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All Journal Jurnal Ilmiah Farmasi Journal of Biomedicine and Translational Research Biota Jurnal Sains dan Teknologi Pangan Science and Technology Indonesia Jurnal Biologi Tropis Martabe : Jurnal Pengabdian Kepada Masyarakat Hearty : Jurnal Kesehatan Masyarakat Jurnal Kreativitas PKM Jurnal Ilmu Kefarmasian Indonesia Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Abdimas Mahakam Majalah Farmasetika CERATA Jurnal Ilmu Farmasi Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ners Jurnal Riset Kefarmasian Indonesia HSG (Health Science Growth) Journal Janaka : Jurnal Pengabdian Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Indobiosains EEICT (Electric, Electronic, Instrumentation, Control, Telecommunication) Jurnal Ilmiah Wahana Pendidikan Jurnal Pijar MIPA Jurnal Farmasetis Parapemikir Jurnal Ilmiah Farmasi Media Farmasi CERATA Jurnal Sains dan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Ahsanal Kasasiah
Universitas Singaperbangsa Karawang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Increasing Understanding of Medicines in the Community Through the Implementation of DAGUSIBU as a Prevention of Antibiotic Resistance in Pasir Jengkol Village, Karawang Regency Zahra, Aliya Azkia; Malau, Jekmal; Kasasiah, Ahsanal; Ratnasari, Devi; Septiani, Dia; Sholih, Mally Ghinan
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 5 (2025): Volume 8 No 5 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i5.18936

Abstract

ABSTRACT Antibiotic resistance occurs when microorganisms become unresponsive to antibiotic treatment, rendering common therapies ineffective against infections. As a result, the infection becomes increasingly challenging to treat, posing a heightened risk of severe disease progression and increasing the risk of spreading the disease. The causes of the emergence of antibiotic resistance include a number of factors, including excessive use of antibiotics from self-medication, to inappropriate disposal of antibiotic drugs. Karawang Regency, a region in West Java which consists of 10 sub-districts and has a population of more than 2.4 million people. Research conducted in Karawang shows the potential for antibiotic resistance based on use and the environment. It is known that the people of Karawang Regency have poor knowledge and perception regarding antibiotic resistance and use, one of which is Pasir Jengkol village. Therefore, it is necessary to increase understanding of medicines among the people of Karawang Regency, including by socializing the DAGUSIBU movement (Dapatkan, Gunakan, Simpan dan Buang Obat) or Proper Use, Storage and Disposal of Medications and its implementation as a measure to prevent antibiotic resistance. The output of this activity is primarily an increase in understanding of public knowledge through questionnaires which are analyzed using statistics. The results obtained were then tested using a statistical test showing a significant influence (Sig 0.002) increase in knowledge through the difference in pre-test and post-test scores. This outreach activity, which provides educational materials on preventing resistance, has positively impacted the Pasir Jengkol community's knowledge. Therefore, this socialization initiative can be replicated in other areas, particularly in Karawang Regency. Keywords: Antibiotic,  Drug Resistance, DAGUSIBU, Karawang.
Konjugat Antibodi-Obat sebagai Pendekatan Pengobatan Alternatif untuk Kanker Paru Bukan Sel Kecil (NSCLC) di Tengah Peningkatan Resistensi Terapi: Tinjauan Sistematis Putri, Meisya Diffa Amalia; Kasasiah, Ahsanal
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.38473

