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UJI EFEK ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN KACAPIRING (Gardenia augusta, Merr) PADA TIKUS PUTIH JANTAN GALUR WISTAR Farida Baroroh; Nurfina Aznam; Hari Susanti
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (112.298 KB) | DOI: 10.12928/pharmaciana.v1i1.515

Abstract

Kaca piring leaf (Gardenia augusta Merr.) was often used in traditional drugs fortreatment diabetes mellitus. This research aim to know the antihiperglycemic effectethanolic extract of kacapiring leaf on white rats male strain of Wistar and how muchantihiperglycemic effect compared with glibenklamid. This study used oral glucosetolerance test method with loading glucose 4,5 g/kgW. Tested animal where 24 whitemale rats strain of Wistar age 2-3 months with weight 180-250 gram, devided into 4groups, each groups consist of 6 rats. Group I was as negative control group givenCMC-Na 1%, group II was as positive control group given glibenklamid dose 1,35mg/kgBB, group III and IV where given ethanolic extract of kacapiring leaf dose 500mg/kgBB and 250 mg/kgBB. Glibenklamid and exstract are given orally 60 minutesbefore glucose. Blood was taken from orbitalis sinus at minute (-90), (-60), 0, 30, 60,120, 180, 240, and 300. Blood glucose level was determined with GOD PAP enzymaticmethod, absorbance was observed using spectrophotometer at 500 nm. The result of the study was performed by giving ethanolic extract of kacapiring leaf dose 500 mg/kgW and 250 mg/kgW had antihiperglycemic effect. Ethanolic extract of kacapiring leaf dose500 mg/kgW and 250 mg/kgW could reduce blood glucoce level 58,97% and 80,60% compared with glibenklamid dose 1,35 mg/kgW could reduce blood glucoce level73,93%.
Pengembangan SSP kimia berbasis pendidikan berkelanjutan untuk meningkatkan literasi kimia dan kesadaran terhadap lingkungan Magfirah Perkasa; Nurfina Aznam
Jurnal Inovasi Pendidikan IPA Vol 2, No 1: April 2016
Publisher : Faculty of Mathematics and Natural Sciences, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (664.271 KB) | DOI: 10.21831/jipi.v2i1.10269

Abstract

Penelitian ini bertujuan untuk mengetahui pengembangan, kelayakan dan efektifitas SSP kimia berbasis pendidikan berkelanjutan untuk meningkatkan literasi kimia dan kesadaran terhadap lingkungan peserta didik SMA. Model pengembangan diadaptasi dari model Dick Carey dengan subjek coba produk pada peserta didik kelas X SMA Negeri 11 Yogyakarta. Instrumen pengumpulan data meliputi lembar validasi, tes literasi kimia berformat benar-salah beralasan, lembar penilaian diri dan lembar penilaian antar teman terkait kesadaran terhadap lingkungan. SSP kimia divalidasi secara kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa: (1) SSP kimia berbasis pendidikan berkelanjutan yang dikembangkan memiliki karakteristik yang meliputi pengembangan melalui model experiential learning pada materi hidrokarbon dan indikator literasi kimia maupun kesadaran terhadap lingkungan diadaptasi dari framework PISA 2015; serta (2) SSP kimia yang dikembangkan layak digunakan dengan kategori sangat baik serta efektif untuk meningkatkan literasi kimia dan kesadaran terhadap lingkungan peserta didik SMA berdasarkan uji Kruskal-Wallis.Kata Kunci: SSP, pendidikan berkelanjutan, experiential learning, literasi kimia, kesadaran terhadap lingkungan Developing a Chemistry Subject Specific Pedagogy Based on Sustainability Education to Enhance Chemical Literacy and Environmental Awareness AbstractThe study aims to reveal the developing, the appropriateness and the effectiveness of a chemistry subject specific pedagogy based on sustainability education to enhance chemical literacy and environmental awareness of senior high school students. Developing model adapted from Dick Carey and the trial of this research product was conducted at SMA Negeri 11 Yogyakarta grade 10th students. The instruments for data collection included validation instrument, a true-false reasoning chemical literacy test, environmental awareness self assessment and peer assessment. The product was validated as qualitative and quatitative validation. The results of research shows: (1) the features of chemistry subject specific pedagogy based on sustainability education is using experiential learning was taught to hydrocarbons and the indicators for chemical literacy test and environmental awareness adapted from framework PISA 2015; and (2) the chemistry subject specific pedagogy based on sustainability education is valid to use with very good category and effective to enhance chemical literacy and environmental awareness based on Kruskal-Wallis test.Keywords: subject specific pedagogy, sustainability education, experiential learning, chemical literacy, environmental awareness.
LKPD IPA berbasis learning cycle 7E terintegrasi potensi lokal pantai Parangtritis untuk meningkatkan critical thinking peserta didik Danik Noor Utami; Nurfina Aznam
Jurnal Inovasi Pendidikan IPA Vol 6, No 1: April 2020
Publisher : Faculty of Mathematics and Natural Sciences, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jipi.v6i1.30404

