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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Biology, Medicine, & Natural Product Chemistry Jurnal Kimia Riset Jurnal Zarah Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat JOPS (Journal Of Pharmacy and Science) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Journal of Applied Engineering and Technological Science (JAETS) JURNAL PENDIDIKAN, SAINS DAN TEKNOLOGI Jurnal Sains dan Edukasi Sains Community Empowerment Jurnal Pengabdian Masyarakat Indonesia East Asian Journal of Multidisciplinary Research (EAJMR) Gemakes: Jurnal Pengabdian Kepada Masyarakat Magistrorum et Scholarium: Jurnal Pengabdian Masyarakat Capacitarea : Jurnal Pengabdian Kepada Masyarakat Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat Jurnal Farmasi Indonesia Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu
Mulatsari, Esti
Universitas Pancasila
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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The Impact of Modified Atmosphere Storage Treatment on Glucose Levels and Mass Transfer Coefficients: A Study Based on Fruit Skin Thickness Agri Suwandi; Wina Libyawati; Esti Mulatsari
Journal of Applied Engineering and Technological Science (JAETS) Vol. 5 No. 2 (2024): Journal of Applied Engineering and Technological Science (JAETS)
Publisher : Yayasan Riset dan Pengembangan Intelektual (YRPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37385/jaets.v5i2.3481

Abstract

Modified atmosphere storage (MAS) has been proven for decades able to decelerate the respirate rate of fruits. The sluggish respirate rate increases the shelf life of fruits. The after-effects of MAS treatment have been investigated from the installation design until gas composition in the storage, however the investigation about the correlation between the treatment level and the fruits characteristic is still limited on the flavor, color, and weight. Therefore, the research goal is to investigate the MAS treatment result based on skin thickness. A series of experiments with full factorial arrangement and three replications, is set in a storage installation.  Skin thickness is classified in to three levels, which are thin, medium, and thick. Each level is represented respectively by orange, banana, and watermelon. Both fruits with and without MAS treatment are quantified by measuring glucose level, to make a comparation.  The outcome of the research from measurement shows fruits which undergo MAS treatment have lower glucose levels than the ones without the treatment, but the weight remains the same.  The mass transfer coefficient with the thickness became a baseline for sudden exchange in the storage.
In Silico Compounds Analysis in Ginger (Zingiber Officinale) as Candidate for Acute Coronary Syndrome Medication James Ibrahim; Dian Ratih Laksmitawati; Esti Mulatsari; Esti Mumpuni
East Asian Journal of Multidisciplinary Research Vol. 2 No. 11 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/eajmr.v2i11.6790

Abstract

Based on the World Health Organization and other authorized health organizations, heart disease is one of the diseases with the largest contributor to death in the world, including Acute Coronary Syndrome with an estimated number of patients of 126 million in 2020. This research entails phytoconstituents of Zingiber officinale as possible Acute Coronary Syndrome medication with in silico methods by altering the activity of HMG-CoA Reductase, PPAR-α, PPAR-γ, NPC1L1, β1-AR, ACE and P2Y12R. This research used Molegro Virtual Docker 6.0 as tool to analyze the compounds with docking computation approach and also utilize Protein Data Bank (PDB) files : 1HWK, 2ZNN, 4EMA, 4AMJ, 2YDM, 4PXZ and 7DFZ. Chemdraw 3D was used in order to minimize the ligand’s energy. Furthermore, to analyze the pharmacokinetics aspects, this study involved pkCSM and SwissADME to predict a few parameters in each aspect, and finalized the research with Dynamic Molecular approach with YASARA.
Analisis Senyawa Bioaktif Averrhoa bilimbi L. sebagai Penghambat Enzim Siklooksigenase-2 Menggunakan Pendekatan in silico Mulatsari, Esti; Sumiyati, Yati; Warni, Warni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1284