Abstract

Kanker paru bukan sel kecil atau non-small cell lung cancer (NSCLC) adalah jenis kanker paru yang paling umum dan memiliki tantangan signifikan dalam pengobatan, terutama terkait dengan resistensi terhadap terapi yang ditargetkan. Resistensi ini sering disebabkan oleh mutasi sekunder atau aktivasi jalur pensinyalan alternatif, yang mengurangi efektivitas terapi yang ada. Konjugat antibodi-obat atau antibody-drug conjugate (ADC) telah muncul sebagai pendekatan terapeutik inovatif yang menjanjikan untuk mengatasi tantangan tersebut. Konjugat antibodi-obat atau antibody-drug conjugate (ADC) menggabungkan antibodi monoklonal spesifik dengan muatan aktif, memungkinkan pengiriman terapi yang lebih tepat dan mengurangi dampak pada jaringan sehat. Dalam artikel ini, kami mengeksplorasi berbagai ADC yang sedang dalam pengembangan dan telah menunjukkan efikasi sebagai alternatif terapi untuk NSCLC, termasuk BL-B01D1, trastuzumab deruxtecan, dan sacituzumab govitecan. Meskipun ADC menawarkan harapan baru, perhatian perlu diberikan pada efek samping signifikan, seperti neutropenia dan anemia, yang dapat mempengaruhi kualitas hidup pasien. Penelitian lebih lanjut diperlukan untuk mengeksplorasi efektivitas jangka panjang, biomarker yang terkait, dan strategi manajemen efek samping. Dengan pendekatan ini, ADC berpotensi menjadi bagian penting dalam strategi terapeutik untuk NSCLC.
Development of Species-Specific Primers Targeting Mitochondrial Cyt b Gene for Porcine DNA Detection in Halal Authentication via Polymerase Chain Reaction (PCR) Malau, Jekmal; Kasasiah, Ahsanal; Zahra, Aliya Azkia; Irwansyah, Silvana Lestari; Siboro, Dewi Pratiwi Purba
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 2: Jurnal Pembelajaran Dan Biologi Nukleus June 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i2.6799

Abstract

Background: The detection of porcine DNA is critical to ensuring adherence to halal standards, particularly in food and pharmaceutical products. This study aimed to design and validate species-specific primers targeting the mitochondrial Cyt b gene of Sus scrofa for porcine DNA identification. Using in silico tools such as NCBI, Primer3Plus, SnapGene, Mega and NetPrimer, four primer pairs were designed and assessed for specificity and efficiency. Methodology: Laboratory validation involved PCR amplification and bi-directional Sanger sequencing. Findings: The findings demonstrated that primers 2F/2R and 3F/3R successfully amplified the target DNA, producing amplicons of 514 bp and 456 bp, respectively. The primers exhibited high specificity, with no amplification observed in non-target DNA samples, including chicken and beef. Sanger sequencing confirmed that the amplified products corresponded to the Cyt b gene sequence of Sus scrofa with 100 % similarity, as validated through BLAST analysis. This study presents an accurate and dependable molecular method for detecting porcine DNA, with valuable applications in halal authentication and molecular diagnostics. Contribution: The developed primers offer an effective tool for accurately identifying porcine-derived components, addressing the critical demand for species-specific DNA detection to support halal compliance.
UTILIZATION OF CHIMERIC ANTIGEN RECEPTOR-T (CAR-T) CELL THERAPY AS AN INNOVATIVE THERAPY FOR NON-SMALL LUNG CANCER (NSLC) Rusdiawan, Fairuz Octora Aulia; Kasasiah, Ahsanal
HEARTY Vol 13 No 3 (2025): JUNI
Publisher : Fakultas Ilmu Kesehatan, Universitas Ibn Khaldun, Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/hearty.v13i3.19878

Abstract

Non-Small Lung Cancer is one of the types of lung cancer with the highest prevalence in Indonesia. So that treatment is needed in an effort to reduce the prevalence rate. Chimeric Antigen Receptor-T (CAR-T) cell therapy is known to have the potential to be an alternative treatment for these types of cancer cells. This research is made with the hope that in the future this research can be further developed by researchers, especially in Indonesia. This literature study was made using the Systematic Literature Review (SLR) design to determine the effectiveness of CAR-T cell therapy targeted at several different genes and tested on mouse xenograft models. The journals used were obtained with a publication range of 2014-2024 and 7 journals were selected based on the results of inclusion and exclusion. Based on the results of the article review, it is known that CAR-T cell therapy targeting genes has good antitumor activity efficacy obtained from the test results by measuring the volume and weight of tumors in mouse xenograft models using a caliper and Bioluminescence Imaging (BLI) irradiation method.
Advancements in Real-Time PCR Technologies: A Comprehensive Review of Probe-Based and Non-Probe-Based Assays for Molecular Diagnostics Malau, Jekmal; Zahro, Aurora Fatimatuz; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Meilani, Nanda Diva; Damara, Dandy Satria; Lestari, Agatha Nabilla; Saryono; Wahyono, Daniel Joko
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.660-677

