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All Journal Althea Medical Journal Majalah Obstetri dan Ginekologi Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of Maternal and Child Health Manuju : Malahayati Nursing Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Pediomaternal Nursing Journal Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Kebidanan Khatulistiwa Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL PROFESSIONAL HEALTH JOURNAL KESANS : International Journal of Health and Science Indonesian Journal of Perinatology Folia Medica Indonesiana
Aldika Akbar, Muhammad Ilham
Department Of Obstetrics And Gynaecology, Dr.Soetomo General Hospital, Universitas Airlangga Hospital/Faculty Of Medicine Airlangga University, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Differences in Physical Activity Density Between Pregnant Women with Gestational Diabetes Mellitus (GDM) and Normal (Non-GDM) Pregnant Women: A Comparative Study Rohmatul Ummah; Muhammad Ilham Aldika Akbar; Bambang Purwanto
PROFESSIONAL HEALTH JOURNAL Vol. 7 No. 1 (2025): December
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v7i1.1008

Abstract

Background: Gestational diabetes mellitus (GDM) is a condition of impaired glucose tolerance that leads to high blood sugar levels and is diagnosed for the first time during pregnancy, with varying degrees of severity. Insufficient physical activity is one of the top global risk factors for premature death. During pregnancy, a lack of physical activity and excessive weight gain are independent risk factors for maternal obesity and related complications, including gestational diabetes mellitus (GDM).Objectives: The aim of this study was to compare the physical activity density between pregnant women diagnosed with gestational diabetes mellitus (GDM) and those with normal pregnancies.Methods: This study utilized an observational analytical approach with a comparative design. A purposive sampling technique was employed, with 32 participants in the case group and 32 in the control group. The research was conducted between August and October 2024 at the Obstetrics and Gynecology clinic of Airlangga University Hospital. Data were analyzed using the non-parametric Mann-Whitney Test.Results: The analysis using the Mann-Whitney Test showed a significant p-value of 0.002, indicating a difference in the physical activity density between pregnant women with gestational diabetes mellitus (GDM) and those with normal pregnancies.Conclusion: Pregnant women without gestational diabetes mellitus (GDM) have higher physical activity density compared to those with gestational diabetes mellitus (GDM). It is suggested that future research adopt an experimental approach, especially focusing on interventions to promote physical activity during pregnancy.
Neonatal Outcome Associated With Birth Order and Chorionicity in Twin Pregnancy Pratama, Nur Aprilianita; Gumilar, Khanisyah Erza; Bachnaas, Muhammad Adrianes; Aldika Akbar, Muhammad Ilham
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 2 April 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i2.2391

Abstract

Objectives: The objective of this study is to examine the neonatal outcomes of twin pregnancies based on the difference of chorionicity and order of delivery. Methods: An observational cross-sectional study was done among all women with >24 completed weeks gestation having twin pregnancies in the Department of Obstetrics and Gynaecology of Dr. Soetomo General Hospital and Universitas Airlangga Hospital, Surabaya, Indonesia in 2023. Results: 49 twin from 1638 birth (2.99%) were recruited for the study. The MC groups had a higher prevalence of preterm birth <37 weeks (83.3 vs 53.8%), preterm birth <34 weeks (52.8 vs 15.4%), VLBW (25 vs 7.7%), ELBW (25 vs 15.4%), low Apgar scores at 5th minutes (50 vs 15.4%), admission to NICU (66.7 vs 15.4%), RDS (41.7 vs 7.7%), early neonatal death (33.3 vs 7.7%), and perinatal death (44.4 vs 15.4%) [p<0.05]. In relation to birth order, there were no significant difference in all neonatal outcomes, except the higher prevalence of lower Apgar scores in 1st (75 vs 50%) and 5th minutes (50 vs 19.4) in the second delivered MC twin (p=0.05). Out of the 98 twin babies, there were a total of 32 perinatal deaths (32.65%), consisting of eight stillbirths and twenty-four neonatal deaths. Conclusions: Chorionicity and birth order were influenced by the neonatal outcomes of twin pregnancies. It is important to manage twin pregnancy in specialized or tertiary care center hospital.
Ethnopharmacological insights and clinical prospects of ten Indonesian medicinal plants for pregnancy, postpartum, and lactation: a systematic review Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Rahardjo, Theresia Monica; Suryawan, Aloysius; Rahardjo, Bambang; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Indonesian Journal of Perinatology Vol. 6 No. 1 (2025): (Available online: 1 June 2025)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v6i1.77

