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All Journal Jurnal Ilmiah Farmasi Journal of Biomedicine and Translational Research Biota Jurnal Sains dan Teknologi Pangan Science and Technology Indonesia Jurnal Biologi Tropis Martabe : Jurnal Pengabdian Kepada Masyarakat Hearty : Jurnal Kesehatan Masyarakat Jurnal Kreativitas PKM Jurnal Ilmu Kefarmasian Indonesia Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Kesmas dan Gizi (JKG) Majalah Farmasetika CERATA Jurnal Ilmu Farmasi Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ners Jurnal Riset Kefarmasian Indonesia HSG (Health Science Growth) Journal Janaka : Jurnal Pengabdian Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Indobiosains EEICT (Electric, Electronic, Instrumentation, Control, Telecommunication) Jurnal Ilmiah Wahana Pendidikan Jurnal Pijar MIPA Jurnal Farmasetis Journal of Pharmaceutical and Sciences. Parapemikir Jurnal Ilmiah Farmasi Media Farmasi CERATA Jurnal Sains dan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia PharmaCine: Journal of Pharmacy, Medical and Health Science Jurnal Abdimas Mahakam
Ahsanal Kasasiah
Universitas Singaperbangsa Karawang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Effect of Mycotoxin Exposure on Stunting and Growth Impairment in Children: A Systematic Literature Review Anisa Aula Rahma; Jekmal Malau; Ahsanal Kasasiah
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.29273

Abstract

Stunting is a critical public health concern in low- and middle-income countries (LMICs), is traditionally attributed to malnutrition and environmental factors. Emerging evidence suggests that mycotoxin exposure is a risk factor. This systematic review, conducted using PRISMA guidelines, investigates the association between mycotoxin exposure and childhood stunting/growth impairment. Twelve relevant studies (predominantly cross-sectional and prospective cohorts) are identified, focusing on children aged 0-5 years in Africa and Asia. Aflatoxins (AFB1, AFM1) and fumonisins (UFB1) are the primary mycotoxins analyzed, measured through biomarkers in biological samples (blood, urine, breast milk). Aflatoxin exposure consistently demonstrates a negative impact on child growth, as evidenced by decreasing anthropometric z-scores (LAZ, WAZ, HAZ). Additionally, it significantly increases the risk of stunting and underweight. Potential mechanisms include disruption of the IGF signaling pathway, oxidative stress, impaired protein synthesis, intestinal barrier dysfunction, and nutrient malabsorption. Fumonisins, both independently and in co-exposure with aflatoxins, are also linked to growth impairment. This review highlights the detrimental effect of mycotoxin exposure on child growth. While aflatoxin exposure appears to be a major contributor, fumonisins warrant further investigation. Elucidating the underlying molecular mechanisms and exploring interactions with other risk factors are crucial next steps. Addressing mycotoxin-related stunting necessitates a multidisciplinary approach.
Konjugat Antibodi-Obat sebagai Pendekatan Pengobatan Alternatif untuk Kanker Paru Bukan Sel Kecil (NSCLC) di Tengah Peningkatan Resistensi Terapi: Tinjauan Sistematis Meisya Diffa Amalia Putri; Ahsanal Kasasiah
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.38473

Abstract

Kanker paru bukan sel kecil atau non-small cell lung cancer (NSCLC) adalah jenis kanker paru yang paling umum dan memiliki tantangan signifikan dalam pengobatan, terutama terkait dengan resistensi terhadap terapi yang ditargetkan. Resistensi ini sering disebabkan oleh mutasi sekunder atau aktivasi jalur pensinyalan alternatif, yang mengurangi efektivitas terapi yang ada. Konjugat antibodi-obat atau antibody-drug conjugate (ADC) telah muncul sebagai pendekatan terapeutik inovatif yang menjanjikan untuk mengatasi tantangan tersebut. Konjugat antibodi-obat atau antibody-drug conjugate (ADC) menggabungkan antibodi monoklonal spesifik dengan muatan aktif, memungkinkan pengiriman terapi yang lebih tepat dan mengurangi dampak pada jaringan sehat. Dalam artikel ini, kami mengeksplorasi berbagai ADC yang sedang dalam pengembangan dan telah menunjukkan efikasi sebagai alternatif terapi untuk NSCLC, termasuk BL-B01D1, trastuzumab deruxtecan, dan sacituzumab govitecan. Meskipun ADC menawarkan harapan baru, perhatian perlu diberikan pada efek samping signifikan, seperti neutropenia dan anemia, yang dapat mempengaruhi kualitas hidup pasien. Penelitian lebih lanjut diperlukan untuk mengeksplorasi efektivitas jangka panjang, biomarker yang terkait, dan strategi manajemen efek samping. Dengan pendekatan ini, ADC berpotensi menjadi bagian penting dalam strategi terapeutik untuk NSCLC.
Suplementasi Butirat dan Modulasi Epigenetik melalui Inhibisi Histon Deacetylase pada Diabetes Melitus Tipe 2: Suatu Tinjauan Naratif dengan Perspektif untuk Indonesia Ainaputri , Aliza Salsabila; Kasasiah, Ahsanal; Malau , Jekmal; Aprillia , Cantika; Siboro , Dewi Pratiwi Purba; Apriyanti , Endeh; Nugraha , Afif Tri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1301

