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All Journal Medula Juke Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Ilmu Kedokteran dan Kesehatan JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kesehatan Tambusai Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Majority JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Iswandi Darwis
Faculty Of Medicine, Universitas Lampung, Bandar Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Tinjauan Penggunaan Metformin tehadap Defisiensi Vitamin B12 pada Pasien Diabetes Melitus Tipe 2 Natasya Hayatillah; Iswandi Darwis
MAJORITY Vol 9 No 2 (2020): MAJORITY
Publisher : Majority

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Abstract

Metformin is the most widely used oral hypoglycemia drug in the world. This drug become the first choice for the treatment of type 2 diabetes melitus (DM). However, metformin is known to have the effect of creating a vitamin B12 deficiency in type 2 DM patients who consume it. The existing hypothesis states that metformin interferes with the absorption of vitamin B12 through the mechanism of intestinal bacterial overgrowth, the disruption of the vitamin B12 complex with calcium and cubulin receptors. The effect of metformin is known to increase with increasing doses and the length of time uses. The incidence of worsening peripheral neuropathy and megaloblastic anemia have been reported to be associated with the effects of vitamin B12 deficiency in type 2 DM patients taking metformin. To date, there are no clear guidelines that discuss how to diagnose, manage and prevent vitamin B12 deficiency due to metformin, but some research results can be taken into consideration. Vitamin B12 deficiency should be suspected in type 2 DM patients who have taken metformin ≥3 years, at a dose of >1500 mg, experiencing hematological abnormalities or worsening peripheral neuropathy. Prevention that can be done is to give vitamin B12 with dose of 1000 μg intramuscularly per year. As for treatment, an intramuscular injection of vitamin B12 can be given a dose of 1000 μg per day for seven days, followed by an injection once a week for four weeks.
Hubungan Derajat Keparahan Gejala dengan Kualitas Tidur Pasien Penyakit Paru Obstruktif Kronik (PPOK) di RSUD Abdul Moeloek Provinsi Lampung Ayu Dinda Fatimah; Iswandi Darwis; Agustyas Tjiptaningrum; Khairun Nisa Berawi
MAJORITY Vol 11 No 1 (2022): MAJORITY
Publisher : Majority

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Chronic Obstructive Pulmonary Disease is a disease that has a high prevalence. The prevalence of COPD is always increasing in every country in the world. Deaths of people with COPD are associated with an increase in the severity of symptoms of the disease. The symptoms of COPD continue to worsen and have an impact on the decline in sleep quality of COPD patients. The Lampung Provincial Government makes COPD as one of the threats in carrying out health development in Lampung Province in 2015 to 2019. The purpose of this study was to determine the relationship relationship between severity of symptoms and sleep quality of patients with Chronic Obstructive Pulmonary Disease (COPD) in Abdul Moeloek regional hospital Lampung Province. It is used observational analytical method with cross sectional design was registered in this research. The sample was 40 COPD patients in Abdul Moeloek Regional Hospital Lampung Province, taken by consecutive sampling method. The study was conducted using the COPD Assessment Test questionnaire and Pittsburgh Sleep Quality Index questionnaire in the hospital, patient’s house, or patient’s office. Then the results of this study were processed using computer software. Result of analysis with Chi Square test with 95% confidence level (α = 0,05) showed p value 0,01 < 0,05. There is a significant association of Severity of Symptoms and Sleep Quality of Patients with Chronic Obstructive Pulmonary Disease (COPD) in Abdul Moeloek Regional Hospital Lampung Province.
Co-Authors Ade Yonata, Ade Agustyas Tjiptaningrum Akbar, Dafa Rafiqi Aldi Setia Aminuyati Angelia, Tisa Anggoro Budi Hartapo Anggoro Budi Hartopo Assidiq, Hans Pratama Ayu Agustira Ayu Dinda Fatimah Buana, Faris Agung Dian Isti Angraini Evingelinda, Shania Fayola, Diva Fitria Saftarina Gultom, Dea Debora Romauli Gusti Ngurah P Pradnya Wisnu Hadibrata, Exsa Hafizh, Ahmad Fauzan Hartapo, Anggoro Budi Hendra Tarigan Sibero Hendri Busman Indri Windarti Intanri Kurniati Janar Wulan, Anggraeni Jausal, Anisa Nuraisa Khairun Nisa Lusina, Septia Eva Marcellia, Selvi Marzel, Rivaldi Muhammad Gahan Sarwiko Muhammad Gahan Sarwiko Muhammad Maulana Muhammad Ricky Ramadhian Natasya Hayatillah Neema Putri Prameswari Probosuseno Probosuseno Prof. Sutyarso Purnama, Dara Marissa Widya Putu Ristyaning Ayu Rahmayani, Fidha Ramadhan, Rifqi Ihza Ratna, Maya Ganda Reni Zuraida Risal Wintoko Rizka Humardewayanti Asdie Roro Rukmi Windi Perdani, Roro Rukmi Saragih, Pieter Sarwiko, Muhammad Gahan Sekar Mentari Sharlene Sabrina Sudarmanto, Syifa Hasna Susianti, Susianti Suwaib Amiruddin Wiwi Febriani