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Qurnianingsih, Ema
Department Of Biochemistry, Faculty Of Medicine, Airlangga University, Surabaya, Indonesia
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Journal : Health Notions

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The Effect of Dandang Gendis Extract (Clinacanthus nutans) on Kidney Histopathological Features of Diabetic Rats Model Miranda Jemyma Mas'ulun; Arifa Mustika; Ema Qurnianingsih
Health Notions Vol 5, No 01 (2021): January
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn50104

Abstract

Changes in kidney homeostasis due to diabetes can cause oxidative stress which then caused tissue damage that leads to diabetic nephropathy. Clinacanthus nutans extract is known to contain antioxidants that are reported to play an important role in the body’s defense system against oxidative stress to minimize tissue damage. This study aims to know the effect of Clinacanthus nutans leaf extract administration on kidney histopathological features of the diabetic rats model. A total of 35 rats were induced by streptozotocin which then divided into 5 groups and given Clinacanthus nutans extract with a dose of 75 mg/kgBW, 150 mg/kgBW and 300 mg/kgBW then compare with CMC-Na as control and metformin as standard drug for 14 days. The kidney histopathology was evaluated under a light microscope against the damage criteria that occurred in the proximal tubules of the kidney. As the result the least amout of kidney damage was on treatment group at dose 300 mg/kgBW, followed by extract with dose 75 mg/kgBW, 150 mg/kgBW, and metformin. In conclusion Clinacanthus nutans extract with a dose of 75 mg/kgBW, 150 mg/kgBW, and 300 mg/kgBW can improve the kidney histopathological feature of the diabetic rats model. Keywords: diabetes mellitus; histopathology; diabetic nephropathy; Clinacanthus nutans
Co-Authors . Kholik Adi, Ginanjar Sasmito Alda Dini Wijayanti Amin, Indah Binti Mohd Amin, Mochammad Anggraeni, Zuhrotul Eka Yulis Arifa Mustika Audi Salman Faza Ayesie Natasha Zulka Bakhtiar, Arief Bakhtiar, Arief Bayu Satria Wiratama Brahmana, Alisha Princessa Choirotussanijjah Damayanti Damayanti Damayanti Dyah Kencono Wungu, Citrawati Eka Arum Cahyaning Putri Elvaretta, Clarissa Ely Rahmatika Nugrahani Ely Rahmatika Nugrahani, Ely Rahmatika Fajar Shamsudin Fajar Syamsudin Ginanjar Sasmito Adi Gosy Endra Vigriawan Hamzah, Arshq Mirza Harianto Notopuro Hendri Susilo Hera, Renata Evania HERAWATI, LILIK Hermina Novida, Hermina Humairah, Ira I'tishom, Reny Indri Safitri Indri Safitri, Indri Jefferson Caesario Jemima Lewi Santoso Kadek Rachmawati Khaerunnisa, Siti Lilia Putri Pratama Lilik Djuari Linda Dewanti Lukitasari, Lina Lukitasari, Lina Mangestuti Agil Maria Inge Lusida Maridsky, Aldilla Afifie Putri Miranda Jemyma Mas'ulun Muhammad Hidayat Palupi, Dian Eka Roro Prabowo, Gwenny Ichsan Pradana, Munawer Purwanta, Marijam Purwitasari, Neny Putri Brillian Betrista Viorizka Ramadhani, Rizqi Nabila Rejeki, Purwo Sri Retno Handajani Rias Gesang Kinanti Riwu, Katty Hendriana Priscilia Rusyda, Aqila sabila Setyawati, Dewi Siti Khaerunnisa Siti Khaerunnisa Soebagijo Adi SOETJIPTO . Sudibyo, Devi Ariani Suhartati Sulistiawati Sulistiawati Susi Wahyuning Asih Susi Wahyuning Asih, Susi Wahyuning Suwandito Suwandito Suwandito, Suwandito Syafa'ah, Irmi Syafa’ah, Irmi Trisniartami Setyaningrum Ummah, Fithriyah Cholifatul Ummah, Fithriyah Cholifatul Ummah Vania Islamey Kusuma Waskito, Langgeng Agung Wungu, Citrawati Dyah Kencono Wungu, Citrawati Dyah Kencono Yasan, Yanna Debby Restifanny Yuri Widia, Yuri Zachawerus, Anjeli Cristina Zuhrotul Eka Yulis Anggraeni Zulka, Ayesie Natasha