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Hubungan Kadar 25-Hidroksivitamin D (25(OH)D) Serum pada Ibu Hamil Trimester III dengan Fetal Outcome Delfina, Delfina; Amir, Arni; Ilmiawati, Cimi
Majalah Kedokteran Andalas Vol 46, No 9 (2024): Supplementary Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1444-1451.2024

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar 25(OH)D serum pada ibu hamil trimester III dengan fetal outcome. Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan cohort terhadap 77 ibu hamil trimester III dan bayi baru lahir, penelitian dilakukan di wilayah kerja Puskesmas Andalas. Pengambilan sampel secara purposive sampling. Pengukuran kadar 25(OH)D serum dilakukan dengan metode ELISA secara dupleks. Data fetal outcome (berat badan, panjang badan, lingkar kepala) didapatkan dari buku Kesehatan Ibu dan Anak. Korelasi antar variabel diuji dengan uji korelasi Pearson atau Spearman. Hasil: Kadar 25(OH)D serum ibu hamil trimester III didapatkan nilai median yaitu 21,10 ng/ml dan 32 ibu hamil yang mengalami defisiensi. Kadar 25(OH)D) serum ibu berkorelasi negatif dengan berat badan bayi lahir (uji Pearson; r=-0,239; p=0,036), namun tidak memiliki korelasi yang bermakna secara statistik dengan panjang badan (uji Spearman; r=-0,106; p=0,360) dan lingkar kepala bayi  (uji Spearman; r=-0,031; p=0,788). Kesimpulan: Disimpulkan bahwa sebagian besar ibu hamil mengalami defisiensi 25(OH)D dan hal ini dapat mempengaruhi fetal outcome.
GAMBARAN TINGKAT PENGETAHUAN SISWA MADRASAH ALIYAH AR RISALAH TENTANG INFERTILITAS PRIA TAHUN 2022 Maharani, Rifty Zhafira; Amir, Arni; Firdawati, Firdawati
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.993

Abstract

Background: The lack of research and knowledge about male infertility among men from adolescence to adulthood in Indonesia make people not aware of the incidence of infertility in the future and do not have time to take preventive measures. Objective: The purpose of the study was to describe the level of knowledge of Madrasah Aliyah Ar Risalah students about male infertility. Methods: This research used an observational descriptive with cross-sectional design. The research sample amounted to 144 people with Total Sampling. This research used primary data taken using a questionnaire. Results: This research indicated that respondents who had good knowledge were 14.6%, 66.7% were sufficient and 18.8% less. The majority of respondents with good knowledge are respondents aged 12-16 years, majoring in science, from outside the city of Padang and who get information from teachers. Conclusion: This research concluded that most of the students had sufficient knowledge about male infertility
Reproductive function after radioactive iodine treatment for differentiated thyroid carcinoma patients: a systematic review Elliyanti, Aisyah; Aziza, Zulva; Kurniawati, Yulia; Khambri, Daan; Amir, Arni; Katar, Yusticia
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257458

Abstract

BACKGROUND Thyroid cancer is one of the most prevalent cancers in the endocrine system, with a rapidly rising incidence over the past 3 decades. Treatment for patients with differentiated thyroid cancer (DTC) typically includes surgery, radioactive iodine (I-131) therapy, and levothyroxine (L-T4) suppressive therapy. This study aimed to explore the potential side effects of I-131 therapy on reproductive function in men and women with DTC. METHODS A literature search was performed using 4 databases (PubMed, ScienceDirect, BioMed Central, and Google Scholar), limited to English publications since 2013. Clinical trials and observational studies that evaluated I-131 in DTC, focused on reproductive-age patients, and included pre-therapy or during-therapy examinations, administered doses, and treatment frequencies of I-131 were selected. The Joanna Briggs Institute Critical Appraisal Checklist is used as a comprehensive evaluation tool, and the literature quality was categorized as high, moderate, and low. RESULTS The final 17 articles examined the effect of I-131, with 13 focusing on women's reproductive function and 4 on men's. Women who received I-131 therapy can lower anti-Mullerian hormone levels and disrupt menstrual cycles within the first year, and it does not affect subsequent pregnancies. For men, the therapy led to elevated levels of follicle-stimulating hormone and luteinizing hormone, along with changes in sperm quantity, morphology, and motility, which tend to normalize within a year post-therapy. CONCLUSIONS The reproductive side effects associated with I-131 therapy are generally transient, with most individuals experiencing a return to normal within 1 year following treatment.
Elevation of miR-210 Expression and Mean Arterial Pressure as Early-onset Pre-eclampsia Biomarkers, while Elevation of Matrix Metalloproteinase-2 as Late-onset Pre-eclampsia Biomarker Nelson, Nelvianti; Yusrawati, Yusrawati; Serudji, Joserizal; Jamsari, Jamsari; Amir, Arni; Afriwardi, Afriwardi; Gumilar, Erry
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3490