Abstract

Background: The perinatal period involves significant physiological and metabolic transitions, particularly concerning hypertensive disorders, preeclampsia, hemorrhage, lactation challenges, and oxidative stress. Although pharmacological therapies are available, their safety and accessibility remain inconsistent, especially in resource-limited settings. Indonesia’s extensive biodiversity and deep-rooted ethnomedicinal traditions offer promising yet underutilized botanical alternatives. This study aimed to review the efficacy of Indonesian medicinal plants used in pregnancy, postpartum, and lactation. Methods: This systematic review investigates ten Indonesian medicinal plants traditionally used during pregnancy, postpartum recovery, and lactation: Sauropus androgynus, Curcuma longa, Moringa oleifera, Nigella sativa, Centella asiatica, Orthosiphon aristatus, Syzygium polyanthum, Andrographis paniculata, Solanum nigrum, and Zingiber officinale. Literature from 2000 to 2025 was reviewed using PRISMA guidelines across global and regional databases. Phytochemical composition, mechanisms of action, therapeutic effects (e.g., antihypertensive, antidiabetic, galactagogue, hemostatic, antioxidant), and clinical relevance were critically evaluated. Results: All ten plants demonstrated pharmacological potential relevant to perinatal health challenges. Notably, Zingiber officinale offers antiemetic and anti-inflammatory benefits during early pregnancy, complementing the lactogenic, antihypertensive, and wound-healing properties of other species. However, gaps persist in human trials, dosage standardization, and regulatory oversight. Conclusion: The review highlights the importance of integrating validated traditional botanicals into perinatal care through interdisciplinary research, targeted clinical trials, and culturally responsive health policies. Bridging ethnopharmacology with maternal health systems offers a scalable, sustainable pathway toward maternal wellness and equity in Indonesia and comparable global settings.
Blood Cadmium and Preterm Birth: A Systems Toxicology Review of Molecular Mechanisms, Placental Disruption, and Translational Obstetric Implications Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Pribadi, Adhi; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.949

