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Potensi Interaksi Penggunaan Obat Antihipertensi di Klinik X Boyolali Tahun 2023: Potential Interactions with the Use of Antihypertensive Drugs at Clinic X Boyolali in 2023 Risma Sakti Pambudi; Helviana Rista Rini
Indonesian Journal of Pharmacy and Natural Product Vol. 7 No. 01 (2024): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v7i01.3045

Abstract

Interactions are events that can occur when two drugs are used together. Giving more than one antihypertensive drug can cause drug interactions which can affect the body's response to the treatment given and can have a therapeutic effect on the patient. The aim of this study was to look at the potential for antihypertensive drug interactions at Clinic X Boyolali. The research used a retrospective descriptive method using medical record data. The population in this study was all medical record data from hypertensive patients at Clinic The method used was purposive sampling by looking at the inclusion criteria, namely patients who used a combination of antihypertensive drugs. In this study, the sample size was 110 patients. The data obtained was then analyzed using drugs.com. The results of the study showed that the highest use of antihypertensive drugs, namely amlodipine and cadesartan, was 72.73% and the potential for drug interactions was 24.55% with a minor interaction level of 57.69%, moderate 38.46% and major 7.69%. The conclusion from this study is that there is potential for drug interactions when using antihypertensive drugs with the majority of interactions being minor.   ABSTRAK Interaksi merupakan kejadian yang dapat terjadi bila dua obat digunakan bersama. Pemberian obat antihipertensi lebih dari satu dapat menimbulkan interaksi obat yang dapat mempengaruhi respon tubuh terhadap pengobatan yang diberikan dan dapat memberikan efek terapi pasien. Tujuan penelitian ini adalah untuk melihat potensi interaksi obat antihipertensi di Klinik X Boyolali. Penelitian menggunakan metode deskriptif retrospektif dengan menggunakan data rekam medis. Populasi pada penelitian ini adalah seluruh data rekam medik pasien hipertensi di Klinik X Boyolali Tahun 2023 dan sampel dalam penelitian yang sesuai dengan kriteria inklusi yaitu menggunakan kombinasi obat antihipertensi. Metode yang digunakan yaitu purposive sampling dengan melihat kriteria inklusi yaitu pasien yang menggunakan kombinasi obat antihipertensi. Pada penelitian ini didapatkan jumlah sampel 110 pasien Data yang didapat kemudian di analisa menggunakan drugs.com. Hasil penelitian menunjukkan bahwa penggunaan obat antihipertensi tertinggi yaitu amlodipine dan cadesartan 72,73% dan potensi terjadinya interaksi obat yaitu 24,55% dengan tingkat inetraksi minor sebesar 57,69%, moderate 38,46% dan mayor 7,69%. Kesimpulan dari penelitian ini adalah terdapat potensi interaksi obat pada penggunaan obat antihipertensi dengan mayoritas interaksi minor.
Kepuasan Pasien Terhadap Layanan KIE di Apotek Sirnoboyo Alvina Nia Diani; Risma Sakti Pambudi; Reni Ariastuti
Demagogi: Journal of Social Sciences, Economics and Education Vol. 2 No. 1 (2024): February
Publisher : Penerbit Hellow Pustaka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61166/demagogi.v2i1.8

Abstract

Apotek Sirnoboyo, sebagai fasilitas kesehatan vital yang mendistribusikan obat kepada masyarakat, khususnya bagi pasien dengan resep dokter, mengakui pentingnya meningkatkan kualitas layanan farmasi. Salah satu aspek yang perlu diperhatikan adalah pelayanan Komunikasi, Informasi, dan Edukasi (KIE) kepada pasien. Penelitian ini bertujuan untuk mengevaluasi tingkat kepuasan pasien terhadap pelayanan KIE di Apotek Sirnoboyo. Dengan pendekatan observasional deskriptif kuantitatif, penelitian ini menggunakan metode survey melalui pendekatan cross-sectional. Penelitian ini melibatkan 100 responden dalam pengambilan data. Evaluasi tingkat kepuasan pasien dilakukan melalui distribusi kuesioner yang dilihat dari layanan kefarmasian dan keramahan petugas. Hasil penelitian menunjukkan bahwa pelayanan yang diberikan di apotek sirnoboyo Pada aspek petugas memberikan informasi aturan pakai obat presentase 67,75%, aspek petugas memberikan informasi indikasi obat mendapatkan presentase 71%, aspek petugas memberikan informasi cara penggunaan obat presentase 83,25%, aspek petugas memberi informasi mengenai efek samping obat presentase 77,5%, serta aspek petugas memberikan informasi cara penyimpanan obat yang benar presentase 78,75%, dan aspek petugas memberikan edukasi mengenai lama pemakaian obat presentase 79,25%. Secara rata-rata, seluruh aspek pelayanan kefarmasian di Apotek Sirnoboyo mendapatkan presentase 76,25% yang masuk dalam kategori puas.
FORMULASI DAN UJI FISIK SALEP KOMBINASI EKSTRAK PUTRI MALU (Mimosa Pudica) DAN DAUN JARAK PAGAR (Jatropha Curcas) Enjelina, Sinta Mei; Pambudi, Risma Sakti; Ramadhani, Mutia; Subiyanto, Abyasa Fajari; Ilmi, Ibnul; Rahmadin, Mega Tri
Jurnal Buana Farma Vol. 4 No. 3 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i3.1114

