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All Journal HAYATI Journal of Biosciences EKSAKTA: Journal of Sciences and Data Analysis Indonesian Journal of Cancer INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Paediatrica Indonesiana Journal of Medicine and Health Molecular and Cellular Biomedical Sciences (MCBS) Syntax Literate: Jurnal Ilmiah Indonesia Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JFL : Jurnal Farmasi Lampung Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Ilmu Kefarmasian Indonesia Majalah Kedokteran Andalas Jurnal Jamu Indonesia Majalah Patologi Indonesia Jurnal Ekonomi Muhammadiyah Journal of Geriatric Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Indonesian Journal of Medical Chemistry and Bioinformatics Jurnal Kefarmasian Indonesia Indonesian Journal of Jamu Journal of Medicine and Health
Wawaimuli Arozal
Universitas Indonesia
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Efek Kombinasi Ekstrak Etanol Acalypha indica dan Centella asiatica pada Jantung Tikus Pascahipoksia: Gen Hif-1a, Troponin I dan Stres Oksidatif Edhiatmi, Marsetyo; Arozal, Wawaimuli; Purwaningsih, Erni H
Jurnal Jamu Indonesia Vol. 1 No. 2 (2016): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v1i2.15

Abstract

Hipoksia meningkatkan pembentukan dan pelepasan spesies oksigen reaktif (ROS). Sel mempunyai mekanisme melindungi diri terhadap kerusakan akibat pembentukan ROS yang terjadi secara alami. Jika pembentukan radikal bebas terjadi berlebihan maka dapat menyebabkan stres oksidatif yang memicu kerusakan sel terutama pada jantung. Sehingga tubuh memerlukan asupan antioksidan. Acalypha indica dan Centella asiatica terbukti memiliki efek antioksidan dan melindungi banyak organ dari kondisi hipoksia, sehingga penelitian ini dilakukan dengan tujuan untuk mengetahui efek antioksidan kombinasi ekstrak etanol Acalypha indica dan Centella asiatica pada organ jantung tikus Spraque-Dawley pascahipoksia. Tiga puluh lima ekor tikus Sprague-Dawley jantan diinduksi hipoksia selama 7 hari dalam ruang khusus, kemudian diberi perlakuan. Ekstrak Acalypha indica, ekstrak Centella asiatica dan kombinasinya diberikan kepada kelompok tikus yang telah dibagi menjadi grup A (hipoksia dan diberi air), B (hipoksia dan diberi kombinasi Acalypha indica 200 mg/kgBB dan Centella asiatica 150 mg/kgBB), C (hipoksia dan diberi kombinasi Acalypha indica 250 mg/kgBB dan Centella asiatica 100 mg/kgBB), D (hipoksia dan diberi Acalypha indica 250 mg/kgBB), E (hipoksia dan diberi Centella asiatica 150 mg/kgBB), F (hipoksia dan diberi vitamin C 100mg/kgBB) dan kelompok normal. Perlakuan diberikan secara oral selama 7 hari setelah hipoksia. Parameter yang diamati adalah ekspresi mRNA HIF-1α, kadar MDA, aktivitas enzim SOD dan ekspresi mRNA cTnI. Tidak terdapat perbedaan bermakna pada ekspresi HIF-1α antara grup A dan kelompok tikus normal (p>0,05). Kadar MDA meningkat signifikan pada grup A (p<0,05) dibanding tikus normal. Kadar MDA grup D mengalami penurunan secara signifikan (p<0,05) dibanding grup A. Aktivitas SOD menurun signifikan pada grup A (p<0,05) dibanding tikus normal. Aktivitas SOD grup B dan E (p<0,05) mengalami peningkatan secara signifikan dibanding grup A. Grup B meningkat signifikan (p<0,05) dibanding grup E. Tidak terdapat perbedaan bermakna antar kelompok perlakuan pada Ekspresi cTnI. Tidak terdapat korelasi antara kadar MDA dan aktivitas SOD serta ekspresi mRNA HIF-1a dan mRNA cTnI. Pemberian kombinasi ekstrak Acalypha indica dan Centella asiatica tidak dapat membantu memproteksi kerusakan jantung pascahipoksia.
Cardioprotective Effect of Quercetin in 5/6-Nephrectomized Rats: Focus on Myocardial fibrosis and Oxidative Stress Yuliani, Tri; Louisa, Melva; Arozal, Wawaimuli; Soetikno, Vivian; Nafrialdi, Nafrialdi; Dewijanti, Indah D
Jurnal Jamu Indonesia Vol. 2 No. 3 (2017): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v2i3.37