Abstract

Averrhoa bilimbi L. is generally used as a food flavor enhancer and traditional medicine to treat inflammation, cancer sores, cough, fever, gout, rectal bleeding, and hemorrhoids. In vivo and in vitro studies on Averrhoa bilimbi L. have shown anti-inflammatory activity, but the active compounds that play a role in anti-inflammatory activity have not been reported. This study aimed to analyze sixtyfour (64) bioactive compounds in the Averrhoa bilimbi L. plant as cyclooxygenase-2 (COX-2) enzyme inhibitors using in silico approach and predict the pharmacokinetic and toxicological profiles of each compound. The cyclooxygenase-2 enzyme is an enzyme that plays a role in the inflammatory process by converting arachidonic acid into prostaglandin. Increased prostaglandins will cause inflammation. The research method used molecular docking with the application of YASARA, PLANTS, Marvinsketch, Pymol, visualization with PLIP and prediction of ADMET with pkCSM. Control compound used celecoxib. The results showed that there were 13 test compounds that were predicted to have better COX-2 inhibitor activity than celecoxib with good pharmacokinetic properties. Erucic acid has the best pharmacokinetic and toxicity profile. Erucic acid has the potential to be developed as a cyclooxygenase-2 enzyme inhibitor drug.
The Demineralization Optimization for Chitosan Synthesis from Crab Shell Waste (Portunus pelagicus) Sari, Intan Permata; Mulatsari, Esti; Mumpuni, Esti; Purwanggana, Agus
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4653

Abstract

Chitosan, gelatin, albumin, and sodium alginate are examples of natural polymers that are often utilized as a basis material for polymeric nanoparticles. The deacetylation of chitin molecules produces the formation of chitosan. Chitin, protein, CaCO3, MgCO3, and astaxanthin pigment are all found in crab shells. Crab shell is an undervalued potential waste. Despite the fact that copious crab shell waste can be used to produce raw materials and industrial products. According to the findings of Mohadi et al (2014), chitosan was extracted with a yield of 70.71% and a deacetylation degree of 76.6%. Previous research on optimizing chitosan synthesis has involved changing the base reagent at the deacetylation stage. The results showed that a 50% concentration of KOH reagent produced the best chitosan properties. Another study on the synthesis of chitosan from crab shells got a yield of 70.4%, and the following analysis showed that this high yield is due to the amount of calcium. Therefore, demineralization in the synthesis of chitosan from crab shells must be optimized. The calcium content was measured after optimization with various solvent concentration variations. The best demineralization optimization results use 3 M hydrochloric acid with a decrease in calcium content of 97.75%.
EDUKASI PENGOLAHAN PANGAN SEHAT BERBASIS BAHAN ALAM DI SDIT ATHALLA CENDEKIA BOGOR Sari, Intan Permata; Mulatsari, Esti; Pratami, Diah Kartika
GEMAKES: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 2 (2024): GEMAKES: Jurnal Pengabdian Kepada Masyarakat
Publisher : Politeknik Kesehatan Kemenkes RI Jakarta I

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36082/gemakes.v4i2.1474

Abstract

Anak sekolah dasar cenderung lebih tertarik untuk membeli jajanan  dengan harga murah, mudah didapat, dan tampilan yang menarik, tanpa memperdulikan kandungan gizi makanan. SDIT Athalla Cendekia berada di lingkungan pemukiman yang dalam kegiatan sehari-hari, banyak penjual jajajan  di sekitar lingkungan sekolah, baik jajanan  dalam kemasan maupun makanan olahan cepat saji yang selalu menarik siswa untuk jajan sepulang sekolah. Seiring perkembangan pengetahuan, pemanfaatan tanaman obat tidak sebatas sebagai obat tradisional melainkan diolah dalam bentuk makanan seperti pudding lidah buaya, minuman segar, permen dan es krim berbahan herbal. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan edukasi tentang pengolahan pangan sehat berbasis bahan alam dari usia sekolah. Kegiatan dilakukan tim dosen bersama tenaga kependidikan dan mahasiswa dengan berkoordinasi dengan guru sekolah. Kegiatan dilakukan dengan beberapa tahap yaitu persiapan, pelaksanaan praktik bersama pengolahan pangan sehat, tahap pelaporan dan Evaluasi. Pangan sehat yang dibuat adalah nugget tempe dan minuman sehat/jamu. Pangan sehat ini dapat menjadi alternatif jajanan bagi siswa dan bisa dipratekkan dalam kehidupan sehari-hari.
Post-Market in vitro bioequivalence study of innovator and generic Gefitinib tablets: evaluation of JKN medicine quality Nurhayati, Fitri; Anggriani, Yusi; Syahruddin, Elisna; Andalucia, Rizka; Ath-Thobari, Jarir; Mulatsari, Esti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1593