Abstract

BACKGROUND: Pre-eclampsia has varying onset patterns, which are challenging to determine due to their association with diverse clinical parameters, including blood pressure regulation, vascular remodeling, and placental hypoxia. These parameters influence the expression of key biomarkers such as microRNAs, metalloproteinases, and arterial pressure indices. Therefore, understanding the associations is crucial for improving early diagnosis and management. This study was conducted to compare miR-210 expression, mean arterial pressure (MAP), and matrix metalloproteinase (MMP)-2 levels between early-onset pre-eclampsia (EOPE) and late-onset pre-eclampsia (LOPE).METHODS: Pregnant women with EOPE (20–34 weeks) and LOPE (35 weeks to term) were included in this cross-sectional comparative study, and their blood samples were collected. miR-210 expression was quantified with reverse transcription polymerase chain reaction (RT-PCR), MAP was measured using sphygmomanometer, while MMP-2 levels were measured using enzyme-linked immunosorbent assay (ELISA).RESULTS: miR-210 expression was more frequently observed in the EOPE group (87.5%) compared to the LOPE group (77.5%), with a significant difference identified between the two groups. The odds ratio for miR-210 expression in EOPE compared to LOPE was 2.03 (95% CI: 1.06–6.72). The MAP was notably higher in the EOPE group (121.15 mmHg) than in the LOPE group (116.15 mmHg), with a significant difference observed. Conversely, MMP-2 levels were significantly higher in the LOPE group (390.99 ng/mL) compared to the EOPE group (271.35 ng/mL).CONCLUSION: There are significant differences in miR-210 expression, MAP and MMP-2 between EOPE and LOPE. These findings suggest that miR-210, MAP, and MMP-2 could be useful biomarkers for distinguishing between EOPE and LOPE, potentially guiding more effective management and intervention strategies.KEYWORDS: miR-210, MAP, MMP-2, EOPE, LOPE, pre-eclampsia
HUBUNGAN HIGIENE MULUT TERHADAP TONSILITIS KRONIS PADA ANAK KELAS 5 DAN 6 DI MIN 04 PADANG. Amri, Siti Salsabilla; Amir, Arni; Asyari, Ade
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 4 (2025): SINERGI : Jurnal Riset Ilmiah, April 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i4.1122

Abstract

Background: Chronic tonsillitis in children may be caused by recurrent acute respiratory tract infection or untreated acute tonsillitis and other cofactors that can increase the risk of chronic tonsillitis such as poor oral hygiene Objective: The aim of this study is to know the the correlation between oral hygiene and chronic tonsillitis in 5th and 6th grades students in Madrasah Ibtidaiyah Negeri 04 Padang. Methods: This research is an analytical cross-sectional study. The samples included all 5th and 6th grades students in MIN 04 Padang who were fulfilled the inclusion criteria, with total 75 samples. The instruments used in the study include the oral hygiene questionnaire and tonsils examination. Data were analyzed by using Chi-square. Results : The result of the analysis showed the number of respondents with poor oral hygiene and chronic tonsillitis is 15 respondents (20%). Respondents with average oral hygiene and chronic tonsillitis is 13 respondents (17,3%), and 5 respondents (6,7%) had good oral hygiene and had chronic tonsillitis. The results have a significant relationship between the oral hygiene and chronic tonsillitis with a p value of 0.000 (<0.05). Conclusion: The conclusion of this study is that there was a significant relationship between the oral hygiene and chronic tonsillitis in 5th and 6th grades students in Madrasah Ibtidaiyah negeri 04 Padang
Breastfeeding Patterns in Stunted and Not Stunted Toddlers Using Infant Feeding Area Graphs in the Working Area of the Pagambiran Health Center, Padang Sari, Maharani Permata; Yusrawati; Afdal; Desmawati; Arni Amir; Finny Fitry Yani
Indonesian Journal of Advanced Research Vol. 3 No. 3 (2024): March 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijar.v3i3.8469

Abstract

One of the nutritional problems of children in Indonesia is stunting. Fulfillment of nutrition in the first 1,000 days of life is related to stunting. WHO recommends breastfeeding and breastfeeding as a method of feeding babies to achieve optimal growth and development. This descriptive study aims to provide an overview of the feeding practices of stunted and non-stunting toddlers as seen in the feeding history included in the Toddler Feeding Area Chart from 0-6 months of age. This research found that giving breast milk alone to stunted toddlers (52.17%) was lower than non-stunting toddlers (66.67%), and the most common feeding pattern for stunted toddlers was formula milk.
Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells Oktavia, Sri; Amir, Arni; Wahyuni, Fatma Sri; Hasmiwati, Hasmiwati
Majalah Kedokteran Andalas Vol. 48 No. 3 (2025): MKA July 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p1174-1179.2023