Abstract

Objectives: Preterm birth (PTB) remains a leading global cause of neonatal morbidity and mortality, with multifactorial origins including inflammation, endocrine disruption, and placental dysfunction. Recent evidence identifies cadmium (Cd), a persistent environmental toxicant, as a modifiable contributor to PTB. This review aims to integrate the mechanistic, molecular, and clinical literature on maternal blood cadmium exposure and its role in the pathogenesis of PTB.Methods: A systematic and integrative review was conducted following PRISMA 2020 guidelines. Literature from 2000 to 2025 was retrieved using PubMed, Scopus, Embase, and Web of Science. Eligible studies included molecular toxicology, animal models, human epidemiological data, and placental mechanistic research addressing cadmium exposure and preterm birth. Inclusion criteria emphasized mechanistic clarity, gestational outcome relevance, and measurable cadmium biomarkers. Figures, tables, and mechanistic diagrams were used to illustrate toxicological convergence pathways.Results: Cadmium disrupts placental homeostasis via oxidative stress, endothelial dysfunction, impaired trophoblast invasion, progesterone suppression, and activation of inflammatory cascades such as the NLRP3 inflammasome. Consistent associations between maternal cadmium burden and PTB risk were found across animal, cellular, and human population studies. However, heterogeneity in exposure assessment, absence of unified risk thresholds, and confounding from co-exposures challenge causal inference. Literature remains fragmented, lacking integration between mechanistic insights and clinical risk models.Conclusions: Cadmium should be reclassified as a central agent in the pathophysiology of PTB. We propose a precision obstetrics framework that includes environmental cadmium screening in high-risk pregnancies, implementation of exposome-informed policies, and prospective multicenter studies with molecular endpoints. Obstetric care must evolve to include toxicological risk profiling as standard practice in the prevention of PTB.Kadmium dalam Darah dan Kelahiran Prematur: Tinjauan Toksikologi Sistemik terhadap Mekanisme Molekuler, Disrupsi Plasenta, dan Implikasi Obstetri TranslasiAbstrakTujuan: Kelahiran Prematur (preterm birth/PTB) tetap menjadi penyebab utama morbiditas dan mortalitas neonatal di seluruh dunia dengan etiologi multifaktorial yang mencakup inflamasi, gangguan endokrin, dan disfungsi plasenta. Bukti terbaru mengidentifikasi kadmium (Cd), suatu toksikan lingkungan persisten, sebagai faktor kontribusi yang dapat dimodifikasi terhadap PTB. Tinjauan ini bertujuan untuk mengintegrasikan literatur mekanistik, molekuler, dan klinis mengenai paparan kadmium dalam darah maternal dan perannya dalam patogenesis PTB.Metode: Tinjauan sistematis dan integratif dilakukan sesuai pedoman PRISMA 2020. Literatur dari tahun 2000 hingga 2025 dikumpulkan melalui database PubMed, Scopus, Embase, dan Web of Science. Studi yang memenuhi syarat mencakup toksikologi molekuler, model hewan, data epidemiologi manusia, dan penelitian mekanistik plasenta yang mengevaluasi hubungan antara paparan kadmium dan kelahiran prematur. Kriteria inklusi menekankan kejelasan mekanistik, relevansi terhadap hasil kehamilan, serta penggunaan biomarker kadmium yang terukur. Gambar, tabel, dan diagram mekanistik digunakan untuk mengilustrasikan jalur konvergensi toksikologis.Hasil: Kadmium mengganggu homeostasis plasenta melalui stres oksidatif, disfungsi endotel, gangguan invasi trofoblas, supresi progesteron, dan aktivasi jalur inflamasi seperti inflammasom NLRP3. Hubungan konsisten antara beban kadmium maternal dan risiko PTB ditemukan dalam studi hewan, seluler, dan populasi manusia. Namun, adanya heterogenitas dalam penilaian paparan, belum adanya ambang risiko yang seragam, serta pengaruh faktor pajanan lainnya menjadi tantangan dalam penarikan kesimpulan kausal. Literatur masih terfragmentasi dan belum mengintegrasikan temuan mekanistik dengan model risiko klinis secara menyeluruh.Kesimpulan: Kadmium seharusnya diklasifikasikan ulang sebagai agen sentral dalam patofisiologi PTB. Kami mengusulkan suatu kerangka kerja obstetri presisi yang mencakup skrining lingkungan terhadap kadmium pada kehamilan berisiko tinggi, menerapkan kebijakan berbasis exposome, serta studi prospektif multisentra dengan titik akhir molekuler. Pelayanan kebidanan harus berkembang dengan mengadopsi profil risiko toksikologis sebagai bagian dari praktik standar dalam pencegahan kelahiran prematur.Kata kunci: Disrupsi Plasenta; Interaksi Endokrin-Inflamasi; Kesehatan Reproduksi Lingkungan; Mekanisme Kelahiran Prematur; Toksisitas Kadmium,
Maternal and fetal characteristics associated with successful Vaginal Birth After Cesarean (VBAC) in Dr. Soetomo and Universitas Airlangga Hospitals, Surabaya, Indonesia Armawa, Syihab; Sulistyono, Agus; Akbar, Muhammad Ilham Aldika; Risa Etika
Majalah Obstetri & Ginekologi Vol. 33 No. 2 (2025): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I22025.105-112

