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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Jurnal Surya Medika JMM (Jurnal Masyarakat Mandiri) Jurnal Teknologi Pendidikan Martabe : Jurnal Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Borneo Journal of Medical Laboratory Technology Jurnal Peduli Masyarakat Indonesian Journal of Global Health research Jurnal Insan Farmasi Indonesia Indonesian Journal of Nursing and Health Sciences (IJNHS) Jurnal Farmasetis Sains Medisina Majalah Cendekia Mengabdi Jurnal Farmasi SYIFA Borneo Journal of Pharmacy Jurnal Sains Farmasi dan Kesehatan Jurnal Pengabdian Masyarakat Wadah Publikasi Cendekia Journal of Pharmascience
Evi Mulyani
Universitas Muhammadiyah Palangkaraya
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Molecular Docking Study of Akar Kuning (Arcangelisia flava) Secondary Metabolites as Src Inhibitor Pratama, Mohammad Rizki Fadhil; Mulyani, Evi; Suratno, Suratno
Indonesian Journal of Cancer Chemoprevention Vol 10, No 3 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss3pp122-130

Abstract

Proto-oncogene tyrosine-protein kinase Src is also known as simply Src is a tyrosine kinase protein which is one of the targets in various cancer therapies such as leukemia. Meanwhile, akar kuning (Arcangelisia flava) has gained significant attention as a medicinal plant that has a cytotoxic effect on various types of cancer cells. This study aims to determine the potential of secondary metabolites of akar kuning as Src inhibitors. Molecular docking was carried out using Autodock Vina 1.1.2 with 2HCK receptors, that quercetin and dasatinib were used as reference ligands. The docking results showed that the highest affinity was shown by berberine with a ΔG value of -9.0 kcal/mol, exceeded quercetin and dasatinib. However, the highest amino acid similarity to quercetin and dasatinib was produced by jatrorrhizine, with 93.33% and 73.91%, respectively. Interestingly, berberine is the ligand with the third-highest similarity after jatrorrhizine and palmatine, while jatrorrhizine has the second-highest affinity after berberine. The results concluded that the combination of berberine and jatrorrhizine is predicted to be optimally used as an Src inhibitor in cancer therapy.
Rambusa (Passiflora foetida L) vs. Free Radicals: In Vitro Study with DPPH Method Dewi Sari Mulia; Evi Mulyani; Muhammad Ikhwan Rizki; Mohammad Rizki Fadhil Pratama
Journal of Pharmascience Vol. 6 No. 2 (2019): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v6i2.7344

Abstract

ABSTRAK             Rambusa (Passiflora foetida L) adalah tumbuhan obat yang banyak terdapat di berbagai daerah di Indonesia, termasuk di Kalimantan Tengah. Beberapa bagian tumbuhan dari rambusa diketahui memiliki aktivitas antioksidan termasuk di bagian daunnya. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari daun rambusa yang berasal dari Kalimantan Tengah. Metode yang digunakan adalah metode 2,2-diphenyl-1-picrylhydrazyl (DPPH) yang diukur serapannya dengan Spektrofotometer UV Vis. Hasil yang diperoleh menunjukkan nilai IC50 dari ekstrak etanol daun rambusa senilai 93,269 μg/mL. Meskipun nilai IC50 yang diperoleh lebih rendah dibandingkan senyawa antioksidan standar seperti kuersetin, nilai IC50 dari ekstrak etanol daun rambusa asal Kalimantan Tengah masih lebih tinggi dibandingkan daun rambusa yang diperoleh dari daerah lain Kata Kunci—antioksidan, DPPH, Kalimantan Tengah, Passiflora foetida, rambusa  ABSTRACT Rambusa (Passiflora foetida L) is a medicinal plant that is widely found in various regions in Indonesia, including in Central Kalimantan. Some parts of the plant of rambusa are known to have antioxidant activities including in the leaves. This study aims to determine the antioxidant activity of rambusa leaves from Central Kalimantan. The method used was 2,2-diphenyl-1-picrylhydrazyl (DPPH) method which was measured by UV Vis spectrophotometer. The results obtained showed IC50 values of ethanol extract of rambusa leaves worth 93.269 μg/mL. Although the IC50 values obtained were lower than the standard antioxidant compounds such as quercetin, the IC50 value of the ethanol extract of the leaves of rambusa from Central Kalimantan was still higher than that of the rambusa leaves obtained from other regions or some other medicinal plant extracts. Keywords— antioxidants, DPPH, Central Kalimantan, Passiflora foetida, rambusa
Formulasi dan Evaluasi Gel Topikal Antibakteri Fraksi Aktif Akar Kuning (Arcangelisia flava Merr.) Evi Mulyani; Suratno Suratno; Mohammad Rizki Fadhil Pratama
Journal of Pharmascience Vol. 7 No. 1 (2020): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8081