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Penelitian ini bertujuan untuk mengetahui kelayakan dan keefektifan LKPD berbasis Learning Cycle 7E terintegrasi Potensi Lokal Pantai Parangtritis dalam meningkatkan critical thinking. Jenis penelitian yang digunakan adalah Penelitian pengembangan metode 4D yaitu define, design, develop, disseminate dengan menggunakan pretest-posttest control group design. Penilaan kelayakan produk dilakukan oleh ahli media dan ahli materi untuk mengetahui kevalidan, kepraktisan yang dilakukan oleh guru, dan keterbacaan peserta didik. Hasil penilian kelayakan oleh ahli materi, media, dan guru berturut-turut sebagai berikut 3,6; 3,56; 3,7 dengan skor maksimal adalah 4 (sangat valid). Uji keterbacaan mendapat nilai sebesar 3,5 dari skor maksimal 4 (sangat baik). Hasil gain skor ternormalisasi menunjukan peningkatan dalam pembelajaran dikelas eksperimen 0,86 tergolong tinggi dan kelas kontrol 0,66 tergolong rendah. Efektivitas penelitian menggunakan uji independentsample t testdengan nilai sig.(2-tailed) 0,000 kurang dari 0,05. Hasil uji menunjukan bahwa LKPD IPA berbasis Learning Cycle 7E efektif untukmeningkatkan critical thinking peserta didik SMP N 1 Bantul. Natural science worksheet based on the 7E learning cycle integrated with local potentials in Parangtritis beach to improve students' critical thinking Abstract: This study aims to determine the feasibility and effectiveness of the integrated Science Worksheet based on 7E Learning Cycle Integrated with local potentials in Parangtritis Beach to improve students’ critical thinking. This type of research is a 4D method development research that is defined, design, develop, disseminate using pretest-posttest control group design. The assessment of the feasibility of the product is carried out by media experts and material experts to find out the validity, practicality carried out by the teacher, and readability of students. The results of the assessment of eligibility by material experts, the media, and teachers are as follows 3.6; 3.56; 3.7 with a maximum score of 4 (very valid). The readability test gets a value of 3.5 from a maximum score of 4 (very good). Normalized score gain results showed an increase in learning in the experimental class 0.86 is high and the control class 0.66 is low. The effectiveness of the study used an independent sample t-test with a value of sig. (2-tailed) 0,000 less than 0.05. The test results show that Science worksheets based on 7E Learning Science Cycle integrated Local Potentials of Parangtritis Beach effective in improving students’ critical thinking.
Cytotoxic Effects of Plant Growth Extracts Temu Giring (Curcuma Heyneana) and Temu Ireng (Curcuma Aeruginosa) against Several Cancer Cells Sri Atun; Nurfina Aznam; Retno Arianingrum; Sri Nurestri
Jurnal Penelitian Saintek Vol 15, No 2: Oktober 2010
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5995.686 KB) | DOI: 10.21831/jps.v15i2.1751

