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All Journal Jurnal Ilmiah Farmasi Journal of Biomedicine and Translational Research Biota Jurnal Sains dan Teknologi Pangan Science and Technology Indonesia Jurnal Biologi Tropis Martabe : Jurnal Pengabdian Kepada Masyarakat Hearty : Jurnal Kesehatan Masyarakat Jurnal Kreativitas PKM Jurnal Ilmu Kefarmasian Indonesia Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Kesmas dan Gizi (JKG) Majalah Farmasetika CERATA Jurnal Ilmu Farmasi Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ners Jurnal Riset Kefarmasian Indonesia HSG (Health Science Growth) Journal Janaka : Jurnal Pengabdian Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Indobiosains EEICT (Electric, Electronic, Instrumentation, Control, Telecommunication) Jurnal Ilmiah Wahana Pendidikan Jurnal Pijar MIPA Jurnal Farmasetis Health Research Journal of Indonesia Journal of Pharmaceutical and Sciences. Parapemikir Jurnal Ilmiah Farmasi Media Farmasi CERATA Jurnal Sains dan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia PharmaCine: Journal of Pharmacy, Medical and Health Science Jurnal Abdimas Mahakam
Ahsanal Kasasiah
Universitas Singaperbangsa Karawang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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DEVELOPMENT OF PLASMID-BASED FOR EXTERNAL CONTROL MATERIALS OF CYP2D6*10 (rs1065852) GENE PCR-BASED DETECTION Malau, Jekmal; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Rahmasari, Ratika; Raekiansyah, Muhareva; Rohmah, Siti; Meilani, Nanda Diva; Septi, Annisa Frastica; Zahro, Aurora Fatimatuz; Annajla, Fathina; Hermosaningtyas, Anastasia Aliesa; Hilmi, Indah Laily
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2557

Abstract

Reliable clinical diagnosis of Single Nucleotide Polymorphisms (SNPs) is necessary for personalizing tamoxifen medication according to CYP2D6*10 genetic variations. Our research aimed to create a recombinant plasmid for external control material with a molecular size of 3812 bp. The recombinant plasmid was achieved by cloning an 838 bp gene insert of CYP2D6*10 rs1065852 into a 2974 bp pJET1.2 plasmid into Escherichia coli DH10B and selection on ampicillin agar medium. Isolated E. coli recombinants provided the plasmid molecules for analysis. Bi-directional sequencing and Real-Time PCR confirmed the presence of wild-type and mutant rs1065852 DNA fragments in the plasmid, namely homozygote CC and TT. The conclusion is that we have successfully introduced a novel recombinant plasmid developed by cloning the SNP rs1065852, which carries the 100C>T mutation, using pJET 1.2/blunt system, which could significantly enhance the accuracy of clinical SNP diagnostics for personalized medicine in breast cancer treatment.
Green synthesis of silver nanoparticles using Pluchea (Pluchea indica (L.)) leaf extract and antibacterial activity against Staphylococcus aureus and Propionibacterium acnes Ratnasari, Devi; Kasasiah, Ahsanal; Sulastri, Sulastri; Aida, Fitri
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1648

Abstract

Nanotechnology is widely used in the biomedical purpose as a drug delivery system, cancer, and tumor biomarkers. Currently, metals are most used as precursor agents to form nanoparticles such as silver, gold, iron, zinc, and metal oxides. Acne is one of the skin problems caused by the growth of S. aureus and P. acnes bacteria. Treatment of acne using inappropriate antibiotics can lead to resistance. Silver nanoparticles are known to have the ability to kill pathogenic microorganisms. Pluchea leaf extract contains flavonoid, polyphenol, and tannin compounds that can work as natural bioreductors in the formation of silver nanoparticles while inhibiting bacterial growth. This study aims to synthesize silver nanoparticles using Pluchea leaf extract and testing antibacterial activity against Staphylococcus aureus and Propionibacterium acnes. Extraction of Pluchea leaves was carried out using the infusion method with the water solvent. The synthesis of silver nanoparticles was used a shaker incubator at a speed of 150 rpm and a temperature of 37 ºC for 48 hours. Characterization of silver nanoparticles using uv-vis spectrophotometry, particle size analyzer (PSA), zeta potential analyzer, and FESEM-EDX. Antibacterial activity test using microdilution method. The characterization results of silver nanoparticles showed a particle size of 20.50 nm, a zeta potential of -38.6 mV, and a spherical morphological shape. Silver nanoparticles have antibacterial activity against S. aureus and P. acnes with a Minimum Inhibitory Concentration (MIC) value of 62.5 ppm and Minimum Bactericidal Concentration (MBC) value >250 ppm.
Probiotic Gummies for Improving Gut Microbiota and Nutritional Status in Stunted Children: A Narrative Review Rusmayanti, Agustina; Kasasiah, Ahsanal; Irgi, Khaeru
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10708