Abstract

Indonesia is a tropical country that has the potential to experience skin diseases. The development of drugs from natural ingredients can be used to treat skin diseases. One of the appropriate pharmaceutical preparations for treating skin infections is ointment. Putri Malu (Mimosa Pudica) and Jatropha Leaves (Jatropha Cuscas) are plants that contain flavonoids, alkaloids, saponins, tannins and phenols which have the potential to inhibit bacterial growth. The aim of this research is to formulate an ointment preparation from the extract of putrimalu (mimosa pudica) and jatropha curcas leaves (jatropha curcas) which meets the requirements of an ointment preparation by means of a physical test of the ointment. This type of research was experimental, which was carried out by making 3 ointment formulations combining Putri Malu and Jatropha leaves using the ointment base Vasellin Album and Adeps Lanae. Physically tested ointment preparations include organoleptic tests, homogeneity tests, pH tests, viscosity tests, spreadability tests, and adhesiveness tests. Based on testing of a combination of ointment preparations from the extract of putrimalu (mimosa pudica) and jatropha leaves (jatrooha cuscas) with a base of vasellin album and adeps lanae, the organoleptic results were blackish brown, distinctive odor, semi-solid consistency, homogeneous ointment with a Ph value of 5 and viscosity test. adhesion and spreading power in accordance with ointment preparation standards. The best formulation of the ointment combination of the extract of the mollusk (mimosa pudica) and jatropha curcas (jatropha cusrcas) leaves is formulation 2 with a ratio of (2:2).
Efektivitas Biaya Antibiotik Pada Pasien Demam Tifoid Di Klinik X Sragen Akhyani, Nur; Pambudi, Risma Sakti; Khusna, Khotimatul
Majalah Farmaseutik Vol 20, No 4 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i4.85941

Abstract

Demam tifoid merupakan penyakit infeksi sistemik bersifat akut yang dapat disebabkan oleh bakteri Salmonella typhi dan dapat diterapi dengan menggunakan obat antibiotik. Penggunaan antibiotik yang tidak tepat dapat menimbulkan potensi peningkatan kejadian bakteri yang resisten terhadap antibiotik dan dapat meningkatkan biaya perawatan. Tujuan penelitian ini adalah untuk mengetahui efektivitas biaya penggunaan antibiotik pada pengobatan pasien demam tifoid di Klinik Pratama Gumilang Larasati Sragen tahun 2022. Penelitian ini bersifat deskriptif yaitu mengambil data secara retrospektif melalui data rekam medis yang berisi data seluruh pasien demam tifoid tahun 2022 yaitu sebanyak 96 rekam medis. Metode analisis biaya yang digunakan adalah Cost Effectiveness Analysis (CEA) dan metode Average Cost Effectiveness Ratio (ACER) untuk menganalisis terapi pengobatan demam tifoid yang paling cost effective. Hasil menunjukkan bahwa penggunaan terapi pasien demam tifoid di Klinik Pratama Gumilang Larasati Sragen tahun 2022 menggunakan terapi antibiotik injeksi cefotaxime dengan nilai ACER Rp. 18.513, injeksi ceftriaxone dengan nilai ACER Rp. 21.306 dan infus levofloxacin dengan nilai ACER Rp. 32.446. Kesimpulan dari penelitian ini adalah obat yang dinilai paling cost effective adalah penggunaan antibiotik injeksi cefotaxime dengan nilai ACER Rp. 18.513.
KAJIAN PENINGKATAN PENGETAHUAN FITOFARMAKA UNTUK SWAMEDIKASI PADA TIM PENGGERAK PKK DI SURAKARTA: A STUDY ON IMPROVING PHYTOPHARMACA KNOWLEDGE FOR SELF-MEDICATION IN THE PKK MOBILIZATION TEAM IN SURAKARTA Pambudi, Risma Sakti; Khusna, Khotimatul; Safitri, Desti Anggi; Windiasari, Farah Puteri
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1755

