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All Journal Jurnal Ilmiah Farmasi Journal of Biomedicine and Translational Research Biota Jurnal Sains dan Teknologi Pangan Science and Technology Indonesia Jurnal Biologi Tropis Martabe : Jurnal Pengabdian Kepada Masyarakat Hearty : Jurnal Kesehatan Masyarakat Jurnal Kreativitas PKM Jurnal Ilmu Kefarmasian Indonesia Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Kesmas dan Gizi (JKG) Majalah Farmasetika CERATA Jurnal Ilmu Farmasi Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ners Jurnal Riset Kefarmasian Indonesia HSG (Health Science Growth) Journal Janaka : Jurnal Pengabdian Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Indobiosains EEICT (Electric, Electronic, Instrumentation, Control, Telecommunication) Jurnal Ilmiah Wahana Pendidikan Jurnal Pijar MIPA Jurnal Farmasetis Health Research Journal of Indonesia Journal of Pharmaceutical and Sciences. Parapemikir Jurnal Ilmiah Farmasi Media Farmasi CERATA Jurnal Sains dan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia PharmaCine: Journal of Pharmacy, Medical and Health Science Jurnal Abdimas Mahakam
Ahsanal Kasasiah
Universitas Singaperbangsa Karawang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Upaya Promotif dan Preventif pada Masa Pandemi Covid-19 di Karawang Aliya Azkia Zahra; Ahsanal Kasasiah; Jekmal Malau; Indah Laily Hilmi
Jurnal Abdimas Mahakam Vol. 7 No. 02 (2023): Juli
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24903/jam.v7i02.2275

Abstract

Coronavirus Disease 2019 (Covid-19) adalah penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV- 2). Angka kasus positif yang kian meningkat, terlebih lagi di Indonesia yang sudah masuk ke dalam 30 besar negara dengan angka kasus Covid-19 yang tinggi di dunia. Pemerintah sudah berupaya untuk menanggulangi situasi pandemi ini, yaitu dengan mensosialisasikan 3M (memakai masker dengan benar, menjaga jarak dan hindari kerumunan dan mencuci tangan pakai sabun). Namun angka Covid-19 di Indonesia masih terhitung tinggi. Berdasarkan data yang dipaparkan oleh satgas Covid-19, Karawang termasuk zonasi daerah dengan risiko tinggi penyebaran Covid-19. Karawang menduduki posisi ke-6 sebagai daerah zonasi risiko tinggi. Oleh karena itu, dibutuhkan kegiatan penyuluhan kepada masyarakat tentang Covid-19 dan strategi preventif menghadapi Covid-19 yang diharapkan dapat mampu meningkatkan kesadaran masyarakat terhadap bahayanya Covid-19 serta masyarakat yang berperan penting dalam memutus rantai penyebaran Covid-19 harus selalu dihimbau untuk melaksanakan protokol kesehatan 3M dan selalu menjaga kesehatan. Dengan hasil setelah dilakukan kegiatan penyuluhan terlihat terdapat peningkatan pengetahuan masyarakat sebesar 10%.
Integrasi Strategi Genomik Presisi dan Perspektif Etika Islam dalam Pencegahan Stunting: Fokus pada Jalur Hormon Pertumbuhan–IGF-1 Hifdzil Qur’ani; Nasywa Khoirun Nisa; Pramudya Pratama; Ahsanal Kasasiah; Jekmal Malau
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1320

Abstract

Stunting remains one of the major chronic nutritional problems in Indonesia. The national prevalence of stunting has decreased from 37.2% in 2013 to 19.8% in 2024; however, this figure is still above the World Health Organization threshold (<20%) and has not yet reached the national target of 14%. The interaction of nutritional, environmental, and genetic factors influences stunting. Genetic variations within the Growth Hormone–Insulin-like Growth Factor One pathway play a significant role in regulating linear growth in children; disruptions in this pathway can increase vulnerability to stunting. In addition, the majority of Indonesia's population adheres to Islam, making religious values a strategic potential for strengthening health interventions. This review article examines the integration of scientific approaches, focusing on genetics and Islamic values, in stunting prevention by highlighting polymorphisms in the IGF1, IGF1R, and GHR genes and their relevance to the principles of maqāsid al-sharī‘ah, particularly hifz al-nasl (protection of lineage). The analysis is conducted using a descriptive-analytical approach based on recent scientific literature and Islamic references, including the Qur’an, prophetic traditions, and scholarly exegesis. The findings indicate a strong alignment between scientific approaches and Islamic teachings, including the importance of adequate nutrition during pregnancy, exclusive breastfeeding, consumption of lawful, nutritious food, genetic screening efforts consistent with the values of divine decree, and vitamin D supplementation to support Insulin-like Growth Factor One levels. This integration has the potential to enhance community acceptance of stunting-prevention programs, strengthen moral and spiritual motivation, and support the achievement of national stunting-reduction targets. Thus, an approach that combines precise genomics and Islamic values may serve as a contextual and sustainable strategy in shaping a generation that is healthy, intelligent, and spiritually resilient.
Comparative Study of World Health Organization Recommended Smallpox Vaccine to Prevent Monkeypox Reas Najla Anugrah; Ahsanal Kasasiah
JURNAL KESMAS DAN GIZI (JKG) Vol. 8 No. 2 (2026): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/0ejez036