Abstract

HIGHLIGHTS High VBAC success rate demonstrated with effective patient selection and intrapartum management. Cervical dilation >4 cm at admission identified as a critical predictor of VBAC success.   ABSTRACT Objective: This study aims to evaluate the maternal and fetal characteristics associated with successful vaginal birth after cesarean (VBAC) at Dr. Soetomo General Academic Hospital and Universitas Airlangga Hospital in Surabaya, Indonesia. Materials and Methods: A retrospective analytic study was conducted using a total sampling method to review medical records from January 2021 to December 2022. Inclusion criteria encompassed singleton pregnancies with a previous one-time low-segment cesarean section, vertex presentation, and no contraindications to vaginal delivery. A total of 46 eligible cases were analyzed following exclusion criteria. Results: Among the studied variables, cervical dilation at admission and the 5-minute Apgar score were significantly associated with successful VBAC (p < 0.05). All patients presenting with cervical dilation >4 cm delivered vaginally, indicating a strong predictive value. In contrast, those with dilation <4 cm had a markedly higher rate of cesarean delivery. A higher Apgar score also correlated positively with VBAC success, suggesting favorable neonatal outcomes in these cases. Maternal BMI did not show a statistically significant association with VBAC success (p > 0.05), likely influenced by the predominance of obesity in the cohort. Other factors, including maternal age, parity, birth interval, gestational age, and neonatal birth weight, were not significantly associated with the outcome. Conclusion: While most maternal and fetal variables did not significantly impact the likelihood of successful VBAC, cervical dilation on admission emerged as a critical clinical predictor. These findings emphasize the importance of intrapartum evaluation, particularly cervical assessment, in guiding delivery planning for women with prior cesarean sections.
The Antibiotic Prescribing Practices of Gynecologists in Abdominal Hysterectomy Tjokroprawiro, Brahmana Askandar; Khoirunnisa Novitasari; Ulhaq, Renata Alya; Aldika Akbar, Muhammad Ilham
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.1954

Abstract

Objective: To evaluate the pattern of antibiotics used for abdominal hysterectomy by gynecologists in infected and non-infected cases. Methods: Data was collected through an online survey of gynecologists in Surabaya, Indonesia. Results: A total of 200 gynecologists were involved in this study. All of them used prophylactic antibiotics in all cases of abdominal hysterectomy, and the most commonly used was cefazoline (70.5%), followed by ceftriaxone (15.5%) and cefotaxime (9%). Most gynecologists (68%) gave 2 grams of prophylactic antibiotic, and 79,5% of antibiotics were administered within 30 minutes before surgery. Additional antibiotics during surgery were given in prolonged surgery (79.01%) and intraoperative bleeding > 1500 mL (48.14%). The most common additional dosage used was 1 gram (72.9%), and most gynecologists (37.2%) continued antibiotics for one day ahead. The type of therapeutic antibiotics used for infected cases was varied, consisting of ceftriaxone (50.5%), metronidazole (42%), cefotaxime (17%), cefazoline (15.5%), gentamicin (12%), ampicillin-sulbactam (4%), and amoxicillin-clavulanic acid (3.5%). Most gynecologists (43.7%) gave these antibiotics for three days. Conclusion: The majority of gynecologists in Surabaya already use prophylactic antibiotics for abdominal hysterectomy and therapeutic antibiotics for infected cases following the existing guidelines
Analisis Penyebab Preeklampsia Pada Ibu Hamil Cerellia, Eka; Wittiarika, Ivon Diah; Akbar, Muhammad Ilham Aldika
Malahayati Nursing Journal Vol 6, No 9 (2024): Volume 6 Nomor 9 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v6i9.13582

