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All Journal Medula Juke Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Ilmu Kedokteran dan Kesehatan JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kesehatan Tambusai Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Majority JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Iswandi Darwis
Faculty Of Medicine, Universitas Lampung, Bandar Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Medula

 1 
Tanaman Sambung Nyawa (Gynura procumbens) sebagai Antihiperglikemi Ayu Agustira; Iswandi Darwis; Dian Isti angraini
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.265

Abstract

Diabetes mellitus is a disease with impaired carbohydrate metabolism identified by high blood glucose levels (hyperglycemia) and the presence of glucose in urine (glycosuria) that occurs due to abnormal insulin secretion, insulin activity or both. Diabetes mellitus is one of the biggest cause of deaths in Indonesia, which is proven by the Data of Sample Registration Survey in 2014 where diabetes became the third cause of death in Indonesia after stroke and coronary heart disease. If not handled properly, it will affect the decrease in productivity, increase disability, premature death, etc. Sambung Nyawa Plants (Grynura Procumbens) has been widely used as a traditional medicine as antihyperglycemic. Sambung Nyawa Plants contains saponin compounds, flavonoids, and alkaloids, which can reduce blood glucose levels. The mechanism of reducing glucose by Sambung Nyawa Plants is by secreting insulin in β-pancreatic cells and regenerating β-pancreatic cell damage, as an antioxidant that can bind free radicals, there by reducing insulin resistance, and inhibiting alpha amylase and alpha glucosidase which can break carbohydrates into monosaccharides that can be absorbed by the intestine
Peran Albumin Glikat Pada Kontrol Glikemik dan Diagnosis Diabetes Mellitus Sharlene Sabrina; Putu Ristyaning Ayu; Iswandi Darwis
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.287

Abstract

Diabetes Mellitus or DM is a chronic metabolic syndrome, which is usually characterized by excess glycemic conditions or hyperglycemia. The incidence of diabetes is increasing rapidly in populations in Asia, especially in countries with fairly fast economic growth. At present, there are around 171-194 million people in the world who suffer from diabetes. Fructosamine, glycated albumin and HbA1c are glycate proteins used to evaluate glycemic control in diabetic patients. Albumin glycate (GA) has a much shorter half-life than erythrocytes, so glycemic albumin can reflect glycemic control on a short-term basis (around 2-3 weeks) compared to HbA1c. In addition, GA has faster and greater changes compared to HbA1c, so GA may be more useful for describing glycemic control. The concentration of albumin glycate can be determined in several ways, namely by using the colorimetric method with thiobarbituric acid, the enzymatic method with proteinase and ketamine oxidase, the HPLC chromatography method, and the mass spectrometry method. Several studies have concluded that there is a strong relationship between glycated albumin, HbA1c and fasting blood glucose so that glycated albumin can be used as a glycemic control tool for early detection of diabetes complications, aiding diagnosis of diabetes and assisting in the selection of adequate management for diabetes patients.
Vasopressin pada Manajemen Syok Septik Iswandi Darwis; Rizka Humardewayanti Asdie; Neema Putri Prameswari
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.288

Abstract

Sepsis is a systemic inflammatory response caused by an infection, which can involve multiple organs. Sepsis and multiple organ dysfunction syndrome (MODS) are the main causes of death in the intensive care unit of a hospital. In sepsis, septic shock, defined as sepsis-induced persistent hypotension despite adequate fluid resuscitation causing tissue hypoperfusion, can occur. Norepinephrine and dopamine are the vasopressors of choice for initial treatment septic shock, but the use of high-dose catecholamine vasopressors can cause adrenergic side effects that can increase mortality. Therefore, a septic shock patient with increased heart rate, it is necessary to use a vasopressor that does not cause adrenergic side effects. Vasopressin is a hormone secreted by the posterior pituitary. In hypotensive condition, vasopressin physiologically helps maintain blood pressure by acting as a potent vasoconstrictor. Vasopressin administration does not cause side effects caused by adrenergic stimulation such as increased tissue oxygen demand, decreased renal and mesenteric flow, increased pulmonary resistance and arrhythmias. This literature review also discusses the effects of vasopressin on blood pressure, the cardiovascular system, the immune system, the coagulation system, the respiratory system, the urinary system and the central nervous system in patients with septic shock.
Ekstrak Lidah Buaya (Aloe Vera) Menurunan Kadar Glukosa Darah Tikus Putih (Rattus Norvegicus) Yang Diinduksi Streptozotocin Marzel, Rivaldi; Darwis, Iswandi; Windarti, Indri
Medula Vol 13 No 7 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i7.857