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The purpose  of this study is to investigate  the cytotoxic  activity of extracts and fractions of the rhizoma from  temu giring and temu ireng against some cancer cells, such as breast carcinoma cells (MCF-7) and cervical carcinoma  (Ca Ski). The research method is to do with  experiments   in  the  laboratory   which   includes   extraction   and fractionation    of compounds  from   the  rhizome  from   temu  giring  and  temu  ireng,  test  the  cytotoxicity against  cancer  cells Breast  carcinoma  (MCF-7)  and cervical  carcinoma  (Ca Ski). Test results  on the activity  of extracts  and fractions  from  tubers from  temu giring  and temu ireng on breast carcinoma  (MCF-7);  Cervical carcinoma  (Ca Ski) showed good activity (below 100 µg/ml), except the methanol  extract temu ireng which shows the IC50  upper of 100 µg/ml. This indicates  that the extracts from  temu giring  and temu ireng great potential for  development  as anticancer drug.Keywoods:  Curcuma heyneana;  Curcuma aeroginosa; cytotoxic effect; anticancer
ANTIVIRAL ACTIVITY TESTS OF SOME ZINGIBERACEAE PLANTS Sri Atun; Nurfina Aznam; Retno Arianingrum; Sri Nurestri
Jurnal Penelitian Saintek Vol 16, No 1: April 2011
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (10252.936 KB) | DOI: 10.21831/jps.v16i1.1735

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Tujuan dari penelitian  ini adalah untuk mengetahui  aktivitas  antiviral dari beberapa rimpang tumbuhan Zingiberaceae di Indonesia. Beberapa rimpang tumbuhan yang diteliti antara lain kunci pepet (Kaemferia  rotunda), temugiring  (Curcuma heyneana Val), lengkuas (Alpinia galanga Sw), dan temuireng (Curcuma aeruginosa Roxb). Uji  aktivitas antiviral dilakukan terhadap virus AI H5Nl, dengan cara membuat suspensi virus AI H5Nl 0,1 mL + 0,5 mL larutan ekstrak 1% ditambah antibiotika penisilin  10.000 IU/mL, streptomycin 10 mg/mL, diinkubasi 37°C selama 30 menit. Suspensi virus tersebut sebanyak 0,1 mL diinokulasikan pada TAB lewat ruang korioalantois.   Telur diinkubasi dalam mesin penetas selama 3 hari. Diamati ada tidaknya kematian embrio setiap hari. Telur disimpan dalam almari es selama 24 jam, kemudian cairan alantois dipanen untuk diuji titer hemaglutinasinya (HA). Uji hemaglutinasi dilakukan  menurut OlE (2008) dengan modifikasi. Pada prinsipnya cairan alantois 0,05 mL diencerkan seri 2 kali kemudian direaksikan dengan eritrosit ayam 0,5%. HA dikatakan positif apabila terjadi hemaglutinasi. Titer HA adalah kebalikan dari pengenceran tertinggi yang masih menunjukkan reaksi positif. Ekstrak dikatakan mempunyai  aktivitas antiviral apabila titer HA berbeda signifikan dengan kontrol atau bahkan titer HA sekitar 2°. Sebagai kontrol digunakan em brio telur yang diinokulasi hanya dengan suspensi virus AI H5N1. Uji aktivitas antiviral terhadap virus AI H5Nl dari ekstrak  maupun fraksi-fraksi dari umbi tumbuhan kunci pepet (Kaemferia rotunda), temugiring   (Curcuma heyneana Val), lengkuas (Alpinia galanga Sw), dan temuireng (Curcuma  aeruginosa Roxb), menunjukkan ekstrak metanol dari kunci pepet, temu ireng, dan  temu  giring menunjukkan aktivitas antiviral rendah, sedangkan fraksi heksan kunci pepet dan-fraksi heksan temu ireng menunjukkan aktivitas antiviral yang tinggi. Kata kunci: obat herbal Nusantara;  antiviral; H5NI 
The Effectiveness of Science Learning Media Using Focusky Software on Junior High School Students’ Higher Order Thinking Skills Agnesi Sekarsari Putri; Nurfina Aznam
Scientiae Educatia: Jurnal Pendidikan Sains Vol 8, No 1 (2019): June 2019
Publisher : Tadris Biologi Fakultas Ilmu Tarbiyah dan Keguruan IAIN SYEKH NURJATI CIREBON

