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All Journal Jurnal Ilmiah Farmasi Journal of Biomedicine and Translational Research Biota Jurnal Sains dan Teknologi Pangan Science and Technology Indonesia Jurnal Biologi Tropis Martabe : Jurnal Pengabdian Kepada Masyarakat Hearty : Jurnal Kesehatan Masyarakat Jurnal Kreativitas PKM Jurnal Ilmu Kefarmasian Indonesia Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Abdimas Mahakam Majalah Farmasetika CERATA Jurnal Ilmu Farmasi Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ners Jurnal Riset Kefarmasian Indonesia HSG (Health Science Growth) Journal Janaka : Jurnal Pengabdian Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Indobiosains EEICT (Electric, Electronic, Instrumentation, Control, Telecommunication) Jurnal Ilmiah Wahana Pendidikan Jurnal Pijar MIPA Jurnal Farmasetis Journal of Pharmaceutical and Sciences. Parapemikir Jurnal Ilmiah Farmasi Media Farmasi CERATA Jurnal Sains dan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Ahsanal Kasasiah
Universitas Singaperbangsa Karawang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Factors Associated with FMT Failure in Clostridioides difficile Infection and Age-Related Considerations: A Review Irgi, Khaeru; Kasasiah, Ahsanal; Rusmayanti, Agustina
Jurnal Pijar Mipa Vol. 20 No. 8 (2025): Special Issue
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i8.10558

Abstract

Clostridioides difficile infection (CDI) is a major cause of nosocomial diarrhea worldwide, and limitations of standard antibiotic therapy have driven the adoption of fecal microbiota transplantation (FMT) as an alternative therapeutic approach. Although FMT achieves clinical success in most patients, treatment failure still occurs in a considerable proportion of cases. Existing literature has examined overall FMT efficacy, yet no review has comprehensively synthesized the multifactorial determinants of FMT failure while incorporating age-related considerations. This narrative review provides an integrative overview of factors contributing to FMT failure in adults with CDI. A literature search of PubMed and Google Scholar identified original research articles published between 2015 and 2025. Evidence indicates that FMT failure is influenced by host-related factors such as comorbidities, immune function, and nutritional status; disease-related characteristics, including CDI severity and recurrence history; technical aspects, such as bowel preparation, donor type, and route of administration; and pharmacological factors, including antibiotic exposure before or after the procedure. These factors collectively affect donor microbiota engraftment and increase the risk of therapeutic failure. Age-related physiological and microbiome changes may additionally modify treatment responses. This review highlights the need for comprehensive patient assessment, standardized procedural protocols, and careful post-FMT monitoring. Addressing current evidence gaps and improving clinical guidance will be essential for optimizing the safety and effectiveness of FMT across different adult age groups.
Narrative Review: The Effect of Inulin on the Growth of Bifidobacterium in the Human Intestine Nurzamani, Salsabila; Kasasiah, Ahsanal
Jurnal Biologi Tropis Vol. 25 No. 4b (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4b.10754

Abstract

Bifidobacterium is an important probiotic bacterium that plays a key role in maintaining gut microbiota balance and supporting digestive health. Inulin has been widely studied as a prebiotic due to its ability to stimulate the growth of Bifidobacterium through fermentation in the colon. This study aims to summarize recent scientific evidence regarding the effects of inulin supplementation on the increase of Bifidobacterium populations in humans. This study aims to summarize recent scientific evidence regarding the effects of inulin supplementation on the increase of Bifidobacterium populations in humans. This article was prepared using a narrative review method based on literature searches conducted in PubMed, ScienceDirect, ClinicalKey, and Google Scholar. A total of nine original research articles that directly reported the effects of inulin supplementation were included. The findings consistently show that inulin increases the abundance of Bifidobacterium, improves gut microbiota balance, and enhances the production of short-chain fatty acids (SCFAs) such as acetate, butyrate, and propionate. These changes are also associated with improvements in metabolic markers among several populations, including obese children, prediabetic patients, and individuals with PCOS. Overall, inulin demonstrates strong bifidogenic effects, although individual responses may vary depending on dosage, duration of intervention, and physiological conditions.
Effect of Mycotoxin Exposure on Stunting and Growth Impairment in Children: A Systematic Literature Review Anisa Aula Rahma; Jekmal Malau; Ahsanal Kasasiah
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.29273

