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Charles Banon
Universitas Bengkulu
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Journal : Jurnal Ilmu Kefarmasian Indonesia

 1 
Aktivitas Antibakteri Secara In-Vitro Ekstrak Metanol Excoecaria cochinchinensis Lour dan Kombinasinya dengan Obat Komersial Nurhasana, Devi; Febriansyah, Rahmaga; Avidlyandi, Avidlyandi; S., Salprima Yudha; Banon, Charles; Oktiarni, Dwita; Adfa, Morina
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1383

Abstract

The purpose of this study was to look into the antibacterial activity of methanolic extract of Excoecaria cochinchinensis as well as the effect of its combination with antibiotics on the growth of Klebsiella pneumoniae, Enterobacter aerogenes, and Staphylococcus epidermidis. The antibacterial activity test was carried out using the well diffusion method, and the combined effect of the extract and antibiotics was observed using the paper strip diffusion method. At various concentrations (25, 50, 75, 100, 150, 200, and 250 mg/mL), the extract significantly inhibited the growth of K. pneumoniae, E. aerogenes, and S. epidermidis. The inhibitory zone's diameter increased proportionally with the extract concentration. The growth of K. pneumoniae and S. epidermidis was then classified as extremely sensitive (+++) to the addition of the extract at 200 and 250 mg/mL concentrations, meanwhile, E. aerogenes’s with 250 mg/mL of the extract. Secondary metabolites such as oleanolic acid, arjunolic acid, scopoletin, kaempferol, quercetin, diterpenoid compounds, tannins, and other phenolics have been reported from E. cochinchinensis leaves and are thought to be responsible for its antimicrobial activity. The effect of the extract’s combination with antibiotics was insignificant compared to their individual activity, thereby classifying them as indifferent.
Co-Authors A.A. Ketut Agung Cahyawan W Agus Martono Agus Martono Hadi Putranto Aldi Reviansyah Amanta, Reyrin Ceria Arif Juliari Kusnanda Asdim Asdim Asdim Asteria, Marissadona Asti Arum Sari Aswanda Aswin Falahudin Aswin Falahudin Avidlyandi, Avidlyandi Azzahra, Istiqoma Bambang Trihadi Bambang Trihadi Cahyani, Aswinda Delia Komala Sari, Delia Komala Deni Agus Triawan Devi Nurhasana Devi Ratnawati Devirizanty, Devirizanty Dina Erliana Dinda Fransiska.D. N Dwi Kamilla Putri Dwita Oktiarni Eka Angasa Esi Agnesa Evi Maryanti Fatkhurrachman Fatkhurrachman Febriansyah, Rahmaga Fika Dwi Andika Gustian , Irfan Gusvita, Nola Helfi Eka Saputra Herlita Widiyanti Hevio, M. Maqbul Farhansyah Ika Diana Evita Ilman Koharudin Indri Anggraini Indriyani, Miranda Dwi Irfan Gustian Irfan Gustian Irfan Gustian Kaus, Noor Haida Mohd Khafit Wiradimafan Khafit Wirdimafan Khusnul Azizah Kurnia Farah Andina Lisa Anggraini Lisna Hamni Morina Adfa Morina Adfa Mudyanto, Andre Munifilia Ekasari Muslimah, Annisa Nadia Refa Fheronica Nanda, Yogie Andika Tri Nesbah Nesbah Nesbah Nizar, Umar Kalmar Novianti, Feni Mia Noza Alika Puteri Nurhasana, Devi Nurmalawati, Susiana Nurwidiyani, Ria Oktarini, Rizki Putri, Mutiara Wulandare ka Jolie Putri, Yona Harianti Qotimah, Wahyu Ningsi Rahmaga Febriansyah Rahmawati, Reza Reza Rahmawati Ria Nurwidiyani Risky Hadi Wibowo Risky Hadi Wibowo Risma Sari, Risma SALPRIMA YUDHA S Salprima Yudha S. Sari, Amalia Upida SEPTI WULANDARI Siburian, Devi Melisa Simanjuntak, Gresanty Oktavia Suryadi Jaya Teja Dwi Sutanto Totok E. Suharto Triawan, Deni Agus Vanessgia, Resika Widia Rahmi Winda Shari Wulandari, Saskia Shaumi Yana, Risti Yoravika Dwiwibangga Zahra, Asty Alifah