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All Journal Jurnal Farmasi Udayana Farmaka Jurnal Matematika & Sains Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Jurnal Kimia Riset Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) JURNAL FARMASI GALENIKA Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Pada Masyarakat International Journal of Health and Medicine

Ellin Febrina

Fakultas Farmasi Universitas Padjadjaran, Bandung

Author-ID : 259157

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METODE SPEKTROSKOPI ATR-FTIR TANDEM PCA UNTUK MENDETEKSI KOPI ROBUSTA SEBAGAI ADULTERAN DALAM SEDIAAN KOPI ARABIKA TORAJA KOMERSIAL Aiyi Asnawi; Erli Berlianti; Ellin Febrina; Nursamsiar Nursamsiar; Sitti Rahmi; Ivan Andriansyah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Toraja arabica coffee is well known for its higher price and quality compared to robusta coffee, but its commercial is often added with other ingredients, including robusta coffee which has low economic value. Visual inspection is unreliable in roasted ground coffee due to the resemblance of its chemical content. The ATR-FTIR method tandem PCA was able to provide an overview of the typical chemical content of the coffee preparation. The purpose of this study was to evaluate the robusta coffee as adulterant in Toraja arabica coffee preparation by using ATR-FTIR. Toraja arabica coffee beans were obtained from three smallholder plantations around Toraja and Robusta coffee beans were obtained from Toraja, Lampung, and West Java coffee plantations. The coffee beans were roasted and then macerated using 96% ethanol for 3Ãƒâ€”24 hours and concentrated using a rotary evaporator until being thick. The IR spectrum of each extract was measured using the ATR-FTIR spectroscopy at a range of 4000-650 cm-1. The results show there is a similarity in the IR spectrum patterns and there is only a small difference in the transmittance of Toraja arabica coffee and robusta coffee. Furthermore, the IR spectrum is clustered by using PCA in R program. The projection of three commercial samples shows that samples 1 and 2 do not contain robusta coffee while sample 3 shows the presence of robusta coffee. In conclusion, the ATR-FTIR spectroscopic method tandem PCA was able to clustered the presence or absence of robusta coffee content in the Toraja arabica coffee.

Binding Modes of Doxorubicin Compared to Estratetrol and Tamoxifen Muchammad R. Ghozaly; Ellin Febrina; Achmad Zaenudin
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Doxorubicin, a compound isolated from Streptomyces peucetius var Caesius, is commonlyused in the treatment of breast cancer. This drug works by interacting on human nucleicacids. This work was aimed to study the binding modes of doxorubicin with estrogen receptoralpha (ERα). Estratetrol and tamoxifen were used as natural ligand and standard drug,respectively. Molecular docking simulations was performed by AutoDock v.3.05 using minimumcoordinates -34, -6, -15 (x, y, z) and the maximum coordinates -13, 13, 3 (x, y, z).Tamoxifen formed one hydrogen bond with Glu353 (Ki=3.78 μM); estratetrol binds to Glu-353, Arg394, Gly521, and His524 (Ki=0.01 μM). Doxorubicin only formed one hydrogenbond with Ser317 (Ki=N/A). In conclusion, doxorubicin could not interact appropriatelywith ERα due to its voluminioues structure which hinder its entrance to binding pocket ofthe macromolecule.Keywords: doxorubicin, estrogen receptor alpha.

PENDIDIKAN KESEHATAN DENGAN METODE HYBRID TENTANG COVID-19 DAN PENYAKIT HIPERTENSI PADA KADER PKK DESA CIKIDANG KECAMATAN LEMBANG Jutti Levita; Sri Adi Sumiwi; Mutakin Mutakin; Tiana Milanda; Irma Melyani Puspitasari; Sriwidodo Sriwidodo; Ellin Febrina; Yasmiwar Susilawati; Indah Suasani Wahyuni; Irma Erika Herawati; Renny Amelia; Gofarana Wilar
Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Vol 11, No 2 (2022): Juni. 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v11i2.34927

Kegiatan Pengabdian Kepada Masyarakat (PPM) di Desa Cikidang sudah dilaksanakan selama tiga tahun berturut-turut. Masyarakat berpartisipasi sangat baik dan menginginkan kegiatan dapat dilakukan secara kontinu serta melibatkan masyarakat yang lebih luas. Desa Cikidang belum memiliki sarana kesehatan dan lokasi Puskesmas terdekat adalah di Desa Cikole, berjarak 3,5 km. Berdasarkan data dari Puskesmas Cikole periode tahun 2019, tercatat bahwa penyakit hipertensi memiliki angka kejadian tertinggi yaitu 135 kejadian. Kegiatan PPM ini bertujuan untuk meningkatkan pemahaman kader PKK tentang penyakit hipertensi dan juga tentang COVID-19. Kegiatan dilakukan dengan menerapkan metode hybrid luring dan daring (gabungan sinkronus dan asinkronus menggunakan media leaflet dan video). Dari sejumlah enam puluh undangan yang disebarkan, kegiatan PPM dihadiri oleh tiga puluh lima peserta. Hasil pre-test dan post-test menunjukkan adanya peningkatan pengetahuan peserta, sehingga dapat disimpulkan bahwa pendidikan kesehatan secara hybrid berhasil meningkatkan pengetahuan kader PKK tentang COVID-19 dan Penyakit Hipertensi sebesar 13,56%.Â

