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All Journal International Journal of Evaluation and Research in Education (IJERE) Cakrawala Pendidikan Jurnal Penelitian Saintek Jurnal Pendidikan dan Pengajaran Jurnal Pendidikan Kimia Indonesia EDUSAINS Pharmaciana: Jurnal Kefarmasian Journal of Educational Science and Technology Jurnal Inovasi Pendidikan IPA Indonesian Journal of Science and Technology Scientiae Educatia: Jurnal Pendidikan Sains Jurnal Penelitian Pendidikan IPA (JPPIPA) Journal of Science Learning Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Biosaintifika: Journal of Biology & Biology Education Molekul: Jurnal Ilmiah Kimia Jurnal Kependidikan: Jurnal Hasil Penelitian dan Kajian Kepustakaan di Bidang Pendidikan, Pengajaran dan Pembelajaran Indonesian Journal of Chemistry and Environment Indonesian Journal of Educational Development (IJED) Molekul: Jurnal Ilmiah Kimia Jurnal Elemen Kimia Jurnal Riset Pembelajaran Kimia Scientiae Educatia: Jurnal Pendidikan Sains
Nurfina Aznam
Chemistry Education Department, Faculty Of Mathematics And Natural Sciences State University Of Yogyakarta, Karangmalang, Yogyakarta Indonesia 55281
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Engineering Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Antiangiogenesis Activity of Indonesian Local Black Garlic (Allium Sativum ‘Solo): Experiments and Bibliometric Analysis Retno Arianingrum; Nurfina Aznam; Sri Atun; S. Senam; Alya Rizkita Irwan; Nida Qurbaniah Juhara; Nadiya Fitri Anisa; Latifah Kurnia Devani
Indonesian Journal of Science and Technology Vol 8, No 3 (2023): (ONLINE FIRST) IJOST: December 2023
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v8i3.63334

Abstract

Cancer is still one of the leading causes of death in the world. Angiogenesis is the formation of new blood vessels, which plays a vital role in the growth of cancer cells. As a result, inhibition of proangiogenic factors such as vascular epidermal growth factor (VEGF) could be used as a cancer treatment strategy. Black garlic (BG) is processed fresh garlic (Allium sativum L.) for several days under controlled high temperature and humidity. The research aims to investigate the effect of Indonesian local BG on antiangiogenic activity through in vivo and in silico studies. The in vivo test was carried out by observing the formation of new blood vessels using the Chorio-Allantoic Membrane Assay (CAM). The in silico study was performed by docking analysis of BG bioactive compounds on the VEGF receptor (VEGFR). The results showed that ethanol extract, ethyl acetate fraction, and n-hexane fraction of BG inhibit new vessel blood formation, with n-hexane fraction having the highest efficacy. The molecular docking assay indicated some similarities in the amino acids involved in the interaction between the BG bioactive compounds and the native ligand in binding to VEGFR. This similarity may lead to interference with VEGFR resulting in angiogenesis inhibition. The study suggests that BG has the potential to be developed as an anticancer agent, which might be through the mechanism of inhibiting the angiogenesis process
PENENTUAN KADAR TOTAL FENOL DAN UJI AKTIVITAS ANTIOKSIDAN KOMBINASI EKSTRAK SARANG SEMUT (Myrmecodia pendens Merr. & L.M. Perry) DAN EKSTRAK KENCUR (Kaempferia galanga Linn.) DENGAN METODE β-CAROTENE BLEACHING Isnaini Amanah; Nurfina Aznam
Jurnal Elemen Kimia Vol 5, No 2 (2016): Jurnal Mahasiswa Kimia FMIPA UNY
Publisher : Universitas Negeri Yogyakarta

