Indonesia, that contain phytoestrogens. The aim of this research was to determine the metabolite profile of n-hexane fraction of Semanggi leaves using UPLC-QToF-MS/MS, and then to predict the neuroprotective activity of compounds with in silico study using PyRX 0.8 software. The 100 ppm of n-hexane fraction of Semanggi leaves in DCM and methanol were injected 5 µl each into the UPLC-QToF-MS/MS, and then analyzed by Masslynx 4.1 software to determine the compounds. The compounds from metabolite profiling then prepared with SwissADME webtool and Avogadro 1.90.0 software, molecular docking was done using Autodock Vina and Biovia Discovery Studio Visualizer 2016 to 3OLS protein. Metabolite profiling process shows a total of 34 predictable compounds and 28 unknown compounds. From in silico study, it shows a total of 7 compounds that are predicted to have activities similar to estrogen. This result indicate that n-hexane fraction of Semanggi leaves has potential as a neuroprotective agent for treatment for postmenopausal women who experience estrogen deficiency.Keywords: Marsilea crenata Presl., phytoestrogens, metabolite profiling, in silico, neuroprotective
Aktivitas Analgesik Ekstrak N-Heksana Daun Marsilea crenata Presl. dengan Metode Geliat pada Mencit Fathia Faza Rahmadanita; Mangestuti Agil; Neny Purwitasari
Journal of Islamic Pharmacy Vol 6, No 2 (2021): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v6i2.14118

Abstract

The objective of this study was to evaluate the analgesic activity of n-hexane extract of Marsilea crenata Presl. The analgesic effect was examined by acetic-acid-induced writhing response. Before intraperitoneally injection of acetic acid 0,6%, drugs were orally administered to Balb/C mice. This animal divided into 5 groups, positive control (Ibuprofen 1,04 mg/20 g BW mice), negative control (10% tween 80), dose 1 (0,27 mg/20 g BW mice), dose 2 (0,54 mg/20 g BW mice), and dose 3 (0,81/20 g BW mice). The number of writhings exhibited by each animal was counted for thirty minute beginning five minute after acetic acid induction. Obtained data were analyzed by one-way ANOVA followed by LSD test with confident level was 0,05. Dose 1, dose 2, and dose 3 showed significant different to negative control (p0,05). Dose 1 (0,27 mg/20 g BW mice) almost equal to positive control (p0,05). This study indicate that n-hexane extract of Marsilea crenata has analgesic effect. The obtained results provide information for the potential use in the treatment of pain
Co-Authors Abdul Hafid B Agnis Pondineka Ria Aditama Ahmaniyah Almay Abidzar Elpasha Amalia, Dilla Anisah Mahardiani Anita Joeliantina Arief Suryadinata Arijanto Jonosewojo Artabah Atik Kurniawati Bambang Wirjatmadi Begum Fauziyah Besin, Valentinus Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma’arif Burhan Ma’arif Burhan Ma’arif Burhan Ma’arif Burhan Ma’arif Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu, Damaranie Denis Denis Mery Mirza Destiya Argo Pamuji Fihuda Dewi Isadiartuti Dilla Amalia Djoko Agus Purwanto Edith Frederika Puruhito, Edith Frederika Eko Pujiono, Feri Elkania Putri, Safira Esti Hendradi Fadlilah, Nazilatul Faisal Akhmal Muslikh Fatah, Mohammad Zainal Fathia Faza Rahmadanita Fihuda, Destiya A. P. Fihuda, Destiya Argo Pamuji Firdausy, Alif Firman Guhir, Abdul Malik Heni Pujiastuti Hening Laswati Putra Herra Studiawan Husnul Khotimah Imam Subadi J. A. Pangkahila Jatmiko, Ricky Arie Juni Ekowati Jusak Nugraha Kusnanto Kusnanto Luthfi Achmad Muchlasi M. Artabah Muchlisin M. Bagus Qomaruddin M. Bagus Qomaruddin Ma'arif, Burhan Marta Ika Riyana Maximus M Taek Meilina Ratna Dianti Melanny Ika Sulistyowaty Merryana Adriyani Mohammad Hasan Machfoed Muslikh, Faisal A. Muslim, Menara Nabila Rosa Naesilla Naesilla Ni Made Mertaniasih Ninis Yuliati, Ninis Notopuro, Paulus Budiono Novia Maulina Nurwijayanti Nyimas Yusma Aemi Oedojo Soedirham Poernomo, A.Toto Pramudita Riwanti Purbosari, Ira Purwitasari, Neny Qurnianingsih, Ema Rahmi Annisa Rakhmawati Rakhmawati Resti Perslami, Resti Retno Widyowati Reyhan Rahma Samudra Ria Ramadhani Dwi Atmaja Riyanti, Anisa Eka S.Pd. M Kes I Ketut Sudiana . Sadli Syarifuddin Saidah, Nisfatul L. Saidah, Nisfatul Lailatus Sari, Dewi Perwito Setyo Wiyono, Anang Shrimarti Rukmini Devy Siswandono Siti Maimunah Suko Hardjono Supriyadi Supriyadi Suwarno Putra, Adryansyah Taek, Maximus M. Tanaya Jati Dharma Dewi Tri Widiandani Tutik Sri Wahyuni Widji Soeratri Wirda Anggraini Yunita Satya Pratiwi Yusniasari, Putri Antika Zulvikar Syambani Ulhaq