Peningkatan Kesiapsiagaan Kader PKK Cibiru Wetan untuk Ketahanan Bencana di Masa Pandemi COVID-19 Nur Intan Hayati Husnul Khotimah; Fauzan Zein Mutaqin; Soni Muhsinin; Widhya Aligita; Eki Pratidina; Iceu Mulyati; Yulianti Anjayani; Untung Sudharmono; Etika Emaliyawati; Ellin Febrina; Aiyi Asnawi
Jurnal Pengabdian Pada Masyarakat Vol 7 No 2 (2022): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

IMPROVİNG THE PREPAREDNESS OF CİBİRU WETAN PKK CADRES FOR DİSASTER RESİLİENCE DURİNG THE COVİD-19 PANDEMİC. Cibiru is a high-risk area for natural and man-made disasters, so efforts must be made to reduce the risk of disaster impacts. One effort that can be made is to strengthen the Cibiru Wetan village's resilience by increasing preparedness to deal with emergency cases caused by disasters, such as cases of respiratory arrest, cardiac arrest, trauma, and respiratory emergencies caused by COVID-19. Community service is performed to improve the preparedness of Cibiru Wetan PKK cadres for disaster-resilient village resilience during the COVID-19 Pandemic. The method of implementing community service by simulating basic life support, trauma event handling, prevention and handling of COVID-19 emergencies, and the production of health drinks made from natural ingredients such as ginger, honey, lime, cardamom, and turmeric to boost immunity. As a result, the Cibiru Wetan PKK cadres were able to simulate basic life support, first aid in the event of trauma, and respiratory disorders caused by COVID-19, as well as process natural ingredients into healthy drinks to increase immunity, thereby increasing the Cibiru Wetan village's resilience.

Potensi Senyawa Aktif Tanaman Herbal untuk Pengobatan Kanker Payudara dengan Metode Penambatan Molekuler: Review Artikel Alma Yunita Sari; Ellin Febrina
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p04

Breast cancer is one of the leading causes of death in women worldwide. Breast cancer can be triggered due to physical, chemical, environmental factors and can be passed down from generation to generation through genetics. Therefore, recently, studies have been intensively conducted on the use of medicinal plants for the treatment of breast cancer as an alternative because they have minimal side effects compared to other chemotherapy. This review aims to describe medicinal plants and their active compounds that have the potential as anticancer therapy which has been carried out in silico studies with molecular anchoring methods. The method used in writing this article is a literature review both nationally and internationally over the last five years using the keywords breast cancer, molecular docking, herbal plants, anticancer, in databases such as PubMed, Cochrane, and Google Scholar. Herbal plants in in silico research that have high potential for further research as cancer therapy include 33 herbal plants with different active compounds and protein targets.

Review Artikel: Spironolakton Sebagai Obat Off-Label Untuk Jerawat Pada Wanita Dewasa Zulfa, Aulia; Febrina, Ellin
Farmaka Vol 21, No 3 (2023): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v21i3.47905

Jerawat merupakan penyakit kulit yang umum terjadi pada remaja dan dewasa. Jerawat dewasa dapat berupa jerawat persisten (jerawat dari sejak remaja) atau onset (jerawat muncul >25 tahun). Prevalensi jerawat dewasa paling banyak terjadi pada wanita dibandingkan laki-laki. Peningkatan produksi sebum menjadi salah satu faktor terjadinya jerawat. Spironolakton sebagai obat anti-adrenergik memiliki efek antagonis reseptor androgen dengan mekanisme inhibisi reseptor androgen secara kompetitif dengan dihidrotestosteron untuk menurunkan produksi sebum. Penggunaan spironolakton untuk jerawat masih tergolong obat off-label. Obat off-label merupakan obat yang digunakan untuk pengobatan gejala klinis tetapi tidak sesuai dengan informasi obat yang disetujui oleh Food and Drug Administration (FDA) atau Badan POM. Penulisan artikel ini bertujuan untuk mengetahui efektifitas dan rentang dosis bagi spironolakton untuk terapi jerawat pada pasien Wanita dewasa. Artikel ini berupa kajian naratif dengan menggunakan database SpringerLink, PubMed dan ScienceDirect dengan kata kunci spironolactone dan acne dari 2013-2023. Hasilnya, beberapa penelitian menunjukkan bahwa spironolakton efektif dan dapat memberikan perbaikan klinis pada jerawat dengan pemberian dosis rendah (50-100 mg/hari). Pematauan serum kalium juga diperlukan untuk menjegah terjadinya efek samping hiperkalemia.