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Abstract

Penelitian ini bertujuan untuk mengetahui kadar totalfenol yang terdapat pada ekstrak sarang semut (Myrmecodiapendens Merr. L.M. Perry) dan ekstrak kencur (Kaempferiagalanga Linn.), aktivitas antioksidan dari kombinasi ekstraksarang semut dan kencur, kombinasi ekstrak sarang semut danekstrak kencur yang paling potensial digunakan sebagaiantioksidan, perbedaan yang signifikan pada aktivitasantioksidan dari kombinasi ekstrak sarang semut dan ekstrakkencur dengan perbandingan 3:0; 2:1; 1:1; 1:2; dan 0:3 padaberbagai variasi konsentrasi, serta adanya sinergisitas darikombinasi ekstrak.Kadar total fenol ditentukan dengan metode Foliin-Ciocalteu. Kombinasi ekstrak sarang semut dan ekstrak kencurdibuat dengan perbandingan 3:0; 2:1; 1:1; 1:2; dan 0:3 padaberbagai variasi konsentrasi yaitu 7,2; 3,6; 1,8; 0,9; dan 0,45mg/L. Uji aktivitas antioksidan dilakukan dengan metode β-Carotene Bleaching. Parameter aktivitas antioksidan yaitu IC50(Inhibititon Concentration).Hasil penelitian menunjukan bahwa kadar total fenolpada sarang semut dan kencur masing-masing adalah 5,675 mgGAE/g dan 5,882 mg GAE/g. Nilai IC50 dari kombinasi ekstraksarang semut dan ekstrak kencur dengan perbandingan 3:0; 2:1;1:1; 1:2; dan 0:3 masing-masing sebesar 5,7368; 7,4435;12,2688; 12,1569; dan 14,9127 mg/L. Aktivitas antioksidanpaling tinggi ditunjukkan pada kombinasi 2:1. Hasil analisisstatistik ANOVA menunjukan ada perbedaan yang signifikanaktivitas antioksidan kombinasi ekstrak sarang semut dengan22ekstrak kencur. Kombinasi ekstrak sarang semut dengan ekstrak kencur tidak menunjukan aksi sinergistis.
PENGARUH PEMBERIAN TEMULAWAK INSTAN TERHADAP KADAR KOLESTEROL TOTAL TIKUS PUTIH JANTAN GALUR WISTAR HIPERKOLESTEROLEMIA Anggi Alham Murfian; Nurfina Aznam
Jurnal Elemen Kimia Vol 6, No 4 (2017): Jurnal Kimia Dasar
Publisher : Universitas Negeri Yogyakarta

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Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian temulawak instanterhadap kadar kolesterol total tikus putih jantan galur wistar hiperkolesterolemia. Tiga puluhekor tikus yang telah diadaptasi dibagi menjadi 6 kelompok perlakuan, yaitu kontrol normal,kontrol negatif (Na-CMC 5%), kontrol positif (simvastatin), dan tiga kelompok perlakuantemulawak instan dengan dosis berbeda (A: 50 mg/kgBB; B: 100 mg/kgBB; C: 200mg/kgBB). Penelitian berlangsung selama enam minggu: dua minggu pertama untuk diethiperkolesterol dan empat minggu terakhir untuk perlakuan masing-masing kelompok.Pengukuran kadar kolesterol total dilakukan dengan metode enzimatik CHOD-PAP. Datadianalisis menggunakan metode one way ANOVA dan independent-T test. Hasil penelitianmenunjukkan bahwa pemberian temulawak instan mampu menurunkan kadar kolesterol totalhewan uji setelah empat minggu perlakuan. Hewan uji yang telah mengalami diethiperkolesterol memiliki nilai kadar kolesterol yang berbeda secara signifikan setelah diberiperlakuan A dan B. Perlakuan A juga memberikan nilai kadar kolesterol yang berbeda secarasignifikan dengan kontrol positif.Kata kunci : temulawak instan, kolesterol total
UJI EFEK ANALGETIK TEMULAWAK INSTAN (Curcuma xanthorrizha Roxb) PADA MENCIT JANTAN DENGAN METODE GELIAT Tanti Wulandari; Nurfina Aznam
Jurnal Elemen Kimia Vol 7, No 1 (2018): Jurnal Kimia Dasar
Publisher : Universitas Negeri Yogyakarta