Abstract

Uremic cardiomyopathy is the leading cause of death in patients with chronic kidney disease. Fluid overload and oxidative stress play important roles in its pathogenesis. This study aims to determine the effect of quercetin on uremic cardiomyopathy in 5/6-nephrectomized rats. To our knowledge, its cardioprotective effect on uremic cardiomyopathy induced in rats by 5/6 nephrectomy has not been investigated yet. Uremia was induced surgically in male Sprague-Dawley rats via 5/6 nephrectomy. Quercetin was administered per orally at a dose of 100 mg/kg/day for 8 weeks prior to sacrifice. Meanwhile, captopril was administered at a dose of 10 mg/kg/day. Lipid peroxidation was assessed using TBARS reaction, while GPX activity was determined to explore the endogen antioxidant mechanism. Myocardial fibrosis was analyzed using Massons’ Trichrome staining and the level of NT-proBNP in plasma was measured as a marker of cardiac dysfunction. Nephrectomy 5/6 had no effects on plasma NT– proBNP levels, cardiac and plasma MDA levels, but induced mild myocardial fibrosis and significant increase in cardiac GPX activity in comparison with normal rat (p<0.05). However, administration of quercetin or captopril did not ameleriote those mild myocardial fibrosis and increased GPX activity. Uremic cardiomyopathy induced by 5/6 nephrectomy demonstrated mild myocardial fibrosis but preservation of cardiac function demonstrated by NT-proBNP levels. Increased of GPX activity in the nephrectomized-rats compared to the control rats (p<0.05) suggests induction of antioxidant defense mechanisms that might not be exhausted yet. This condition highlighted a compensatory phase which was unchanged following chronic administration of either quercetin or captopril.
Analisis Pemberian N-acetylcysteine Dosis Tinggi Terhadap Fungsi Ginjal Pasien yang Didiagnosis Acute Kidney Injury Periode Januari – Desember 2021 di RSPON Jakarta Ulya, Nurul; Sumarny, Ros; Arozal, Wawaimuli; Musridharta, Eka
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i8.16797

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh efek pemberian N-acetylcysteine dosis tinggi 5000 mg iv terhadap fungsi ginjal pasien terdiagnosis AKI dilihat dari serum Kreatinin, GFR dan Ureum. Studi ini merupakan penelitian deskriptif analitik dengan cross sectional retrospektif. Penelitian ini menggunakan data rekam medis. Analisa perbedaan fungsi ginjal dengan parameter hasil lab ureum, kreatinin, dan GFR pasien AKI baik kelompok kontrol maupun kelompok uji, sebelum dan sesudah diberikan N-acetylcysteine dosis tinggi 5000 mg iv. Data dianalisis secara bivariat dengan uji T berpasangan dan uji T Independent untuk perbedaan antar kelompok pada p ≤0.05.Terdapat 60 total sampel kemudian terbagi menjadi 30 pasien AKI yang diberikan N-acetylcysteine dan 30 pasien tanpa diberikan N-acetylcysteine. Analisis hubungan sebelum dan sesudah pemberian N-acetyceyteine pada masing-masing kelompok Terjadi perbedaan bermakna pada kelompok uji yaitu pada nilai Serum Kreatinin (p=0,002) dan GFR (p=0,001). Sedangkan pada uji beda pada kedua kelompok didapatkan hasil terjadi perbedaan bermakna pada nilai Serum kreatinin yaitu (p=0,003) dan nilai GFR yaitu (p=0.014). Hasil tersebut menunjukan bahwa ada perbedaan yang bermakna pada perbaikan fungsi ginjal antara kelompok yang diberikan N-acetylcysteine (uji) dengan kelompok pasien tanpa N-acetylcysteine (kontrol) yaitu dilihat pada nilai SCr dan GFR. Kelompok uji memberikan efek perbaikan fungsi ginjal yang lebih baik dibandingkan dengan kelompok Kontrol.
Evaluation Of Antibiotic Use In Sepsis Patients In The ICU Treatment Room, Gatot Soebroto Rspad Period January 2020–December 2021 Ria Anggraeni; Wawaimuli Arozal; Yati Sumiyati; Marliana Sri Rejeki
Jurnal Ekonomi Vol. 13 No. 02 (2024): Jurnal Ekonomi, Edition April - June 2024
Publisher : SEAN Institute