The Health Profile of Students and Teachers in Madrasah Al Ihsan, Kecamatan Ciparay, Kabupaten Bandung Febrina, Ellin; Herawati, Irma E.; Wahyuni, Indah S.; Rusdianto, Aziiz M.; Hendriani, Rini; Puspitasari, Irma M.; Mutakin, Mutakin; Halimah, Eli; Sumiwi, Sri A.; Levita, Jutti
Pharmacology and Clinical Pharmacy Research Vol 9, No 2 (2024)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v9i2.51203

The prevalence of diabetes mellitus and hypertension in Indonesia is increasing both in low- and high-income communities. Therefore, health awareness should be started from a younger age for the prospective future generation. This study, included in a community engagement activity, aims to assess the health profile, in terms of blood pressure (BP) and total cholesterol, of the students (by cross-sectional method) and teachers (by cohort method) of a private madrasah in the rural area of Kecamatan Ciparay, Kabupaten Bandung, West Java. 54 students and 10 teachers participated in this study. Results revealed that the students' average systolic and diastolic BP were 120.23 mmHg and 78.67 mmHg, respectively. The average systolic BP of the teachers in August 2021, January 2022, and August 2022 was 136.8 mmHg, 128.1 mmHg, and 131.9 mmHg, respectively. The average diastolic BP of the teachers in August 2021, January 2022, and August 2022 were 91.6 mmHg, 87.3 mmHg, and 87.1 mmHg, respectively. Moreover, the average cholesterol levels of the students (148.38 mg/dL) and the teachers (190.81 mg/dL) were categorized as normal. Taken together, the health profile of the students and the teachers in Madrasah Al Ihsan is within the normal range. This activity gets positive support from the school and needs sustainability.

Review Neutrophil Gelatinase-Associated Lipocalin (NGAL): Perannya sebagai Biomarker pada Kerusakan Ginjal Akut Syadiah, Ami Rahmati; Febrina, Ellin; Levita, Jutti
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 1 (2021): J Sains Farm Klin 8(1), April 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.1.35-42.2021

Kerusakan ginjal akut merupakan penyakit yang berisiko tinggi menyebabkan pasien kritis hingga kematian, membutuhkan diagnosis yang cepat dalam penanganannya. Saat ini pendeteksian penyakit kerusakan ginjal akut masih terbatas dan belum dilakukan secara umum untuk dijadikan standar biomarker yang cepat dan tepat. Neutrophil gelatinase-associated lipocalin (NGAL) merupakan protein lipocalin 25 kDa yang terdapat pada sel epitel ginjal dan hati. NGAL dapat merespon langsung terjadinya kerusakan pada sel tubular epitel, ditandai dengan meningkatnya NGAL dalam urin dan plasma, sehingga NGAL dapat dijadikan penanda kerusakan ginjal akut dengan cepat dengan sensitivitas dan spesifisitas tinggi. Metode yang digunakan dalam review artikel ini menggunakan penelusuran melalui PubMed. Tujuan review artikel ini adalah untuk menunjukkan bahwa NGAL dapat dijadikan penanda gagal ginjal akut yang cepat dan sensitif.Kata Kunci: Kerusakan ginjal akut; biomarker NGAL; pengujian NGAL; sensitivitas; selektfitas.

Penambatan Molekul dan Dinamika Molekul beberapa Fitokimia dari Acalypha Indica L. sebagai Inhibitor Matriks Metalloproteinase9 Asnawi, Aiyi; Febrina, Ellin; Aligita, Widhya; Yuliantini, Anne; Arfan, Arfan
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 1 (2023): J Sains Farm Klin 10(1), April 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.1.62-70.2023