Abstract

Diabetes mellitus (DM) is a chronic disorder in the metabolism of protein, fat and carbohydrates. Diabetes mellitus is described as an increase in blood glucose. DM cases in Indonesia rapidly increases. Diabetes mellitus  is a disease that requires anti-diabetes drugs continuously. Continuous use will have side effects that  encourages patients to look for alternative treatments that are cheaper, efficacious, without side effects, and easy to obtain such as herbal medicines. Many medicinal plants around the world contain antihyperglycemic compounds, such as Aloe vera.This is study experimental study using a randomized controlled design method with Post-test only Control Group Design. There were 24 rats consist of 4 treatment groups (K1, K2, K3, K4). (K1) = rats  were given by a standard diet. K2 = rats induced streptozotocin 40 mg/kgBW.K3 = rats were treated with metformin. K4 = rats were treated with Aloe vera extract 250 mg/kg BW. After 21st day,  blood glucose levels were measured. The research was conducted at the animal house of the Faculty of Medicine, University of Lampung. Samples were analyzed using the one way Annova test. Blood glucose levels of the 4 treatment groups were K1 = 67.16 mg/dl, K2 = 366.33 mg/ dl, K3 = 77.83 mg/dl, K4 = 127.16 mg /dl. The blood glucose level in the control and treatment groups were significantly different (p<0,05).  Aloe vera extract ameliorates blood glucose levels of streptozotocin-induced diabetes in white rats (Rattus norvegicus).
Efek Pemberian Ekstrak Biji Jintan Hitam (Nigella sativa) terhadap Penurunan Kadar Glukosa Darah Tikus Putih (Rattus norvegicus) yang diinduksi Streptozotocin Evingelinda, Shania; Kurniawati, Evi; Janar Wulan, Anggraeni; Darwis, Iswandi
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.860

Abstract

Diabetes mellitus (DM) is a heterogeneous disease, characterized by chronic hyperglycemia caused by defects in insulin secretion, insulin action, or both. However, in diabetes mellitus therapy, oral hypoglycemia drugs cause side effects in form of digestive tract complaints in patients, hypoglycemia,and weight loss. Black cumin seed extract as a herbal therapy can reduce blood glucose levels. This study aims to determine effect of administering Black Cumin (Nigella sativa) extract in reducing blood glucose levels in white rats induced by streptozotocin. This study used a pre and post test control group design with a sample size of 32 white rats divided into 4 groups with treatment for 21 days. The groupK- was given 2 ml of distilled water. The group K+ was given an injection of 20 mg/kgBW streptozotocin. Thegroup P1 was given an injection of streptozotocin 20 mg/kgBW and metformin 40 mg/kgBW. Thegroup P2 was given an injection of 20 mg/kgBWstreptozotocin and 200 mg/kgBW black cuminseed extract. Assessment of blood glucose levels is carried out using a glucometer. The results of the difference in the mean pre and post test blood glucose levels at K1, K2, P1, and P2 respectively were 2,34 mg/dl, 157,4 mg/dl, 251,33 mg/dl, and 185,33 mg/dl. This study used a one-way ANOVA parametric test (p<0.05) and continued with the post-hoc Bonferroni test (p<0.05). Administration of black cumin seed extract (Nigella sativa) can have effect of reducing blood glucose levels in white rats (Rattus norvegicus) induced by streptozotocin.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN LUARAN PENDERITA INFEKSI SUSUNAN SARAF PUSAT DI BANGSAL RAWAT INAP ALAMANDA RSUD Dr. Hi. ABDUL MOELOEK PROVINSI LAMPUNG Assidiq, Hans Pratama; Perdani, Roro Rukmi Windi; Darwis, Iswandi; Berawi, Khairun Nisa
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1066

