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All Journal Journal of Food and Pharmaceutical Science Jurnal Ilmiah Farmasi Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Cancer Chemoprevention Pharmacon Pharmascience Berkala Kedokteran Jurnal Surya Medika PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Indonesian Journal of Chemical Analysis (IJCA) Journal of Midwifery and Nursing Jurnal Jamu Indonesia Fullerene Journal of Chemistry CERATA Jurnal Ilmu Farmasi JURNAL PENDIDIKAN MIPA Pharmacoscript Jurnal Farmamedika (Pharmamedica Journal) Jurnal Jejaring Matematika dan Sains Science Midwifery International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi Indonesia Berdaya Hydrogen: Jurnal Kependidikan Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pijar MIPA Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Journal of Pharmaceutical Care and Sciences Jurnal Farmasi Sains dan Praktis Jurnal Bakti Untuk Negeri Gunung Djati Conference Series Jurnal Nusantara Berbakti Jurnal Pengabdian Masyarakat Indonesia Sejahtera Jurnal Farmasi SYIFA Journal of Food and Pharmaceutical Sciences CERATA Jurnal Pengabdian Masyarakat Panacea Jurnal Sains dan Kesehatan
Samsul Hadi
ULM
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Pemodelan Protein dengan Homology Modeling menggunakan SWISS-MODEL: Protein Modeling with Homology Modeling using SWISS-MODEL Komari, Noer; Hadi, Samsul; Suhartono, Eko
Jurnal Jejaring Matematika dan Sains Vol. 2 No. 2 (2020): Edisi Desember 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/jjms.2020.v2.i2.408

Abstract

The three-dimensional (3D) structure of proteins is necessary to understand the properties and functions of proteins. Determining protein structure by laboratory equipment is quite complicated and expensive. An alternative method to predict the 3D structure of proteins in the in silico method. One of the in silico methods is homology modeling. Homology modeling is done using the SWISS-MODEL server. Proteins that will be modeled in the 3D structure are proteins that do not yet have a structure in the RCSB PDB database. Protein sequences were obtained from the UniProt database with code A0A0B6VWS2. The results showed that there were two models selected, namely model-1 with the PDB code template 1q0e and model-2 with the PDB code template 3gtv. The results of sequence alignment and model visualization show that model-1 and model-2 are identical. The evaluation and assessment of model-1 on the Ramachandran Plot have a Favored area of ??97.36%, a MolProbity score of 0.79, and a QMEAN value is 1.13. Model-1 is a good 3D protein structure model.
Skrining Senyawa dari Tanaman Rhodomyrtus tomentosa (Aiton) Hassk terhadap SARS-CoV-2 ORF3a Samsul Hadi
Jurnal Surya Medika (JSM) Vol 6 No 2 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i2.2134

Abstract

The ORF3a protein from SARS-CoV has functions in terms of ion channel activity, modulates the trafficking properties of SARS-CoV spike (S) protein, increases fibrinogen expression in pulmonary epithelial cells, and induces apoptosis. So that research is needed to overcome the ORF3a experiment. The method in this research uses the computational screening method with autodok4 software. The results of this study resulted in free binding energy between Hassk Rhodomyrtus tomentosa (Aiton) and ORF3a compounds, namely: α-tocopherol-quinone (-5.86); blumeatin (-4.98); methyl cinnamate (-4.44); myricetin (-4.49); naringenin (-4.93); quercetin (-4,9); rhodomyrtone (-6); rhodomyrtosone B (-7.11); rhodomyrtosone C (-6.77); tetrahydroxyflavanone (-4.91); α-tocopherol A (-6.72); verimol K (-4.89); watsonianone A (-7.55). Based on the data obtained, the ligand with the most potential due to the stability of the bond is watsonianone A.
Penetapan Kadar Air Dan Kadar Protein Pada Biskuit Yang Beredar Di Pasar Banjarbaru Normilawati; Fadlilaturrahmah; Samsul Hadi; Normaidah
CERATA Jurnal Ilmu Farmasi Vol 10 No 2 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Many biscuits circulating in the community are not labeled and do not include the value of water and protein content in accordance with SNI. Therefore, it is necessary to determine the water content and protein content in the biscuits. Determination of water content and protein content in biscuits was carried out on 2 biscuit samples taken at the Banjarbaru Market. The water content test on the sample was carried out by the gravimetric method and the protein content test was carried out by the Kjeldahl method. The results obtained were the test of water content of 2 biscuit samples respectively at 4.43% and 3.84%. While the results of the protein content test from 2 samples are 5.31% and 6.89%, respectively. According to SNI 01-2973-2011 the water content limit does not exceed 5% while the protein content limit is a minimum of 5%. The results of 2 samples showed the water content and protein content in accordance with SNI.
Skrining Inhibitor NF-κB Combretum indicum dengan Metode Docking Samsul Hadi; Amalia Khairunnisa; Sefa Nur Khalifah; Sintya Oktaviani; Sri Oktaviana Sari; Umi Nur Hapifah
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i2.15780

Abstract

Nuclear factor kappa B (NF-κB) is a transcription factor that regulates the expression of genes important for innate and adaptive immune responses. NF-κB overactivation is associated with inflammatory diseases such as autoimmune, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This study aims to screen the chemical content of C.indicum against NF-κB-inducing kinase inhibitors. There are two methods used in this study, namely through PASSonline and docking. The docking method used was PLANTS. The results of PASSonline compounds that have P.a values above 0.7 weree arachidonic acid, linoleic acid, rutin, methyl urasolate, while the docking scores obtained were asquisqualic acid: -60.0382; arachidonic acid : -100,9410; linoleic acid: -93.8730; routine : -102,9320; methyl urasolate: -47,9166. This negative docking score indicates that the reaction between the compound and the target occurs easily. In conclusion, the compound predicted to have a potential as an inhibitor of NF-κB is Rutin.
Stabilization of the Interaction of the Compunds of Mallotus paniculatus Müll.Arg. on Gluthations S-Transferase (GSTs) Samsul Hadi
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.984 KB) | DOI: 10.20527/jbk.v17i2.11668

