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All Journal Althea Medical Journal Folia Medica Indonesiana Majalah Obstetri dan Ginekologi Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of Maternal and Child Health Manuju : Malahayati Nursing Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Pediomaternal Nursing Journal Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Kebidanan Khatulistiwa Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL PROFESSIONAL HEALTH JOURNAL KESANS : International Journal of Health and Science Indonesian Journal of Perinatology
Aldika Akbar, Muhammad Ilham
Department Of Obstetrics And Gynaecology, Dr.Soetomo General Hospital, Universitas Airlangga Hospital/Faculty Of Medicine Airlangga University, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Perinatal exposure to ultraprocessed foods and its impact on maternal gut dysbiosis, placental inflammation, and neonatal immune programming: A systematic review Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Pribadi, Adhi; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.236-248

Abstract

HIGHLIGHTS Perinatal ultraprocessed food (UPF) exposure disrupts maternal gut microbiota composition, increasing pro‑inflammatory taxa and systemic endotoxemia. Placental immune activation and oxidative stress represent key mediators linking maternal diet to fetal immune and metabolic programming. Neonatal outcomes include altered regulatory T‑cell development, Th2 immune skewing, allergic sensitization, and early metabolic risk. Integrated dietary counseling, microbiota‑targeted interventions, and public health policies are urgently needed to mitigate transgenerational immune health risks.   ABSTRACT Objective: To synthesize and critically evaluate evidence linking perinatal exposure to ultraprocessed foods (UPFs) with maternal gut dysbiosis, placental inflammation, and neonatal immune programming, and to identify translational implications for perinatal care. Materials and Methods: A systematic narrative review was conducted following PRISMA 2020 guidelines, without PROSPERO registration. Literature searches of major databases (2000–March 2025) identified 1,845 records. After screening and eligibility assessment, 20 studies were included. Study quality was appraised using validated tools, and data were synthesized thematically into evidence domains covering maternal microbiota, inflammatory pathways, placental changes, and neonatal immune outcomes. Results: Maternal UPF consumption was associated with gut dysbiosis characterized by reduced microbial diversity, increased pro-inflammatory taxa, and systemic endotoxemia. Elevated inflammatory biomarkers including lipopolysaccharide, interleukin‑6, tumor necrosis factor‑a, and C‑reactive protein were frequently reported. Limited placental studies revealed increased innate immune activation and oxidative stress. Neonatal immune alterations included regulatory T cell suppression, T helper 2 skewing, increased allergic sensitization, and metabolic programming changes. Evidence strength was highest for maternal gut dysbiosis and immune programming but limited for direct placental mechanisms. Translational opportunities include dietary counseling, microbiota-targeted interventions, and public health strategies aimed at improving maternal diet quality. Conclusion: Perinatal exposure to UPFs adversely impacts the maternal gut–placenta–fetal immune axis. Integrated dietary interventions and population-level nutrition policies are urgently needed to mitigate downstream transgenerational immune risk.
Co-Authors Adhi Pribadi Aditiawarman Aditiawarman, Aditiawarman Agus Sulistyono Aldiansyah, Dudy Alfiana, Monica Octa Aloysius Suryawan Amelia Rahmah Kartika Amila Anasantrianisa Andonotopo, Wiku Armawa, Syihab Askandar Tjokroprawiro Atika Atika Atika Atika Bachnaas, Muhammad Adrianes Bachnas, Muhammad Adrianes Bambang Purwanto Bambang Rahardjo Bayu Agung Sangkara Putra Bila, Zakia Jihan Salsa Budi Santoso BUDI UTOMO Cerellia, Eka Cut Meurah Yeni Dwi Budi Santoso Ecccita Raheestyningtyas Endyka Erye Frety Ernawati Ernawati Evert Solomon Pangkahila Fadhilah Rahmawati Faqihati Husna Hapsari Kinanti Haris Rasyid Ridho Hermanto Tri Joewono I Nyoman Hariyasa Sanjaya Indah Mayang Sari INDRA YULIATI, INDRA Intan Dewi Angia Sari Ivon Diah Wittiarika Izzati, Dwi Jimmy Yanuar Anas Julian Dewantiningrum Khanisyah Erza Gumilar Khoirunnisa Novitasari Kurjak, Asim Lady Aqnes Kurniawati Laksana, Muhammad Ardian Cahya Lucyana Septia Pramita Made Chindy Dwiyanti Marheni Putri Martono Tri Utomo Mau, Imelda Yovita Monika Mongang Manuk Muhammad Adrianes Bachnas Nadira Zahra Maulidya Permana Naomy Simanungkalit Nuswil Bernolian Nuzulul Azizah Ramdan Wulandari Pramono, Mochammad Besari Adi Pratama, Nur Aprilianita Pudji Lestari PUNGKY MULAWARDHANA, PUNGKY Risa Etika, Risa Rize Budi Amalia Rohmatul Ummah Ryan Saktika Mulyana Samsriyaningsih Handayani Sri Sulistyowati Stanojevic, Milan Theresia Monica Rahardjo Ulhaq, Renata Alya Umiastuti, Pirlina Wardhana, Manggala Pasca Widati Fatmaningrum Wiradnyana, Anak Agung Gede Putra