Abstract

Infection of the Central Nervous System is a disease that can cause death and serious disability if not detected and treated appropriately. Meningitis was a specific cause of death for children under 5 years old during 2000-2013. In the Alamanda Inpatient, RSUD Dr. Hi. Abdul Moeloek, Lampung Province, during 2020-2021 there were 50 cases of CNS infections. The aim of this study was to determine the factors associated with the outcomes of CNS infection sufferers in the Alamanda Inpatient, RSUD Dr. Hi. Abdul Moeloek, Lampung Province. This research uses an observational analysis method with a cross sectional research design. The population of this study were pediatric patients with a medical diagnosis of central nervous system infection at the Alamanda Inpatient, RSUD Dr. Hi. Abdul Moeloek, Lampung Province, for the period January 2020 – May 2021, totaling 50 patients with a total sample population. Univariate analysis showed that 39 sufferers of CNS infections in the Alamanda Inpatient, RSUD Dr. Hi. Abdul Moeloek, Lampung Province, mostly aged > 1 year as much as 79.6%, male as much as 51.3%, type of infection is meningitis or encephalitis as much as 66.7%, GPCS score not comatose 79.5%, normal nutritional status 69.2%, long hospitalization >5 days 69.2% and survival outcome is 82.1%. Bivariate analysis using the Chi-Square test showed that the factors that had the most influence on the outcomes of CNS infection sufferers in the Alamanda Inpatient, RSUD Dr. Hi. Abdul Moeloek, Lampung Province., in order of long hospitalization, GCPS coma score, nutritional status, type of infection, and age. Meanwhile, gender does not influence the outcome of CNS infection sufferers in the Alamanda Inpatient, RSUD Dr. Hi. Abdul Moeloek, Lampung Province.
Literature Review: Gagal Ginjal Akut Akibat Nefrotoksisitas Gentamisin Akbar, Dafa Rafiqi; Yonata, Ade; Ratna, Maya Ganda; Darwis, Iswandi
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1312

Abstract

Acute kidney failure or Acute Kidney Injury (AKI) is a sudden decline in kidney function that is often caused by various factors such as sepsis, ischemia, and nephrotoxicity. One of the significant causes of nephrotoxicity is gentamicin, an aminoglycoside antibiotic commonly used to treat Gram-negative bacterial infections. Although effective, gentamicin has nephrotoxic side effects, especially at high doses or long-term use, which can cause damage to the renal tubular epithelium and trigger AKI. This literature review aims to describe and study more deeply the relationship between gentamicin consumption and the incidence of acute kidney failure. Gentamicin works by inhibiting bacterial protein synthesis on the 30S ribosome. Still, its mechanism of action also has the potential to cause nephrotoxicity through drug accumulation in kidney cells, impaired mitochondrial function, increased production of reactive oxygen species (ROS), and mesangial contractions that reduce the glomerular filtration rate. Signs of gentamicin nephrotoxicity include increased serum creatinine levels, blood urea nitrogen, albuminuria, and decreased glomerular filtration rate, accompanied by structural damage such as tubular necrosis and edema in the proximal tubular epithelium. Previous studies have shown that high doses of gentamicin can increase the number of necrotic cells in the kidney and cause renal fibrosis in test animals. In humans, the incidence of gentamicin-induced nephrotoxicity has been reported to reach 10-25% of therapeutic use, with an estimated incidence of AKI of around 15% of total AKI cases. The importance of proper monitoring and management for patients using gentamicin to reduce the risk of nephrotoxicity. Prevention strategies include monitoring kidney function, dose adjustment, adequate hydration, and considering various alternative antibiotic therapies for patients at high risk of nephrotoxicity.
Analisis Klinis Dispepsia pada Pasien Kolelitiasis: Studi Literatur Gultom, Dea Debora Romauli; Ramadhian, Muhammad Ricky; Lusina, Septia Eva; Darwis, Iswandi
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1377

Abstract

Cholelithiasis, also known as gallstones, is a health problem that has been increasing in prevalence worldwide. Some patients with cholelithiasis experience dyspepsia, a condition that causes discomfort in the upper digestive tract. This study aims to analyze the clinical relationship between cholelithiasis and dyspepsia based on a literature review. The articles used in this study were collected from scientific sources such as PubMed, Google Scholar, and Science Direct. A descriptive analysis was conducted to identify the prevalence, risk factors, and mechanisms linking cholelithiasis with dyspepsia. The results show that most patients with cholelithiasis and dyspepsia are female. The most frequently reported symptoms are abdominal pain (100%), nausea (69%), and vomiting (27%). Eating fatty foods can make these symptoms worse. While many patients feel better after having cholecystectomy, about 30% still experience dyspepsia even after surgery. This connection may be due to issues with gastrointestinal motility disorders, bile reflux, and other multifactorial causes. However, the relationship between cholelithiasis and dyspepsia remains a subject of debate, requiring further research to uncover its mechanisms and develop more effective diagnostic and therapeutic strategies.
The Literatur Review: Hubungan Kadar Hemoglobin terhadap Lama Rawat Inap Pasien Laparotomi: - Buana, Faris Agung; Darwis, Iswandi; Marcellia, Selvi; Susianti, Susianti
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1432