Abstract

Type 2 diabetes mellitus is a multifactorial metabolic disorder characterized by insulin resistance, chronic inflammation, and epigenetic dysregulation. Emerging evidence indicates that butirat supplementation may improve metabolic homeostasis through histon deacetylase inhibition and modulation of gene expression involved in insulin signaling and inflammatory pathways. This review aims to evaluate preclinical and clinical evidence on the role of butirat as an epigenetic modulator in type 2 diabetes mellitus and to discuss its translational relevance, including perspectives for Indonesia. A structured literature search was conducted to identify original research articles published between 2015 and 2025. The selected studies demonstrate that butirat enhances insulin sensitivity, improves glycemic control, and attenuates inflammatory responses through increased histon acetylation. However, direct clinical evidence remains limited. In Indonesia, available data are largely derived from dietary or probiotic interventions that increase endogenous butirat production. Therefore, well designed controlled clinical trials are required to evaluate the therapeutic potential of direct butirat supplementation in populations with type 2 diabetes mellitus.
Menelusuri Perkembangan, Kondisi Terkini, dan Prospek Masa Depan Pengujian DNA dalam Aplikasi Forensik Manusia dan Non-Manusia: Tinjauan Naratif Siboro, Dewi Pratiwi Purba; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Malau, Jekmal; Aprillia, Cantika; Ainaputri, Aliza Salsabila; Nugraha, Afif Tri; Aprianti, Endeh
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1389

Abstract

DNA typing has become a cornerstone of modern forensic science, profoundly influencing criminal investigations, forensic human identification, and non-human forensic applications. Since its introduction in the mid-1980s, forensic DNA analysis has evolved from restriction fragment length polymorphism-based methods to polymerase chain reaction-based short tandem repeat profiling, and more recently to sequence-based approaches enabled by massively parallel sequencing, resulting in substantial improvements in analytical sensitivity, robustness, and discriminatory power. This narrative review aims to trace the historical development, examine the current state, and explore future directions of DNA typing in both human and non-human forensic contexts, with particular emphasis on empirical case studies from Asia. A narrative review methodology was employed through a comprehensive analysis of peer-reviewed literature published between 2015 and 2026, sourced from major scientific databases including Google Scholar, PubMed, and ScienceDirect, with studies selected based on forensic relevance, methodological rigor, and regional significance. The review highlights the extensive application of DNA typing in routine criminal casework, disaster victim identification, missing persons investigations, wildlife forensic genetics, food fraud detection, and biosecurity, and documents emerging technologies such as portable DNA systems and CRISPR-based detection. Despite these advances, significant challenges remain related to data interpretation, validation requirements, contamination control, ethical and legal governance, and uneven forensic capacity across regions. Overall, this review underscores the continuing evolution of forensic DNA typing and emphasizes the importance of standardized protocols, interdisciplinary collaboration, and region-specific validation to ensure the reliable and responsible application of DNA evidence in modern forensic science.
PENYULUHAN PENGGUNAAN OBAT RASIONAL DAN PEMANFAATAN TANAMAN OBAT KELUARGA SEBAGAI MINUMAN ALTERNATIF KESEHATAN DI DESA WARUNG BAMBU KARAWANG Indah Laily Hilmi; Ahsanal Kasasiah; Muhammad Naufal Nurhadi Hidayat; Sophy Wulandari
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 6, No 8 (2023): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v6i8.2864-2870

