Claim Missing Document
Check
Articles

Found 37 Documents
Search

Antiangiogenesis Activity of Indonesian Local Black Garlic (Allium Sativum ‘Solo): Experiments and Bibliometric Analysis Retno Arianingrum; Nurfina Aznam; Sri Atun; S. Senam; Alya Rizkita Irwan; Nida Qurbaniah Juhara; Nadiya Fitri Anisa; Latifah Kurnia Devani
Indonesian Journal of Science and Technology Vol 8, No 3 (2023): (ONLINE FIRST) IJOST: December 2023
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v8i3.63334

Abstract

Cancer is still one of the leading causes of death in the world. Angiogenesis is the formation of new blood vessels, which plays a vital role in the growth of cancer cells. As a result, inhibition of proangiogenic factors such as vascular epidermal growth factor (VEGF) could be used as a cancer treatment strategy. Black garlic (BG) is processed fresh garlic (Allium sativum L.) for several days under controlled high temperature and humidity. The research aims to investigate the effect of Indonesian local BG on antiangiogenic activity through in vivo and in silico studies. The in vivo test was carried out by observing the formation of new blood vessels using the Chorio-Allantoic Membrane Assay (CAM). The in silico study was performed by docking analysis of BG bioactive compounds on the VEGF receptor (VEGFR). The results showed that ethanol extract, ethyl acetate fraction, and n-hexane fraction of BG inhibit new vessel blood formation, with n-hexane fraction having the highest efficacy. The molecular docking assay indicated some similarities in the amino acids involved in the interaction between the BG bioactive compounds and the native ligand in binding to VEGFR. This similarity may lead to interference with VEGFR resulting in angiogenesis inhibition. The study suggests that BG has the potential to be developed as an anticancer agent, which might be through the mechanism of inhibiting the angiogenesis process
Implementation of The Merdeka Curriculum in The High School Chemistry Learning Process: Analysis of Variations in Hydrocarbon Material Fajar Naqsyahbandi; Nova Irawati Simatupang; Fapriyan Wijoyo Mulyopratikno; Retno Arianingrum; Sri Atun
Jurnal Inovasi Pembelajaran Kimia (Journal of Innovation in Chemistry Education) Vol 6, No 1 (2024): APRIL 2024 EDITION
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jipk.v6i1.57380

Abstract

This study aims to analyze the characteristics of hydrocarbon chemicals in the Merdeka curriculum and curriculum 13, as well as explore variations of hydrocarbon materials taught by teachers in various schools under the Merdeka Curriculum. The type of research used is descriptive qualitative through survey methods. Respondents in this study involved 24 chemistry teachers who worked in DKI Jakarta and Yogyakarta. The selection of respondents was random. The results of this study show that there are differences in the characteristics of hydrocarbon materials taught in the 2013 curriculum and the Merdeka curriculum. In the Merdeka curriculum, most chemistry teachers still do not differ much from each other even though they have been given freedom in teaching, with only slight variations in the selection of the material. Teachers consider materials in hydrocarbon topics very important and must be taught thoroughly because they will be useful in learning the next topic. In making decisions to teach hydrocarbon material, teachers should increase their understanding of learning objectives, student heterogeneity, limited reference sources, school facilities, and students' initial knowledge.
Type of Active Learning Implementation in Science Education: A Systematic Review Ridani, Maulida; Arianingrum, Retno
Indonesian Journal of Educational Research and Review Vol. 7 No. 2 (2024): July 2024
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/ijerr.v7i2.65623