Abstract

Hemoglobin is an important protein in the blood whose job is to transport oxygen to body tissues. Low hemoglobin levels (anemia) in laparotomy patients can affect postoperative recovery time, including the duration of hospitalization. This study aims to evaluate the relationship between pre-operative hemoglobin levels and length of stay in laparotomy patients. Data were obtained from medical records of patients who underwent laparotomy at the hospital, including hemoglobin levels before surgery, length of stay, and additional variables such as Body Mass Index (BMI) and Surgical Apgar Score (SAS). The analysis showed that patients with low hemoglobin levels had a greater risk of experiencing longer hospital stays. This is due to suboptimal oxygen supply to the tissue, thereby slowing wound healing and increasing the risk of complications, such as infection and organ failure. Treating anemia with blood transfusions or iron supplementation has proven effective in increasing hemoglobin levels and speeding up patient recovery, with the average length of stay reduced to less than four days. Apart from hemoglobin levels, factors such as BMI, SAS, level of complexity of surgery, and the patient's health condition also influence the length of treatment. These findings emphasize the importance of monitoring and correcting hemoglobin levels before surgery as a preventive measure to speed recovery, minimize complications, and reduce hospital operational burden, especially in health facilities with limited resources. Further research is needed to determine the most effective clinical interventions in managing anemia in preoperative patients.
Dermatitis Seboroik: Etiologi & Faktor Risiko, Patofisiologi, Diagnosis, dan Tatalaksana Sudarmanto, Syifa Hasna; Sibero, Hendra Tarigan; Ratna, Maya Ganda; Darwis, Iswandi
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1327

Abstract

Seborrheic dermatitis is a type of chronic skin inflammation caused by the fungus Malassezia sp. which is often found among patients. The prevalence reaches 4.38% on a global scale and 2% - 30% in Asia. Often found in infantile (self-limited) and adult (chronic) patients. This disease is considered to reduce the patient's quality of life. The high number of cases and the rate of decline in patient quality of life due to seborrheic dermatitis became the basis for conducting this research. Research was conducted to collect and analyze articles that raise topics related to clinical aspects of seborrheic dermatitis. The research design used was a literature review. Article collection was carried out using relevant article search applications such as Google Scholar, PubMed, and Prospero. The articles used have a range of publication criteria in 2013-2024. Based on the articles collected, results were obtained in the form of risk factors, pathophysiology, diagnosis and management of seborrheic dermatitis. Risk factors that are considered to trigger seborrheic dermatitis include high sebaceous gland activity, low body immunity, physical environmental factors in the form of humidity and temperature, and a history of poor personal hygiene. The appearance of the disease is in the form of reddish lesions covering fine colored scales, sometimes accompanied by oil or white powder. The severity of the disease is determined through the SDASI score or Seborrhoeic Dermatitis Area Severity Index. Healing therapy aims to reduce symptoms and improve skin function. The type of therapy given is based on the lesion severity index and the patient's response to therapy.
Co-Authors Ade Yonata, Ade Agustyas Tjiptaningrum Akbar, Dafa Rafiqi Aldi Setia Aminuyati Angelia, Tisa Anggoro Budi Hartapo Anggoro Budi Hartopo Assidiq, Hans Pratama Ayu Agustira Ayu Dinda Fatimah Buana, Faris Agung Dian Isti Angraini Evingelinda, Shania Fayola, Diva Fitria Saftarina Gultom, Dea Debora Romauli Gusti Ngurah P Pradnya Wisnu Hadibrata, Exsa Hafizh, Ahmad Fauzan Hartapo, Anggoro Budi Hendra Tarigan Sibero Hendri Busman Indri Windarti Intanri Kurniati Janar Wulan, Anggraeni Jausal, Anisa Nuraisa Khairun Nisa Lusina, Septia Eva Marcellia, Selvi Marzel, Rivaldi Muhammad Gahan Sarwiko Muhammad Gahan Sarwiko Muhammad Maulana Muhammad Ricky Ramadhian Natasya Hayatillah Neema Putri Prameswari Probosuseno Probosuseno Prof. Sutyarso Purnama, Dara Marissa Widya Putu Ristyaning Ayu Rahmayani, Fidha Ramadhan, Rifqi Ihza Ratna, Maya Ganda Reni Zuraida Risal Wintoko Rizka Humardewayanti Asdie Roro Rukmi Windi Perdani, Roro Rukmi Saragih, Pieter Sarwiko, Muhammad Gahan Sekar Mentari Sharlene Sabrina Sudarmanto, Syifa Hasna Susianti, Susianti Suwaib Amiruddin Wiwi Febriani