Abstract

ABSTRACT In Indonesia, bleeding accounts for 28% of all maternal deaths, preeclampsia/eclampsia accounts for 24%, and infection accounts for 11%. Preeclampsia can progress to eclampsia in extreme cases when seizure signs are added. The aim of this study was to determine the causes of preeclampsia and factors that increase the likelihood of women developing eclampsia during pregnancy. This type of study for binary logistic data analysis was used to conduct quantitative research. Model for binary logistic regression. 82 participants were sampled. Data collection was done by observation and document collection. Maternal age, birth spacing, gravida, multiple pregnancy, history of diabetes mellitus, body mass index, history of hypertension, history of preeclampsia, and gestational age were the independent variables in this study. Preeclampsia/eclampsia was the dependent variable. The results of this study revealed a significant simultaneous association between gestational age and preeclampsia/eclampsia, gestational age and preeclampsia, maternal age, birth spacing, gravida, multiple pregnancy, history of diabetes mellitus, body mass index, history of hypertension, and history of preeclampsia. In the model, gravida, body mass index, and hypertension all had a considerable partial impact on preeclampsia. Preeclampsia was not significantly affected in the model by maternal age, birth spacing, multiple pregnancy, history of diabetes mellitus, history of preeclampsia, or gestational age. To reduce maternal mortality, it is important to examine the risk factors for eclampsia and preeclampsia, as well as the possibility that these conditions may lead to complications. Keywords: Preeclampsia, Eclampsia, Gravida  ABSTRAK Di Indonesia, perdarahan menyumbang 28% dari semua kematian ibu, preeklampsia/ eklamsia menyumbang 24%, dan infeksi menyumbang 11%. Preeklampsia dapat berkembang menjadi eklampsia dalam kasus ekstrim ketika tanda kejang ditambahkan. Dari penelitian ini adalah untuk mengetahui penyebab preeklampsia dan faktor-faktor yang meningkatkan kemungkinan wanita mengalami eklampsia selama kehamilan. Jenis penelitian ini untuk analisis data logistik biner digunakan untuk melakukan penelitian kuantitatif. Model untuk regresi logistik biner. 82 peserta dijadikan sampel penelitian. Pengumpulan data dilakukan dengan observasi dan pengumpulan dokumen. Usia ibu, jarak kelahiran, gravida, kehamilan kembar, riwayat diabetes melitus, indeks massa tubuh, riwayat hipertensi, riwayat preeklampsia, dan usia kehamilan merupakan variabel bebas dalam penelitian ini. Preeklampsia/ eklampsia adalah variabel dependen penelitian. Hasil penelitian ini mengungkapkan hubungan simultan yang signifikan antara usia kehamilan dengan preeklampsia/ eklampsia , usia kehamilan dengan preeklampsia, usia ibu, jarak kelahiran, gravida , kehamilan kembar, riwayat diabetes mellitus, indeks massa tubuh, riwayat hipertensi, dan riwayat preeklampsia. Dalam model, gravida , indeks massa tubuh, dan hipertensi semua memiliki dampak parsial yang cukup besar pada preeklampsia. Preeklampsia tidak dipengaruhi secara signifikan dalam model oleh usia ibu, jarak kelahiran, kehamilan ganda, riwayat diabetes melitus, riwayat preeklampsia, atau usia kehamilan. Untuk menurunkan angka kematian ibu, sangat penting untuk meneliti faktor risiko eklampsia dan preeklampsia, serta kemungkinan bahwa kondisi ini dapat menyebabkan komplikasi. Kata Kunci: Preeklampsia, Eklampsia, Gravida
Cadmium Exposure and Preeclampsia: A Systematic Review of Environmental Risk in Pregnancy Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Pribadi, Adhi; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.951