Abstract

ABSTRAK Akar kuning (Arcangelisia flava Merr.) merupakan salah satu tanaman yang tumbuh di Kalimantan Tengah dan secara turun temurun digunakan sebagai pilihan pengobatan beberapa penyakit kulit dan terbukti mempunyai aktivitas antibakteri. Pembuatan sediaan topikal antibakteri berbahan fraksi aktif A. flava sangat potensial dilakukan untuk mengoptimalkan penggunaan dalam pengobatan sekaligus meningkatkan nilai ekonomis dari A. flava. Tujuan penelitian ini untuk mendapatkan formula gel fraksi aktif A. flava sebagai antibakteri yang paling baik secara fisik.Formula gel dibuat dengan variasi jenis dan konsentrasi gelling agent.Gel fraksi aktif A. flava diuji secara fisika, kimia, dan biologi seperti organoleptis, homogenitas, daya sebar, pH, daya lekat, dan daya hambat terhadap Staphylococcus aureus. Hasil formulasi sediaan gel fraksi aktif A. flava dengan basis NaCMC memenuhi syarat sifat fisik dan zona hambatan 11,6 mm pada Formula 1 dan 13,4 mm pada Formula 2, sedangkan sediaan gel dengan basis Carbophol 943 pada Formula 1 dan 2 memenuhi syarat sifat fisik dan zona hambat 10,9 mm pada Formula 2.Formula gel yang memenuhi kriteria secara fisik adalah Formula 2 dengan Carbophol 1,5% sebagai gelling agent. Kata Kunci: Akar kuning, antibakteri, gel, Staphylococcus aureus  ABSTRACT Akar kuning (Arcangelisia flava Merr.) is a plant that grows in Central Kalimantan and has been used as a treatment option for several skin diseases and has been shown to have antibacterial activity. The making of topical antibacterial preparations made from the active fraction of A. flava is very potential to be done to optimize the use in treatment while increasing the economic value of A. flava. The purpose of this study was to obtain the active A. flava fraction gel formula as the best natural antibacterial. The gel formula was made with variations in the type and concentration of the gelling agent. Arcangelisia flava Merr. active fraction gel was tested physical, chemical, and biological, such as organoleptic, homogeneity, spreadability, pH, adhesion, and bacterial inhibitionagainst Staphylococcus aureus. The results of the formulation of the active gel of A. flava based on NaCMC base fulfills physical condition requirements and shows an inhibition zone of 11.6 mmin Formula 1 and 13.4 mm in Formula 2, while gel preparation based on Carbophol 943 Formula 1 and 2 fulfill the physical characteristic requirements and show the inhibition zone of 10.9 mm in Formula 2.Gel formula that meets the physical criteria is Formula 2, with 1.5% Carbophol as a gelling agent. Keywords: Akar kuning, antibacterial, gel, Staphylococcus aureus
Kolaborasi Fakultas Farmasi UMPR dan UPTD Puskesmas Kereng Bangkirai dalam Mewujudkan Kampus Sehat Melalui Cek Kesehatan Gratis Rika Arfiana Safitri; Syahrida Dian Ardhany; Susi Novaryatiin; Halida Suryadini; Guntur Satrio Pratomo; Risqika Yulia Tantri Paramawidhita; Nurul Qamariah; Evi Mulyani; Husna Fauzia; Mohammad Rizki Fadhil Pratama; Rabiatul Adawiyah; Rezqi Handayani; Dewi Sari Mulia
Jurnal Pengabdian Masyarakat Wadah Publikasi Cendekia Vol 3 No 2 (2026): Jurnal Pengabdian Masyarakat WPC
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/jpmwpc.v3i2.1423