Abstract

The decision between probe-based and non-probe-based qPCR assays is crucial, influenced by diagnostic goals and sample characteristics. This review provides an in-depth evaluation of these two assay types, analyzing their principles, strengths, drawbacks, and applications. A thorough review of the literature, primarily sourced from PubMed, was undertaken to explore prominent assay systems, including TaqMan, KASP, rhAmp, HRM, and SYBR Green. Probe-based qPCR assays, exemplified by TaqMan and rhAmp, are distinguished by their high specificity, aptitude for multiplex analysis, and reduced risk of false positives, making them highly suitable for SNP genotyping and pathogen detection. However, their elevated costs and intricate design requirements remain significant challenges. Conversely, non-probe-based assays, such as SYBR Green and HRM, present cost-effective alternatives with straightforward designs. HRM, in particular, is effective in identifying genetic variations like SNPs with remarkable sensitivity. Nonetheless, these methods are susceptible to non-specific amplifications, requiring careful optimization to maintain reliability. The selection of a suitable qPCR assay depends on various factors, including precision, affordability, and multiplexing capabilities, with applications spanning infectious disease detection and genetic disorder analysis. This review emphasizes the indispensable role of qPCR in molecular diagnostics while showcasing recent technological advances that aim to mitigate existing constraints and enhance diagnostic precision and accessibility.
Pemanfaatan Beberapa Tanaman sebagai Sumber Antioksidan dan Obat Alternatif untuk Diabetes Melitus Utami, Marsah Rahmawati; Sholih, Mally Ghinan; Kasasiah, Ahsanal
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 6, No 3 (2023): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v6i3.4848

Abstract

World Health Organization (WHO) menyatakan bahwa diabetes melitus (DM) termasuk salah satu pembunuh terbesar di Asia tenggara dan Pasifik barat. Salah satu penyebab timbulnya penyakit diabetes melitus adalah Stres oksidatif dan kerusakan oksidatif pada jaringan. Indonesia merupakan negara megabiodiversity yang memiliki jenis tumbuhan yang berkhasiat sebagai obat. diantaranya adalah berkhasiat sebagai sumber antioksidan dan antidiabetes. Namun sayang kekayaan alam tersebut tampaknya masih belum dimanfaatkan secara optimal untuk kesehatan khususnya untuk pengobatan maupun pencegahan penyakit diabetes Mellitus. Desa Sindangmulya merupakan salah satu desa di kabupaten karawang yang tingkat penderita penyakit degenaratifnya cukup tinggi, yang diantaranya adalah diabetes mellitus. Berdasarkan hal itu, kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan masyarakat tentang  pemanfaatan tanaman herbal  sebagai sumber antioksidan dan antidiabetes. Kegiatan dilakukan dengan metode penyuluhan dan pelatihan. Hasil kegiatan pengabdian masyarakat yang telah dilakukan menunjukkan bahwa setelah dilakukan penyuluhan dan pelatihan, pengetahuan para peserta  tentang tanaman herbal dan pemanfaatannya sebagai sumber antioksidan dan antidiabetes serta cara pembuatannya meningkat dengan rata-rata peningkatan sebesar 127,4%.
The Relationship Between COMT and MAO-B Gene Polymorphisms with Levodopa in Parkinson’s Disease Patients; A Review Hasna, Vina Luthfiana; Kasasiah, Ahsanal; Manalu, Rosario Trijuliamos; Malau, Jekmal
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 10, No 1: Jurnal Pembelajaran Dan Biologi Nukleus March 2024
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v10i1.5228