Abstract

Stunting remains a major nutritional problem in Indonesia and is often linked to gut microbiota imbalance that can limit nutrient absorption and weaken intestinal function. This article reviews evidence on how probiotics can support gut health and examines the potential of gummy formulations that children can consume easily. The review process used Publish or Perish to search scientific articles from 2016 to 2025 in Google Scholar, PubMed and Scopus. Titles, abstracts and full texts were screened to ensure relevance. A total of 17 studies were included in the analysis. The findings show that probiotics can increase SCFA-producing bacteria, improve the gut mucosal barrier and support the absorption of minerals such as calcium and iron. Several studies also report better digestive comfort and improved microbiota diversity after probiotic intake. Probiotic gummies show good stability, maintain viable cells and are well accepted by children, which makes them a practical delivery system. The evidence from these 17 studies suggests that probiotic gummies have potential to support gut health and contribute to stunting prevention. Longer studies are still needed to measure their direct impact on child growth and guide future nutritional interventions.
Factors Associated with FMT Failure in Clostridioides difficile Infection and Age-Related Considerations: A Review Irgi, Khaeru; Kasasiah, Ahsanal; Rusmayanti, Agustina
Jurnal Pijar Mipa Vol. 20 No. 8 (2025): Special Issue
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i8.10558

Abstract

Clostridioides difficile infection (CDI) is a major cause of nosocomial diarrhea worldwide, and limitations of standard antibiotic therapy have driven the adoption of fecal microbiota transplantation (FMT) as an alternative therapeutic approach. Although FMT achieves clinical success in most patients, treatment failure still occurs in a considerable proportion of cases. Existing literature has examined overall FMT efficacy, yet no review has comprehensively synthesized the multifactorial determinants of FMT failure while incorporating age-related considerations. This narrative review provides an integrative overview of factors contributing to FMT failure in adults with CDI. A literature search of PubMed and Google Scholar identified original research articles published between 2015 and 2025. Evidence indicates that FMT failure is influenced by host-related factors such as comorbidities, immune function, and nutritional status; disease-related characteristics, including CDI severity and recurrence history; technical aspects, such as bowel preparation, donor type, and route of administration; and pharmacological factors, including antibiotic exposure before or after the procedure. These factors collectively affect donor microbiota engraftment and increase the risk of therapeutic failure. Age-related physiological and microbiome changes may additionally modify treatment responses. This review highlights the need for comprehensive patient assessment, standardized procedural protocols, and careful post-FMT monitoring. Addressing current evidence gaps and improving clinical guidance will be essential for optimizing the safety and effectiveness of FMT across different adult age groups.
Narrative Review: The Effect of Inulin on the Growth of Bifidobacterium in the Human Intestine Nurzamani, Salsabila; Kasasiah, Ahsanal
Jurnal Biologi Tropis Vol. 25 No. 4b (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4b.10754