Abstract

Involving students in active learning is associated with positive learning outcomes. Despite the evidence supporting the positive learning outcomes of active learning, the adoption of active learning has been slow. Numerous education researchers have documented their application of active learning. However, there is no research yet that systematically analyzes these studies regarding the type of active learning implementation in science education. This systematic review analysis study was conducted to review the type of active learning implementation in science education. The main criteria for the selection of articles is the implementation of active learning in the field of science education with a period ranging from 2012 to 2022 from the well-known international database. There were 20 articles were obtained that fit into the criteria using the Active Learning keyword. The review was focused on the course, type of active learning, aims, method, samples, and data collection tools. The results show that the most studied course is interdisciplinary chemistry. Active learning types coded Not applicable, Others, Hybrid learning, Group work, Online-based learning, Hands-on Learning, and Inquiry. Articles aim to investigate active learning effects using quantitative methods. Undergraduate student samples enriched these studies, with data collected through surveys and descriptions. These findings can inspire science educators to adopt suitable active learning strategies, impacting students' achievements in science education.
Pengembangan E-LKPD Berbasis Problem Based Learning untuk Meningkatkan Keterampilan Berpikir Kritis pada Materi Kesetimbangan Kimia Putri, Rizka Maylaffayza; Arianingrum, Retno
Jurnal Riset Pembelajaran Kimia Vol 9, No 2 (2024): Jurnal Riset Pembelajaran Kimia
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jrpk.v9i2.20733

Abstract

Penelitian ini bertujuan untuk menentukan kelayakan, kepraktisan, dan uji keterbacaan e-LKPD berbasis Problem Based Learning (PBL) pada pembelajaran kesetimbangan kimia. Penelitian pengembangan berikut dilakukan dengan mengadopsi model 4D yang terdiri dari empat tahapan, yaitu Define, Design, Develop, dan Disseminate. Pengumpulan data dilakukan melalui wawancara dengan lima guru kimia, angket analisis kebutuhan peserta didik, lembar validasi kepada dua ahli media dan materi, angket kepraktisan diberikan kepada lima guru kimia, serta angket keterbacaan peserta didik diberikan kepada 60 peserta didik kelas XI MIPA SMA Negeri di Yogyakarta. Data kuantitatif dikumpulkan dengan angket berskala likert. Hasil penelitian menunjukkan bahwa e-LKPD dinyatakan layak oleh validator ahli media dan materi dengan revisi sesuai saran. Hasil uji kepraktisan menunjukkan e-LKPD memiliki tingkat kepraktisan 88% dengan kategori sangat baik dan hasil keterbacaan mendapat skor sebesar 86% dengan kategori sangat baik.
Pendampingan pembuatan souvenir dari sampah anorganik Rohaeti, Eli; Yosephine Louise, Isana Supiah; Budiasih, Kun Sri; Arianingrum, Retno; Aznam, Nurfina; Mercuriani, Ixora Sartika; Fitriyana, Nur; Rinawati, Wika
Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Vol. 8 No. 2 (2024): Vol 8, No 2 (2024)
Publisher : Yogyakarta State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jpmmp.v8i2.69891

Abstract

Permasalahan yang akan dicarikan solusinya, yaitu mencari solusi terhadap penumpukkan limbah anorganik yang dihasilkan oleh kegiatan masyarakat, meningkatkan literasi masyarakat tentang pengolahan limbah anorganik, serta meningkatkan keterampilan masyarakat dalam mengolah limbah anorganik menjadi berbagai produk souvenir sehingga masalah lingkungan dan ekonomi dapat terselesaikan.  Tujuan kegiatan pelatihan pendampingan ini, yaitu untuk meningkatkan pemahaman masyarakat terkait cara pengolahan sampah anorganik serta untuk meningkatkan keterampilan masyarakat dalam mengolah sampah anorganik menjadi berbagai produk souvenir yang memiliki nilai ekonomi tinggi. Solusi yang ditawarkan yaitu melalui kegiatan pelatihan dan pendampingan cara mengolah limbah anorganik menjadi berbagai produk souvenir seperti bros, tempat pensil, dompet, dan tas, menjadi media tanam, dan ecobrick. Target pelatihan yaitu para pemuda, warga masyarakat sekitar Taman Kyai Langgeng (TKL) Magelang, serta para pendidik di lingkungan kota Magelang. Hasil kegiatan pelatihan menunjukkan adanya peningkatan pengetahuan dan keterampilan peserta, terutama dalam mengolah limbah anorganik, kesempatan kepada peserta dan mitra untuk membiasakan diri peka terhadap lingkungan, terutama pemisahan sampah/limbah anorganik dari rumah tangga atau lingkungan sekitar dan mampu mengolahnya menjadi produk bermanfaat dan bernilai ekonomi, serta mempraktekkannya dalam kehidupan sehari-hari.
PENDAMPINGAN PENGOLAHAN LIMBAH ORGANIK MENJADI ECOENZYME BAGI GURU-GURU SMP SEKABUPATEN MAGELANG Yosephine Louise, Isana Supiah; Rohaeti, Eli; Aznam, Nurfina; Arianingrum, Retno; Budiasih, Kun Sri; Mercuriani, Ixora Sartika; Rinawati, Wika; Fitriyana, Nur
Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Vol. 8 No. 2 (2024): Vol 8, No 2 (2024)
Publisher : Yogyakarta State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jpmmp.v8i2.71193