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Abstract

Temulawak diketahui memiliki sifat sebagai analgetik karena mengandung senyawa kurkumin.Tujuan dari penelitian ini adalah untuk mengetahui efek analgetik pemberian temulawak instan (Curcumaxanthoriza Roxb) pada mencit jantan serta untuk mengetahui dosis efektif instan dan seberapa efektifnyabila dibandingkan dengan asetosal. Penelitian ini menggunakan 25 ekor tikus jantan galur Swiss berumur2-3 bulan dengan berat 20-40 gram yang dibagi menjadi 5 kelompok, yaitu kelompok kontrol negatifdiberi Na-CMC 1%, kelompok kontrol positif diberi asetosal dengan dosis 65 mg/KgBB, kelompokperlakuan pertama, kedua, dan ketiga berturut-tururt diberi temulawak instan 187,5 mg/KgBB; 375mg/KgBB; dan 750 mg/KgBB. Masing-masing kelompok dihitung frekuensi geliat dengan menggunakanmetode geliat. Hasil penelitian menunjukkan temulawak instan dosis 750 mg/KgBB memberikan efekanalgetik pada mencit jantan. Dosis 750 mg/KgBB memberikan efek analgetik yang setara denganpemberian asetosal dalam penurunan jumlah gelia tmencit dan merupakan dosis efektif analgetik.Sedangkan harga IC50 yaitu 700 mg/KgBB.
Studi Literasi Kimia yang Berkaitan dengan Etika Kimia Berdasarkan Fenomena Lokal Sehari-hari: Kasus Minyak Jelantah Faiz Ilham Pratama; Nurfina Aznam; Eli Rohaeti
Jurnal Penelitian Pendidikan IPA Vol. 9 No. 9 (2023): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i9.3224

Abstract

Literation level, one of them is scientific literation, is possible to be the measurement of a national improvement in education. Scientific literation could be specified by chemistry literation which has four aspects; one of them is the affective domain. In this study, the research focuses on the affective domain consisting of five phases; phase of receiving, phase of responding, phase of valuing, phase of organizing, and phase of characterizing by value set. The study aims to describe the students' chemistry attitude skills related to hydrocarbon materials by integrating local case of everyday life. The local case taken is the cooking oil used in the “penyetan” stall. The research is descriptive qualitative research. The participants of this research are whole students of grade eleventh in a senior high school in Magelang who had been taught hydrocarbon materials. The sample of this research is 70 students of grade eleventh. Questionary is used in the research as a data collection method. The instrument used is a form of a questionnaire, which was a close-ended questionnaire with four possible answers; strongly disagree, disagree, agree, and strongly agree. The result shows the skill of chemistry attitude of hydrocarbon material is 69.12857%. It means that the student's skill chemistry attitude is in a category of fair.
Sikap siswa terhadap penggunaan video podcast pada materi Larutan Penyangga Fazita Apritama Dewi Fau; Nurfina Aznam
Jurnal Penelitian Pendidikan IPA Vol. 9 No. 9 (2023): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i9.3301

Abstract

The use of video podcasts has positively impacted student learning and engagement in various educational settings. In the specific case of learning about buffer solutions, video podcasts can effectively present key concepts and principles in an engaging and interactive way. This study aims to analyze students' attitudes toward the Video Podcast on Buffer Solution Material. The instrument used in this study is a closed-ended questionnaire consisting of 17 questions with six aspect categories: Overall, Explanation, Learning Features, Tempo, Interest, and Further Purpose. Then, 34 students from X MIPA at SMAN 1 Cangkringan were involved in this study. Total number of visitors for 5 days completed is 54 times. The students in this study had positive attitudes toward video podcast used to teach buffer solution concepts. It can be seen that the results of the student’s attitude towards podcast that overall students liked the podcast that was posted (80%). The result revealed that, in general, students liked the posted podcast, and the video helped them understand the buffer solution material. However, the effectiveness of video podcasts may depend on various factors, including the quality and relevance of the content, the integration of the podcasts into the overall teaching and learning process, and individual student needs and preferences. To ensure the best possible outcomes, teachers should carefully consider these factors when using video podcasts as a learning tool for buffer solution concepts.
Development of HOTS (High Order Thinking Skill) Question Instrument on Thermochemistry Material Mizzan Ayubi; Vegha Dwi Arthamena; Nurfina Aznam
Jurnal Penelitian Pendidikan IPA Vol 9 No 11 (2023): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i11.5162