Abstract

Parkinson's disease is a degenerative nervous system disorder caused by the death of dopamine-producing cells in the substantia nigra. Dopaminergic treatment could alleviate motor symptoms for a period. One of the effective dopaminergic medications for symptomatic relief was Levodopa and dopamine agonists. Clinically, Levodopa was always combined with Dopa Decarboxylase (DDC) inhibitors, which redirected Levodopa metabolism towards the COMT pathway, increasing its bioavailability in the central nervous system. The purpose of this article was to investigate the relationship between COMT and MAO-B gene polymorphisms and Levodopa in Parkinson's disease patients, starting by gathering literature on the association between COMT and MAO-B polymorphisms and Levodopa in Parkinson's disease patients using various databases. Reviewed literature revealed that the most frequent polymorphism in the COMT gene was rs4680. Some polymorphisms significantly impacted the treatment of Parkinson's disease patients. However, despite efforts to identify genetic factors influencing the risk of side effects or treatment ineffectiveness, the role of pharmacogenetics in Parkinson's disease has not been fully explored and lacks consistent clinical recommendations. Further research was needed to tailor treatment to individual polymorphisms so that pharmacogenomic approaches could be applied more consistently
DEVELOPMENT OF PLASMID-BASED FOR EXTERNAL CONTROL MATERIALS OF CYP2D6*10 (rs1065852) GENE PCR-BASED DETECTION Malau, Jekmal; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Rahmasari, Ratika; Raekiansyah, Muhareva; Rohmah, Siti; Meilani, Nanda Diva; Septi, Annisa Frastica; Zahro, Aurora Fatimatuz; Annajla, Fathina; Hermosaningtyas, Anastasia Aliesa; Hilmi, Indah Laily
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2557

Abstract

Reliable clinical diagnosis of Single Nucleotide Polymorphisms (SNPs) is necessary for personalizing tamoxifen medication according to CYP2D6*10 genetic variations. Our research aimed to create a recombinant plasmid for external control material with a molecular size of 3812 bp. The recombinant plasmid was achieved by cloning an 838 bp gene insert of CYP2D6*10 rs1065852 into a 2974 bp pJET1.2 plasmid into Escherichia coli DH10B and selection on ampicillin agar medium. Isolated E. coli recombinants provided the plasmid molecules for analysis. Bi-directional sequencing and Real-Time PCR confirmed the presence of wild-type and mutant rs1065852 DNA fragments in the plasmid, namely homozygote CC and TT. The conclusion is that we have successfully introduced a novel recombinant plasmid developed by cloning the SNP rs1065852, which carries the 100C>T mutation, using pJET 1.2/blunt system, which could significantly enhance the accuracy of clinical SNP diagnostics for personalized medicine in breast cancer treatment.
DEVELOPMENT OF PLASMID-BASED FOR EXTERNAL CONTROL MATERIALS OF CYP2D6*10 (rs1065852) GENE PCR-BASED DETECTION Malau, Jekmal; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Rahmasari, Ratika; Raekiansyah, Muhareva; Rohmah, Siti; Meilani, Nanda Diva; Septi, Annisa Frastica; Zahro, Aurora Fatimatuz; Annajla, Fathina; Hermosaningtyas, Anastasia Aliesa; Hilmi, Indah Laily
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2557

Abstract

Reliable clinical diagnosis of Single Nucleotide Polymorphisms (SNPs) is necessary for personalizing tamoxifen medication according to CYP2D6*10 genetic variations. Our research aimed to create a recombinant plasmid for external control material with a molecular size of 3812 bp. The recombinant plasmid was achieved by cloning an 838 bp gene insert of CYP2D6*10 rs1065852 into a 2974 bp pJET1.2 plasmid into Escherichia coli DH10B and selection on ampicillin agar medium. Isolated E. coli recombinants provided the plasmid molecules for analysis. Bi-directional sequencing and Real-Time PCR confirmed the presence of wild-type and mutant rs1065852 DNA fragments in the plasmid, namely homozygote CC and TT. The conclusion is that we have successfully introduced a novel recombinant plasmid developed by cloning the SNP rs1065852, which carries the 100C>T mutation, using pJET 1.2/blunt system, which could significantly enhance the accuracy of clinical SNP diagnostics for personalized medicine in breast cancer treatment.
Green synthesis of silver nanoparticles using Pluchea (Pluchea indica (L.)) leaf extract and antibacterial activity against Staphylococcus aureus and Propionibacterium acnes Ratnasari, Devi; Kasasiah, Ahsanal; Sulastri, Sulastri; Aida, Fitri
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1648