Abstract

Kesehatan sivitas akademika merupakan faktor krusial dalam mendukung terciptanya lingkungan perguruan tinggi yang produktif dan berdaya saing. Penyakit tidak menular (PTM) sering kali terlambat dideteksi karena banyak kasus baru baru disadari pada tahap lanjut. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kesadaran dan kepedulian kesehatan sivitas akademika melalui pemeriksaan kesehatan gratis yang terintegrasi dengan edukasi kesehatan dasar, serta menjaring faktor risiko PTM sejak dini. Metode pelaksanaan program dilakukan secara partisipatif melalui tahapan persiapan, sosialisasi, pendaftaran, pelaksanaan cek kesehatan gratis (registrasi, pengukuran identitas, pemeriksaan tekanan darah dan gula darah sewaktu), edukasi interpersonal melalui konseling meja, tindak lanjut rujukan, serta evaluasi kegiatan. Hasil pelaksanaan menunjukkan adanya peningkatan pengetahuan peserta secara signifikan, di mana rata-rata skor melonjak dari 68,9 pada pre-test menjadi 90,8 pada post-test setelah diberikan edukasi singkat. Berdasarkan hasil skrining fisik terhadap peserta, ditemukan bahwa 65,0% peserta memiliki tekanan darah normal, sedangkan 21,7% mengalami pre-hipertensi, dan 13,3% menderita hipertensi klinis. Untuk parameter kadar gula darah sewaktu (GDS), sebanyak 90,0% peserta berkategori normal dan 10,0% teridentifikasi mengalami hiperglikemia.
Description of Blood Sugar Levels of Male Wistar Rats after Administration of Ethanol Extract of Rambusa Leaves (Passiflora Foetida Linn.) from Central Kalimantan Evi Mulyani; Noor Alris Ferdiansyah; Halida Suryadini; Husna Fauzia
Indonesian Journal of Global Health Research Vol 7 No 1 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i1.3856

Abstract

Rambusa (Passiflora foetida Linn.) is a type of plant that is often found creeping on other plants. Usually found in watery areas such as swamps and rivers. The rambusa plant contains chemical compounds which are useful sources and can be developed as medicine. Several previous studies explained that Rambusa (Passiflora foetida Linn.) which grows in several areas shows antidiabetic properties. The aim of this study was to determine the blood sugar levels of male Wistar rats after administration of ethanol extract of rambusa leaves (Passiflora foetida Linn.) from Central Kalimantan. This research was carried out using an experimental or experimental method (experiment research) in the laboratory which was carried out with a series of experiments using the GCU Check strip. The results of this study show that ethanol extract of rambusa leaves from Central Kalimantan can reduce blood sugar levels of male Wistar rats at doses of 1.5 mg/Kgbb and 2 mg/Kgbb.
Kepatuhan Peserta Prolanis: Tinjauan Faktor Pelayanan Kesehatan dan Perilaku Kesehatan: Narrative Review Noni Widiawatie; Evi Mulyani
Indonesian Journal of Nursing and Health Sciences Vol 6 No 2 (2025): Indonesian Journal of Nursing and Health Sciences: October 2025
Publisher : CV. Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijnhs.v6i2.7524

Abstract

Program Pengelolaan Penyakit Kronis (Prolanis) merupakan strategi BPJS Kesehatan untuk meningkatkan kualitas hidup peserta yang menderita penyakit kronis, khususnya diabetes mellitus dan hipertensi. Kepatuhan peserta merupakan faktor kunci dalam keberhasilan program ini. Tujuan penelitian ini adalah kepatuhan peserta Prolanis dengan pengelolaan penyakit kronis di pelayanan kesehatan primer. Metode yang digunakan adalah Narrative Review, proses pencarian literatur dilakukan melalui database Google Scholar, Garuda, Pubmed, dan Sciencedirect menggunakan kata kunci “pelayanan kesehatan”, “perilaku kesehatan”, “kepatuhan”, “Prolanis”. Dari total 25 artikel yang ditemukan, 16 artikel di eksklusi karena terdapat duplikasi, tidak menyertakan data hasil yang lengkap (tidak ada abstrak) dan fokus yang tidak relevan sehingga total yang digunakan sebanyak 9 artikel. Hasil tinjauan menunjukkan bahwa kepatuhan peserta Prolanis dipengaruhi oleh berbagai faktor multidimensional, termasuk faktor individu (lamanya keanggotaan, tingkat pengetahuan, dan pendidikan), faktor layanan kesehatan (komunikasi dengan tenaga kesehatan, partisipasi dalam konseling, dan intervensi pendidikan), serta faktor dukungan sosial dan keluarga. Kesimpulannya, penguatan implementasi Prolanis perlu difokuskan pada pendekatan pendidikan yang berkelanjutan, peningkatan kualitas komunikasi oleh tenaga kesehatan, dan keterlibatan aktif keluarga dan masyarakat dalam pengelolaan penyakit kronis.
Analisis Kelengkapan Administratif dan Farmasetik E-Resep Pasien Rawat Inap di RS X Kota Palangka Raya Iswatun Desyla Puranti; Evi Mulyani; Mohammad Rizki Fadhil Pratama
Jurnal Farmasi SYIFA Vol 4 No 1 (2026): Jurnal Farmasi SYIFA
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/jfs.v4i1.1005

