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All Journal JPMS (Jurnal Pendidikan Matematika dan Sains) MAJALAH ILMIAH PEMBELAJARAN Jurnal Penelitian Saintek INOTEKS : Jurnal Inovasi Ilmu Pengetahuan, Teknologi, dan Seni EKSAKTA: Journal of Sciences and Data Analysis Jurnal Pendidikan Kimia Indonesia Jurnal Sains Dasar Jurnal Matematika & Sains Indonesian Journal of Biotechnology Indonesian Journal of Science and Technology Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Molekul: Jurnal Ilmiah Kimia Musamus Journal of Primary Education Chemistry Education Practice Jurnal Inovasi Pembelajaran Kimia (Journal Of Innovation in Chemistry Education) Indonesian Journal Of Educational Research and Review Molekul: Jurnal Ilmiah Kimia Jurnal Riset Pembelajaran Kimia Jurnal Pendidikan MIPA

Retno Arianingrum

Universitas Negeri Yogyakarta

Author-ID : 231928

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics Social Sciences Other

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ANTIPLASMODIAL ACTIVITY OF METHANOL EXTRACT HERBAL DRUG PLANTS IN VIVO Sri Atun; Retno Arianingrum
Jurnal Penelitian Saintek Vol 17, No 1: April 2012
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antiplasmodial dari ekstrak metanol tiga jenis spesies tumbuhan, yaitu pegagan, meniran, dan pulai. Metode penelitian yang akan dilakukan adalah dengan melakukan eksperimen di laboratorium, yang di awali dengan pemilihan dan pengumpulan tiga jenis sampel tumbuhan serta dilakukan determinasi di laboratorium Biologi UGM. Selanjutnya dari berbagai jaringan tumbuhan yang biasa digunakan untuk pengobatan, seperti pegagan (semua bagian tumbuhan), meniran (semua bagian tumbuhan), dan pulai (kulit batang), dilakukan ekstraksi secara maserasi dengan pelarut metanol. Ekstrak metanol dari masing-masing spesies tumbuhan dikeringkan dan digunakan untuk uji aktivitas biologi sebagai antiplasmodial secara in vivo. Uji aktivitas antiplasmodial secara in vivo dilakukan dengan cara 4 days suppressive test pada mencit Swiss yang diinfeksi P. berghei. Mencit dibagi menjadi kelompok kontrol (tanpa bahan uji) dan kelompok perlakuan masing-masing menggunakan 5 ekor mencit. Jumlah kelompok perlakuan 5 (lima) sesuai dengan peringkat dosis ekstrak yang digunakan, yaitu 37,25; 62,5;125; 250; dan 500 mg/BB. Hasil penelitian uji aktivitas antiplasmodial secara in vivo ekstrak metanol kulit batang pulai menunjukkan nilai efektivitas dosis (ED50) sebesar 29,78 mg/BB yang termasuk dalam kategori sangat baik, sedangkan aktivitas antiplasmodial dari ekstrak pegagan dan meniran masing-masing dengan ED50 sebesar 970,29 dan 1018,59 mg/BB, sehingga termasuk dalam kelompok tidak aktif. Kata kunci: pegagan (Centella asiatica), meniran (Phyllanthus niruri); pulai (Alstonia scholaris), antiplasmodial (antimalaria)

SITOTOXIC TESTS OF SOME MONO COMPONENTS OF COCON HYDROXES ON CANCER CELL LINE T47D Retno Arianingrum; Indyah Sulistyo Arty; Sri Atun
Jurnal Penelitian Saintek Vol 16, No 2: Oktober 2011
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

The aim of this research was to study cytotocix activity from some mono para hydroxy compounds (MPHC) i.e. MPHC A, MHPC B, MPHC MPHC D, and MPHC E against T47D cancer cell lines. Those compounds were synthesized from benzaldehyde derivatives and acetofenon derivates through cross aldol reaction under acid condition. Separation and purification of these compounds were conducted by recrystallization technique using suitable eluent. Identification and structure elucidation was done by comparing the data of thin-layer chromatography (TLC) with marker (compounds that have been found previously), and also used the data of IR spectrum. Each compound then was performed cytotoxicity test by in vitro against T47D cells using MTT assay. Observation of cell morphological changes was observed using phase contrast microscopy. The results showed that the compound MPHC A, MPHC B, MPHC C, and MPHC D had cytotoxic activity against T47D cancer cell line, while the compound MPHK E did not have cytotoxic activity. The highest toxicity was MPHK A with LC50= 66.44 Pg/mL. The presence of hydroxyl groups contributed to the enhancement of cytotoxic effect.

