Article Per Year (5 Year)
p-Index From 2020 - 2025
3.354
P-Index
This Author published in this journals
All Journal International Journal of Public Health Science (IJPHS) Farmasains : Jurnal Farmasi dan Ilmu Kesehatan BALI MEDICAL JOURNAL (BMJ) Media Penelitian dan Pengembangan Kesehatan Jurnal Tumbuhan Obat Indonesia Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Majalah Obat Tradisional JURNAL PENGABDIAN KEPADA MASYARAKAT UNEJ e-Proceeding Journal of Islamic Pharmacy The Indonesian Biomedical Journal Jurnal Farmasi Sains dan Komunitas Journal Of Vocational Health Studies FITOFARMAKA: Jurnal Ilmiah Farmasi PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Madaniya Humanism : Jurnal Pengabdian Masyarakat Farmasis: Jurnal Sains Farmasi Pharmaceutical Sciences and Research (PSR) Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Mangestuti Agil
Faculty Of Pharmacy, Universitas Airlangga
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Public Health Social Sciences

Published : 33 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : The Indonesian Biomedical Journal

 1 
Thymoquinone Modulates Local MMP-9, IL-10, and IgG in Sciatic Nerve Crush Injury Animal Model Valentinus Besin; Abdul Hafid Bajamal; I Ketut Sudiana; Mangestuti Agil; Jusak Nugraha; Mohammad Hasan Machfoed; Paulus Budiono Notopuro; Naesilla Naesilla
The Indonesian Biomedical Journal Vol 14, No 3 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i3.2011

Abstract

BACKGROUND: Interleukin (IL)-10 is involved in Wallerian degeneration after peripheral nerve crush injury. Oral thymoquinone was previously observed to decrease local immunoglobulin-G (IgG) in a crush-injured rat model. No study has evaluated the pathway of various thymoquinone dosages on local IgG and IL-10 in this injury.METHODS: This experimental study used 126 Rattus norvegicus Wistar rats that were divided into 18 groups: six groups received a placebo, the other six groups received thymoquinone at 100 mg/kg/day and the last six groups received thymoquinone at 250 mg/kg/day, respectively. Rats were sacrificed at 12, 18, 24, 5x24, 6x24, and 7x24 hours. Matrix metalloproteinase-9 (MMP-9), IL-10, and local IgG levels were assessed by Enzyme-Linked Immunosorbent Assay (ELISA). The nuclear factor KappaB (NF-κB) expressions on Schwann cells were examined by flow cytometry. Path analysis was performed using SmartPLS.RESULTS: The path analysis showed that 100mg/kg/day of thymoquinone significantly decreased NF-κB expression. However, NF-κB did not affect local MMP-9, and MMP-9 had no significant relationship with local IL-10 and IgG. Thymoquinone 250 mg/kg/day also significantly inhibited NF-kB expression, decreased local MMP-9, and, in turn, decreased local IL-10 and IgG.CONCLUSION:  Administration of oral thymoquinone 250 mg/kg/day decreases local IgG and IL-10 levels via suppressing NF-κB expression and MMP-9 levels.KEYWORDS: thymoquinone, crush injury, IgG, IL-10, MMP-9, NF-κB
Co-Authors Abdul Hafid B Agnis Pondineka Ria Aditama Ahmaniyah Almay Abidzar Elpasha Amalia, Dilla Anisah Mahardiani Anita Joeliantina Arief Suryadinata Arijanto Jonosewojo Artabah Atik Kurniawati Bambang Wirjatmadi Begum Fauziyah Besin, Valentinus Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma’arif Burhan Ma’arif Burhan Ma’arif Burhan Ma’arif Burhan Ma’arif Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu, Damaranie Denis Denis Mery Mirza Destiya Argo Pamuji Fihuda Dewi Isadiartuti Dilla Amalia Djoko Agus Purwanto Edith Frederika Puruhito, Edith Frederika Eko Pujiono, Feri Elkania Putri, Safira Esti Hendradi Fadlilah, Nazilatul Faisal Akhmal Muslikh Fatah, Mohammad Zainal Fathia Faza Rahmadanita Fihuda, Destiya A. P. Fihuda, Destiya Argo Pamuji Firdausy, Alif Firman Guhir, Abdul Malik Hajar Sugihantoro Heni Pujiastuti Hening Laswati Hening Laswati Putra Herra Studiawan Husnul Khotimah Imam Subadi, Imam J. A. Pangkahila Jatmiko, Ricky Arie Juni Ekowati Jusak Nugraha Kusnanto Kusnanto Luthfi Achmad Muchlasi M. Artabah Muchlisin M. Bagus Qomaruddin M. Bagus Qomaruddin Ma'arif, Burhan Marta Ika Riyana Maximus M Taek Meilina Ratna Dianti Melanny Ika Sulistyowaty Merryana Adriyani Mohammad Hasan Machfoed Muslikh, Faisal A. Muslim, Menara Nabila Rosa Naesilla Naesilla Ni Made Mertaniasih Ninis Yuliati, Ninis Notopuro, Paulus Budiono Novia Maulina Nyimas Yusma Aemi Oedojo Soedirham Poernomo, A.Toto Pramudita Riwanti Purbosari, Ira Purwitasari, Neny Qurnianingsih, Ema Rahmi Annisa Rakhmawati Rakhmawati Resti Perslami, Resti Retno Widyowati Reyhan Rahma Samudra Ria Ramadhani Dwi Atmaja Riyanti, Anisa Eka S.Pd. M Kes I Ketut Sudiana . Sadli Syarifuddin Saidah, Nisfatul L. Saidah, Nisfatul Lailatus Sari, Dewi Perwito Setyo Wiyono, Anang Shrimarti Rukmini Devy Siswandono Siti Maimunah Suko Hardjono Supriyadi Supriyadi Suwarno Putra, Adryansyah Taek, Maximus M. Tanaya Jati Dharma Dewi Tri Widiandani Tutik Sri Wahyuni Widji Soeratri Wirda Anggraini Yunita Satya Pratiwi Yusniasari, Putri Antika Zulvikar Syambani Ulhaq