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WAHYU IRAWATI
Universitas Pelita Harapan
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Journal : Biotropika

 1 
Potensi dan Efektivitas Salmonella Typhimurium Hasil Rekayasa Genetika Sebagai Terapi Antikanker Glioblastoma Muhamad Ananda; Fiska Ivana Pratami Putri Tokede; Srigika Natalia Boru Ginting; Rani Nurlina Tifen; Delfania Apang Madao; Ellen Nur Endah Pangesti; Wahyu Irawati
Biotropika: Journal of Tropical Biology Vol 9, No 2 (2021)
Publisher : University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2021.009.02.01

Abstract

Kanker adalah penyakit mematikan karena perkembangan sel yang abnormal sehingga tidak terkendali oleh tubuh. Penyakit kanker telah menyerang laki-laki maupun perempuan dengan jenis kanker berbeda, seperti kanker paru-paru, kolorektum, kanker serviks. Pengobatan kanker terdapat beberapa cara salah satunya terapi. Pengobatan ini banyak diimplementasikan di beberapa jenis kanker, termasuk kanker otak, yaitu glioblastoma. Penelitian beberapa tahun terakhir menunjukkan bahwa pendekatan terapi dengan bakteri Salmonella Typhimurium berhasil memproduksi enzim antikanker, dan mensekresikan antigen sekaligus antibodi spesifik kanker untuk mengobati penyakit ini. Penulisan ini bertujuan mengkaji potensi dan efektivitas Salmonella Typhimirium sebagai agen terapi antikanker melalui rekayasa genetika galur gen VN20009 yang dilemahkan. Pengkajian dilakukan secara kualitatif dengan memaparkan secara deskriptif melalui kajian literatur. Hasil kajian menunjukkan bahwa Salmonella Typhimurium merupakan bakteri Gram negatif, fakultatif anaerob, dan bersifat motil. Bakteri ini berikatan secara spesifik pada sel-sel kanker dengan mentransferkan RNA onkogen serta menghambat pertumbuhan sel kanker. Pengembangan bakteri Salmonella menjadi kandidat terapi sebagai strategi terapi utama dalam pengobatan kanker karena spesifik menargetkan sel kanker sehingga menghambat pertumbuhannya dan meningkatkan kelangsungan hidup penderita kanker. Hasil kajian menunjukkan bahwa Salmonella Typhimurium memiliki prospek yang menjanjikan untuk penyembuhan penyakit kanker serta menjadi referensi untuk penelitian selanjutnya dalam pengembangan dan pemanfaatan Salmonella Typhimurium sebagai antikanker.
Insertion of Cold Shock Gene From Escherichia Coli in Wheat Plants to Produce Drought Tolerant Properties Rimpan, Takashi Reymond; Dwany, Naomi; Meyners, Geraldy John; Ayustin, Yohana Delvia; Irawati, Wahyu
Biotropika: Journal of Tropical Biology Vol. 10 No. 1 (2022)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2022.010.01.03

Abstract

Drought is a threat that affects plant growth and development. Wheat crops are very sensitive to heat and drought stress during flowering and grain development, which negatively affects grain yield and quality. Wheat with drought tolerant properties is a genetically modified plant obtained by inserting a cold shock protein gene from Escherichia coli so that it can increase the ability of wheat to adapt to drought. This literature review aims to provide information about the role of cold shock protein gene insertion from Escherichia coli in wheat plants to produce drought tolerant traits. The results of the literature review showed that the CspA gene from Escherichia coli inserted into DNA could increase gene expression by changing the nucleotides in the DNA sequence to increase G+C. Gene insertion produces recombinant DNA with specific nucleotide changes. Nucleotide changes were carried out to increase the overall G+C amino acid content without changing the existing CspA and CspB protein sequences. These changes played an important role in helping wheat adapt to drought. The leaves on the transgenic wheat showed a decrease in the rate of water loss because the stomata in these plants closed faster than in the ordinary wheat so that the transgenic wheat became more drought tolerant.
Potential Use of Insulin Patch Technology as Transdermal Drug Delivery in Efforts to Treat Diabetes Mellitus PutrI, Nadya Aurelia Ratna; Harefa, Dellania Yvonne; Sianturi, Golda Santiur; Irawati, Wahyu
Biotropika: Journal of Tropical Biology Vol. 10 No. 3 (2022)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2022.010.03.02