Abstract

Background: Monkeypox is a zoonotic disease caused by the monkeypox virus (MPXV) from the Orthopoxvirus genus and has shown a global increase in cases since 2022. Currently, no specific vaccine is available; however, smallpox vaccines provide cross-protection and are recommended by the World Health Organization (WHO) for prevention. Objective: This review aims to compare the efficacy and safety of WHO-recommended smallpox vaccines (MVA-BN, LC16m8, and ACAM2000) in preventing monkeypox. Methods: This literature review searched Google Scholar and Publish or Perish with the keywords “monkeypox vaccine”, “MVA-BN,” “LC16,” “ACAM2000,” “efficacy,” and “safety.” Articles published between 2015 and 2025 were included. Of 155 identified records, 9 met the inclusion criteria and were analyzed. Results: All vaccines were effective in preventing monkeypox through humoral and cellular immune responses. MVA-BN showed the highest efficacy and best safety profile, while LC16m8 provided long-term protection with mild adverse effects. ACAM2000 was effective but associated with mild cardiovascular adverse events, limiting its use in certain populations. Conclusion: WHO-recommended smallpox vaccines are effective and relatively safe, with MVA-BN considered the most optimal option. Further development of monkeypox-specific vaccines using mRNA and DNA technologies is needed, as these platforms allow more specific antigen targeting and may enhance immune response and safety.
Uji Aktivitas Penyembuhan Luka Sayat Menggunakan Gel Ekstrak Daun Sukun (Artocarpus altilis) Dalam Sediaan Topikal Pada Mencit (Mus musculus) Jantan Putih Naila Fathna Nurul Hamidah; Vriezka Mierza; Ahsanal Kasasiah
Health Research Journal of Indonesia Vol 4 No 5 (2026): Health Research Journal of Indonesia
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/hrji.v4i5.1264

Abstract

Luka sayat merupakan salah satu jenis luka terbuka yang memerlukan penanganan yang tepat agar proses penyembuhan berlangsung optimal dan terhindar dari infeksi. Proses ini berlangsung melalui empat fase utama, yaitu fase hemostasis, fase inflamasi, fase proliferasi, dan fase maturasi, yang secara berurutan berperan dalam menghentikan perdarahan, membersihkan jaringan yang rusak, membentuk jaringan baru, dan memperkuat jaringan hasil regenerasi. Daun sukun diketahui mengandung golongan metabolit sekunder seperti flavonoid, tanin, dan saponin, steroid, alkaloid, dan glikosida yang berpotensi sebagai antiinflamasi, antibakteri, serta mempercepat proses regenerasi jaringan. Penelitian ini bertujuan untuk mengetahui aktivitas penyembuhan luka sayat dengan menggunakan gel ekstrak daun sukun (Artocarpus altilis) dalam sediaan topikal pada mencit (Mus musculus) jantan putih. Penelitian ini menggunakan lima kelompok perlakuan: kontrol positif (Gel Bioplacenton), kontrol negatif (basis gel), gel ekstrak daun sukun konsentrasi 2,5%, 5%, dan 7,5%. Hasil penelitian menunjukkan bahwa gel ekstrak daun sukun konsentrasi 7,5% secara signifikan dapat mempercepat penyembuhan luka sayat. Data dianalisis terlebih dahulu dengan uji normalitas dan homogenitas. Jika data terdistribusi normal dan homogen digunakan uji One Way ANOVA untuk menguji interaksi antara waktu dan perlakuan. Jika data tidak memenuhi asumsi tersebut, digunakan uji Kruskal-Wallis dan Mann-Whitneyy untuk mengidentifikasi pasangan kelompok yang berbeda signifikan. Penelitian ini menunjukkan bahwa gel ekstrak daun sukun berpengaruh terhadap percepatan penyembuhan luka sayat.
Genetic Studies On The GHSR and IGF1R and Their Relationship With Stunting: A Systematic Literature Review Saarah Hamidah Asmara Indratno; Jekmal Malau; Ahsanal Kasasiah
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 10, No 2: Jurnal Pembelajaran Dan Biologi Nukleus July 2024
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v10i2.5731