Abstract

Bifidobacterium is an important probiotic bacterium that plays a key role in maintaining gut microbiota balance and supporting digestive health. Inulin has been widely studied as a prebiotic due to its ability to stimulate the growth of Bifidobacterium through fermentation in the colon. This study aims to summarize recent scientific evidence regarding the effects of inulin supplementation on the increase of Bifidobacterium populations in humans. This study aims to summarize recent scientific evidence regarding the effects of inulin supplementation on the increase of Bifidobacterium populations in humans. This article was prepared using a narrative review method based on literature searches conducted in PubMed, ScienceDirect, ClinicalKey, and Google Scholar. A total of nine original research articles that directly reported the effects of inulin supplementation were included. The findings consistently show that inulin increases the abundance of Bifidobacterium, improves gut microbiota balance, and enhances the production of short-chain fatty acids (SCFAs) such as acetate, butyrate, and propionate. These changes are also associated with improvements in metabolic markers among several populations, including obese children, prediabetic patients, and individuals with PCOS. Overall, inulin demonstrates strong bifidogenic effects, although individual responses may vary depending on dosage, duration of intervention, and physiological conditions.
Effect of Mycotoxin Exposure on Stunting and Growth Impairment in Children: A Systematic Literature Review Anisa Aula Rahma; Jekmal Malau; Ahsanal Kasasiah
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.29273

Abstract

Stunting is a critical public health concern in low- and middle-income countries (LMICs), is traditionally attributed to malnutrition and environmental factors. Emerging evidence suggests that mycotoxin exposure is a risk factor. This systematic review, conducted using PRISMA guidelines, investigates the association between mycotoxin exposure and childhood stunting/growth impairment. Twelve relevant studies (predominantly cross-sectional and prospective cohorts) are identified, focusing on children aged 0-5 years in Africa and Asia. Aflatoxins (AFB1, AFM1) and fumonisins (UFB1) are the primary mycotoxins analyzed, measured through biomarkers in biological samples (blood, urine, breast milk). Aflatoxin exposure consistently demonstrates a negative impact on child growth, as evidenced by decreasing anthropometric z-scores (LAZ, WAZ, HAZ). Additionally, it significantly increases the risk of stunting and underweight. Potential mechanisms include disruption of the IGF signaling pathway, oxidative stress, impaired protein synthesis, intestinal barrier dysfunction, and nutrient malabsorption. Fumonisins, both independently and in co-exposure with aflatoxins, are also linked to growth impairment. This review highlights the detrimental effect of mycotoxin exposure on child growth. While aflatoxin exposure appears to be a major contributor, fumonisins warrant further investigation. Elucidating the underlying molecular mechanisms and exploring interactions with other risk factors are crucial next steps. Addressing mycotoxin-related stunting necessitates a multidisciplinary approach.
Konjugat Antibodi-Obat sebagai Pendekatan Pengobatan Alternatif untuk Kanker Paru Bukan Sel Kecil (NSCLC) di Tengah Peningkatan Resistensi Terapi: Tinjauan Sistematis Meisya Diffa Amalia Putri; Ahsanal Kasasiah
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.38473

Abstract

Kanker paru bukan sel kecil atau non-small cell lung cancer (NSCLC) adalah jenis kanker paru yang paling umum dan memiliki tantangan signifikan dalam pengobatan, terutama terkait dengan resistensi terhadap terapi yang ditargetkan. Resistensi ini sering disebabkan oleh mutasi sekunder atau aktivasi jalur pensinyalan alternatif, yang mengurangi efektivitas terapi yang ada. Konjugat antibodi-obat atau antibody-drug conjugate (ADC) telah muncul sebagai pendekatan terapeutik inovatif yang menjanjikan untuk mengatasi tantangan tersebut. Konjugat antibodi-obat atau antibody-drug conjugate (ADC) menggabungkan antibodi monoklonal spesifik dengan muatan aktif, memungkinkan pengiriman terapi yang lebih tepat dan mengurangi dampak pada jaringan sehat. Dalam artikel ini, kami mengeksplorasi berbagai ADC yang sedang dalam pengembangan dan telah menunjukkan efikasi sebagai alternatif terapi untuk NSCLC, termasuk BL-B01D1, trastuzumab deruxtecan, dan sacituzumab govitecan. Meskipun ADC menawarkan harapan baru, perhatian perlu diberikan pada efek samping signifikan, seperti neutropenia dan anemia, yang dapat mempengaruhi kualitas hidup pasien. Penelitian lebih lanjut diperlukan untuk mengeksplorasi efektivitas jangka panjang, biomarker yang terkait, dan strategi manajemen efek samping. Dengan pendekatan ini, ADC berpotensi menjadi bagian penting dalam strategi terapeutik untuk NSCLC.
PENYULUHAN PENGGUNAAN OBAT RASIONAL DAN PEMANFAATAN TANAMAN OBAT KELUARGA SEBAGAI MINUMAN ALTERNATIF KESEHATAN DI DESA WARUNG BAMBU KARAWANG Indah Laily Hilmi; Ahsanal Kasasiah; Muhammad Naufal Nurhadi Hidayat; Sophy Wulandari
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 6, No 8 (2023): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v6i8.2864-2870