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.62 KB) | DOI: 10.24235/sc.educatia.v8i1.3886

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This research aimed to identify the effectiveness of science learning media using focusky software on junior high school students’ High Order Thinking Skill (HOTS). Quasi-experiment is applied in pre-test – post-test non-equivalent control group design. The sampling technique applied wass cluster random sampling. Meanwhile, the instrument used was HOTS pre-test – post-test question. Data analysis techniques used were normality test, homogeneity test, Paired Sample T-test, Independent Sample T-test, and effect size. The result of this study indicates that the increase in HOTS of students in the experimental class was 50. It is higher than in the control class, which was only 30. The average post-test of the experimental class was 75.90, with 87% of students achieving the minimum criterion, while the average post-test of the control class was 60.25, with 75 % of students reach the minimum criterion. Based on the result of the Independent Sample T-test, it was shown that there were differences in HOTS abilities between the experimental class students and the control class students, and the effectiveness of the medium-sized learning media assisted by science learning media with an effect size of 0.7.
WEB MODUL IPA BERBASIS INKUIRI TERBIMBING UNTUK MENINGKATKAN THINKING SKILL Agnesi Sekarsari Putri; Nurfina Aznam
EDUSAINS Vol 12, No 1 (2020): EDUSAINS
Publisher : Faculty of Education and Teacher Training, UIN (State Islamic University) Syarif Hidayatul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/es.v12i1.11034

Abstract

SCIENCE WEB MODULE BASED ON GUIDED INQUIRY TO IMPROVE THINKING SKILLAbstractThe science web module is a systematically structured teaching material to achieve electronic learning objectives using website applications in which writing, animation, video, and navigation are exciting, interactive, active, and motivating learning that can facilitate students' thinking skills. Guided inquiry is a model that trains students to be actively involved in investigations with questions raised by teachers to direct students to find concepts. Guided inquiry-based web modules are used to improve students' thinking skills measured through written tests. This study uses a pretest-posttest control group design. Based on the results of the analysis using the Kruskal Wallis test, there are differences in the experimental class using the science web module based on guided inquiry and the control class using the science teaching materials commonly used by teachers. The results showed an increase in higher thinking skills in the experimental class than in the control class, resulting in the high effect size category so that the experimental class increased the thinking skills more effectively than the control class. AbstrakWeb modul IPA merupakan bahan ajar yang disusun sistematis untuk mencapai tujuan pembelajaran berbentuk elektronik menggunakan aplikasi website yang didalamnya terdapat tulisan, animasi, video, serta navigasi yang menjadi pembelajaran yang menarik, interaktif, aktif, dan memotivasi belajar yang dapat memfasilitasi thinking skill peserta didik. Inkuiri terbimbing merupakan model yang melatih peserta didik terlibat aktif dalam penyelidikan dengan pertanyaan-pertanyaan yang diajukan guru untuk mengarahkan peserta didik menemukan konsep. Web modul berbasos inkuiri terbimbing digunakan untuk meningkatkan thinking skill peserta didik. Penelitian ini menggunakan pretest posttest control group design. Thinking skill diukur melalui tes tertulis. Berdasarkan hasil analisis menggunakan uji Kruskal Wallis terdapat perbedaan kelas eksperimen yang menggunakan web modul IPA berbasis inkuiri terbimbing dengan kelas kontrol yang menggunakan bahan ajar IPA yang biasa digunakan guru. Hasil penelitian menunjukkan bahwa terdapat peningkatan thinking skill yang lebih tinggi pada kelas eksperimen daripada kelas kontrol, dengan hasil effect size kategori tinggi, sehingga kelas eksperimen meningkatkan thinking skill yang lebih efektif daripada kelas kontrol. 
MEDIA PADLET BERBANTUAN PHET SIMULATION PADA MATERI ATOM TERHADAP HASIL BELAJAR KOGNITIF DAN RESPON SISWA PADA MASA PANDEMI COVID-19 ST Afifah; Ani Nurhidayanti; Jumadi Jumadi; Nurfina Aznam
Jurnal Pendidikan Kimia Indonesia Vol. 5 No. 2 (2021)
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jpk.v5i2.35612