Abstract

Gefitinib is one of Tyrosine Kinase Inhibitors (TKIs), as first line therapy for Non-Small Cell Lung Cancer (NSCLC) with positive EGFR mutation. Gefitinib started to be accommodated in Jaminan Kesehatan Nasional (JKN) insurance in 2015 with the innovator gefitinib and was replaced by a generic product in middle of 2021. This research was conducted to see whether the quality of generic gefitinib equivalent to the innovator through post-market in vitro bioequivalence test. Assay method refers to previous research by Sandhya et al 2013 wih High Performance Liquid Chromatography (HPLC), while the dissolution test method is in accordance with the Food and Drug Association (FDA) 2010. We collected innovator from the official distributor and 3 batches (all batches that have been used in JKN program) of generic product from hospitals where lung cancer therapy services were provided. We evaluated the dissolution profile with similarity and unsimilarity factors and assess based on standard specification of dissolution profile that informed in innovator’s BPOM-approved brochure (avarage of 6 samples > 85% and no individual result < 75% at 45 minutes). The assay results met the requirements of ± 5% of what is stated on the label. Although dissolution profile of generic and innovator were not equal through difference and similarity factors calculation, but one batch of generics met dissolution profile standard of innovator. So, both generic and innovator drug met the standards of assay and dissolution, even though the dissolution profile were not equivalent.
In Silico Analysis of Bioactive Compounds in The Faloak (Sterculia quadrifida R. Br) Stem Bark to Identify Antidiabetic Activity Utami, Fajar Dwi; Achmad Daud, Rizqi Akbar Fandi; Nurmayati, Adi; Ratumakin, Monika Buka Kopon; Siung, Chris Nicholas; Stephanie, Adiva; Fadillah, Almufti; Mulatsari, Esti; Mumpuni, Esti; Prasetyo, Andri
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.177-184

Abstract

Sterculia quadrifida R. Br or known as the faloak plant is a typical plant originating from the East Nusa Tenggara region, Indonesia. This plant has long been used by local people in the treatment of diabetes. In vivo, bioactive compounds from the extract of stem bark Sterculia quadrifida R. Br have been reported to have antidiabetic activity. The present study aims to analyse the potential of bioactive compounds in the faloak stem bark as inhibitors of the enzymes ?-glucosidase, PPAR-?, SGLT2, and DPP-IV. The preparation of bioactive compounds and their comparison was conducted utilising ChemDraw 2D & 3D, while proteins were obtained from the Protein Data Bank (PDB). The docking process used Molegro Virtual Docker, and visualisation was performed using BIOVIA Discovery Studio. Pharmacokinetic prediction (ADMET) was also carried out using the pkCSM website. The results of molecular docking with DPP-IV receptors showed that three bioactive compounds of faloak have better affinity than the comparative compounds, namely beta sisterol (-98.8838) to Alogliptin, Linagliptin, and Sitagliptin. While epicatechin (-83.9022) and cathecin (-83.4336) have better affinity than the comparative compounds Vidagliptin, Saxagliptin.
Peningkatan Kualitas Produk Pangan Produksi Poklahsar Mawar Karya Mandiri melalui Program Edukasi Produksi Higienis, Pengetahuan Nutrisi, dan Strategi Pemasaran Produk Andayani, Nurita; Mulatsari, Esti; Nisa, Chaerani; Wutun, Maria Yuliana Nigun; Ratumakin, Monika Buka Kopon; Fitriyana, Aidina; Aisah, Nur; Hermawati, Lilik; Makin, Wilfridus Resiama; Juniarti, Asti; Afifah F, Salsa
Abdi Implementasi Pancasila:Jurnal Pengabdian kepada Masyarakat Vol 5 No 1 (2025): Mei
Publisher : Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/v7v5ht42