Abstract

Nanotechnology is widely used in the biomedical purpose as a drug delivery system, cancer, and tumor biomarkers. Currently, metals are most used as precursor agents to form nanoparticles such as silver, gold, iron, zinc, and metal oxides. Acne is one of the skin problems caused by the growth of S. aureus and P. acnes bacteria. Treatment of acne using inappropriate antibiotics can lead to resistance. Silver nanoparticles are known to have the ability to kill pathogenic microorganisms. Pluchea leaf extract contains flavonoid, polyphenol, and tannin compounds that can work as natural bioreductors in the formation of silver nanoparticles while inhibiting bacterial growth. This study aims to synthesize silver nanoparticles using Pluchea leaf extract and testing antibacterial activity against Staphylococcus aureus and Propionibacterium acnes. Extraction of Pluchea leaves was carried out using the infusion method with the water solvent. The synthesis of silver nanoparticles was used a shaker incubator at a speed of 150 rpm and a temperature of 37 ºC for 48 hours. Characterization of silver nanoparticles using uv-vis spectrophotometry, particle size analyzer (PSA), zeta potential analyzer, and FESEM-EDX. Antibacterial activity test using microdilution method. The characterization results of silver nanoparticles showed a particle size of 20.50 nm, a zeta potential of -38.6 mV, and a spherical morphological shape. Silver nanoparticles have antibacterial activity against S. aureus and P. acnes with a Minimum Inhibitory Concentration (MIC) value of 62.5 ppm and Minimum Bactericidal Concentration (MBC) value >250 ppm.
Co-Authors Adi Pancoro Adinda Christianti Suparno Adrian Hartanto, Adrian Aida, Fitri Aliya Azkia Zahra Anisa Aula Rahma Annajla, Fathina Asman Hitopik Astika, Eriyanti Cartas Cartas Dadang Sumardi Damara, Dandy Satria Daniel Joko Wahyono Devi - Ratnasari Devi Ratnasari Devi Ratnasari Dinda Nugrahan Eriyanti Astika Fika Setra Rikantara Fikri, Al Mukhlas Fuji Ayu Diniarti Hasna, Vina Luthfiana Hendiana, Siti Nurazizah Aghisna Hermosaningtyas, Anastasia Aliesa Hitopik, Asman Indah Laily Indah Laily Hilmi Indratno, Saarah Hamidah Asmara insani abadi bangsa Irgi, Khaeru Irwansyah, Silvana Lestari Jekmal Malau Jekmal Malau Lely Sulfiani Saula Lestari, Agatha Nabilla Mally G Sholih Mally Ghinan Sholih Manalu, Rosario Trijuliamos Marsah Rahmawati Utami Meilani, Nanda Diva Meliana Sari, Meliana Muhammad Naufal Nurhadi Hidayat Muhareva Raekiansyah Nabila Rubinadzari Nur Khafipah Nur Komala Fitri Nuraeni Putri Nurhadis, Nurhadis Priscinya Christiana Debora Putri, Meisya Diffa Amalia Rahma, Anisa Aula Rahmasari, Ratika Ratnasari, Devi Rivandia Listi Rizky Abdul Majid Rosa Arum Rusdiawan, Fairuz Octora Aulia Rusmayanti, Agustina Saarah Hamidah Asmara Indratno Salman Salman Saryono Sekar Andjung Tresnawati Septi, Annisa Frastica Septiani, Dia Sholih, Mally Ghinan Siboro, Dewi Pratiwi Purba Siti Rohmah Sophy Wulandari Sudarjat, Hadi Sulastri Sulastri Syeli Syawaliyah Urbaningrum, Lestari Mahardika Vesara Ardhe Gatera Zahra, Aliya Azkia Zahro, Aurora Fatimatuz