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Masa pandemi Covid-19 pada saat ini sangat bergantung pada Kemajuan teknologi. Pembelajaran secara online menyebabkan suatu masalah kecemasan, ketidaksetaraan antara anak-anak karena akses, beresiko kecanduan internet, tidak memiliki disiplin belajar yang diperlukan dalam pendidikan individu Sehingga pada penelitian ini bertujuan untuk menganalisis hasil belajar dan respon siswa setelah pembelajaran menggunakan media padlet berbantuan phet simulation. Metode penelitian yang digunakan adalah quasi eksperimental desain dengan desain penelitian one group pretest and posttest. Subjek penelitian adalah siswa kelas IX. Teknik analysis data menggunakan uji paired sample t test . Hasil uji normalitas pretest dan posttest di peroleh nilai hasil pretest sebesar 0,053 dan hasil postest 0,056. Sehingga dapat disimpulkan bahwa data terdistribusi normal. Hasil uji hipotesis menunjukkan bahwa nilai siginifikansi 2 arah yaitu 0,000<0,05 yang menunjukkan bahwa H0 ditolak dan H1 diterima. Berdasarkan hasil penelitian diperoleh bahwa hasil belajar siswa antara tes pretest dan tes posttest setelah menggunkaan media padlet berbantuan phet simulation meningkat adapun respon siswa menyatakan baik terhadap penggunaaan media padlet berbantuan phet simulation ketika pembelajaran online. Jadi penggunaan media padlet berbantuan phet simulation cocok digunakan ketika proses pembelajaran online.
Motivation and Satisfaction Level of Graduate Student: The Blended Learning with Peer Tutor (BL-PT) Model in New Normal Era Nurfina Aznam; Jumadi Jumadi; Heru Nurcahyo; Yusman Wiyatmo; Riki Perdana
Journal of Educational Science and Technology (EST) Volume 7 Number 1 April 2021
Publisher : Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26858/est.v7i1.17423

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In higher Education, Graduate Students have a special characteristic of the learning process. Especially in the new normal era, Higher Education needs the best learning model that fits and comfortable for graduate students. This study aims to examine the effectiveness of Blended Learning with Peer Tutor (BL-PT) for graduate students in the new normal era, especially on the aspect of motivation and service satisfaction. It is descriptive quantitative research with the random sampling technique. In addition, this study also examined whether the level of satisfaction had an effect on student motivation in learning in the new normal period. There were 43 Graduate Students from Graduate School Program, Yogyakarta State University as participants in this study. The technique of data analyses was used comparative-descriptive and paired sample t-test using SPSS 24. The study reveals: (1) The BL-PT model has a positive impact on students motivation and service satisfaction of Higher Education; (2) there is not a significant difference in students motivation of male and female graduate students; (3) there is no significant difference of students service satisfaction level after learning with BL-PT. Learning with the BL-PT model can be an alternative for policymakers, Higher education Institution, and lecture to solve the learning model that fit and comfortable with graduate students in the New Normal Era
Characterization of Curcuminoid from Curcuma xanthorrhiza and Its Activity Test as Antioxidant and Antibacterial Sri Atun; Nurfina Aznam; Retno Arianingrum; Senam Senam; Bian Ihda An Naila; Astuti Lestari; Nur Aini Purnamaningsih
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (569.917 KB) | DOI: 10.20884/1.jm.2020.15.2.540