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Abstract

Hypertension is Sepsis is a systemic inflammatory response syndrome caused by infection. Globally, the incidence of sepsis has increased with increasing mortality. Antibiotics used appropriately are considered to reduce mortality in sepsis. Destination of this study was to evaluate the use of antibiotics in septic patients in room care Gatot Army Hospital ICU Soebroto by qualitative with method old nor quantitative with method ATC / DDD. Method : Study this is study descriptive analytic and data collection is done retrospectively. The study was conducted by looking at the medical records of patients receiving antibiotic therapy who were treated at the hospital room Gatot Army Hospital ICU Soebroto period January 2020- December 2021. Results : Between 97 patient, 63 patient of them are male ( 64.9 %) and 34 patient Others are female ( 35.0 %). The highest age range is in the age of > 65 as many years ( 43.3 %). d result From the evaluation of the quality of antibiotics, it was found that the use of antibiotics was appropriate k (79%), possible appropriate (20.4%) and no exactly as much (0.52%). while the quantity of antibiotic use is obtained in total DDD/100 patient day take care as much 326.52 with antibiotics the most is usage meropenem 97.75 DDD/100 patient-day take care.
Potentially Inappropriate Medication (PIM) Prescribing According to Beers Criteria among Elderly Outpatients at Pasar Minggu Hospital, Jakarta Pebriani, Mala; Sumarny, Ros; Arozal, Wawaimuli; Eviarini, Prawitasari; Ismaya, Nurwulan Adi
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Elderly patients generally have physiological changes that cause multipathological conditions, so they require several drugs to treat these conditions, it is necessary to evaluate the use of drugs to optimize the treatment of geriatric patients. Beers Criteria 2019 is a criteria that is commonly used to present Potentially Inappropriate Medication (PIM). This study aimed to examine the inaccuracy of prescription drugs in the elderly using Beer's criteria 2019. This research is an observational analytic study with a cross-sectional descriptive design. The Beer's 2019 criteria classify PIM into five categories. Data were taken retrospectively as many as 847 prescriptions met the inclusion criteria at the Pasar Minggu Hospital Outpatient Polyclinic. Data were analysed by Univariate and Bivariate. The results showed that from 847 prescriptions for geriatric patients, there are 160 prescriptions for geriatric patients who experienced PIM (18.89%). Percentage of PIM incidents by category; namely, category 1 was 29.17%, category 2 was 6.77%, category 3 was 44.79%, category 4 was 16.67%, and category 5 was 2.60%. The results of the analysis showed that there was a significant relationship between the number of drugs and Heart Failure and CAD with the incidence of PIM with a p value of 0.000 and 0.035. DM and Heart Failure are 2 diseases that significantly influence the incidence of PIM. This study concludes that the elderly are at risk for receiving potentially inappropriate medications.
Therapeutic reassessment of first-line antiepileptic drugs in pediatric patients unresponsive to second-line agents: a randomized trial in Jakarta Perdani, Roro Rukmi Windi; Arozal, Wawaimuli; Mangunatmadja, Irawan; Kaswandani, Nastiti; Handryastuti, Setyo; Medise, Bernie Endyarni; Wardani, Amanda Saphira; Thandavarayan, Rajarajan Amirthalingam; Oswari, Hanifah; Lee, Hee Jae
Paediatrica Indonesiana Vol. 65 No. 6 (2025): November 2025
Publisher : Indonesian Pediatric Society