Abstract

UMKM (Usaha Mikro, Kecil, dan Menengah) sebagai salah satu wadah pemberdayaan masyarakat merupakan usaha produktif yang dapat menyerap banyak tenaga kerja sehingga berperan penting dalam mendorong pertumbuhan perekonomian negara. Namun pengetahuan dan pengalaman pelaku UMKM di Indonesia masih perlu ditingkatkan, oleh karena itu dilakukan edukasi tentang nutrisi ikan lele, produksi pangan olahan yang higienis, dan strategi pemasaran di Poklahsar Mawar Karya Mandiri, Kabupaten Bogor. Kegiatan edukasi ini mencakup penyuluhan tentang cara Produksi Pangan Olahan yang Baik (CPPOB), perbaikan kemasan dan pemasaran melalui media digital, tata cara pengurusan Sertifikat Produksi Pangan Industri Rumah Tangga (PIRT). dan diversifikasi produk olahan ikan. Selain itu, dilakukan program peningkatan kinerja produksi dengan penyerahan bantuan alat produksi dan pelatihan tentang Cara Produksi Pangan Olahan yang Baik (CPPOB). Hasil kegiatan edukasi menunjukkan adanya peningkatan pengetahuan anggota Poklahsar yang ditunjukkan dengan nilai Posttest yang lebih tinggi dari pretest. Program ini diharapkan dapat memperluas pasar dan meningkatkan daya saing produk Poklahsar di tingkat nasional. Kegiatan ini juga mencerminkan komitmen terhadap pemberdayaan masyarakat melalui kolaborasi antara lembaga pendidikan, pemerintah, dan masyarakat setempat.
Molecular Docking Study of Bioactive Compounds in Senggugu (Clerodendrum serratum (L.) Moon) as Antidiabetics Rhahmadini, Yahdi Thia; Mulatsari, Esti; Taqwa, Iqbal Ananda; Dhani, Muhammad; Mawijaya, Agus; Susanti, Evi; Simanjuntak, Josua Donrio; Mumpuni, Esti; Prasetiyo, Andri
Jurnal Kimia Riset Vol. 10 No. 1 (2025): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v10i1.68455

Abstract

Senggugu has the potential to be a source of natural medicine through its compounds. Using in silico approaches is an effective strategy for exploring compounds from natural products in the screening process. In vivo studies on senggugu have indicated that the plant has antidiabetic activity, although the active compounds involved in this activity are unknown. This study aims to explore the content of bioactive compounds of Senggugu (Clerodendrum serratum (L.) Moon) and its mechanism of action as an antidiabetic in silico with Molegro Virtual Docker software, ChemDraw, visualization with Discovery Studio, and ADMET prediction with pkCSM. The study was conducted by simulating the molecular docking of 31 bioactive compounds in Senggugu (Clerodendrum serratum (L.) Moon) with comparison compounds using glibenclamide, miglitol, rosiglitazone, linagliptin, and empagliflozin. The validated target proteins comprised 5 (five) receptors with PDB ID codes 4YVP, 5NN6, 7AWC, 6Y0F, and 7VSI. Based on this study, the compound predicted to be active as an antidiabetic is [(1S,2S,6R,7S,11R)-11-hydroxy-5,9,13-trimethylidene-4-oxo-3,14-dioxatricyclo [9.2.1.02,6] tetradecan-7-yl]2-methylprop-2-enoate at receptor 4YVP with a rerank score of -107.663 kcal/mol with glibenclamide -94.8299 kcal/mol and [3-hydroxy-4-[(2R)-6-methylhept-5-en-2yl]phenyl]methyl3-methylbut-2-enoate at 5NN6 receptor with a rerank score of -87.8719 with miglitol -64.7212 kcal/mol.
FORMULATION DRINK HEALTH MATERIAL BASE OF BUTTERFLY PEA FLOWER (Clitoria ternatea L.) AND BUSINESS DESIGN INNOVATION Syabriena, Tarra; Mumpuni, Esti; Mulatsari, Esti
PENDIDIKAN SAINS DAN TEKNOLOGI Vol 12 No 3 (2025)
Publisher : STKIP PGRI Situbondo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47668/edusaintek.v12i3.1762