Abstract

Public knowledge related to the use of traditional medicine is still low and does not know other traditional medicine classes such as OHT (Standardized Herbal Medicine) and phytopharmaca groups. The purpose of this study was to determine the level of knowledge of the use of phytopharmaca for self-medication in the PKK team of Surakarta city. The method in this study used quantitative research with a quasi experimental design with one group pre and post test design. The pre-test was used at the time of the delivery of the material with the aim of knowing the extent to which the material was understood by the respondents. While the post-test is carried out at the end of the material treatment process with the aim of knowing the extent of understanding of the material provided.  Analyze respondents' knowledge by looking at the formula to measure the percentage of answers obtained from the questionnaire. The results showed the level of knowledge of respondents during the pre-test, namely having good knowledge (39.22%), sufficient knowledge (48.04%) and less (12.75%). After being given treatment, respondents filled out a questionnaire and obtained a value for the post-test knowledge level, namely good (63.73%), sufficient (30.39%), and less (12.75%). The results showed that there was a difference in the pre and post test scores of respondents after being treated with a sig value (2-tailed) of 0.000, which is <0.05. The conclusion of this study is that there is an average difference between pre and post and there is an effect with a sig value of 0.000, which is <0.05. Keywords:  Medicine, Phytopharmaca, Knowledge, Self-medication, Surakarta
Gambaran Potensi Interaksi Obat Hipoglikemia Oral (OHO) dengan Obat Lain pada Pasien Diabetes Mellitus Tipe II di Puskesmas Pajang sofia, Sofia alvani kambayong; Sakti Pambudi, Risma
FASKES : Jurnal Farmasi, Kesehatan, dan Sains Vol. 2 No. 2 (2024): Bulan November 2024 Faskes : Jurnal Farmasi, Kesehatan, dan Sains
Publisher : Program Studi Farmasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32665/faskes.v2i2.3298

Abstract

Latar Belakang : Diabetes Mellitus (DM) merupakan gangguan metabolisme yang ditandai dengan tingginya kadar gula darah karena gangguan produksi insulin. Diabetes Mellitus juga mempunyai komplikasi sehingga menimbulkan kematian, komplikasi yang muncul yaitu makrovaskuler dan mikrovaskuler. Tujuan : penelitian ini yaitu melihat pemahaman masyarakat tentang gambaran potensi interaksi OHO (Obat Hipoglikemia Oral) dengan obat lain pada pasien Diabetes Mellitus Tipe II di Puskesmas Pajang. Metode : Penelitian ini bersifat deskriptif dengan mengambil data secara restrospektif. Data penelitian akan dilakukan analisis interaksi obat OHO dengan kombinasi terapi obat lainnya berdasarkan Drug Interaction Cheker. Hasil : penelitian menunjukan bahwa profil pengunaan obat hipoglikemia oral (OHO)158 obat yang terdiri dari metformin 84 obat, glimepiride 72 obat dan glibenklamid 2 obat dan obat non hipoglikemia oral (Non OHO) 260 obat yaitu amlodipin 58 obat, natrium dsiklofenat 27 obat dan simvastatin 24 obat. Berdasarkan penelitian yang dilakukan maka Kesimpulan dan Saran : profil penggunaan obat yang diperoleh yaitu OHO  158 obat (37,79%) non OHO 260 obat (62,20%), Interaksi obat secara farmakokinetik sebanyak 8 kejadian (11,59%), farmakodinamik sebanyak 61 kejadian (88,40%) dan jenis mekanisme interaksi obat berdasarkan signifikansi yaitu minor sebanyak 31 kejadian (44,92%), moderate 38 kejadian (55,07%).
Edukasi Pada Ibu PKK Tapak Siring Tentang Sistem Informasi Pengelolaan Obat Mandiri (SIPOM) Pambudi, Risma Sakti; Khusna, Khotimatul; Fitriyadi, Farid
Reswara: Jurnal Pengabdian Kepada Masyarakat Vol 6, No 1 (2025)
Publisher : Universitas Dharmawangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46576/rjpkm.v6i1.4987