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Abstract

Background Epilepsy has a significant incidence in children, with 20-25% resistance to standard antiepileptic drugs (AEDs). Drug-resistant epilepsy (DRE) refers as the failure of two or more AEDs, either as monotherapies or in combination, to achieve seizure freedom, which includes the absence of all seizure types, even auras. Treatment algorithms for children with epilepsy range from starting with the lowest effective dose to using add-on or substitution therapy of AEDs. It usually started from using first-line AEDs (valproic acid, phenytoin, phenobarbital, carbamazepine) with titrated dose based on the patient condition, if seizure persist, another first-line AEDs may be added or substituted. Second-line AEDs (topiramate, levetiracetam, oxcarbazepine) are introduced when seizure persist despite optimal doses of first-line drugs with good compliance. Epilepsy treatment response is a dynamic process, not a fixed state. In some cases, repeating the medication cycle remains an option, as patient may initially appear drug-resistant but later respond to treatment. Thus, first-line AEDs may also serve as substitution therapy in children unresponsive to second-line agents as studies show comparable effectiveness between the two regimens. Objective To evaluate the efficacy and safety of first-line AEDs as substitution therapy (intentional replacement of patient’s current medication) in children resistant to second-line AEDs. Methods This 12-week, open-label, multicenter, randomized controlled trial was conducted in 91 epileptic children. Children aged 1 – 18 years with DRE, were randomized into the intervention (patients who received substitution therapy:  one AEDs was changed to first-line of AEDs) and control (patients who got standard therapy: one AEDs was changed to second-line of AEDs) groups. The primary outcome was the difference in the proportion of responders between the two groups. Secondary outcomes were analyzing the different improvements in quality of life (QoL), EEG feature, and time to achieve seizure reduction in both groups. The QoL was assessed by Quality of Life in Childhood Epilepsy Questionnaire 55 (QOLCE-55) to assess cognitive, emotional, social, and physical functions. Results There were no significant differences in the proportion of responders between the substitution therapy group (62.5%) and the standard therapy group (68.4%). Both groups experienced substantial reductions in seizure frequency, ranging from 78% to 80%. For further analysis, the average difference of seizure frequency before and after intervention was statistically significant in each group, it was P=0.000 in substitution group and P=0.00 in standard group. The analysis of quality of life showed the mean of total score in both groups was low even though the score was higher in the substitution group. For spesific function of quality of life, the cognitive and social function, was improved significantly in the group p<0.05). However, there were no significant differences of EEG improvement, seizure duration, time to achieve seizure frequency reduction, or adverse effects between the two groups. Conclusions First-line AEDs have comparable efficacy as second-line AEDs with mild to moderate adverse effects in DRE children. Thus, the repeated use of first-line AEDs as substitution therapy might be an option for children who resistant to second line AEDS.
Co-Authors Agatha Grace Agian Jeffilano Barinda Andrea Laurentius Arleni Bustami Aryo Tedjo Barinda, Again Jeffilano Bernie Endyarni Medise Cong, Tzeto Han Deni Rahmat Dewi Sukmawati Dewi, Yulia Ratna Djumhana Atmakusuma Djumhana Atmakusuma, Djumhana Dwita, Nounik Cheri Edhiatmi, Marsetyo Erlina, Linda Erni H Purwaningsih Erni H Purwaningsih, Erni H Erni Hernawati Purwaningsih, Erni Hernawati Ernie Purwaningsih Eviarini, Prawitasari Eziefule, Oluebube Magnificient Fadhillah, Muhamad Rizqy Fadilah Fadilah Fadilah, Fadilah Fajarido, Ariski Femmi Dwinda Agustini Franciscus D. Suyatna Gregorius Bhaskara Wikanendra Gusti Khatimah, Nurul Hanifah Oswari Hedi R. Dewoto Heri Wibowo Hesty Utami Husna, Fauzul Indah D Dewijanti Indah D Dewijanti, Indah D Irawan Mangunatmadja Jusman, Sri Widia Azraki Kapuangan, Christopher Kartika, Kartika Handayani Kenichi Watanabe Khatimah, Nurul Gusti Kuncoro, Daviet Dwi Kurniasari Kurniasari Kusmardi Kusmardi Kusmardi Kusmardi Laurentius, Andrea Lee, Hee Jae Marliana Sri Rejeki Marliana Sri Rejeki Marliana Sri Rejeki Marselina Marselina Marsetyo Edhiatmi Meilei Ma Melva Louisa Muhamad Sadam Safutra Musridharta, Eka Nabillah, Deya Adiby Nafrialdi Nafrialdi Nastiti Kaswandani Ni Made Dwi Sandhiutami Novi Silvia Hardiany Nur Azizah Nurwulan Adi Ismaya Pebriani, Mala Primadhani, Suci Widya Punniyakoti T. Veeraveedu Puspita Eka Wuyung Puspita Eka Wuyung Putri, Rizky Clarinta Radiana Dhewayani Antarianto Radoti Merlin Rani Hendiyani Rani Sauriasari Rani Sauriasari, Rani Raymond R. Tjandrawinata Rejeki, Marliana Sri Ria Anggraeni Rianto Setiabudy Rianto Setiabudy Riski Amanda, Clara Roro Rukmi Windi Perdani, Roro Rukmi ROS SUMARNY Ros Sumarny Rosyidah, Citra Safutra, Muhamad Sadam Safutra, Sadam Sagala, Radoti Merlin SEPTELIA INAWATI WANANDI Sesilia Keban Sesilia Keban, Sesilia Setyo Handryastuti Shimizu, Ippei Silmi Hanifah Soni Siswanto Sumiati, Yati Supraja Dwiyono Suyatna, Franciscus D Syarifah Dewi Thandavarayan, Rajarajan Amirthalingam Tri Yuliani Tri Yuliani, Tri Triana, Novi Tzeto Han Cong Ulfa T Wahyuni Ulya, Nurul Vetnizah Juniantito Vivian Soetikno Vivian Soetikno Wahyunia Likhayati Septiana Wardani, Amanda Saphira Wikanendra, Gregorius Bhaskara Yati Sumiyati