Berbagai efek farmakologis telah dikaji terhadap ekstrak dan islolat dari Acalypha Indica L. terutama terkait dengan aktifitas anti kanker. Matrix metalloproteinases MMP9 merupakan contoh yang sangat baik dari kelompok proteinase terpenting yang terlibat dalam sel metastatic/kanker. MMP9 telah dikaitkan dengan berbagai macam penyakit, termasuk sistem pernapasan, sistem autoimun, dan bahkan kanker. Maka dari itu, makalah ini bertujuan untuk mendapatkan senyawa pemandu dari beberapa fitokimia Acalypha Indica L. yang bertanggung jawab dalam migrasi sel dengan menggunakan penambatan molekul dan dinamika molekul. Ligan ditambatkan ke situs aktif struktur kristal MMP9 (PDB ID: 5UE4) menggunakan aplikasi AutoDock Release 4.2.6. Proses penambatan molekul divalidasi dengan melakukan penambatan ulang ligan alami pada sisi aktif MMP9. Selanjutnya, menggunakan GROMACS dilakukan simulasi dinamika molekul (MD) ditandem dengan algoritma gmx_MMGBSA dan gmx_MMGBSA_ana untuk menghitung energi ikatan dan kontribusi residu terhadap terhadap kestabilan kompleks. Hasil menunjukkan hanya satu ligan dari 36 ligan yang dievaluasi tidak mampu berikatan dengan sisi aktif MMP9, dan enam dari ligan mampu mengikatnya lebih negatif daripada ligan alami. Kompleks dengan ligan S54 dan S56 yang memiliki energi paling negatif tetapi dari sisi parameter lainnya, kompleks S56 paling stabil. Dapat disimpulkan, g-sitosterol asetat (S56) memiliki potensi untuk berfungsi sebagai senyawa pemandu untuk MMP9

Evaluation of Antihypertensive Medication Suitability at Bandung-Based General Hospital August-October 2024 Daffa Anjabtsawa; Ellin Febrina; Annisa Desy Aryanti
International Journal of Health and Medicine Vol. 2 No. 3 (2025): July : International Journal of Health and Medicine
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhm.v2i3.419

Pharmaceutical services in hospitals must comply with the standards set forth in Minister of Health Regulation No. 72 of 2016 to ensure the safe, effective, and efficient use of medications. One crucial aspect of clinical pharmacy services is evaluating the appropriateness of drug use in accordance with the National Formulary (Fornas), particularly in antihypertensive therapy, which is widely used in clinical practice. This study aims to evaluate the conformity level of antihypertensive drug use with Fornas at Bandung-Based General Hospital and analyze its economic impact. This research is a retrospective descriptive study that collects data on antihypertensive drug use from various service units from August to October 2024. The analysis was conducted by calculating the percentage of conformity based on the number of drug units used compared to the Fornas list, as well as assessing the economic value of the drugs utilized. The results showed a very high adherence rate to Fornas, with the highest conformity percentage reaching 99.88% in September 2024 and the lowest at 99.81% in August 2024, surpassing the minimum compliance standard of 80% set by the Hospital Minimum Service Standards. These findings reflect the effectiveness of the National Formulary policy and the hospital's commitment to rational therapy. Collaboration among pharmacists, doctors, and the medical team, along with continuous education, is necessary to ensure safe, regulatory-compliant, and efficient therapy.

Co-Authors Abdurahman Ridho Achmad Zaenudin Ade Zuhrotun Aiyi Asnawi Aiyi Asnawi Aiyi Asnawi Aligita, Widhya Aliya Nur Hasanah Alma Yunita Sari Aminah Nurhadiyah Anas Subarnas Andriansyah, Ivan Annisa Desy Aryanti Arfan Arfan Daffa Anjabtsawa Dana Nasrullah Deden Indra Dinata, Deden Indra Destiani, Dika P. Dewi Kurnia Dika Destiani Dika P. Destiani Eki Pratidina Eli Halimah Eli Halimah, Eli Erli Berlianti Etika Emaliyawati Farizan Nur Fazrina Fauzan Zein Mutaqin Fikri Nazaruddin Ghozaly, Muchammad R. Gofarana Wilar Herawati, Irma E. Iceu Mulyati Indah Suasani Wahyuni Irma Erika Herawati Irma M. Puspitasari, Irma M. Irma Melyani Puspitasari Ivan Andriansyah Jutti Levita MEGA HIJRIAWATI Muchammad R. Ghozaly Mutakin Mutakin Mutakin Mutakin Naja, Syahrul Nur Intan Hayati Husnul Khotimah Nurhadiyah, Aminah Nursamsiar Nursamsiar Pradipta, Ivan S. Priskila, Miranda PUTY PRIANTI NOVIRA Ramadaini, Tiara Ratnawati, Rani Renny Amelia Ridwan, Muhammad H. Rini Hendriani Rusdianto, Aziiz M. Silviana, Lilis Sitti Rahmi Soni Muhsinin Sri Adi Sumiwi Sriwidodo Sriwidodo Sumiwi, Sri A. Syadiah, Ami Rahmati Syahrul Naja TIANA MILANDA Untung Sudharmono Wahyuni, Indah S. Widhya Aligita Yasmiwar Susilawati Yulianti Anjayani Yuliantini, Anne Zaenudin, Achmad Zulfa, Aulia

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