Comparison on Isolation Technique of Vaninilin from Vanili Fruit (Vanilla planifolia Andrews Winarto Haryadi; Sri Handayani; Retno Arianingrum
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 11, ISSUE 2, August 2010
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

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Isolation of vanilin from vanili fruit by two method; maseration and Soxhlet using ethylacetate, ethanol and chloroform solvents has been investigated. Extraction result was hydrolized using sodium hydroxide by acidification using chloride acid. Filtrate was extracted by using chloroform and the targeted vanilin was separated by evaporation. Putrification was enganged by rechrystallization using aquadest-ethanol. Elucidation to the compound structure was performed by FTIR spectrophotometer, H-NMR, C-NMR, HMQC and HMBC. It is noted that vanilin isolation by soxhletazion procedure was more effective compared to maseration. Ethylacetate was more effective solvent than chloroform and conversely ethanol is inefective for the isolation. Keywords: vanilin isolation, soxhlet isolation, maseration

Cytotoxic Effects of Plant Growth Extracts Temu Giring (Curcuma Heyneana) and Temu Ireng (Curcuma Aeruginosa) against Several Cancer Cells Sri Atun; Nurfina Aznam; Retno Arianingrum; Sri Nurestri
Jurnal Penelitian Saintek Vol 15, No 2: Oktober 2010
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

The purpose of this study is to investigate the cytotoxic activity of extracts and fractions of the rhizoma from temu giring and temu ireng against some cancer cells, such as breast carcinoma cells (MCF-7) and cervical carcinoma (Ca Ski). The research method is to do with experiments in the laboratory which includes extraction and fractionation of compounds from the rhizome from temu giring and temu ireng, test the cytotoxicity against cancer cells Breast carcinoma (MCF-7) and cervical carcinoma (Ca Ski). Test results on the activity of extracts and fractions from tubers from temu giring and temu ireng on breast carcinoma (MCF-7); Cervical carcinoma (Ca Ski) showed good activity (below 100 µg/ml), except the methanol extract temu ireng which shows the IC50 upper of 100 µg/ml. This indicates that the extracts from temu giring and temu ireng great potential for development as anticancer drug.Keywoods: Curcuma heyneana; Curcuma aeroginosa; cytotoxic effect; anticancer

ANTIVIRAL ACTIVITY TESTS OF SOME ZINGIBERACEAE PLANTS Sri Atun; Nurfina Aznam; Retno Arianingrum; Sri Nurestri
Jurnal Penelitian Saintek Vol 16, No 1: April 2011
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antiviral dari beberapa rimpang tumbuhan Zingiberaceae di Indonesia. Beberapa rimpang tumbuhan yang diteliti antara lain kunci pepet (Kaemferia rotunda), temugiring (Curcuma heyneana Val), lengkuas (Alpinia galanga Sw), dan temuireng (Curcuma aeruginosa Roxb). Uji aktivitas antiviral dilakukan terhadap virus AI H5Nl, dengan cara membuat suspensi virus AI H5Nl 0,1 mL + 0,5 mL larutan ekstrak 1% ditambah antibiotika penisilin 10.000 IU/mL, streptomycin 10 mg/mL, diinkubasi 37°C selama 30 menit. Suspensi virus tersebut sebanyak 0,1 mL diinokulasikan pada TAB lewat ruang korioalantois. Telur diinkubasi dalam mesin penetas selama 3 hari. Diamati ada tidaknya kematian embrio setiap hari. Telur disimpan dalam almari es selama 24 jam, kemudian cairan alantois dipanen untuk diuji titer hemaglutinasinya (HA). Uji hemaglutinasi dilakukan menurut OlE (2008) dengan modifikasi. Pada prinsipnya cairan alantois 0,05 mL diencerkan seri 2 kali kemudian direaksikan dengan eritrosit ayam 0,5%. HA dikatakan positif apabila terjadi hemaglutinasi. Titer HA adalah kebalikan dari pengenceran tertinggi yang masih menunjukkan reaksi positif. Ekstrak dikatakan mempunyai aktivitas antiviral apabila titer HA berbeda signifikan dengan kontrol atau bahkan titer HA sekitar 2°. Sebagai kontrol digunakan em brio telur yang diinokulasi hanya dengan suspensi virus AI H5N1. Uji aktivitas antiviral terhadap virus AI H5Nl dari ekstrak maupun fraksi-fraksi dari umbi tumbuhan kunci pepet (Kaemferia rotunda), temugiring (Curcuma heyneana Val), lengkuas (Alpinia galanga Sw), dan temuireng (Curcuma aeruginosa Roxb), menunjukkan ekstrak metanol dari kunci pepet, temu ireng, dan temu giring menunjukkan aktivitas antiviral rendah, sedangkan fraksi heksan kunci pepet dan-fraksi heksan temu ireng menunjukkan aktivitas antiviral yang tinggi. Kata kunci: obat herbal Nusantara; antiviral; H5NI