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Curcuminoids are the main component found in many Zingiberaceae family plants. The aim of this study was to characterize curcuminoid and its activity test as an antioxidant and antibacterial. Dryed powder of C. xanthorrhiza (1 kg) was macerated with ethanol for 24 hours at room temperature. Ethanol extract of C. xanthorrhiza was subsequently fractionated with n-hexane and chloroform to take the yellow or orange indicated contain of curcuminoids. Analysis of total phenolic levels was carried out by the Follin-Ciaocalteau method. The isolation of curcuminoid componens from this fraction  was carried out by chromatographic method and the structure elucidation was performed by interpretation of spectroscopic data, including UV, IR, 1H and 13C NMR 1D and 2D. The antioxidant activity test used the DPPH (2,2-diphenylpicrylhydrazyl) method, while the antibacterial activity test used Kirby Bauer test diffusion method. The results showed that the curcuminoid fraction yield was 10.06%  from ethanol extract C. xanthorrhiza. The total phenolic content of curcuminoids fraction was 745.45 ± 18.5 mg galic acid (GA)/g extract. Curcuminoids fraction was isolated a known compound desmethoxycurcumin (1). The content of demethoxycurcumin (1) in curcuminoid fraction is 20.97 %.The antioxidant activity of curcuminoids fraction showed strongest activity with IC50 24.98 µg/ml. Antibacterial activity against of the four pathogenic bacteria showed medium activity. The study suggests that curcuminoids extract from C. xanthorrhiza rhizome have potential compounds could be suitable for antioxidant and the treatment of various infections caused of microbial.
Co-Authors Adauyah, Robiatul Afifah, ST Agnesi Sekarsari Putri Agung Nugroho Catur Saputro Alya Rizkita Irwan Amaliyah, Nur Inayah Anding, Imanuel Anggi Alham Murfian Ani Nurhidayanti Arfan, Septian Arini Miftaqul Jannah Arthamena, Vegha Dwi Assari, Andra Meisantry Astuti Lestari Ayyubi, Mizzan Azeeza, Sabira Nurul Baroroh, Farida Bian Ihda An Naila Crys Fajar Partana Danik Noor Utami Defista, Chesa Dewi, Shofrina Surya Eli Rohaeti Faiz Ilham Pratama Farida Baroroh Faridah Baroroh Fau, Fazita Apritama Dewi Fazita Apritama Dewi Fau Hadaina Zulfah Hafsah, Devina Siti Handayani, Sri Hari Susanti Heru Nurcahyo Insih Wilujeng Isana Supiah Yosephine Louise Isnaini Amanah Ixora Sartika Mercuriani Jumadi Jumadi Jumadi Jumadi Kun Sri Budiasih Kusmiyati kusmiyati Latifah Kurnia Devani Magfirah Perkasa Mamluaturrahmatika, Annisa Manarisip, Alessandro Jeremi Masatake Niwa Masatake Niwab Mizzan Ayubi Munnal Hani'ah Nadiya Fitri Anisa Nafisa Rahmah Nida Qurbaniah Juhara Nindi Mediartika Novitasari, Karina Wahyu Ayu Nur Aini Purnamaningsih Nur Fitriyana Nurason, Febri Nurhidayanti, Ani Pratama, Faiz Ilham Putri, Sarmila Eka Retiyanto, Hana' Fadhilah Retno Arianingrum Riki Perdana Risky Nugraheni Purnamawati Rumahorbo, Shinta S. Senam Sangal, Aditi Senam Senam Shiddiqi, Muhammad Habib Ash Sri Atun Sri Atun Sri Atun SRI ATUN Sri Handayani Sri Handayani Sri Handayani Sri Nurestri Sri Nurestri ST Afifah St Afifah Susila Kristianingrum Suwardi Suyanta Suyanta Tanti Wulandari Vegha Dwi Arthamena Wika Rinawati Yusman Wiyatmo Zulfah, Hadaina