Abstract

Stunting, also known as short stature, is a condition that occurs in children where children grow too short for their age. It can be influenced by several external and internal factors. This study explored various databases including Pubmed, Science Direct, Sage Journal, Springer Link, with keywords: "stunting OR short stature AND GHSR AND IGF1R AND genetic". There are 114 articles that match the PICOTS elements to be further reviewed using the PRISMA diagram. In this review article, 10 research articles published in 2011-2024 were used as sources of information. This review article discusses that internal factors of stunting can be caused by genetic factors influenced by growth genes, one of which is GHSR and IGF1R. Whole genome sequencing revealed potential genes involved in the growth pathway that showed an association between genetic variation in GHSR and IGF with the risk of the body's production or response to growth hormone that causes delayed child growth. The evidence highlights the possibility that these putative genetic markers could offer more effective treatment by focusing on the pathophysiology associated with development stunting. Due to lack of genetic studies on stunting genes carried out in Asian nations, genetic testing has not been used in clinical practice as a routine evaluation in the current national implementation, especially in Indonesia
Influence of LEAP2 (Liver Expressed Antimicrobial Peptide-2) and Ghrelin Binding to GHSR Gene Receptor as Factors Obesity Incidence: A Literature Review Asman Hitopik; Ahsanal Kasasiah; Jekmal Malau
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 10, No 3: Jurnal Pembelajaran Dan Biologi Nukleus November 2024
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v10i3.5834

Abstract

Obesity is a serious issue in global health, which requires a more comprehensive understanding for the development of effective therapies. This study explores the role of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) and its interaction with Ghrelin in regulating Growth Hormone Secretagogue Receptor (GHSR) as a potential obesity event. This method used in this review is a systematic literature analysis. The results obtained show that LEAP2, originally known as an antimicrobial, plays a significant role in metabolic regulation and body weight regulation. LEAP2 acts as a Ghrelin antagonist, reduces orexigenic effects and inhibits food intake, and exerts positive effects in tackling the effects of obesity such as hyperlipidemia and inflammation. The study also highlighted the potential of LEAP2 as a therapeutic target in obesity treatment, with palmitoylation modification showing increased stability and effectiveness of LEAP2. However, further understanding and clinical trial studies are needed to validate the preclinical findings and evaluate the long-term effects of LEAP2 regulation on human body weight and metabolic health, thus providing a basis for exploring potential clinical applications in future anti-obesity drug development
Gut Microbiota Types between Well-Grown and Stunted Children: A Systematic Review Eriyanti Astika; Ahsanal Kasasiah; Jekmal Malau; Al Mukhlas Fikri
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 10, No 2: Jurnal Pembelajaran Dan Biologi Nukleus July 2024
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v10i2.5871

Abstract

Stunting, one of the malnutrition in the prenatal period up to the first two years of life and often exacerbated by recurrent gastrointestinal infections after birth. This study explores from various databases including Pubmed, Scopus, Science Direct, Sage Journal, Springer Link, with keywords: "stunting, gut microbiota, toddler". In this study, 10 open access articles published in 2016-2024 were used as sources of information using PRISMA 2020 guideline. It was found that the presence of gut microbiota plays a role in stunting. Gastrointestinal infections have specific mechanisms that can lead to impaired growth and postnatal growth. Deficiency of non-pathogenic gut microbiota is considered to be the main cause. Changes in gut bacterial composition in children under five are associated with increased gastrointestinal frequency, which in turn leads to chronic growth disorders.
The Potential of Probiotics for Modulating The Gut-Brain Axis to Enhance Cognitive Function: A Narrative Review Farhan Aimarsa Latuconsina; Ahsanal Kasasiah
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.12768