Abstract

Pengobatan secara mandiri tanpa pengetahuan yang baik dapat memiliki risiko terjadi kesalahan dalam penggunaan obat.  Terdapat Masyarakat yang kebingungan dalam mengelola obat yang tidak terpakai atau obat sisa di rumah. Semakin meningkatnya kemajuan teknologi informasi yang digunakan untuk berbagai aspek. Tujuan kegiatan Pengabdian Kepada Masyarakat ini adalah untuk memberikan pemahaman tentang pengelolaan obat mandiri melalui edukasi DAGUSIBU dengan menggunakan sistem informasi. Metode yang dilakukan yaitu dengan memberikan edukasi melalui media website dan diskusi. Evaluasi kegiatan dilakukan dengan melihat pemahaman peserta tentang menggunakan website SIPOM dan informasi penggunaan obat baik sebelum dan sesudah dilakukannya edukasi. Evaluasi kegiatan pengabdian dilihat dari jawaban peserta saat menjawab pertanyaan diberikan oleh pemateri. Hasil menunjukkan jumlah peserta kegiatan ini adalah 24 peserta. Hasil evaluasi menunjukkan terdapat peningkatan pengetahuan sebelum diberikan edukasi terdapat 10 orang (41,67%) yang memahami tentang pengelolaan obat secara mandiri dan setelah dilakukan edukasi terjadi peningkatan peserta yang memahami yaitu menjadi 24 peserta (100%) yang diuji dengan SPSS dengan nilai sig2-tailed p<0.05. Kesimpulan dari kegiatan ini adalah Kegiatan pengabdian masyarakat terkait edukasi SIPOM dapat mempermudah keterjangkauan Masyarakat dalam mencari informasi pengelolaan obat secara mandiri. 
Profil Penggunaan Obat Antibiotik di Apotek X Karanganyar Pambudi, Risma Sakti Pambudi
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p74-77

Abstract

A drug is a compound that is used to treat disease. Antibiotics from the hard drug class can be obtained using a prescription from a doctor. The availability of pharmaceutical preparations is important in supporting public health so it needs to be managed well. Therefore, it is necessary to know the profile of drug use as a basis for making drug plans. The aim of this research is to find out the percentage of antibiotic drug use in Karanganyar x pharmacies. This research method is included in the type of descriptive research with retrospective data collection based on stock card records and sales records and prescriptions at the Rizky Peni Farma Pharmacy. The samples in the study were all antibiotics sold in January-December 2023 at the Rizky Peni Farma Pharmacy. The results show that the use of 6 types of antibiotics at the Rizky Peni Farma pharmacy in the January-December 2023 period was used as a sample. In Antibiotic Sales, it was found that the three antibiotics that were frequently used were Cefadroxil 500 mg (42.92%), Amoxicillin (20.52%) and Metronidazole 500 mg (16.27%). Over a period of 12 months, Cefadroxil 500 mg was sold to 182 drugs, Amoxicilin to 87 drugs, and Metronidazole 500 mg to 69 drugs.
Identifikasi Drug Related Problems Pasien Hipertensi dengan Gagal Ginjal Kronik di Instalasi Rawat Inap RSUD Raja Ahmad Tabib Kepulauan Riau Ruth Eva Betriana; Risma Sakti Pambudi; Khotimatul Khusna
An-Najat Vol. 3 No. 2 (2025): Mei : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i2.2525

Abstract

Hypertension is one of the risk factors for cardiovascular disease and kidney disease with prevalence increasing every year. Medications for a long period of time and using a combination of drugs (polypharmacy) are at risk of Drug Related Problems (DRPs). DRPs are events or conditions associated with drug therapy that actually or potentially interfere with desired clinical health outcomes. The purpose of this study was to determine the identification of Drug Related Problems that occurred in hypertensive patients with chronic renal failure in the inpatient installation of Raja Ahmad Tabib Hospital Riau Islands. The research method used is non-experimental, descriptive and retrospective research. The number of samples was 60 who met the inclusion criteria. The sample used is data from medical records of hypertensive patients with chronic renal failure for the period January to December 2022. Based on the results of the study, it was found that 52 patients (86.67%) experienced DRPs, with the number of potential DRPs indications without therapy as many as 5 patients (8.33%), inappropriate drug selection as many as 2 patients (3.33%) and drug interactions. as many as 45 patients (75%).
Tingkat Kepatuhan Penggunaan Obat Anti Tuberkulosis pada Pasien TB di Puskesmas Kota II, Kabupaten Mappi, Provinsi Papua Selatan Grace Agnes Theresa Konowok; Khotimatul Khusna; Risma Sakti Pambudi
An-Najat Vol. 3 No. 2 (2025): Mei : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i2.2528