Abstract

Pengetahuan mengenai kesehatan sangat dibutuhkan oleh setiap orang, demi terwujudnya kehidupan yang sehat dan sejahtera. Peran tenaga kesehatan saat ini tidak lagi hanya sekedar memberikan pelayanan yang baik, tetapi juga bertugas untuk memberikan edukasi yang baik mengenai kesehatan kepada masyarakat. Penggunaan obat dan antibiotik dengan cara dan dosis yang tidak tepat menjadi salah satu permasalahan besar di masyarakat yang berdampak buruk untuk kesehatan pengguna obat tersebut. Tujuan dari kegiatan pengabdian masyarakat ini untuk mengedukasi kepada masyarakat khususnya di Desa Warung Bambu mengenai cara penggunaan obat yang tepat dan rasional serta alternatif lain dalam menghindari resistensi obat-obatan dengan menggunakan Tanaman Obat Keluarga (TOGA). Umumnya TOGA dibuat menjadi seduhan kebugaran yang dapat menjadi salah satu cara alternatif pengobatan tanpa menyebabkan resistensi karena menggunakan bahan alami, dengan cara pengolahan yang benar. Berdasarkan hasil dari pengisian kuesioner Pre-test dan Post-test yang telah dilakukan oleh peserta, didapatkan hasil peningkatan nilai yang menunjukan bahwa terdapat peningkatan pengetahuan kesehatan masyarakat di Desa Warung Bambu.
Kejadian Diare pada Balita di Desa Karyasari Kecamatan Rengasdengklok Kabupaten Karawang dan Kaitannya dengan Pemberian Susu Formula Ahsanal Kasasiah; Siti Nurazizah Aghisna Hendiana
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 1 No. 1 (2020): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v1i1.4408

Abstract

Abstrak : Diare adalah suatu keadaan pengeluaran tinja yang tidak normal/ tidak seperti biasanya. Angka kejadian dan kematian diare pada anak-anak di negara berkembang masih tinggi terutama pada anak yang mendapat susu formula, karena susu formula tidak mengandung zat antibodi serta tidak mudah dicerna oleh bayi. Penelitian ini bertujuan untuk mengetahui adakah hubungan antara pemberian susu formula dengan kejadian diare pada bayi usia 0-11 bulan di Desa Karyasari Kecamatan Rengasdengklok Kabupaten Karawang. Desain penelitian ini menggunakan rancangan kuantitatif observasional dengan menggunakan metode deskriptif analitik melalui pendekatan cross sectional. Penelitian ini akan dilakukan di Desa Karyasari Kecamatan Rengasdengklok Kabupaten Karawang. Populasi pada penelitian ini adalah seluruh data bayi yang berusia 0-11 bulan sebanyak 79 individu. Penelitan ini menggunakan sampel jenuh.jenis data yang diambil adalah data primer, teknik pengumpulan data dengan menyebar kuesioner kepada ibu yang mempunyai bayi usia 0-11 bulan, analisis data menggunakan SPSS dengan uji chi-square. Kesimpulan dari penelitian ini bahwa terdapat hubungan bermakna antara pemberian susu formula dengan kejadian diare dengan hasil p= 0,001 (p<0,05). Kata Kunci : Diare, Susu Formula, ASI
UJI RESISTENSI BAKTERI Escherichia coli DARI SUMBER AIR BAKU DI KARAWANG TERHADAP ANTIBIOTIK SIPROFLOKSASIN Diniarti, Fuji Ayu; Kasasiah, Ahsanal; Hilmi, Indah Laily
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.281