Abstract

This study aims to make High Order Thinking Skill (HOTS) items in the form of multiple-choice types of thermochemistry material for SMA/MA. The development of the HOTS question instrument was carried out to produce valid and reliable question items. The HOTS question instrument development method uses the Mc development model. Intire. Data results in development research can be carried out using rater validation and test results. Based on the results of the rater, it can be stated that the items are feasible to test by looking at the average value of validity, which is 0.727 so that they are included in the high category by looking at aspects, namely material, construction and language aspects. Based on the calculation of the results by producing 15 questions with thermochemical material for SMA/MA which are valid with the criteria for the average level of difficulty, namely (0.584), the criteria for discriminating power of the average questions, namely (0.576) with the criteria for the average validity test, namely (0.493) reliability criteria with an average of (0.686). The conclusion obtained from the data is that the HOTS question instrument can be declared suitable for student use.
Development of E-Worksheet Based on Flipped-Guided Inquiry Learning (FGIL) in Thermochemistry for Phase F Defista, Chesa; Aznam, Nurfina
Jurnal Pendidikan Kimia Indonesia Vol. 8 No. 1 (2024)
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jpki.v8i1.74638

Abstract

Thermochemistry has abstract and mathematical material which makes it difficult for students to understand this material. Students are required to discuss this material in depth so teaching materials are needed that support student learning flexibly. Thus, the research purpose is to develop a thermochemistry e-worksheet based on FGIL for high school students in phase F. The research type is R&D with the ADDIE model which is limited to the Development stage. Content validity was carried out with four validators and practicality was obtained from 36 phases F high school students. The research instruments were validation sheets and student response questionnaires. The validity value is determined by Aiken's V test, if the V value is > 0.40 then an aspect is declared valid. The research findings demonstrated that the average assessment on the material aspect was 0.92 (very valid); the media aspect 0.96 (very valid); and the language aspect was 0.83 (very valid), while the average percentage of student responses was 96% (very practical). So, it can be said that the developed thermochemistry e-worksheet based on FGIL is valid and practical to use.  
Pendampingan pembuatan souvenir dari sampah anorganik Rohaeti, Eli; Yosephine Louise, Isana Supiah; Budiasih, Kun Sri; Arianingrum, Retno; Aznam, Nurfina; Mercuriani, Ixora Sartika; Fitriyana, Nur; Rinawati, Wika
Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Vol. 8 No. 2 (2024): Vol 8, No 2 (2024)
Publisher : Yogyakarta State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jpmmp.v8i2.69891

Abstract

Permasalahan yang akan dicarikan solusinya, yaitu mencari solusi terhadap penumpukkan limbah anorganik yang dihasilkan oleh kegiatan masyarakat, meningkatkan literasi masyarakat tentang pengolahan limbah anorganik, serta meningkatkan keterampilan masyarakat dalam mengolah limbah anorganik menjadi berbagai produk souvenir sehingga masalah lingkungan dan ekonomi dapat terselesaikan.  Tujuan kegiatan pelatihan pendampingan ini, yaitu untuk meningkatkan pemahaman masyarakat terkait cara pengolahan sampah anorganik serta untuk meningkatkan keterampilan masyarakat dalam mengolah sampah anorganik menjadi berbagai produk souvenir yang memiliki nilai ekonomi tinggi. Solusi yang ditawarkan yaitu melalui kegiatan pelatihan dan pendampingan cara mengolah limbah anorganik menjadi berbagai produk souvenir seperti bros, tempat pensil, dompet, dan tas, menjadi media tanam, dan ecobrick. Target pelatihan yaitu para pemuda, warga masyarakat sekitar Taman Kyai Langgeng (TKL) Magelang, serta para pendidik di lingkungan kota Magelang. Hasil kegiatan pelatihan menunjukkan adanya peningkatan pengetahuan dan keterampilan peserta, terutama dalam mengolah limbah anorganik, kesempatan kepada peserta dan mitra untuk membiasakan diri peka terhadap lingkungan, terutama pemisahan sampah/limbah anorganik dari rumah tangga atau lingkungan sekitar dan mampu mengolahnya menjadi produk bermanfaat dan bernilai ekonomi, serta mempraktekkannya dalam kehidupan sehari-hari.
PENDAMPINGAN PENGOLAHAN LIMBAH ORGANIK MENJADI ECOENZYME BAGI GURU-GURU SMP SEKABUPATEN MAGELANG Yosephine Louise, Isana Supiah; Rohaeti, Eli; Aznam, Nurfina; Arianingrum, Retno; Budiasih, Kun Sri; Mercuriani, Ixora Sartika; Rinawati, Wika; Fitriyana, Nur
Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Vol. 8 No. 2 (2024): Vol 8, No 2 (2024)
Publisher : Yogyakarta State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jpmmp.v8i2.71193