Characterization of Curcuminoid from Curcuma xanthorrhiza and Its Activity Test as Antioxidant and Antibacterial Sri Atun; Nurfina Aznam; Retno Arianingrum; Senam Senam; Bian Ihda An Naila; Astuti Lestari; Nur Aini Purnamaningsih
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Curcuminoids are the main component found in many Zingiberaceae family plants. The aim of this study was to characterize curcuminoid and its activity test as an antioxidant and antibacterial. Dryed powder of C. xanthorrhiza (1 kg) was macerated with ethanol for 24 hours at room temperature. Ethanol extract of C. xanthorrhiza was subsequently fractionated with n-hexane and chloroform to take the yellow or orange indicated contain of curcuminoids. Analysis of total phenolic levels was carried out by the Follin-Ciaocalteau method. The isolation of curcuminoid componens from this fraction was carried out by chromatographic method and the structure elucidation was performed by interpretation of spectroscopic data, including UV, IR, 1H and 13C NMR 1D and 2D. The antioxidant activity test used the DPPH (2,2-diphenylpicrylhydrazyl) method, while the antibacterial activity test used Kirby Bauer test diffusion method. The results showed that the curcuminoid fraction yield was 10.06% from ethanol extract C. xanthorrhiza. The total phenolic content of curcuminoids fraction was 745.45 ± 18.5 mg galic acid (GA)/g extract. Curcuminoids fraction was isolated a known compound desmethoxycurcumin (1). The content of demethoxycurcumin (1) in curcuminoid fraction is 20.97 %.The antioxidant activity of curcuminoids fraction showed strongest activity with IC50 24.98 µg/ml. Antibacterial activity against of the four pathogenic bacteria showed medium activity. The study suggests that curcuminoids extract from C. xanthorrhiza rhizome have potential compounds could be suitable for antioxidant and the treatment of various infections caused of microbial.

IDENTIFICATION AND ANTIOXIDANT ACTIVITY TEST OF SOME COMPOUNDS FROM METHANOL EXTRACT PEEL OF BANANA (Musa paradisiaca Linn.) Sri Atun; Retno Arianingrum; Sri Handayani; Rudyansah Rudyansah; Mary Garson
Indonesian Journal of Chemistry Vol 7, No 1 (2007)
Publisher : Universitas Gadjah Mada

The objective of these research was measured activity as antioxidant some compounds in methanol extracts of peel of banana (Musa paradisiaca Linn.), isolated some compounds which had activities as antioxidant, and determined this structure. Method of this study was extracted powdered peel of banana with methanol at room temperature. Extract was concentrated in vaccuo and then successively was partitioned with n-hexane, chloroform, etyl acetate, and buthanol. Antioxidant test from each fractions was measured by hydroxyl radical scavenger test with Fenton reaction method. The result of this study showed activity each fractions as hydroxyl radical scavenger activity of chloroform, etyl acetate, and buthanol fraction were IC50 693.15; 2347.40; and 1071.14 mg/mL respectively. The isolation of secondary metabolite compounds from chloroform fraction obtained two isolate compounds. Identification by spectroscopy IR, MS, 1H and 13C NMR one and two dimension showed that the compounds are 5,6,7,4'-tetrahidroxy-3,4-flavan-diol and a new compound cyclohexenon derivative (2-cyclohexene-1-on-2,4,4-trimethyl-3-O-2'-hydroxypropyl ether).