Abstract

Stunting is a critical public health concern in low- and middle-income countries (LMICs), is traditionally attributed to malnutrition and environmental factors. Emerging evidence suggests that mycotoxin exposure is a risk factor. This systematic review, conducted using PRISMA guidelines, investigates the association between mycotoxin exposure and childhood stunting/growth impairment. Twelve relevant studies (predominantly cross-sectional and prospective cohorts) are identified, focusing on children aged 0-5 years in Africa and Asia. Aflatoxins (AFB1, AFM1) and fumonisins (UFB1) are the primary mycotoxins analyzed, measured through biomarkers in biological samples (blood, urine, breast milk). Aflatoxin exposure consistently demonstrates a negative impact on child growth, as evidenced by decreasing anthropometric z-scores (LAZ, WAZ, HAZ). Additionally, it significantly increases the risk of stunting and underweight. Potential mechanisms include disruption of the IGF signaling pathway, oxidative stress, impaired protein synthesis, intestinal barrier dysfunction, and nutrient malabsorption. Fumonisins, both independently and in co-exposure with aflatoxins, are also linked to growth impairment. This review highlights the detrimental effect of mycotoxin exposure on child growth. While aflatoxin exposure appears to be a major contributor, fumonisins warrant further investigation. Elucidating the underlying molecular mechanisms and exploring interactions with other risk factors are crucial next steps. Addressing mycotoxin-related stunting necessitates a multidisciplinary approach.
Konjugat Antibodi-Obat sebagai Pendekatan Pengobatan Alternatif untuk Kanker Paru Bukan Sel Kecil (NSCLC) di Tengah Peningkatan Resistensi Terapi: Tinjauan Sistematis Meisya Diffa Amalia Putri; Ahsanal Kasasiah
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.38473

Abstract

Kanker paru bukan sel kecil atau non-small cell lung cancer (NSCLC) adalah jenis kanker paru yang paling umum dan memiliki tantangan signifikan dalam pengobatan, terutama terkait dengan resistensi terhadap terapi yang ditargetkan. Resistensi ini sering disebabkan oleh mutasi sekunder atau aktivasi jalur pensinyalan alternatif, yang mengurangi efektivitas terapi yang ada. Konjugat antibodi-obat atau antibody-drug conjugate (ADC) telah muncul sebagai pendekatan terapeutik inovatif yang menjanjikan untuk mengatasi tantangan tersebut. Konjugat antibodi-obat atau antibody-drug conjugate (ADC) menggabungkan antibodi monoklonal spesifik dengan muatan aktif, memungkinkan pengiriman terapi yang lebih tepat dan mengurangi dampak pada jaringan sehat. Dalam artikel ini, kami mengeksplorasi berbagai ADC yang sedang dalam pengembangan dan telah menunjukkan efikasi sebagai alternatif terapi untuk NSCLC, termasuk BL-B01D1, trastuzumab deruxtecan, dan sacituzumab govitecan. Meskipun ADC menawarkan harapan baru, perhatian perlu diberikan pada efek samping signifikan, seperti neutropenia dan anemia, yang dapat mempengaruhi kualitas hidup pasien. Penelitian lebih lanjut diperlukan untuk mengeksplorasi efektivitas jangka panjang, biomarker yang terkait, dan strategi manajemen efek samping. Dengan pendekatan ini, ADC berpotensi menjadi bagian penting dalam strategi terapeutik untuk NSCLC.
Suplementasi Butirat dan Modulasi Epigenetik melalui Inhibisi Histon Deacetylase pada Diabetes Melitus Tipe 2: Suatu Tinjauan Naratif dengan Perspektif untuk Indonesia Ainaputri , Aliza Salsabila; Kasasiah, Ahsanal; Malau , Jekmal; Aprillia , Cantika; Siboro , Dewi Pratiwi Purba; Apriyanti , Endeh; Nugraha , Afif Tri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1301

Abstract

Type 2 diabetes mellitus is a multifactorial metabolic disorder characterized by insulin resistance, chronic inflammation, and epigenetic dysregulation. Emerging evidence indicates that butirat supplementation may improve metabolic homeostasis through histon deacetylase inhibition and modulation of gene expression involved in insulin signaling and inflammatory pathways. This review aims to evaluate preclinical and clinical evidence on the role of butirat as an epigenetic modulator in type 2 diabetes mellitus and to discuss its translational relevance, including perspectives for Indonesia. A structured literature search was conducted to identify original research articles published between 2015 and 2025. The selected studies demonstrate that butirat enhances insulin sensitivity, improves glycemic control, and attenuates inflammatory responses through increased histon acetylation. However, direct clinical evidence remains limited. In Indonesia, available data are largely derived from dietary or probiotic interventions that increase endogenous butirat production. Therefore, well designed controlled clinical trials are required to evaluate the therapeutic potential of direct butirat supplementation in populations with type 2 diabetes mellitus.
Menelusuri Perkembangan, Kondisi Terkini, dan Prospek Masa Depan Pengujian DNA dalam Aplikasi Forensik Manusia dan Non-Manusia: Tinjauan Naratif Siboro, Dewi Pratiwi Purba; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Malau, Jekmal; Aprillia, Cantika; Ainaputri, Aliza Salsabila; Nugraha, Afif Tri; Aprianti, Endeh
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1389