Abstract

Objective: To systematically evaluate current scientific evidence on the association between cadmium (Cd) exposure and the risk of preeclampsia in pregnant women, and to explore underlying mechanisms and population-specific patterns.Methods: This systematic review was conducted according to PRISMA guidelines. Comprehensive literature searches were performed across PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar without time restriction, focusing on the past 15 years. Inclusion criteria encompassed original human studies measuring cadmium exposure—biological, dietary, or environmental—and reporting preeclampsia as an outcome. Risk of bias was assessed using the Newcastle-Ottawa Scale.Results: Twenty-five eligible studies were included, spanning case-control, cohort, and cross-sectional designs across diverse geographic regions. Most studies found a positive association between cadmium exposure and increased preeclampsia risk, though methodological heterogeneity exists. Proposed mechanisms include cadmium-induced oxidative stress, endothelial dysfunction, placental insufficiency, and hormonal dysregulation. Evidence also highlights differences in risk based on diet, region, and environmental regulation. However, inconsistencies in exposure metrics and population stratification remain.Conclusion: The cumulative evidence suggests cadmium is a plausible environmental risk factor for preeclampsia. Future research must standardize exposure assessments and address population-specific modifiers. This review provides critical groundwork for hypothesis-driven studies and policy frameworks addressing toxic metal exposure in maternal health.Paparan Kadmium dan Preeklampsia: Tinjauan Sistematis terhadap Risiko Lingkungan pada KehamilanAbstrakTujuan: Penelitian ini bertujuan untuk melakukan tinjauan sistematis terhadap bukti ilmiah terkini mengenai hubungan antara paparan kadmium (Cd) dan risiko preeklampsia pada ibu hamil, serta mengeksplorasi mekanisme biologis yang mendasari dan pola risiko spesifik populasi.Metode: Tinjauan sistematis ini disusun berdasarkan pedoman PRISMA. Pencarian literatur dilakukan secara menyeluruh melalui basis data PubMed, Scopus, Web of Science, ScienceDirect, dan Google Scholar tanpa batasan waktu, dengan fokus pada publikasi 15 tahun terakhir. Kriteria inklusi meliputi penelitian asli pada manusia yang mengukur paparan kadmium—baik secara biologis, dietetik, maupun lingkungan—dan melaporkan preeklampsia sebagai luaran. Risiko bias dinilai menggunakan Newcastle-Ottawa Scale.Hasil: Sebanyak 25 studi memenuhi kriteria dan dianalisis, mencakup desain studi kasus-kontrol, kohort, dan potong lintang dari berbagai wilayah geografis. Mayoritas studi menunjukkan adanya hubungan positif antara paparan kadmium dan peningkatan risiko preeklampsia, meskipun terdapat heterogenitas metodologis. Mekanisme yang diusulkan meliputi stres oksidatif akibat kadmium, disfungsi endotel, insufisiensi plasenta, dan disregulasi hormonal. Bukti juga menunjukkan perbedaan risiko berdasarkan pola diet, lokasi geografis, dan tingkat pengawasan lingkungan. Namun, masih terdapat ketidakkonsistenan dalam metrik paparan dan stratifikasi populasi.Kesimpulan: Bukti kumulatif mendukung bahwa kadmium merupakan faktor risiko lingkungan yang potensial terhadap preeklampsia. Penelitian selanjutnya perlu menstandarkan metode pengukuran paparan dan mempertimbangkan faktor-faktor spesifik populasi. Tinjauan ini memberikan landasan penting bagi studi berbasis hipotesis dan penyusunan kebijakan terkait paparan logam toksik dalam kesehatan maternal.Kata kunci: Komplikasi kehamilan; paparan kadmium; preeklampsia; stres oksidatif; toksikologi lingkungan
Perinatal exposure to ultraprocessed foods and its impact on maternal gut dysbiosis, placental inflammation, and neonatal immune programming: A systematic review Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Pribadi, Adhi; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.236-248