Abstract

Penggunaan e-resep merupakan inovasi digital di rumah sakit yang bertujuan untuk meminimalkan medication error dan meningkatkan standar mutu pelayanan kefarmasian. Penelitian ini bertujuan untuk memberikan gambaran profil kelengkapan e-resep pada pasien rawat inap di RS X Kota Palangka Raya periode Juli – Desember 2025. Jenis penelitian ini adalah deskriptif kuantitatif dengan pengambilan data secara retrospektif menggunakan 360 sampel e-resep yang diambil melalui teknik simple random sampling dengan rumus Slovin. Sistem digital rumah sakit menunjukkan performa sangat baik pada komponen invocatio dan subscriptio dengan tingkat kelengkapan mencapai 100%. Namun, efektivitas sistem masih terbatas pada komponen inscriptio (0%), prescriptio (22,78%), signatura (14,44%), dan pro (0%). Implementasi e-resep di RS X Kota Palangka Raya telah berhasil mengotomatisasi aspek legalitas waktu dan asal resep secara sempurna. Meskipun demikian, diperlukan perbaikan sistemik pada integrasi data klinis pasien (usia, berat badan, tinggi badan) serta pemutakhiran tampilan SIP dokter guna menjamin kelengkapan administratif dan keamanan pasien secara komprehensif.
Molecular Basis for the Enhanced CDK2 Inhibition by Artesunate: Superior Binding Affinity to the ATP-Catalytic Site Mohammad Rizki Fadhil Pratama; Evi Mulyani; Suratno Suratno; Punet Kumar; Daryono Hadi Tjahjono; Tutus Gusdinar Kartawinata
Jurnal Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24555

Abstract

This study aimed to identify the most potent CDK2 inhibitor among seven artemisinin derivatives and, critically, to elucidate its binding mechanism and compare its affinity with that of the natural ligand, ATP. Molecular docking was performed using AutoDock 4.2.6 toward inactive and active forms of CDK2. Ligands were optimized using the Hartree-Fock method basis set 6-311G. Blind docking on the active form was used to determine the inhibition mechanism, employing the free energy of binding (ΔG) and dissociation constant (Ki) as affinity markers. Artesunate was the most potent derivative, exhibiting the highest affinity towards the active CDK2 form, with a ΔG of -11.7 kcal/mol and a Ki of 2.66 nM. Blind docking confirmed an ATP-competitive inhibition mechanism. Remarkably, Artesunate's Ki was significantly lower than that of ATP (8.73 nM). This enhanced affinity is attributed to specific interactions between the hemisuccinate side chain and the critical amino acid region, from 13-Gly to 16-Gly. Artesunate is suggested as a potent, ATP-competitive CDK2 inhibitor with an affinity exceeding that of ATP. These hypothesis-generating results suggest anticancer potential, yet require validation via MD or assays; limitations like scoring bias and protein flexibility necessitate cautious interpretation regarding the 13-Gly to 16-Gly target.
Co-Authors Abda Abda Ade Irawati Aditama Reyhan Agung Pribadi Ahmad Asmadi Al Rasyid, Raihan Aminuyati Anita Sukmawati APRILIANA, APRILIANA Asma'ul Ayuriska Sari Aulia, Raisa Bersiani Bersiani Binar Asrining Dhiani Chandra Anugrah Putra Chandra Putra Daryono Hadi Tjahjono Dewi Sari Mulia Dewi Sari Mulia Drenikha Sikhe R Dwi Purbayanti Endang Darmawan Endang Darmawan Erindyah Retno Wikantyasning Fera Sartika Guntur Satrio Pratomo Hairi, Dewi Gulyla Halida Suryadini Husna Fauzia Iswatun Desyla Puranti Lestari, Oktavia Nanda Lestari, Ririn Puji Lia Indriana Marsela, Marsela Mohammad Rizki Fadhil Pratama Muhammad Ikhwan Rizki Muhammad Priyadi Mulyani, Risya Mustofa Mustofa Noni Widiawatie Noor Alris Ferdiansyah Nur Azizah Nur Chairin Hanifa, Deasy Nurmila Dewi Nurul Chusna Nurul Qamariah Nurul Qamariah, Nurul Panji Ratih Suci, Panji Ratih Punet Kumar Rabiatul Adawiyah Rabiatul Adawiyah Rezqi Handayani Rianiko Rianiko Riauwati, Rossa Rika Arfiana Safitri Rinny Ardina Rismadani Safitri Risqika Yulia Tantri Paramawidhita Rizka Rahmadina Putri Santi Hasari, Widarika Satrio P, Guntur Suratno Suratno Suratno Suratno Suratno Suratno Suratno Suratno Susi Novaryatiin Syahrida Dian Ardhany Ternate, Agustinawati Umi Tutus Gusdinar Kartawinata Windya Nazmatur Rahmah