Abstract

Infectious diseases are included in the ten most common diseases in Indonesia. The disease can be overcome by the use of antimicrobials, one of which is antibiotics. Antibiotics are drugs used to treat infections caused by bacteria. Excessive use of antibiotics without clear indications can have an impact on the occurrence of bacterial resistance to these antibiotics. One of the bacteria that is resistant to antibiotics is Escherichia coli. This study aims to determine the sensitivity of Escherichia coli isolated from raw water sources in Karawang to the antibiotic ciprofloxacin. Samples were obtained from irrigation water which is the source of raw water for one branch of Perumdam in Karawang. The samples were tested using Lactose Broth (LB) media, then confirmed using Eosin Methylene Blue (EMBA) media to confirm the presence of Escherichia coli bacteria equipped with Gram stain. Bacterial resistance test was carried out using Mueller Hinton Agar (MHA) media with disc diffusion method. The results showed that the average diameter of the clear zone formed around the paper disc was 30.16 mm. The isolates showed intermediate results against the antibiotic ciprofloxacin.
Co-Authors Adi Pancoro Adinda Christianti Suparno Adrian Hartanto, Adrian Afif Tri Nugraha Aida, Fitri Al Mukhlas Fikri Aliya Azkia Zahra Aliza Salsabila Ainaputri Anisa Aula Rahma Anisa Aula Rahma Annajla, Fathina Asman Hitopik Asman Hitopik Cantika Aprillia Cartas Cartas Dadang Sumardi Damara, Dandy Satria Daniel Joko Wahyono Devi - Ratnasari Devi Ratnasari Devi Ratnasari Dewi Pratiwi Purba Siboro Dinda Nugrahan Diniarti, Fuji Ayu Endeh Apriyanti Eriyanti Astika Eriyanti Astika Farhan Aimarsa Latuconsina Fika Setra Rikantara Fikri, Al Mukhlas Fuji Ayu Diniarti Hasna, Vina Luthfiana Hendiana, Siti Nurazizah Aghisna Hermosaningtyas, Anastasia Aliesa Hifdzil Qur’ani Hitopik, Asman Indah Laily Indah Laily Hilmi insani abadi bangsa Irgi, Khaeru Irwansyah, Silvana Lestari Jekmal Malau Jekmal Malau Jekmal Malau Lely Sulfiani Saula Lestari, Agatha Nabilla Mally G Sholih Mally Ghinan Sholih Manalu, Rosario Trijuliamos Marsah Rahmawati Utami Meilani, Nanda Diva Meisya Diffa Amalia Putri Meliana Sari, Meliana Muhammad Naufal Nurhadi Hidayat Muhareva Raekiansyah Nabila Rubinadzari Naila Fathna Nurul Hamidah Nasywa Khoirun Nisa Nur Khafipah Nur Komala Fitri Nuraeni Putri Nurhadis, Nurhadis Nurzamani, Salsabila Pramudya Pratama Priscinya Christiana Debora Rahmasari, Ratika Ratnasari, Devi Reas Najla Anugrah Rivandia Listi Rizky Abdul Majid Rosa Arum Rusdiawan, Fairuz Octora Aulia Rusmayanti, Agustina Saarah Hamidah Asmara Indratno Saarah Hamidah Asmara Indratno Salman Salman Saryono Sekar Andjung Tresnawati Septi, Annisa Frastica Septiani, Dia Sholih, Mally Ghinan Siti Nurazizah Aghisna Hendiana Siti Rohmah Sophy Wulandari Sudarjat, Hadi Sulastri Sulastri Syeli Syawaliyah Urbaningrum, Lestari Mahardika Vesara Ardhe Gatera Vriezka Mierza Zahra, Aliya Azkia Zahro, Aurora Fatimatuz