Abstract

Sampah rumah tangga umumnya berupa sampah organik, demikian juga limbah/sampah pedagang lotis/rujak, jus, sayur dan buah, yang umumna hanya dibuang begitu saja, menumpuk dan menyebabkan aroma tidak sedap dan menyebabkan sarang lalat, yang berakibat terhadap kesehatan masyarakat sekitar. Untuk itu perlu diupayakan pengolahan limbah rumah tangga, penjual lotis/rujak, jus, sayur dan buah yang berupa limbah/sampah organik menjadi produk yang bermanfaat dan memiliki nilai ekonom. Pada kegiatan pendampingan guru-guru SMP se-Kabupaten Magelang dengan dana dari Program MF (Matching Fund) 2023 (Ristekdikti) telah dikenalkan produk ecoenzim sebagai produk fermentasi limbah/sampah organik, yang memiliki banyak manfaat, antara lain, pupuk, insektisida, dan memiliki khasiat obat (obat luar). Selama kegiatan pendampingan, peserta tidak hanya dikenalkan produk ecoenzim secara teori, tetapi langsung mempraktekkan pembuatan ecoenzim, dengan bahan-bahan dan peralatan yang telah disediakan. Peserta sangat menikmati dan sangat bersemangat selama pendampingan, secara umum peserta menyatakan bahwa kegiatan ini sangat bermanfaat, penyampaian materi dapat diterima dnegan sangat baik, metoda yang digunakan sangat sesuai dan kegiatan ini sangat membantu membuka wawasan peserta pendampingan.
Co-Authors Afifah, ST Agnesi Sekarsari Putri Agung Nugroho Catur Saputro Alessandro Jeremi Manarisip Alya Rizkita Irwan Anding, Imanuel Anggi Alham Murfian Ani Nurhidayanti Annisa Mamluaturrahmatika Arini Miftaqul Jannah Assari, Andra Meisantry Astuti Lestari Azeeza, Sabira Nurul Baroroh, Farida Bian Ihda An Naila Chesa Defista Crys Fajar Partana Danik Noor Utami Defista, Chesa Devina Siti Hafsah Eli Rohaeti Faiz Ilham Pratama Farida Baroroh Faridah Baroroh Fazita Apritama Dewi Fau Hadaina Zulfah Handayani, Sri Hari Susanti Heru Nurcahyo Insih Wilujeng Isana Supiah Yosephine Louise Isnaini Amanah Ixora Sartika Mercuriani Jumadi Jumadi Jumadi Jumadi Kun Sri Budiasih Kusmiyati kusmiyati Latifah Kurnia Devani Magfirah Perkasa Masatake Niwa Masatake Niwab Mizzan Ayubi Mizzan Ayyubi Muhammad Habib Ash shiddiqi Munnal Hani'ah Nadiya Fitri Anisa Nafisa Rahmah Nida Qurbaniah Juhara Nindi Mediartika Novitasari, Karina Wahyu Ayu Nur Fitriyana Nur Inayah Amaliyah Nuraini, Anisa Syahra Nurhidayanti, Ani Purnamaningsih, Nur Aini Putri, Sarmila Eka Retno Arianingrum Riki Perdana Risky Nugraheni Purnamawati Robiatul Adauyah Rumahorbo, Shinta S. Senam Sangal, Aditi Sarmila Eka Putri Senam Senam Shofrina Surya Dewi Sri Atun Sri Atun SRI ATUN Sri Atun Sri Handayani Sri Handayani Sri Handayani Sri Nurestri Sri Nurestri ST Afifah St Afifah Susila Kristianingrum Suwardi Suyanta Suyanta Tanti Wulandari Tasya Noor Nabila Vegha Dwi Arthamena Wika Rinawati Yusman Wiyatmo Zulfah, Hadaina