Abstract

Pengetahuan mengenai kesehatan sangat dibutuhkan oleh setiap orang, demi terwujudnya kehidupan yang sehat dan sejahtera. Peran tenaga kesehatan saat ini tidak lagi hanya sekedar memberikan pelayanan yang baik, tetapi juga bertugas untuk memberikan edukasi yang baik mengenai kesehatan kepada masyarakat. Penggunaan obat dan antibiotik dengan cara dan dosis yang tidak tepat menjadi salah satu permasalahan besar di masyarakat yang berdampak buruk untuk kesehatan pengguna obat tersebut. Tujuan dari kegiatan pengabdian masyarakat ini untuk mengedukasi kepada masyarakat khususnya di Desa Warung Bambu mengenai cara penggunaan obat yang tepat dan rasional serta alternatif lain dalam menghindari resistensi obat-obatan dengan menggunakan Tanaman Obat Keluarga (TOGA). Umumnya TOGA dibuat menjadi seduhan kebugaran yang dapat menjadi salah satu cara alternatif pengobatan tanpa menyebabkan resistensi karena menggunakan bahan alami, dengan cara pengolahan yang benar. Berdasarkan hasil dari pengisian kuesioner Pre-test dan Post-test yang telah dilakukan oleh peserta, didapatkan hasil peningkatan nilai yang menunjukan bahwa terdapat peningkatan pengetahuan kesehatan masyarakat di Desa Warung Bambu.
Kejadian Diare pada Balita di Desa Karyasari Kecamatan Rengasdengklok Kabupaten Karawang dan Kaitannya dengan Pemberian Susu Formula Ahsanal Kasasiah; Siti Nurazizah Aghisna Hendiana
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 1 No. 1 (2020): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v1i1.4408

Abstract

Abstrak : Diare adalah suatu keadaan pengeluaran tinja yang tidak normal/ tidak seperti biasanya. Angka kejadian dan kematian diare pada anak-anak di negara berkembang masih tinggi terutama pada anak yang mendapat susu formula, karena susu formula tidak mengandung zat antibodi serta tidak mudah dicerna oleh bayi. Penelitian ini bertujuan untuk mengetahui adakah hubungan antara pemberian susu formula dengan kejadian diare pada bayi usia 0-11 bulan di Desa Karyasari Kecamatan Rengasdengklok Kabupaten Karawang. Desain penelitian ini menggunakan rancangan kuantitatif observasional dengan menggunakan metode deskriptif analitik melalui pendekatan cross sectional. Penelitian ini akan dilakukan di Desa Karyasari Kecamatan Rengasdengklok Kabupaten Karawang. Populasi pada penelitian ini adalah seluruh data bayi yang berusia 0-11 bulan sebanyak 79 individu. Penelitan ini menggunakan sampel jenuh.jenis data yang diambil adalah data primer, teknik pengumpulan data dengan menyebar kuesioner kepada ibu yang mempunyai bayi usia 0-11 bulan, analisis data menggunakan SPSS dengan uji chi-square. Kesimpulan dari penelitian ini bahwa terdapat hubungan bermakna antara pemberian susu formula dengan kejadian diare dengan hasil p= 0,001 (p<0,05). Kata Kunci : Diare, Susu Formula, ASI
UJI RESISTENSI BAKTERI Escherichia coli DARI SUMBER AIR BAKU DI KARAWANG TERHADAP ANTIBIOTIK SIPROFLOKSASIN Diniarti, Fuji Ayu; Kasasiah, Ahsanal; Hilmi, Indah Laily
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.281