Abstract

Cognitive decline is an important health issue because it is closely linked to chronic inflammation, oxidative stress, impaired intestinal barrier function, and microbial imbalance, all of which accelerate neuronal aging and increase the risk of neurodegenerative diseases. This article aims to review and analyze the biological mechanisms through which probiotics modulate communication between the digestive tract and the brain and how these mechanisms relate to cognitive outcomes. This review discusses key mechanistic pathways reported in the literature, including enhanced production of neurotransmitters such as gamma aminobutyric acid, serotonin, and dopamine; increased short chain fatty acids; improved integrity of the intestinal barrier and the blood–brain barrier; reduced inflammatory activity; increased neurotrophic factors; and regulation of physiological stress responses. Synthesis of the seven included studies shows that probiotics improve cognition through interconnected pathways that support memory performance, synaptic plasticity, and mood stability, and may prevent cognitive impairment associated with aging, inflammation, or postoperative stress. The implications of these findings suggest that probiotics hold considerable potential as a supportive approach for brain health, although their effectiveness depends on strain selection, dose, and duration. This article provides a comprehensive overview of mechanistic consistency across studies and offers a foundation for future research aimed at identifying optimal probiotic strategies to enhance cognitive function.
Suplementasi Butirat dan Modulasi Epigenetik melalui Inhibisi Histon Deacetylase pada Diabetes Melitus Tipe 2: Suatu Tinjauan Naratif dengan Perspektif untuk Indonesia Aliza Salsabila Ainaputri; Ahsanal Kasasiah; Jekmal Malau; Cantika Aprillia; Dewi Pratiwi Purba Siboro; Endeh Apriyanti; Afif Tri Nugraha
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1301

Abstract

Type 2 diabetes mellitus is a multifactorial metabolic disorder characterized by insulin resistance, chronic inflammation, and epigenetic dysregulation. Emerging evidence indicates that butirat supplementation may improve metabolic homeostasis through histon deacetylase inhibition and modulation of gene expression involved in insulin signaling and inflammatory pathways. This review aims to evaluate preclinical and clinical evidence on the role of butirat as an epigenetic modulator in type 2 diabetes mellitus and to discuss its translational relevance, including perspectives for Indonesia. A structured literature search was conducted to identify original research articles published between 2015 and 2025. The selected studies demonstrate that butirat enhances insulin sensitivity, improves glycemic control, and attenuates inflammatory responses through increased histon acetylation. However, direct clinical evidence remains limited. In Indonesia, available data are largely derived from dietary or probiotic interventions that increase endogenous butirat production. Therefore, well designed controlled clinical trials are required to evaluate the therapeutic potential of direct butirat supplementation in populations with type 2 diabetes mellitus.
Co-Authors Adi Pancoro Adinda Christianti Suparno Adrian Hartanto, Adrian Afif Tri Nugraha Aida, Fitri Al Mukhlas Fikri Aliya Azkia Zahra Aliza Salsabila Ainaputri Anisa Aula Rahma Anisa Aula Rahma Annajla, Fathina Asman Hitopik Asman Hitopik Cantika Aprillia Cartas Cartas Dadang Sumardi Damara, Dandy Satria Daniel Joko Wahyono Devi - Ratnasari Devi Ratnasari Devi Ratnasari Dewi Pratiwi Purba Siboro Dinda Nugrahan Diniarti, Fuji Ayu Endeh Apriyanti Eriyanti Astika Eriyanti Astika Farhan Aimarsa Latuconsina Fika Setra Rikantara Fikri, Al Mukhlas Fuji Ayu Diniarti Hasna, Vina Luthfiana Hendiana, Siti Nurazizah Aghisna Hermosaningtyas, Anastasia Aliesa Hifdzil Qur’ani Hitopik, Asman Indah Laily Indah Laily Hilmi insani abadi bangsa Irgi, Khaeru Irwansyah, Silvana Lestari Jekmal Malau Jekmal Malau Jekmal Malau Lely Sulfiani Saula Lestari, Agatha Nabilla Mally G Sholih Mally Ghinan Sholih Manalu, Rosario Trijuliamos Marsah Rahmawati Utami Meilani, Nanda Diva Meisya Diffa Amalia Putri Meliana Sari, Meliana Muhammad Naufal Nurhadi Hidayat Muhareva Raekiansyah Nabila Rubinadzari Naila Fathna Nurul Hamidah Nasywa Khoirun Nisa Nur Khafipah Nur Komala Fitri Nuraeni Putri Nurhadis, Nurhadis Nurzamani, Salsabila Pramudya Pratama Priscinya Christiana Debora Rahmasari, Ratika Ratnasari, Devi Reas Najla Anugrah Rivandia Listi Rizky Abdul Majid Rosa Arum Rusdiawan, Fairuz Octora Aulia Rusmayanti, Agustina Saarah Hamidah Asmara Indratno Saarah Hamidah Asmara Indratno Salman Salman Saryono Sekar Andjung Tresnawati Septi, Annisa Frastica Septiani, Dia Sholih, Mally Ghinan Siti Nurazizah Aghisna Hendiana Siti Rohmah Sophy Wulandari Sudarjat, Hadi Sulastri Sulastri Syeli Syawaliyah Urbaningrum, Lestari Mahardika Vesara Ardhe Gatera Vriezka Mierza Zahra, Aliya Azkia Zahro, Aurora Fatimatuz