Abstract

Tuberculosis (TB) is an infectious disease caused by the Mycobacterium tuberculosis bacteria. Transmission of TB can be transmitted through droplets from people infected with tuberculosis bacilli. Tuberculosis is very much determined by the success of treatment in order to prevent all complications caused by tuberculosis. This study aims to determine the level of compliance with the use of anti-tuberculosis drugs in TB patients at the Kota II health center, Mappi Regency, South Papua Province. This study is a study using a descriptive observational method. The research instrument used in this study was the MMAS-8 (Modified MoriskyAdherence 8-Scale) questionnaire with 8 questions that have been tested for validation and reliability. Based on the results of the study, it was found that 25% of patients had a good level of compliance, 21.25% of patients had a sufficient level of compliance, and 53.75% had a low level of compliance. The researcher's conclusion shows that most of the respondents at the Kota II Community Health Center, Mappi Regency, South Papua Province had a low level of compliance with a presentation of 53.75%.
Co-Authors abdul, ahwan Abyasa Fajari Subiyanto Adi Wardhana Amrullah Ahmad Ghofar Wicaksono Ahwan Ahwan Ahwan Ahwan, Ahwan Akhyani, Nur Alvina Nia Diani Alvina Nia Diani Anniez Rachmawati Musslifah Ariastuti, Reni Arvia Wahyu Widodo Arvita Sari Ashinta, Faridani Anggun Astri Charolina Astuti, Winanti Puji Atika Azizah Widodo Bella Novela Dwi Utari Cahyani, Tiwi Nur Danik Miftakhul Jannah Desti Anggi Safitri Dewi, Oktaria Pratama Dhea Asyifa Nurmalika dila wahyu utami Dwi Jayanti Indah Isnasari Dwi Jayanti Isnasari Endah Astuti Astuti Enjelina, Sinta Mei Evelyne Henny Lukitasari Evelyne Henny Lukitasari Fadilah Qonitah Fadilah Qonitah Faqih Purnomosidi Farah Puteri Windiasari Firra Lurenza Pratiwi Fitriyadi, Farid Grace Agnes Theresa Konowok Grace Hestrivina Puren Hafidz, Rosyadah Hanafi, Affan Hasna Fadlu Rahma Helviana Rista Rini Helviana Rista Rini Heni Rusita Ilmi, Ibnul Irfan Al Fahmi Ishariyanto, Riski Jannah, Danik Miftakhul Khotimatul Khusna Khotimatul Khusna Khusna, Khotimatul Kristianingsih, Kiki Kurniasari, Anisa Lana, Bima Perkasa Putra Listiana, Endah Litta ‘Ifina Machfiroh Setianing Hati Mahmudah, Endar Asih Manek, Yohanes Stephen Megananda, Jenny Meiga Susana Meri Agustina Nabilah Rarayanthi. A Nada Novena Wulandari Novitasari, Nur Cahyani Nur Cahyani Nur Cahyani Novitasari Novitasari Nurfadillah Nurfadillah Nursi, Ivan Nurdin Oktaria Pratama Dewi Primania Maria Puren Putri, Alinda Putri, Tania Ardea Rahmadin, Mega Tri Ramadhani, Mutia Ratih Sakti Prastiwi Rebecawati, Linda Rini, Helviana Rista Riska Dwi Astuti Rita Septiana Rita Septiana Rita Septiana Astuti Rizal, Rafli Adnan Rosliana Patandung Rosliana Patandung Rosliana Patandung Ruth Eva Betriana Safitri, Desti Anggi Septiana, Rita Septiningrum, Chintya Hayu Sindi Wahyu Yuliana Siti Annisa Alfia Laili Solong, Sriwidyawati A. Sri Suwarni Subiyanto, Abyasa Fajari Suci Fitriani, Suci Suci, Dwi Buana Syifa Febiana Temok , Maria Gabriela M Tika Dwiyanti Tri Na'imah Ulfah Nur Hanna Ulfah, Amalia Utami, Winanti Puji Widagdo, Arisena Widodo, Arvia Wahyu Winanti Puji Utami Windiasari, Farah Puteri Yunita Primasanti Zuliana Styarini Zuriyah, Putri