Abstract

Infectious diseases are included in the ten most common diseases in Indonesia. The disease can be overcome by the use of antimicrobials, one of which is antibiotics. Antibiotics are drugs used to treat infections caused by bacteria. Excessive use of antibiotics without clear indications can have an impact on the occurrence of bacterial resistance to these antibiotics. One of the bacteria that is resistant to antibiotics is Escherichia coli. This study aims to determine the sensitivity of Escherichia coli isolated from raw water sources in Karawang to the antibiotic ciprofloxacin. Samples were obtained from irrigation water which is the source of raw water for one branch of Perumdam in Karawang. The samples were tested using Lactose Broth (LB) media, then confirmed using Eosin Methylene Blue (EMBA) media to confirm the presence of Escherichia coli bacteria equipped with Gram stain. Bacterial resistance test was carried out using Mueller Hinton Agar (MHA) media with disc diffusion method. The results showed that the average diameter of the clear zone formed around the paper disc was 30.16 mm. The isolates showed intermediate results against the antibiotic ciprofloxacin.
Upaya Promotif dan Preventif pada Masa Pandemi Covid-19 di Karawang Aliya Azkia Zahra; Ahsanal Kasasiah; Jekmal Malau; Indah Laily Hilmi
Jurnal Abdimas Mahakam Vol. 7 No. 02 (2023): Juli
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24903/jam.v7i02.2275

Abstract

Coronavirus Disease 2019 (Covid-19) adalah penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV- 2). Angka kasus positif yang kian meningkat, terlebih lagi di Indonesia yang sudah masuk ke dalam 30 besar negara dengan angka kasus Covid-19 yang tinggi di dunia. Pemerintah sudah berupaya untuk menanggulangi situasi pandemi ini, yaitu dengan mensosialisasikan 3M (memakai masker dengan benar, menjaga jarak dan hindari kerumunan dan mencuci tangan pakai sabun). Namun angka Covid-19 di Indonesia masih terhitung tinggi. Berdasarkan data yang dipaparkan oleh satgas Covid-19, Karawang termasuk zonasi daerah dengan risiko tinggi penyebaran Covid-19. Karawang menduduki posisi ke-6 sebagai daerah zonasi risiko tinggi. Oleh karena itu, dibutuhkan kegiatan penyuluhan kepada masyarakat tentang Covid-19 dan strategi preventif menghadapi Covid-19 yang diharapkan dapat mampu meningkatkan kesadaran masyarakat terhadap bahayanya Covid-19 serta masyarakat yang berperan penting dalam memutus rantai penyebaran Covid-19 harus selalu dihimbau untuk melaksanakan protokol kesehatan 3M dan selalu menjaga kesehatan. Dengan hasil setelah dilakukan kegiatan penyuluhan terlihat terdapat peningkatan pengetahuan masyarakat sebesar 10%.
Comparative Study of World Health Organization Recommended Smallpox Vaccine to Prevent Monkeypox Reas Najla Anugrah; Ahsanal Kasasiah
JURNAL KESMAS DAN GIZI (JKG) Vol. 8 No. 2 (2026): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/0ejez036

Abstract

Background: Monkeypox is a zoonotic disease caused by the monkeypox virus (MPXV) from the Orthopoxvirus genus and has shown a global increase in cases since 2022. Currently, no specific vaccine is available; however, smallpox vaccines provide cross-protection and are recommended by the World Health Organization (WHO) for prevention. Objective: This review aims to compare the efficacy and safety of WHO-recommended smallpox vaccines (MVA-BN, LC16m8, and ACAM2000) in preventing monkeypox. Methods: This literature review searched Google Scholar and Publish or Perish with the keywords “monkeypox vaccine”, “MVA-BN,” “LC16,” “ACAM2000,” “efficacy,” and “safety.” Articles published between 2015 and 2025 were included. Of 155 identified records, 9 met the inclusion criteria and were analyzed. Results: All vaccines were effective in preventing monkeypox through humoral and cellular immune responses. MVA-BN showed the highest efficacy and best safety profile, while LC16m8 provided long-term protection with mild adverse effects. ACAM2000 was effective but associated with mild cardiovascular adverse events, limiting its use in certain populations. Conclusion: WHO-recommended smallpox vaccines are effective and relatively safe, with MVA-BN considered the most optimal option. Further development of monkeypox-specific vaccines using mRNA and DNA technologies is needed, as these platforms allow more specific antigen targeting and may enhance immune response and safety.
Integrasi Strategi Genomik Presisi dan Perspektif Etika Islam dalam Pencegahan Stunting: Fokus pada Jalur Hormon Pertumbuhan–IGF-1 Hifdzil Qur’ani; Nasywa Khoirun Nisa; Pramudya Pratama; Ahsanal Kasasiah; Jekmal Malau
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1320