Abstract

DNA typing has become a cornerstone of modern forensic science, profoundly influencing criminal investigations, forensic human identification, and non-human forensic applications. Since its introduction in the mid-1980s, forensic DNA analysis has evolved from restriction fragment length polymorphism-based methods to polymerase chain reaction-based short tandem repeat profiling, and more recently to sequence-based approaches enabled by massively parallel sequencing, resulting in substantial improvements in analytical sensitivity, robustness, and discriminatory power. This narrative review aims to trace the historical development, examine the current state, and explore future directions of DNA typing in both human and non-human forensic contexts, with particular emphasis on empirical case studies from Asia. A narrative review methodology was employed through a comprehensive analysis of peer-reviewed literature published between 2015 and 2026, sourced from major scientific databases including Google Scholar, PubMed, and ScienceDirect, with studies selected based on forensic relevance, methodological rigor, and regional significance. The review highlights the extensive application of DNA typing in routine criminal casework, disaster victim identification, missing persons investigations, wildlife forensic genetics, food fraud detection, and biosecurity, and documents emerging technologies such as portable DNA systems and CRISPR-based detection. Despite these advances, significant challenges remain related to data interpretation, validation requirements, contamination control, ethical and legal governance, and uneven forensic capacity across regions. Overall, this review underscores the continuing evolution of forensic DNA typing and emphasizes the importance of standardized protocols, interdisciplinary collaboration, and region-specific validation to ensure the reliable and responsible application of DNA evidence in modern forensic science.
Co-Authors Adi Pancoro Adinda Christianti Suparno Adrian Hartanto, Adrian Aida, Fitri Ainaputri , Aliza Salsabila Ainaputri, Aliza Salsabila Aliya Azkia Zahra Anisa Aula Rahma Anisa Aula Rahma Annajla, Fathina Aprianti, Endeh Aprillia , Cantika Aprillia, Cantika Apriyanti , Endeh Asman Hitopik Astika, Eriyanti Cartas Cartas Dadang Sumardi Damara, Dandy Satria Daniel Joko Wahyono Devi - Ratnasari Devi Ratnasari Devi Ratnasari Dinda Nugrahan Eriyanti Astika Fika Setra Rikantara Fikri, Al Mukhlas Fuji Ayu Diniarti Hasna, Vina Luthfiana Hendiana, Siti Nurazizah Aghisna Hermosaningtyas, Anastasia Aliesa Hitopik, Asman Indah Laily Indah Laily Hilmi Indratno, Saarah Hamidah Asmara insani abadi bangsa Irgi, Khaeru Irwansyah, Silvana Lestari Jekmal Malau Jekmal Malau Lely Sulfiani Saula Lestari, Agatha Nabilla Malau , Jekmal Mally G Sholih Mally Ghinan Sholih Manalu, Rosario Trijuliamos Marsah Rahmawati Utami Meilani, Nanda Diva Meisya Diffa Amalia Putri Meliana Sari, Meliana Muhammad Naufal Nurhadi Hidayat Muhareva Raekiansyah Nabila Rubinadzari Nugraha , Afif Tri Nugraha, Afif Tri Nur Khafipah Nur Komala Fitri Nuraeni Putri Nurhadis, Nurhadis Nurzamani, Salsabila Priscinya Christiana Debora Rahmasari, Ratika Ratnasari, Devi Rivandia Listi Rizky Abdul Majid Rosa Arum Rusdiawan, Fairuz Octora Aulia Rusmayanti, Agustina Saarah Hamidah Asmara Indratno Salman Salman Saryono Sekar Andjung Tresnawati Septi, Annisa Frastica Septiani, Dia Sholih, Mally Ghinan Siboro , Dewi Pratiwi Purba Siboro, Dewi Pratiwi Purba Siti Rohmah Sophy Wulandari Sudarjat, Hadi Sulastri Sulastri Syeli Syawaliyah Urbaningrum, Lestari Mahardika Vesara Ardhe Gatera Zahra, Aliya Azkia Zahro, Aurora Fatimatuz