Abstract

Sampah rumah tangga umumnya berupa sampah organik, demikian juga limbah/sampah pedagang lotis/rujak, jus, sayur dan buah, yang umumna hanya dibuang begitu saja, menumpuk dan menyebabkan aroma tidak sedap dan menyebabkan sarang lalat, yang berakibat terhadap kesehatan masyarakat sekitar. Untuk itu perlu diupayakan pengolahan limbah rumah tangga, penjual lotis/rujak, jus, sayur dan buah yang berupa limbah/sampah organik menjadi produk yang bermanfaat dan memiliki nilai ekonom. Pada kegiatan pendampingan guru-guru SMP se-Kabupaten Magelang dengan dana dari Program MF (Matching Fund) 2023 (Ristekdikti) telah dikenalkan produk ecoenzim sebagai produk fermentasi limbah/sampah organik, yang memiliki banyak manfaat, antara lain, pupuk, insektisida, dan memiliki khasiat obat (obat luar). Selama kegiatan pendampingan, peserta tidak hanya dikenalkan produk ecoenzim secara teori, tetapi langsung mempraktekkan pembuatan ecoenzim, dengan bahan-bahan dan peralatan yang telah disediakan. Peserta sangat menikmati dan sangat bersemangat selama pendampingan, secara umum peserta menyatakan bahwa kegiatan ini sangat bermanfaat, penyampaian materi dapat diterima dnegan sangat baik, metoda yang digunakan sangat sesuai dan kegiatan ini sangat membantu membuka wawasan peserta pendampingan.
Antioxidant Activity of Aloe vera and Prediction of Interaction Mechanisms on ROS1 Kinase and Collagenase Receptorsco Atun, Sri; Aznam, Nurfina; Arianingrum, Retno; Azeeza, Sabira Nurul; Sangal, Aditi
Molekul Vol 19 No 3 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.3.11427

Abstract

The Aloe vera plant has been widely used as a food ingredient, medicine and cosmetics. This research aims to test the gel and ethanol extract of Aloe vera leaves as an antioxidant and absorber of UV light in vitro, as well as predicting the interaction mechanism for ROS1 kinase and collagenase receptors in silico.The antioxidant activity test method was carried out in vitro using DPPH (1,1-Diphenyl-2-Picrylhydrazyl-Hydrazine) reagent. Activity as a UV light absorber is carried out by calculating the sun protected factor (SPF) value. The antiaging activity test was carried out by predicting the interaction mechanism of the ROS1 kinase and collagenase receptors in silico using several phenolic compounds that have been found in Aloe vera. The total phenolic content of Aloe vera ethanol extract was 379.136 ± 0.34 GAE/g sample, while that of Aloe vera gel was 0.0619 ± 0.04 GAE/g sample. Aloe vera ethanol extract showed moderate antioxidant activity with an IC50 of 101.9 µg/mL, and is able to absorb UV light at concentrations of 0.05% and 0.1% with ultra protection criteria. Several phenolic compounds found in Aloe vera plants showed high binding energy to ROS1 kinase and collagenase receptors. Isoquercitrin showed the highest binding energy to the ROS1 kinase receptor, while isovitexin showed the highest binding energy to the collagenase receptor. The conclusion of this research showed that Aloe vera leaves contain compounds that have potential as antioxidants and antiaging. Keywords: Aloe vera, antioxidant, antiaging, ROS1 kinase, collagenase
The Effect of STAD-Cooperative Learning Model with Concept Maps in Promoting Students’ Self-Efficacy and Conceptual Understanding of Thermochemistry Sani, Ida Nurjelita; Arianingrum, Retno
Jurnal Pendidikan Kimia Indonesia Vol. 8 No. 2 (2024)
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jpki.v8i2.76461