Abstract

Stunting remains one of the major chronic nutritional problems in Indonesia. The national prevalence of stunting has decreased from 37.2% in 2013 to 19.8% in 2024; however, this figure is still above the World Health Organization threshold (<20%) and has not yet reached the national target of 14%. The interaction of nutritional, environmental, and genetic factors influences stunting. Genetic variations within the Growth Hormone–Insulin-like Growth Factor One pathway play a significant role in regulating linear growth in children; disruptions in this pathway can increase vulnerability to stunting. In addition, the majority of Indonesia's population adheres to Islam, making religious values a strategic potential for strengthening health interventions. This review article examines the integration of scientific approaches, focusing on genetics and Islamic values, in stunting prevention by highlighting polymorphisms in the IGF1, IGF1R, and GHR genes and their relevance to the principles of maqāsid al-sharī‘ah, particularly hifz al-nasl (protection of lineage). The analysis is conducted using a descriptive-analytical approach based on recent scientific literature and Islamic references, including the Qur’an, prophetic traditions, and scholarly exegesis. The findings indicate a strong alignment between scientific approaches and Islamic teachings, including the importance of adequate nutrition during pregnancy, exclusive breastfeeding, consumption of lawful, nutritious food, genetic screening efforts consistent with the values of divine decree, and vitamin D supplementation to support Insulin-like Growth Factor One levels. This integration has the potential to enhance community acceptance of stunting-prevention programs, strengthen moral and spiritual motivation, and support the achievement of national stunting-reduction targets. Thus, an approach that combines precise genomics and Islamic values may serve as a contextual and sustainable strategy in shaping a generation that is healthy, intelligent, and spiritually resilient.
Co-Authors Adi Pancoro Adinda Christianti Suparno Adrian Hartanto, Adrian Aida, Fitri Ainaputri, Aliza Salsabila Aliya Azkia Zahra Anisa Aula Rahma Anisa Aula Rahma Annajla, Fathina Aprianti, Endeh Aprillia , Cantika Aprillia, Cantika Apriyanti , Endeh Asman Hitopik Astika, Eriyanti Cartas Cartas Dadang Sumardi Damara, Dandy Satria Daniel Joko Wahyono Devi - Ratnasari Devi Ratnasari Devi Ratnasari Dinda Nugrahan Diniarti, Fuji Ayu Eriyanti Astika Fika Setra Rikantara Fikri, Al Mukhlas Fuji Ayu Diniarti Hasna, Vina Luthfiana Hendiana, Siti Nurazizah Aghisna Hermosaningtyas, Anastasia Aliesa Hifdzil Qur’ani Hitopik, Asman Indah Laily Indah Laily Hilmi Indratno, Saarah Hamidah Asmara insani abadi bangsa Irgi, Khaeru Irwansyah, Silvana Lestari Jekmal Malau Jekmal Malau Jekmal Malau Lely Sulfiani Saula Lestari, Agatha Nabilla Malau , Jekmal Mally G Sholih Mally Ghinan Sholih Manalu, Rosario Trijuliamos Marsah Rahmawati Utami Meilani, Nanda Diva Meisya Diffa Amalia Putri Meliana Sari, Meliana Muhammad Naufal Nurhadi Hidayat Muhareva Raekiansyah Nabila Rubinadzari Nasywa Khoirun Nisa Nugraha , Afif Tri Nugraha, Afif Tri Nur Khafipah Nur Komala Fitri Nuraeni Putri Nurhadis, Nurhadis Nurzamani, Salsabila Pramudya Pratama Priscinya Christiana Debora Rahmasari, Ratika Ratnasari, Devi Reas Najla Anugrah Rivandia Listi Rizky Abdul Majid Rosa Arum Rusdiawan, Fairuz Octora Aulia Rusmayanti, Agustina Saarah Hamidah Asmara Indratno Salman Salman Saryono Sekar Andjung Tresnawati Septi, Annisa Frastica Septiani, Dia Sholih, Mally Ghinan Siboro , Dewi Pratiwi Purba Siboro, Dewi Pratiwi Purba Siti Nurazizah Aghisna Hendiana Siti Rohmah Sophy Wulandari Sudarjat, Hadi Sulastri Sulastri Syeli Syawaliyah Urbaningrum, Lestari Mahardika Vesara Ardhe Gatera Zahra, Aliya Azkia Zahro, Aurora Fatimatuz