Abstract

Piperine, the primary alkaloid of Piper nigrum and Piper longum, is believed to have anticancer properties. Although research on cervical cancer is still in its early stages, piperine's anticancer capabilities have been established in numerous types of cancer and have been shown to target pathways involved in the cell cycle and apoptosis. This study aims to determine how piperine administration time and concentration affect the viability of Hela cells. The MTT method was used to conduct this study. The concentration of piperine utilized was 1,000; 500; 250; 125, and 62.5 µg/mL, and it was administered for 24 and 48 hours. The IC50 values, obtained after incubation for 24 and 48 hours, were 711.21 µg/mL and 419.75 µg/mL, respectively. We may conclude that the viability of HeLa cells is influenced by piperine in a time- and concentration-dependent manner (p<0.05).
Hubungan Kadar 25-Hidroksivitamin D (25(OH)D) Serum pada Ibu Hamil Trimester III dengan Fetal Outcome Delfina, Delfina; Amir, Arni; Ilmiawati, Cimi
Majalah Kedokteran Andalas Vol. 48 No. 2 (2025): MKA April 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1444-1451.2024

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar 25(OH)D serum pada ibu hamil trimester III dengan fetal outcome. Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan cohort terhadap 77 ibu hamil trimester III dan bayi baru lahir, penelitian dilakukan di wilayah kerja Puskesmas Andalas. Pengambilan sampel secara purposive sampling. Pengukuran kadar 25(OH)D serum dilakukan dengan metode ELISA secara dupleks. Data fetal outcome (berat badan, panjang badan, lingkar kepala) didapatkan dari buku Kesehatan Ibu dan Anak. Korelasi antar variabel diuji dengan uji korelasi Pearson atau Spearman. Hasil: Kadar 25(OH)D serum ibu hamil trimester III didapatkan nilai median yaitu 21,10 ng/ml dan 32 ibu hamil yang mengalami defisiensi. Kadar 25(OH)D) serum ibu berkorelasi negatif dengan berat badan bayi lahir (uji Pearson; r=-0,239; p=0,036), namun tidak memiliki korelasi yang bermakna secara statistik dengan panjang badan (uji Spearman; r=-0,106; p=0,360) dan lingkar kepala bayi  (uji Spearman; r=-0,031; p=0,788). Kesimpulan: Disimpulkan bahwa sebagian besar ibu hamil mengalami defisiensi 25(OH)D dan hal ini dapat mempengaruhi fetal outcome.
Co-Authors Ade Asyari Adeline Sacharissa Firdaus Afdal Afriwardi Afriwardi Ahmad Kurniawan Akbar Aisyah Elliyanti Amri, Siti Salsabilla Andani Eka Putra Andi Friadi Aziza, Zulva Berliana Irianti, Berliana Cimi Ilmiawati, Cimi Daan Khambri Darmayanti Siregar Dedi Afandi Defrin, Defrin Delfina, Delfina Delmi Sulastri Desmawati Desmawati Desmawati Desmiwarti Desmiwarti Dina Khaira Mizana Dolly Irfandy Elizabeth Bahar Ellyza Nasrul Endrinaldi Ermawati Ermawati Eryati Darwin Eti Yerizel Fadil Oenzil Faradila, Selvy Fatma Sri Wahyuni Fika Tri Anggraini Finny Fitry Yani Firdawati, Firdawati Furqan, Muhammad Afif Gumilar, Erry Hadya Gorga Haifa Wahyu Hasmiwati Hillbertina, Noza Hudilla Rifa Karmia Ibrahim Ibrahim Ihsan, Indra Indah Wahyuni Insani, Aldina Ayunda Jamsari Jamsari Joserizal Serudji Linosefa Linosefa Lisma Evareny Maharani, Rifty Zhafira Mardiah, Ainal Masrul Mayetti - Mega Ulfah Miranie Safaringga Mohammad Tegar Indrayana Muchtar, Masrul Muhammad Reza Nelson, Nelvianti Netti Suharti Netty Suharti Noni Humaira Nur Indrawaty Lipoeto Nuzulia Irawati Oea Khairsyaf Oktavia, Sri Pratama, Weno Putri Sri Lasmini Rafika Oktova Rahmat Nurul Yuda Putra Rahmatina B Herman Rahmi Junaida Randa Novalino Rani Armalita Rika Susanti Roslaili Rasyid Saptino Miro, Saptino Saputri, Mona Sari, Maharani Permata Sari, Nur Purnama Setiawan, Mentari Adinda Seto, Astari Suminta RS, Teresia Syahid MP, Miskah Indah Syahputra, Roni Eka Tri Rahayuningsih Ulya Uti Fasrini Utama, Bobby Indra Vaulinne Basyir Vinda Dwi Apriora Yanwirasti Yanwirasti Yulia Kurniawati Yuniar Lestari Yusrawati - Yusrawati Yusrawati Yusticia Katar, Yusticia