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All Journal Best Journal (Biology Education, Sains and Technology) Jurnal Penelitian Farmasi dan Herbal JURNAL PENELITIAN KEPERAWATAN MEDIK International Journal Of Science, Technology & Management (IJSTM) Jurnal Pengabdian Masyarakat Putri Hijau
Syafitri, Anggun
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UJI EFEKTIVITAS EKSTRAK ETANOL DAUN GAGATAN HARIMAU (Vitis gracilisWall) TERHADAP PENAMBAH STAMINA PADA MENCIT JANTAN Syafitri, Anggun; Sianipar, Masria Phetheresia; Agustina, Putri
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2202

Abstract

Stamina is the ability of human endurance to withstand fatigue within a certain time limit, where activities are carried out with high intensity and always use energy that can be treated with traditional medicine derived from plants. One example of plants that can increase stamina is tiger gagatan leaves which contain flavonoids that can increase the motor activity of mice by inhibiting the absorption of calcium ions entering the sarcoplasmic reticulum after that with the obstacle causing high calcium ion levels in sarcoplasm and containing tonic effects. The purpose of the study was to determine the effect of giving tiger gagatan leaf extract in increasing stamina compared to caffeine. This research was conducted by experimental method, samples were extracted maceration using 96% ethanol solvent and concentrated with a rotary evaporator. Using 25 mice and divided into 5 groups. The control group was negative CMC-Na 0.5%, the control group positive for caffeine 0.13mg/kgBB, EDGH with a dose of 50mg/kgBB, EDGH with a dose of 100mg/kgBB, EDGH with a dose of 200mg/kgBB. Then observed the endurance time of mouse stamina and calculated the average physical endurance time of mice by swimming method. From the results of the study that the EDGH dose of 200mg/kgBB had optimal effectiveness close to the positive control group with swimming endurance time of 52.18 minutes, while EDGH with a dose of 100mg / kggBB showed a physical endurance time of mice of 49.07 minutes, and EDGH 50mg / kg BB showed a physical endurance time of mice of 48.24 minutes. So it can be concluded that tiger gagatan leaf extract at a dose of 200mg/kgBB has an effectiveness equivalent to caffeine in increasing stamina against male white mice.
PENGEMBANGAN FACEMIST KOMBINASI EKSTRAK DAUN BIDARA (Ziziphus spina cristi (L.) Desf) DAN DAUN BENALU DUKU (Dendrophthoe pentandra (L.) Miq ) SEBAGAI ANTIOKSIDAN PADA KULIT WAJAH anggara, Elysa; syafitri, anggun; sari, tio ranti
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2257

Abstract

The skin needs antioxidant compounds that can ward off free radicals caused by several factors, one of which is air pollution. Bidara leaves (Zizipus spina Cristi (L) Desf) and benalu duku leaves (Dendrophthoe pentandra (L.) Miq) contain flavonoid compounds that function as antioxidants that can ward off free radicals. This study aims to formulate bidara leaf extract and benalu duku leaf into the form of Facemist preparation and determine the best Facemist product formula with the addition of bidara leaf extract, benalu leaf, and a combination of two extracts through antioxidant activity parameters. The antioxidant activity test was carried out using the DPPH (1,1-dipenyl-2-picrylhydrazyl) method. The Facemist sample was formulated into a Facemist with concentration variations: F1 : EEDB 5%, F2 : EEDBD : 5%, F3 : EEDB : 2.5% EEDBD 2.5%, F4 : EEDB : 5% EEDBD : 5%, F5 : EEDB : 10% EEDBD : 10%. Facemist preparations are eval_uated for their physical characteristics, namely organoleptic test, homogeneity test, pH test, viscosity test, dry time test, irritation test. The results showed that Facemist was a combination of bidara leaf extract and benalu duku leaf homogeneous, pH <7, had a viscosity value of <500 cps, a good drying time of <5 minutes and did not cause irritation to the skin. The formulation of Facemist preparation that has the best antioxidant activity value is F5 with antioxidant activity (IC50) of 58.33 ppm in the strong category.
The Effect of Dendrophthoe pentandra (L.) Miq Ethanol Extract on Malondialdehyde (MDA) in Hyperglycemic Rats Syafitri, Anggun; Yuandani, Yuandani; Widyawati, Tri
International Journal of Science, Technology & Management Vol. 4 No. 2 (2023): March 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i2.758

