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All Journal Resital: Jurnal Seni Pertunjukan (Journal of Performing Arts) PROMUSIKA: Jurnal Pengkajian, Penyajian, dan Penciptaan Musik Harmonia: Journal of Research and Education Journal of Urban Society´s Arts Biota Jurnal Pendidikan dan Kajian Seni Konversi MUDRA Jurnal Seni Budaya Jurnal Bahasa Rupa Jurnal Biodjati Didaktis: Jurnal Pendidikan dan Ilmu Pengetahuan Gondang: Jurnal Seni dan Budaya Pelataran Seni : Jurnal Pendidikan dan Kajian Seni Sorai: Jurnal Pengkajian dan Penciptaan Musik Abdi Seni Dewa Ruci : Jurnal Pengkajian dan Penciptaan Seni Gelar : Jurnal Seni Budaya Jurnal Seni Tari Jurnal Litbang Sukowati : Media Penelitian dan Pengembangan AKURASI: Jurnal Riset Akuntansi dan Keuangan Bisman (Bisnis dan Manajemen): The Journal of Business and Management Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Alwatzikhoebillah : Kajian Islam, Pendidikan, Ekonomi, Humaniora International Journal of Research in Community Services Enggang: Jurnal Pendidikan, Bahasa, Sastra, Seni, dan Budaya Jurnal Akuntansi dan Keuangan (JAK) Transekonomika : Akuntansi, Bisnis dan Keuangan Jurnal Kajian Seni Jurnal bahasa, sastra, seni, dan pengajarannya Musik Etnik Nusantara Soshum: Jurnal Sosial dan Humaniora Media Informasi Journal of Biotechnology and Natural Science Jurnal Bahasa Rupa Exploration In Early Childhood Research Akurasi (JSM) Jurnal Seni Musik Harmonia: Journal of Arts Research and Education Jurnal Bahasa Rupa Jurnal bahasa, sastra, seni, dan pengajarannya
Aris Setiawan
Institut Seni Indonesia (ISI) Surakarta
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Journal : Biota

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Protective Effects of Acetone Extract of Portulaca oleracea L. on Liver Histopathology in Hypoxia-Induced Sprague-Dawley Rats Maliza, Rita; Syaidah, Rahimi; Setiawan, Haris; Galih Yatalaththov, Febriofca; Yashiro, Takashi; Arya, Bramadi; Aini, Wardatul
Biota Vol 12 No 1 (2026): Jurnal Biota 2026
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/biota.v12i1.28808

Abstract

Hypoxia, a condition characterized by insufficient oxygen supply, can cause tissue damage in vital organs, including the liver. The liver is particularly vulnerable to hypoxic injury, which may result in impaired function and hepatocyte death. Purslane (Portulaca oleracea L.) is known for its antioxidant properties, largely attributed to its flavonoid content, which can inhibit the production of reactive oxygen species (ROS). This experimental study aimed to evaluate the effects of acetone extracts of purslane herb on hepatic histopathological changes in hypoxia-induced rats. Five experimental groups were established, each consisting of six rats (n = 6): normal control (N), hypoxia (H), hypoxia treated with dexamethasone (H+DEXA), hypoxia treated with purslane extract at 150 mg/kg body weight (HP1), and hypoxia treated with purslane extract at 300 mg/kg body weight (HP2). Purslane extract was prepared using the acetone maceration method. Hypoxia was induced by exposing rats to a gas mixture of 10% O₂ and 90% N₂ for 10 consecutive days. Liver tissues were processed using paraffin embedding and stained with hematoxylin–eosin for histopathological evaluation, focusing on hepatocyte necrosis, inflammatory cell infiltration, and hemorrhage. Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Duncan’s post hoc test. The results showed that the 300 mg/kg dose of purslane extract significantly reduced hepatocyte necrosis (35.33 ± 2.52 cells), inflammatory cell infiltration area (2488.51 ± 112.82 µm²), and hemorrhage area (1031.10 ± 17.38 µm²) compared with the hypoxia group (p < 0.05). In conclusion, acetone extracts of purslane demonstrated significant hepatoprotective effects in hypoxia-induced rats, suggesting their potential as a natural therapeutic agent for the management of hypoxia-related liver injury.
Co-Authors Adham, Ibnu Adillah, Egga Aditya, Friska Agustian, Muhammad Rizki Aida Mahmudah Aini, Wardatul Alhari Aminuddin, Ahamad Apriandy, Roynaldi Buwono Apris Yulianto Saefatu Araftake Blikololong, Yohanes Gala Arif, M. Fauzan Azali, Aulia Syafadilla Barasa, Zepanya Saputra Bayu Aji, Nur Seto Belinda Astriddana Bondan Aji Manggala Bondet Wrahatnala Bramadi Arya Darlenis, Teti Dekanipa, Gendot Deki Prasetya Ardiansyah Diajeng Stevani Dwi Ismiati Ega Damayanti Emilia, Yenni Fakih, Choerul Ferawati, Sri Rahayu Galih Yatalaththov, Febriofca Handriyotopo Handriyotopo Hermawan, Endang Hisbullah, Muhammad Ilham I Nyoman Sukerna, I Nyoman Ida Ayu Putu Sri Widnyani Ilham Ali Ismiati, Dwi Ji Pyo, Chung Jungkung Setyo Utomo Lambangsari, Sonia Pangesti Livera, Kristen Angela Maliza, Rita Maulana, Syaiful Adam Mukhtar Effendi Mutiara Dewi Fatimah Nanik Sri Prihatini Nugraha, Wisma Ch. R. Nurazizah, Intan Faya Nurrohiim, Annisaa’ Panakajaya Hidayatullah Putro, Galuh Argo Rachman, Anung Rifa'i, M.Rifa'i Rosy Tristanti Satria, Dioda Sidik, Adi Permana Simatupang, Gabriel Roosmargo Lono Lastoro Simparmin br Ginting Soladi, Soladi Sonia Pangesti Lambangsari Sri Rahayu Ferawati Sri Rochana Widyastutieningrum sugeng Nugroho Sugiyanto - Suyanto - Suyanto Suyanto Suyoto Suyoto Suyoto Suyoto Suyoto Syaidah, Rahimi Timur, Yuddan Fijar Sugma Uray Andrey Indra Maulana Utama, Satria Rizky Wahyu Widanarto, Wahyu Wardana, Sapto Wardani, Diah Kartika Widyastuti, Reni Dwi Widyastutieningrum, Sri Rochana Yashiro, Takashi Yuli Darni Yuningsih, Siti Hadiaty Zulkarnain Mistortoify