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All Journal Jurnal Farmasi Udayana Farmaka Jurnal Matematika & Sains Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Jurnal Kimia Riset Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) JURNAL FARMASI GALENIKA Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Pada Masyarakat International Journal of Health and Medicine
Ellin Febrina
Fakultas Farmasi Universitas Padjadjaran, Bandung
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Shallot (Allium ascalonicum): An overview of antidiabetic activity by α-glucosidase inhibition Ramadaini, Tiara; Sumiwi, Sri Adi; Febrina, Ellin
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.52104

Abstract

Allium ascalonicum (shallot) is a medicinal plant with promising potential in the management of type 2 diabetes mellitus (T2DM). This review summarizes the phytochemical constituents, mechanisms of action, and existing research gaps that warrant further exploration for targeted drug development. A systematic literature search was performed using PubMed, ScienceDirect, and Google Scholar to identify relevant studies published between 2013 and 2023. Only full-text original research articles in English were included, while reviews and incomplete studies were excluded. The search strategy employed the keywords: “Allium ascalonicum OR shallot AND α-glucosidase.” The findings indicate that A. ascalonicum demonstrates significant antidiabetic activity across in vitro, in vivo, and limited human studies, primarily through inhibition of the α-glucosidase enzyme. This activity is largely attributed to quercetin and other flavonoid compounds, which play an essential role in reducing blood glucose levels and mitigating oxidative stress. Collectively, the evidence highlights the therapeutic potential of A. ascalonicum as a natural α-glucosidase inhibitor. However, further clinical investigations and comprehensive toxicity assessments are required to establish its efficacy and safety as a standardized herbal medicine and future phytopharmaceutical candidate for diabetes management.
Review: Single Chain Fragment Variable sebagai Pemandu Diagnosis dan Terapi Bertarget Human Epidermal Growth Factor Receptor 2 Kanker Payudara Priskila, Miranda; Febrina, Ellin
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 2 (2023): J Sains Farm Klin 10(2), Agustus 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.2.155-161.2023

Abstract

Single chain fragment variable (scFv) merupakan antibodi rekombinan yang terdiri dari bagian fragmen antigen-binding (Fab) antibodi dengan ukuran sangat kecil sekitar 26 -27 kDa. Secara umum scFv bersifat stabil ,dikode oleh satu gen sehingga akan mempermudah modifikasi genetik. Dibandingkan dengan antibodi lengkap, scFv yang memiliki aktivitas pengikatan antigen yang serupa memiliki kelebihan lain diantaranya adalah ukurannya yang kecil, penetrasi ke pembuluh darah dan jaringan yang lebih baik, serta imunogenisitas yang lebih rendah. Oleh karena itu, scFv memiliki potensi yang sangat baik untuk digunakan sebagai senyawa pemandu diagnosis maupun terapi penyakit. Hasil dari berbagai penelitian menunjukkan scFv anti-HER2 (Human Epidermal Growth Factor Receptor 2) dapat digunakan sebagai pemandu pada diagnosis kanker payudara HER2+ baik menggunakan Magnetic Resonance Imaging (MRI) ataupun positron-emission tomography (PET). Pada terapi kanker payudara bertarget reseptor HER2, scFv anti HER2 juga memiliki potensi digunakan sebagai pemandu untuk imunotoksin, antibody drug conjugate (ADC), prodrug, dan pretargeted radioimmunotherapy (PRIT).
Molecular Docking and Molecular Dynamics Study of Phlorotannin-Derived Metabolites from Brown Macroalgae (Sargassum sp.) as Potential α-Amylase Inhibitors Asnawi, Aiyi; Silviana, Lilis; Andriansyah, Ivan; Kurnia, Dewi; Febrina, Ellin; Dinata, Deden Indra
Jurnal Kimia Riset Vol. 10 No. 2 (2025): December
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkimris.v10i2.75900

Abstract

Type 2 diabetes mellitus (T2DM) is a widespread global health issue, characterized by insulin resistance and impaired a-amylase activity—an enzyme essential for carbohydrate metabolism. Phenolic compounds derived from brown macroalgae have been identified as potential a-amylase inhibitors and are promising candidates for the development of novel antidiabetic agents. This study aimed to explore the molecular interactions between phlorotannin-derived metabolites from Sargassum sp. and the α-amylase enzyme (PDB ID: 1B2Y) through in silico approaches, including molecular docking and molecular dynamics simulations. Molecular docking was performed using AutoDock 4.2, followed by molecular dynamics (MD) simulations using GROMACS to assess the stability of the ligand–enzyme complexes. The results revealed that dieckol (S06) and 6,6′-bieckol (S07) showed the strongest binding affinity with a docking score of -9.57 and -8.95 kcal/mol, respectively and the most favorable binding free energy (ΔTOTAL -56.87 kcal/mol), suggesting its strong potential for stable interaction with the enzyme. These results highlight the potential of dieckol and 6,6′-bieckol as effective α-amylase inhibitors.
Co-Authors Abdurahman Ridho Achmad Zaenudin Ade Zuhrotun Aiyi Asnawi Aiyi Asnawi Aiyi Asnawi Aligita, Widhya Aliya Nur Hasanah Alma Yunita Sari Aminah Nurhadiyah Anas Subarnas Andriansyah, Ivan Annisa Desy Aryanti Arfan Arfan Daffa Anjabtsawa Dana Nasrullah Deden Indra Dinata, Deden Indra Destiani, Dika P. Dewi Kurnia Dika Destiani Dika P. Destiani Eki Pratidina Eli Halimah Eli Halimah, Eli Erli Berlianti Etika Emaliyawati Farizan Nur Fazrina Fauzan Zein Mutaqin Fikri Nazaruddin Ghozaly, Muchammad R. Gofarana Wilar Herawati, Irma E. Iceu Mulyati Indah Suasani Wahyuni Irma Erika Herawati Irma M. Puspitasari, Irma M. Irma Melyani Puspitasari Ivan Andriansyah Jutti Levita MEGA HIJRIAWATI Muchammad R. Ghozaly Mutakin Mutakin Mutakin Mutakin Naja, Syahrul Nur Intan Hayati Husnul Khotimah Nurhadiyah, Aminah Nursamsiar Nursamsiar Pradipta, Ivan S. Priskila, Miranda PUTY PRIANTI NOVIRA Ramadaini, Tiara Ratnawati, Rani Renny Amelia Ridwan, Muhammad H. Rini Hendriani Rusdianto, Aziiz M. Silviana, Lilis Sitti Rahmi Soni Muhsinin Sri Adi Sumiwi Sriwidodo Sriwidodo Sumiwi, Sri A. Syadiah, Ami Rahmati Syahrul Naja TIANA MILANDA Untung Sudharmono Wahyuni, Indah S. Widhya Aligita Yasmiwar Susilawati Yulianti Anjayani Yuliantini, Anne Zaenudin, Achmad Zulfa, Aulia