Abstract

Dendrophthoe pentandra (L.) Miq is a parasitic plant with medicinal potential found in 3000 other plant species. The duku parasite is usually considered a parasite on the duku plant and is often discarded because it is thought to interfere with the growth of the duku plant. The purpose of this study was to see the effect of the duku parasite leaf extract on the reduction of malondialdehyde (MDA) in hyperglycemic rats. MDA levels were measured by thiobarbituric acid-reactive substance (TBARS) assay with doses of duku mistletoe leaf ethanol extract of 400, 200, and 100 mg/kg BW. MDA levels were analysed using rat blood plasma, which was measured using a spectrophotometer at a wavelength of 532 nm. Oral administration of EEDBD 400, 200, and 100 mg/kg BW reduced MDA levels in hyperglycemic rats. However, only EEDBD 400 mg/kg BW showed a significant difference between the negative control (CMC-Na), but with glibenclamide and the normal groups, there was no significant difference.
Uji Efektivitas Anti Diabetes Ekstrak Etanol Daun Ulam Raja (Cosmos caudatus K.) Pada Tikus Jantan Putih (Galur wistar) Yang Diinduksi Streptozotocin Dan Nicotinamide Syafitri, Anggun; Rahmah, Siti
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 2 (2025): September 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i2.13054

Abstract

Diabetes melitus adalah gangguan metabolik yang ditandai dan diidentifikasi oleh kadar glukosa darah yang tinggi atau dikenal sebagai hiperglikemia. Kondisi ini berkaitan dengan berbagai kelainan dalam metabolisme karbohidrat, lemak, dan protein yang disebabkan oleh gangguan sekresi insulin akibat kerusakan sel beta pankreas, penurunan sensitivitas insulin, atau kombinasi keduanya. Namun, penggunaan obat sintetis secara terus-menerus juga berisiko menyebabkan berbagai efek samping lainnya, seperti gangguan saluran pencernaan dan hati, edema perifer, sakit kepala, batuk, hiperkalemia, gangguan rasa, apnea tidur, disfungsi ereksi, dan angioedema. Oleh karena itu, alternatif terapi yang lebih aman berdasarkan bahan alami sangat dibutuhkan. Salah satu tanaman yang berpotensi sebagai antidiabetes adalah daun king ulam (Cosmos cauvdatus K.), yang mengandung senyawa flavonoid seperti quercetin dan kaemferol. Senyawa ini bersifat antioksidan, mampu melindungi sel beta pankreas, dan meningkatkan penyerapan glukosa ke dalam otot melalui aktivasi jalur AMPK. Studi ini bertujuan untuk menganalisis efektivitas ekstrak etanol daun king ulam (Cosmos cauvdatus K) sebagai antidiabetes pada tikus yang diinduksi streptozotocin dan nikotinamida, membandingkan efektivitasnya dengan glibenklamida, dan menganalisis dosis ekstrak etanol daun king ulam yang paling efektif sebagai antidiabetes. Penelitian ini dilakukan dengan metode eksperimental pada 25 tikus jantan putih (galur Wistar) yang dibagi menjadi 5 kelompok perlakuan, yaitu kontrol negatif (Na-CMC) 0,5%, kontrol positif (Glibenklamida 0,45 mg/kgBB), EEVDUR dosis 100 mg/kgBB, EEVDUR 200 mg/kgBB, dan EEVDUR 400 mg/kgBB. Hasil analisis statistik menunjukkan bahwa EEVDUR mampu menurunkan kadar glukosa darah secara signifikan pada tikus dan memiliki efektivitas yang setara dengan glibenklamida. Dosis EEVDUR 400 mg/kgBB menunjukkan efek paling optimal sebagai antidiabetes. Hasil ini mendukung potensi penggunaan daun king ulam sebagai terapi alternatif yang lebih aman dalam pengelolaan diabetes melitus
Co-Authors Amar, Ageng AZ amar, ageng azhar Anggara, Elysa Br Barus, Lidia Klorida Fantika, Ardhana Harahap, Nurul Dahlia Harnis, Zola Efa Hayati, Silmi Laia, Sardamai MARBUN, VIKTOR EDYWARD Mardatillah, Hazimah Fithryyah Putri Agustina Rahmi, Sofia sari, tio ranti Sembiring, Johannes Sembiring, Pintata Sianipar, Masria Phetheresia Siti Rahmah Tamba, Agnes Clara Tri Widyawati, Tri Yuandani