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Qurnianingsih, Ema
Department Of Biochemistry, Faculty Of Medicine, Airlangga University, Surabaya, Indonesia
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Journal : INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY

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Effects of Ethanol Extract of Rosa damascene on HbA1c Level and NF-κB Expression in Diabetic Rats Choirotussanijjah Choirotussanijjah; Harianto Notopuro; Ema Qurnianingsih
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 3 No 2 (2021): Molecule analysis to advance laboratory diagnosis
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v3i2.2151

Abstract

Diabetes mellitus (DM) is a chronic hyperglycemic that can cause complications in several organs. It could lead glycosylated hemoglobin or HbA1c formation which has ability undergo further changes into Advanced Glycation End Products (AGEs) and stimulate activation of transcription factors such as nuclear factor kappa B (NF-κB). Some studies showed that anthocyanin has antioxidant and anti-inflammatory activity and it has been found Rosa damascene contain high level of anthocyanin. Total anthocyanin content was 0.459 ± 0.003 mg/L. The aim of this study was to investigate inhibitory effect of R. damascena extract on HbA1c levels and NF-κB activation in diabetic rats. Male wistar rats (n=24) were divided into 6 groups as normal control (KN), streptozotocin-induced diabetic control (KP), diabetic treated with R. damascene (P1, P2, P3; 250, 500 and 1000 mg/kg/d respectively) and diabetic treated with metformin (KM; 500 mg/kg/d). This was carried out for 28 days. The inhibition mode of R. damascene extract was examined by measuring HbA1c levels and expression of NFκB by immunohistochemistry. The results showed p values ​​> 0.05 for HbA1c and p < 0.05 for NFκB. From immunohistochemical staining, it seen the expression of NFκB was low in treated group (P1, P2, P3 and KM) compared with KP. Thus, oral administration of R. damascene extract for 28 days could not reduce HbA1c levels, but can supress NFκB expression.
Co-Authors . Kholik Adi, Ginanjar Sasmito Alda Dini Wijayanti Amin, Indah Binti Mohd Amin, Mochammad Anggraeni, Zuhrotul Eka Yulis Arifa Mustika Audi Salman Faza Ayesie Natasha Zulka Bakhtiar, Arief Bakhtiar, Arief Bayu Satria Wiratama Brahmana, Alisha Princessa Choirotussanijjah Damayanti Damayanti Damayanti Dyah Kencono Wungu, Citrawati Eka Arum Cahyaning Putri Elvaretta, Clarissa Ely Rahmatika Nugrahani Ely Rahmatika Nugrahani, Ely Rahmatika Fajar Shamsudin Fajar Syamsudin Ginanjar Sasmito Adi Gosy Endra Vigriawan Hamzah, Arshq Mirza Harianto Notopuro Hendri Susilo Hera, Renata Evania HERAWATI, LILIK Hermina Novida, Hermina Humairah, Ira I'tishom, Reny Indri Safitri Indri Safitri, Indri Jefferson Caesario Jemima Lewi Santoso Kadek Rachmawati Khaerunnisa, Siti Lilia Putri Pratama Lilik Djuari Linda Dewanti Lukitasari, Lina Lukitasari, Lina Mangestuti Agil Maria Inge Lusida Maridsky, Aldilla Afifie Putri Miranda Jemyma Mas&#039;ulun Muhammad Hidayat Palupi, Dian Eka Roro Prabowo, Gwenny Ichsan Pradana, Munawer Purwanta, Marijam Purwitasari, Neny Putri Brillian Betrista Viorizka Ramadhani, Rizqi Nabila Rejeki, Purwo Sri Retno Handajani Rias Gesang Kinanti Riwu, Katty Hendriana Priscilia Rusyda, Aqila sabila Setyawati, Dewi Siti Khaerunnisa Siti Khaerunnisa Soebagijo Adi SOETJIPTO . Sudibyo, Devi Ariani Suhartati Sulistiawati Sulistiawati Susi Wahyuning Asih Susi Wahyuning Asih, Susi Wahyuning Suwandito Suwandito Suwandito, Suwandito Syafa'ah, Irmi Syafa’ah, Irmi Trisniartami Setyaningrum Ummah, Fithriyah Cholifatul Ummah, Fithriyah Cholifatul Ummah Vania Islamey Kusuma Waskito, Langgeng Agung Wungu, Citrawati Dyah Kencono Wungu, Citrawati Dyah Kencono Yasan, Yanna Debby Restifanny Yuri Widia, Yuri Zachawerus, Anjeli Cristina Zuhrotul Eka Yulis Anggraeni Zulka, Ayesie Natasha