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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Health Notions Halaman Olahraga Nusantara : Jurnal Ilmu Keolahragaan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Madaniya CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Buletin Pengabdian Folia Medica Indonesiana
Qurnianingsih, Ema
Department Of Biochemistry, Faculty Of Medicine, Airlangga University, Surabaya, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Biomolecular and Health Science Journal

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The Effect of Simvastatin and Virgin Coconut Oil (VCO) Combination Therapy as Triglyceride Plasma Lowering Agent in White Dyslipidemic Male Rat (Rattus norvegicus) Jefferson Caesario; Soebagijo Adi; Ema Qurnianingsih
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.29762

Abstract

Introduction: Dyslipidemia is a major health problem in Indonesia which leads to other diseases. Triglycerides (TG) is one of the increased lipid fractions which is related to dyslipidemia. Simvastatin is the main therapy in Indonesia to lower TG levels. The use of virgin coconut oil (VCO) becomes popular as a blood cholesterol-lowering agent even though the effects on TG level remains elusive. Since there is no empirical evidence VCO as a complementary therapy of simvastatin on TG levels, this experimental trial is conducted to determine the effect of simvastatin and VCO combination therapy on blood TG levels in dyslipidemic male white rats.Methods: 42 white rats (Rattus norvegicus) divided into 5 treatment groups and preliminary test of dyslipidemia. The blood was collected intracardially and TG level was measured by using spectrophotometric methods. Independent variables are simvastatin and VCO and combination therapy while the dependent variable is TG levels of white rats. The data was afterwards analyzed using Mann-Whitney U test.Results: The control group’s triglyceride plasma level, receiving standard diet, is 59±13,4 mg/dl. The VCO-only group shows 72±35,4 mg/dl while simvastatin-only group shows 61,9±22,6 mg/dl triglyceride level. Combination therapy of simvastatin and VCO shows 62,3±31,3 mg/dl (p>0,05).Conclusion: There were no significant differences between groups with control. However,the use of VCO with particular dose and duration of therapy, will significantly decrease triglyceride level in the blood as effective as simvastatin. VCO has no efficacy while used as combination therapy of simvastatin.
A Systematical Review of The Effect of Ketogenic Diet on Bcl-2 (B-cell lymphoma-2) Expression as An Apoptosis Marker in Cancer Treatment Vania Islamey Kusuma; Reny I’tishom; Ema Qurnianingsih; Purwo Sri Rejeki
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.30173

Abstract

Introduction: Ketogenic diet seems to be in a great demand nowadays as a lot of people are interested in adopting it into their lifestyle. It is also found that the ketogenic diet shows several beneficial effects including cancer prevention. However, the detail mechanism still remains unknown. Therefore, this review was aimed to find out the effect of ketogenic diet on Bcl-2 (B-cell lymphoma-2) expression in cancer.Methods: We searched published literatures in PubMed through 2011-2020 using specific keywords. The literatures were filtered according to inclusion and exclusion criteria. Animal model, total sample size, underlying condition/inflammatory process occurs, details of the intervention/diet including diet contents in control group and high-fat group, and the duration of the intervention, Bcl-2 results, and p-value were extracted.Results: 7 studies were included in this review. Bcl-2 expression found decrease in 5 out of 6 studies. Similar result also obtained in Bcl-2 protein level, which measured by western blot. Bcl-2 protein level shows a decrease in 2 out of 3 studies.Conclusion: This review shows that high-fat diet that contained in ketogenic diet most likely lead to decrease in Bcl-2 expression. Therefore, indicating the ability of ketogenic diet to affect cancer progression by inducing apoptosis process.
Co-Authors . Kholik Adi, Ginanjar Sasmito Alda Dini Wijayanti Amin, Indah Binti Mohd Amin, Mochammad Anggraeni, Zuhrotul Eka Yulis Arifa Mustika Audi Salman Faza Ayesie Natasha Zulka Bakhtiar, Arief Bakhtiar, Arief Bayu Satria Wiratama Brahmana, Alisha Princessa Choirotussanijjah Damayanti Damayanti Damayanti Dyah Kencono Wungu, Citrawati Eka Arum Cahyaning Putri Elvaretta, Clarissa Ely Rahmatika Nugrahani Ely Rahmatika Nugrahani, Ely Rahmatika Fajar Shamsudin Fajar Syamsudin Ginanjar Sasmito Adi Gosy Endra Vigriawan Hamzah, Arshq Mirza Harianto Notopuro Hendri Susilo Hera, Renata Evania HERAWATI, LILIK Hermina Novida, Hermina Humairah, Ira I'tishom, Reny Indri Safitri Indri Safitri, Indri Jefferson Caesario Jemima Lewi Santoso Kadek Rachmawati Khaerunnisa, Siti Lilia Putri Pratama Lilik Djuari Linda Dewanti Lukitasari, Lina Lukitasari, Lina Mangestuti Agil Maria Inge Lusida Maridsky, Aldilla Afifie Putri Miranda Jemyma Mas'ulun Muhammad Hidayat Palupi, Dian Eka Roro Prabowo, Gwenny Ichsan Pradana, Munawer Purwanta, Marijam Purwitasari, Neny Putri Brillian Betrista Viorizka Ramadhani, Rizqi Nabila Rejeki, Purwo Sri Retno Handajani Rias Gesang Kinanti Riwu, Katty Hendriana Priscilia Rusyda, Aqila sabila Setyawati, Dewi Siti Khaerunnisa Siti Khaerunnisa Soebagijo Adi SOETJIPTO . Sudibyo, Devi Ariani Suhartati Sulistiawati Sulistiawati Susi Wahyuning Asih Susi Wahyuning Asih, Susi Wahyuning Suwandito Suwandito Suwandito, Suwandito Syafa'ah, Irmi Syafa’ah, Irmi Trisniartami Setyaningrum Ummah, Fithriyah Cholifatul Ummah, Fithriyah Cholifatul Ummah Vania Islamey Kusuma Waskito, Langgeng Agung Wungu, Citrawati Dyah Kencono Wungu, Citrawati Dyah Kencono Yasan, Yanna Debby Restifanny Yuri Widia, Yuri Zachawerus, Anjeli Cristina Zuhrotul Eka Yulis Anggraeni Zulka, Ayesie Natasha