BALANOCARPOL AND AMPELOPSIN H, TWO OLIGORESVERATROLS FROM STEM BARK OF Hopea odorata (DIPTEROCARPACEAE) Sri Atun; Nurfina Aznam; Retno Arianingrum; Masatake Niwa
Indonesian Journal of Chemistry Vol 6, No 3 (2006)
Publisher : Universitas Gadjah Mada

Two oligoresveratrol, namely balanocarpol (2) and ampelopsin H (3) had been isolated from the steam bark of Hopea odorata (Dipterocarpaceae). The structures of these compounds were elucidated based on physical and spectroscopic data (MS, 1H and 13C NMR 1D and 2D). The activity of these compounds was evaluated against the 2-deoxyribose degradation induced by the hydroxyl radical generated via a Fenton-type reaction. The result showed that activity each compounds as radical hydroxyl scavenger of balanocarpol, and ampelopsin H with an IC50 1802.3 and 4840.0 μg/mL, respectively. Each compound showed low activity. Vitamin C (IC50 83.9 μg/mL) and butylated hydroxyl toluene (1328.0 μg/mL) were used as positif controls. These results suggest that oligoresveratrols from stem bark of H. odorata may be useful as potential sources of natural antioxidants.

BALANOCARPOL AND HEIMIOL A, TWO RESVERATROLS DIMER FROM STEM BARK Hopea mengarawan (Dipterocarpaceae) Sri Atun; Nurfina Aznam; Retno Arianingrum; Masatake Niwa
Indonesian Journal of Chemistry Vol 6, No 1 (2006)
Publisher : Universitas Gadjah Mada

Isolation and structure elucidation of two resveratrols dimer, namely balanocarpol (1) and heimiol A (2) from stem bark of Hopea mengarawan had been done. The isolation of those compounds was carried out by chromatographic method and structure elucidation was performed by interpretation of spectroscopic data, including UV, IR, 1H and 13C NMR 1D and 2D, and FABMS.

STRUCTURE IDENTIFICATION OF A TRIMER STILBENOID COMPOUND FROM STEM BARK Hopea nigra (DIPTEROCARPACEAE) Sri Atun; Nurfina Aznama; Retno Arianingrum; Masatake Niwab
Indonesian Journal of Chemistry Vol 5, No 3 (2005)
Publisher : Universitas Gadjah Mada

Bioactivity as antihephatotoxic directed fractionation of aceton extract from the stem bark of Hopea nigra (Dipterocarpaceae) afforded a stilbenoid trimer, namely vaticanol G (1). The structure of this compound were elucidated based on physical and spectroscopic data (UV, IR, MS, 1H and 13C NMR 1D and 2D).

Co-Authors Alya Rizkita Irwan Arbain, Cipto Aris, Asmi Ariswan Ariswan Astuti Lestari Azeeza, Sabira Nurul Bian Ihda An Naila Chaniago, Muhammad Akbar Das Salirawati Das Salirawati Eddy Sulistyowati Eddy Sulistyowati Edy Meiyanto Eli Rohaeti Fajar Naqsyahbandi Fapriyan Wijoyo Mulyopratikno Gistiana, Ilyas Hanafia, Hafiizhoh Hari Sutrisno Heri Retnawati Indyah Sulistyo Arty Isana Supiah Yosephine Louise Ixora Sartika Mercuriani Kun Sri Budiasih Latifah Kurnia Devani Marpaung, Dewi Natalia Mary Garson Masatake Niwa Masatake Niwab Mulyopratikno, Fapriyan Wijoyo Nadiya Fitri Anisa Naqsyahbandi, Fajar Nida Qurbaniah Juhara Niwa Masatake Nova Irawati Simatupang Nova Irawati Simatupang, Nova Irawati Nur Aini Purnamaningsih Nur Fitriyana Nurfina Aznam Prastika, Farera Nareswari Kirana Putri, Rizka Maylaffayza Retno Sunarminingsih Sudibyo Ridani, Maulida Rudyansah Rudyansah S. Senam Sangal, Aditi Sani, Ida Nurjelita Senam Senam Shiddiqi, Muhammad Habib Ash Siti Sulastri Siti Sulastri Sofia Mubarika Haryana Sri . Handayani Sri Atun SRI ATUN Sri Atun Sri Atun Sri Handayani Sri Handayani Sri Nurestri Sri Nurestri Susila Kristianingrum Togu Gultom Wijoyo Mulyopratikno, Fapriyan Wika Rinawati Winarto Haryadi Winarto Haryadi Zulfi Hendri

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