Abstract

HIGHLIGHTS Perinatal ultraprocessed food (UPF) exposure disrupts maternal gut microbiota composition, increasing pro‑inflammatory taxa and systemic endotoxemia. Placental immune activation and oxidative stress represent key mediators linking maternal diet to fetal immune and metabolic programming. Neonatal outcomes include altered regulatory T‑cell development, Th2 immune skewing, allergic sensitization, and early metabolic risk. Integrated dietary counseling, microbiota‑targeted interventions, and public health policies are urgently needed to mitigate transgenerational immune health risks.   ABSTRACT Objective: To synthesize and critically evaluate evidence linking perinatal exposure to ultraprocessed foods (UPFs) with maternal gut dysbiosis, placental inflammation, and neonatal immune programming, and to identify translational implications for perinatal care. Materials and Methods: A systematic narrative review was conducted following PRISMA 2020 guidelines, without PROSPERO registration. Literature searches of major databases (2000–March 2025) identified 1,845 records. After screening and eligibility assessment, 20 studies were included. Study quality was appraised using validated tools, and data were synthesized thematically into evidence domains covering maternal microbiota, inflammatory pathways, placental changes, and neonatal immune outcomes. Results: Maternal UPF consumption was associated with gut dysbiosis characterized by reduced microbial diversity, increased pro-inflammatory taxa, and systemic endotoxemia. Elevated inflammatory biomarkers including lipopolysaccharide, interleukin‑6, tumor necrosis factor‑a, and C‑reactive protein were frequently reported. Limited placental studies revealed increased innate immune activation and oxidative stress. Neonatal immune alterations included regulatory T cell suppression, T helper 2 skewing, increased allergic sensitization, and metabolic programming changes. Evidence strength was highest for maternal gut dysbiosis and immune programming but limited for direct placental mechanisms. Translational opportunities include dietary counseling, microbiota-targeted interventions, and public health strategies aimed at improving maternal diet quality. Conclusion: Perinatal exposure to UPFs adversely impacts the maternal gut–placenta–fetal immune axis. Integrated dietary interventions and population-level nutrition policies are urgently needed to mitigate downstream transgenerational immune risk.
Poedji Rochjati Score Card as Media for Preconception Counseling Simanungkalit, Naomy; Handayani, Samsriyaningsih; Akbar, Muhammad Ilham Aldika
Folia Medica Indonesiana Vol. 57, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlight:• The PCC counseling effect using Poedji Rochjati Score Card (PRSC) on premarital knowledge about high-risk pregnancies was studied. • PRSC for preconception counseling is effective for women to improve knowledge about high-isk pregnancy. Abstract: Preconception care (PCC) is a health approach that includes promotive and preventive activities to detect risk factors and interventions carried out to expectant mothers by considering biological, behavioral, and social aspects that affect their health. This study studied the effect of PCC counseling using Poedji Rochjati Score Card (PRSC) on premarital knowledge about high-risk pregnancies. This study was quasi-experimental with 52 respondents divided into 4 groups, namely intervention and control groups, 2 groups with partners, and 2 groups without partners that were chosen through total sampling by applying inclusion and exclusion criteria. Knowledge was measured using pretest and posttest questionnaires. The intervention given was in the form of counseling using PRSC for ± 20 minutes. There were differences in knowledge between the intervention and control group among respondents without partners. Preconception counseling using PRSC was effective for women attending premarital health checks. Applying PRSC as media for counseling could improve knowledge in high-risk pregnancy that could be avoided.
Co-Authors , Ernawati Adhi Pribadi Aditiawarman Aditiawarman, Aditiawarman Agus Sulistyono Aldiansyah, Dudy Alfiana, Monica Octa Aloysius Suryawan Amelia Rahmah Kartika Amila Anasantrianisa Anas, Jimmy Yanuar Andanaputra, Waskita Ekamaheswara Kasumba Andonotopo, Wiku Anita Deborah Anwar Armawa, Syihab Askandar Tjokroprawiro Atika Atika Atika Atika Bachnaas, Muhammad Adrianes Bachnas, Muhammad Adrianes Bambang Purwanto Bambang Rahardjo Bayu Agung Sangkara Putra Bila, Zakia Jihan Salsa Budi Santoso BUDI UTOMO Cerellia, Eka Cut Meurah Yeni Darmawan, Ernawati Dharma, Wibisana Andika Krista Djanas, Dovy Dwi Budi Santoso Ecccita Raheestyningtyas Efendi Lukas Endyka Erye Frety Eric Edwin Yuliantara Ernawati Ernawati Evert Solomon Pangkahila Fadhilah Rahmawati Faqihati Husna Hapsari Kinanti Haris Rasyid Ridho Harry Kurniawan Gondo Hermanto Tri Joewono I Nyoman Hariyasa Sanjaya Indah Mayang Sari INDRA YULIATI, INDRA Intan Dewi Angia Sari Ivon Diah Wittiarika Izzati, Dwi Jimmy Yanuar Anas Julian Dewantiningrum Khanisyah Erza Gumilar Khoirunnisa Novitasari Kurjak, Asim Kusuma, Anak Agung Ngurah Jaya Lady Aqnes Kurniawati Laksana, Muhammad Ardian Cahya Lucyana Septia Pramita Made Chindy Dwiyanti Marheni Putri Martono Tri Utomo Mau, Imelda Yovita Monika Mongang Manuk Muhammad Adrianes Bachnas Nadira Zahra Maulidya Permana Naomy Simanungkalit Nugraha, Laksmana Adi Krista Nuswil Bernolian Nuzulul Azizah Ramdan Wulandari Pramono, Mochammad Besari Adi Pratama, Nur Aprilianita Pudji Lestari PUNGKY MULAWARDHANA, PUNGKY Putra, Ridwan Abdullah Raheestyningtyas, Ecccita Risa Etika, Risa Rize Budi Amalia Rohmatul Ummah Ryan Saktika Mulyana Samsriyaningsih Handayani Simanungkalit, Naomy Sri Sulistyowati Stanojevic, Milan Theresia Monica Rahardjo Ulhaq, Renata Alya Umiastuti, Pirlina Wardhana, Manggala Pasca Widati Fatmaningrum Wiradnyana, Anak Agung Gede Putra WISNU PRABOWO