Abstract

The research sought to explore how employing the Student Team Achievement Division (STAD) cooperative learning model, along with concept maps, impacts the enhancement of students' self-efficacy and grasp of thermochemistry concepts. This study employed a quasi-experimental approach using a pretest-posttest control group design. It was carried out among 127 11th-grade science students from MAN 1 Bengkulu City, chosen through cluster random sampling. The information was gathered by utilizing self-efficacy questionnaires and conceptual understanding tests and was analyzed using Multivariate Analysis of Variance (MANOVA). The findings indicated that the obtained p-value was less than 0.05 (p<0.05), revealing a statistically significant difference in self-efficacy and conceptual understanding between students in the experimental and control groups. This suggests that students in the experimental group showed greater enhancements in self-efficacy and conceptual understanding when compared to those in the controlled group. Thus, These findings revealed that STAD-cooperative learning with concept maps had a better influence in enhancing self-efficacy and student conceptual understanding of thermochemistry.
Penerapan Pembelajaran IPA Berbasis Etnosains melalui Kearifan Lokal untuk Meningkatkan Keterampilan Proses Sains dan Berpikir Kritis: Kajian Literatur Marpaung, Dewi Natalia; Retnawati, Heri; Arianingrum, Retno
Musamus Journal of Primary Education Vol 7 No 1 (2024)
Publisher : Faculty of Teacher Training and Education, Musamus University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35724/musjpe.v7i1.6691

Abstract

Science learning based on local wisdom is increasingly gaining attention in the context of learning, especially ethnoscience approach that connects science with traditional knowledge of the local wisdom. This study aims to make science learning more relevant and contextual for students by connecting scientific concepts with local wisdom in the community. The research method used literature review study by collecting reference sources from Google Scholar. Literature studies that examine various studies related to the application of science learning based on local wisdom to use local wisdom in science education in schools. The data analysis technique used in this literature study research is content analysis that contains science process skill and critical thinking skills. The journals that are in accordance with the topic consist of 10 articles. The results of this study indicate that the application of ethnoscience through local wisdom can improve students' understanding of scientific concepts, strengthen their involvement in the learning process, can improve students' science process skills, such as observing, experimenting, analysing, and concluding data, and encouraging the development of critical thinking skills.
PEMANFAATAN LIMBAH KULIT lKAN MENJADI KERUPUK (RAMBAK) Kristianingrum, Susila; Arianingrum, Retno; Sulastri, Siti
INOTEKS: Jurnal Inovasi Ilmu Pengetahuan,Teknologi, dan Seni Vol 10, No 1 (2006)
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6961.798 KB) | DOI: 10.21831/ino.v10i1.5136

Abstract

This   program   of  implementation    Science,   Technology    and  Arts (Ipteks)  intended  to  introduce  and  give  skill  training  about  making  chips from  fish skins (kerupuk  kulit  ikan)  to the community   in Tanjungsari   Sub­ district,  Gunungkidul   Regency.  In this  area,  there  are  plenty  of  fish  skins that can pollute  and disturb  the beauty  of the environment.   Producing  chips from fish skins can reduce the pollutant  and increase  the value of fish skins.The  program   was  held  by  giving   information   and  demonstration methods  in two locations  with different  participants.   The first program  was held  in Tanjungsari  Sub-district   Hall  for 35 participants,   who  were  village chiefs'    wives.   The   second   program   was   held   at  Baron   beach   hall   to accommodate  20 participants,  consisting  of fishermen's   wives and members of youth group.The questionnaire  result  of first program  showed  that  85.71 % of theparticipants   considered  this  program  profitable   and  74.28%  said  that  they were  interested  to  develop  business  in  producing   fish  skin  chips.  All  the participants   (100%)   of  the  second   program   said  that   the  program   was profitable  and  they  were  interested  to  develop   business   in producing   fish skin  chips.  Thus,  the  program   succeeded   in  broadening   the  participants' perspectives  and  skills  on how  to make  use  of   waste,  turning  it into fish skin  chips  and  to  motivate  the  participants   to  develop   business  using  the knowledge  and skills already obtained.Key words:fish skin waste.fish skin drips