Abstract

The COVID-19 pandemic has increased the use of herbal supplements, creating opportunities for developing butterfly pea flower (Clitoria ternatea L.) as a health beverage. This study aimed to formulate a stable, preferred product and design its business scheme. Four formulations with 2 grams of butterfly pea flower, varying amounts of mint leaves (0.8 g or 0.5 g) and lemon (0.35 g or 0.5 g) were tested. A hedonic test with 20 semi-trained panelists determined the most preferred formula. The selected formula underwent moisture content analysis using the thermogravimetric method at 105°C. Shelf life was evaluated with the ASLT Arrhenius model at 25°C, 35°C, and 45°C over 20 days, assessing moisture content, organoleptic properties, and pH. Microbial contamination, including Total Plate Count (ALT) and Yeast and Mold Count (AKK), as well as heavy metal levels (As, Hg, Cd, Pb) using AAS, were also examined. Results showed Formula 2 as the most preferred, with 8.13% moisture content and a shelf life of 6.9 months at 25°C in sealed packaging. Aroma was the most affected parameter during storage. Microbial analysis recorded ALT at 3×10³ CFU/g and AKK at 5×10² CFU/g. Heavy metal content met BPOM and SNI standards. Thus, Formula 2 was identified as the best formulation for commercial development.
Co-Authors Achmad Daud, Rizqi Akbar Fandi Afifah F, Salsa Agus Purwanggana Agus Purwanggana Alifah Wardah Zahiroh Andalucia, Rizka Andayani, Nurita Andika Muhammad Hidayat Andri Prasetiyo Andri Prasetyo Anggiyasari Anggiyasari Anisah Kholilah Arfin Ahsanul Ihsan Ath-Thobari, Jarir Audrey, Cresentia Chaerani Nisa, Chaerani Dewi, Nidya Luciana Dhani, Muhammad Diah Kartika Pratami Dian Ratih Laksmitawati Elisna Syahruddin Esti Mumpuni Esti Mumpuni Esti Mumpuni Esti Mumpuni Esti Mumpuni Esti Mumpuni, Esti Evi Susanti Fadillah, Almufti Fauzia Noprima Okta Feriza Sandayu Fitri Nurhayati Fitriyana, Aidina Gressty F Swandiny Gumilar Adhi Nugroho Hermawati, Lilik Hidayat, Andika Muhammad Ikhsan Ramadhan Indriani, Aqilah Idelia Intan Permata Sari intan permata sari Iqbal Ananda Taqwa James Ibrahim Juniarti, Asti Kevin Sandy Liliek Nurhidayati Makin, Wilfridus Resiama Martati, Titiek Maryanto, Kenny Mawijaya, Agus Moordiani Moordiani Nadira Zahra Salsabila Nathalia Perdhani Soemantri Natthawani, Amitta Nidya Luciana Dewi Noerfa, Tri Kumala Noviyantih, Noviyantih Nur Aisah Nurita Andayani Nurmayati, Adi Purwanggana, Agus R. Sapto Hendri Boedi Soesatyo Ramadhan, Islami Al-Kaffah Ramadhani, Karina Natasya Rasdianti, Putri Ratumakin, Monika Buka Kopon Reise Manninda Rhahmadini, Yahdi Thia Rizqya Cahya Handayani Roro Dyah Ayu Ryan Pratama S.Farm., M.Farm., Apt, Sondang Khairani Safi La'rosa Linson Queeny Sandayu, Feriza Sarah Zaidan Shirly Kumala Simanjuntak, Josua Donrio Siti Marsha Dyah Kusumaningtyas Siung, Chris Nicholas Stephanie, Adiva Syabriena, Tarra Taqwa, Iqbal Ananda Tri Kumala Noerfa Trisna Permadi Utami, Fajar Dwi Warni Warni, Warni Widiya Chourinisa Wina Libyawati, Wina Wutun, Maria Yuliana Nigun YATI SUMIYATI Yati Sumiyati, Yati Yogaswara, Amira Thufailla Yusi Anggriani Zahra Afifah Zahra, Nurulita Az