Abstract

Diabetes Mellitus (DM) in Indonesia continues to increase from 2013 to 2018. Diabetes Mellitus is associated with the production of the hormone insulin in the cells of the pancreas. An increase in blood sugar levels can stimulate insulin secretion. There are several ways to treat Diabetes Mellitus, namely by using drugs, herbal methods, and insulin injections. In addition, one of the DM treatments that can reduce pain is using insulin patch technology as a transdermal treatment. The manuscript for this publication was made to find out the potential of using insulin patch technology as transdermal drug delivery to treat DM. Using a literature review research method that discusses four focus studies, including 1) the structure of the pancreas gland, 2) the mechanism of insulin hormone production by the pancreas gland, 3) the causes, symptoms, and conditions of patients with DM, and 4) insulin patch technology as a transdermal drug in the treatment of diabetes. DM treatment efforts. In the Langerhans section of the pancreas, some cells function to produce the hormone insulin. The amino acids that make up insulin are encoded by exons formed in insulin cells. Some causes of DM namely genetics, age, the influence of food, lack of physical activity, and an unhealthy lifestyle. Some of the symptoms, namely polyuria, polydipsia, polyphagia, etc. Patients with DM need insulin intake to help balance blood sugar levels, one of which is by using an insulin patch in which there is a microneedle containing insulin n-vinylpyrrolidone (NVP) and the enzyme glucose oxidase. After a literature review, it can be concluded that the insulin patch has excellent potential and promise because during the study tested on rats and pigs obtained good results and was able to lower blood sugar levels, although development is still needed. The manuscript of this publication still has shortcomings, so the author suggested to the next author to be able to multiply the latest sources related to insulin patch. Through the creation of the publication, the manuscript realized that diabetes mellitus is a form of human negligence in maintaining the body that God has designed carefully and regularly.
Co-Authors . PATRICIA Aaron Hasthosaputro ABYATAR HUGO BASKORO Alvionita Thana Ambarita, Polin P. Ambarita, Polin Parulian Andara Frida Sheilaliany Daely Angelica, Apriliana Anggun Anggun Aninditya Sri Nugraheni Argoby Simanullang Argorby Simanullang Artha, David Dharmawan Ashiong P Munthe Ashiong Parheheon Munthe Ayustin, Yohana Delvia Bellen Mouretta Bermuli, Jessica Elfani Bora, Merliana Ina Charles Immanuel Chelvieana A. Christanti Christeven Mevotema Christian, Grace Purnamasari Christian, Salomo Clement Khrisman Laia Clement Khrisman Laia Daely, Andara Frida Sheilaliany Damai Yanti Manalu David L Gultom Debora V. Widyanti Delfania Apang Madao Desi L. Sihombing Destya Waty Silalahi, Destya Waty Dipakalyano Dipakalyano Dipakalyano, Dipakalyano Djoko Prasetyo Dominica Feni Valentina Dr. Adolf J.N. Parhusip Dwany, Naomi Dwi N. Susilowati Egilia Lucky Elisabeth Tita Ellen Nur Endah Pangesti Elysabeth Simatupang Eunike Bunga Marvella Eunike Bunga Marvella Eunike Bunga Marvella Fernando Christofer Fernando Christofer Fernando Corneles Moniharapon Fiska Ivana Pratami Putri Tokede Floreta D. Icasari Frichilya Intan Lawa Padang Gaol, Riris Lumban Georgine Gladis Paula Sulardi Gim Mi Kyong Giri, Mutiara Yaemeliza Venderry Grace Charity Mary Cartir Greisnaningsi Greisnaningsi Harefa, Dellania Yvonne HARI HARTIKO Helen Melenia Sianipar Herna Siahaan Hernawati Siahaan Hutauruk, Kristian I Made Samudra Imanuel Adhitya Wulanata, Imanuel Adhitya Intan Cidarbulan Matita Iren Asima Situmorang Jennie Agatherania Listira JOEDORO SOEDARSONO Josephine Elsa Diani Putranto Karnelasatri, . Keisha Hillary Pangalila Kosi, Ice Frans Krisdarwindah Mardiana Kristin Armis Pasaribu Laia , Clement Khrisman Laia, Clement Khrisman Laoli, Beta Mualiman Lastiar R. Sitompul Lastiar Roselyna Sitompul, Lastiar Roselyna Legesang, Eddowardho Otniel Lucia Kusumawati Lusiana Haris Maha, Paldevina Br Maharaja, Dwi P. Malau, Robeka Risky Manalu, Damai Y. Manalu, Damai Yanti Marcellie, Jessica Margaretha, Cecilia Marvella, Eunike Bunga Melany Djami Meyners, Geraldy John Mia Parhusip Muhamad Ananda Munthe, Ashiong P. Munthe, Sri Wahyu Ningsih Naomi Dwany Nexson Parhusip, Adolf Jan Nida Sopiah Nida Sopiah Nida Sopiah Nommensen Pangihutan Ompusunggu Nommensen Pangihutan Ompusunggu Novera, Rusliani S. Orah, Eklesia Taysa Pahotkon Purba Pangaribuan, Medeliene Christine Patricia Patricia Pebrianti Pebrianti, Pebrianti Pingkan Imelda Wuisan Polin Parulian Ambarita Ponagadi, Merry Adisty Prasetyo, Djoko Purba, Friska Juliana Purwanti, Ester Ayu Sri PutrI, Nadya Aurelia Ratna Rahmawati, Sintia Y. Rahul Simon Situmeang Rani Nurlina Tifen Raudhatunnur Reinhard Pinontoan Resky Megawati Tammu Resti Nopriyanti Rido, Elisabeth M.T. Rimpan, Takashi Reymond Rosiva Betaria Purba Ruben Patrick Adhiwijaya Ruth Y. Purba Sabar Manampin Giawa Salomo Christian Shaday, Vannesa El Sherina Juliana Sherina Juliana Siane Indriani, Siane Siane Indriyani Sianturi, Golda Santiur Silaban, Grace Niche Agnesa Silalahi, Ramses Silvana Putri Tarigan Simamora, Tanti Marsanda Sindy Friska Siringo-ringo, Sisilya Situmorang, Stefani Situmorang, Widya Srigika Natalia Boru Ginting Stephanus Jordan Jans Steven Anggawinata Sudarsono Siburian Suhartono, Andreas Valiant Sukri, Urbanus Susi Sulistia Susi Sulistia, Susi Tabitha Grace Larasati Tahya, Candra Tahya, Candra Yulius Tammu, Reisky Megawati Tinambunan , Christine Febriandini Torreno, Jovan Nathanael Tri P. Priyatno Triwibowo Yuwono Vania Austine Callista Timotius Vannesa El Shaday Ruth Advenita Viona Heryani Arla Waruwu, A'azokhi Xaveria, Jessica Yadi Suryadi Yantra Wijaya YENNY SORAYA Yesica C. Rhenata Yohana Ayustin Yohanes Edi Gunanto Yolanda, Shelomita Feby Yovanka P.P Tumakaka Zebua, Satria Putri Aryani Zega, Yeni Angelina