Abstract

Abstract: Gluthathione s-transferases (GSTs) play an important role against carcinogens, therapeutic drugs, and various types of cellular oxidative damage. Judging from its role in overcoming cellular oxidative damage, the activity of GSTs is one of the antioxidant enzymes. One of the plants that has been tested for its antioxidant ability is M. paniculatus. The content of M. paniculatus has been found so that it can be used to test the stability of the interaction between ligands and receptors. The aim of this research is to find compounds from M. paniculatus that have the potential to stabilize the interaction with the receptors. This docking method begins with ligand preparation and protein preparation followed by docking, visualization of interactions and analysis of the results. The research resulted in various docking scores with the various proteins involved. The stability of the interaction is obtained when the ligand binds to Glutathione S-transferase type A3 is hesperetin, sitosterol and sitosterol, to Glutathione S-transferase type theta-2 is β-daucostero, to Glutathione S-transferase type P is quercetin. Keywords: GSTs, M. paniculatus, docking
Penambatan Molekul Kandungan Eurycoma longifolia Jack. (Pasak bumi) terhadap Human Phosphodiesterase 5 Samsul Hadi; Khoerul Anwar; Amalia Khairunnisa; Noer Komari
Jurnal Pharmascience Vol 7, No 2 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i2.8731

Abstract

Pasak bumi sebagai obat tradisional pria telah digunakan oleh masyarakat melayu, khususnya orang Sumatra dan kalimantan, akan tetapi mekanisme secara molekuler belum dikatahui dengan jelas. Salah satu pendekatan yang dapat digunakan untuk mengetahui mekanisme pasak bumi sebagai obat tradisional yang bermanfaat mengatasi disfungsi ereksi adalah penambatan molekul. Penambatan melekul dilakukan dengan cara melihat interaksi ligand dengan reseptor. Ligand yang berasal dari pasak bumi adalah 5-methoxycanthin-6-one, 9-methoxycanthin-6-one, eurycomalactone, eurycomalide A, eurycomanone, eurycomaoside, laurycolactone A, longilactone, niloticin, picrasidine O. Sehingga kesepuluh ligand ini didocking menggunakan salah satu aplikasi docking yaitu PLANTS 1.1 untuk melihat ikatan dengan PDE5. Sebelum dilakukan docking terhadap ligand pasak bumi, terlebih dahulu dilakukan docking terhadap ligand Sildenafil untuk melhat nilai RMSD. RMSD ini diperlukan sebagai alat validasi metode, berdasarkan percobaan, nilai RMSD dari Sildenafil adalah 1,2517 A0. Hasil terbaik dari penambatan molekul pasak bumi adalah niloticin dengan skor doking -97,8802, sehingga nilai interaksinya terhadap reseptor sebesar 93,71% dari Sildenafil.Pasak bumi as traditional male medicine has been used by Malay people, especially Sumatra and Borneo people, but the molecular mechanism is not yet known clearly. One approach that can be used to determine the mechanism of the Pasak Bumi as a traditional medicine that is useful to overcome erectile dysfunction is docking molecules. Molecular docking is done by looking at the interaction of ligands with receptors. Ligands originating from the Pasak Bumi are 5-methoxycanthin-6-one, 9-methoxycanthin-6-one, eurycomalactone, eurycomalide A, eurycomanone, eurycomaoside, laurycolactone A, longilactone, niloticin, picrasidine O. docking application namely PLANTS 1.1 to see the bond with PDE5. Before docking Pasak Bumi ligand, it is first docking Sildenafil ligand to see the RMSD value. The RMSD is needed as a method validation method, based on experiments, the RMSD value of Sildenafil is 1.2517 A0. The best results from docking of the Pasak bumi molecule is niloticin with a doctor score of -97.8802, so interaction skor to the receptor is 93.71% of Sildenafil.Keywords: Pasak Bumi, PDE5, PLANTS
Optimasi Suhu dan Waktu Ekstraksi Akar Pasak Bumi (Eurycoma longifolia jack.) Menggunakan Metode RSM (response surface methodology) dengan Pelarut Etanol 70% Khoerul Anwar; Farida Istiqamah; Samsul Hadi
Jurnal Pharmascience Vol 8, No 1 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i1.9085

Abstract

Akar pasak bumi (Eurycoma longifolia Jack.) telah lama dimanfaatkan sebagai obat tradisional oleh masyarakat Indonesia sebagai aprodisiaka. Ekstraksi akar tumbuhan ini dilakukan dengan berbagai pelarut yang salah satunya menggunakan etanol 70%.  Pemilihan pelarut ini dilakukan untuk memperoleh kandungan zat berkhasiat semaksimal mungkin yang ditandai dengan rendemen yang tinggi. Penelitian ini bertujuan untuk menentukan suhu dan waktu ekstraksi optimum pada proses ekstraksi akar E. longifolia dengan pelarut etanol 70%. Metode OFAT (One Factor at The Time) digunakan pada uji pendahuluan dan metode RSM (Response Surface Methodology) digunakan pada desain eksperimen dengan bantuan software MINITAB 17. Penelitian dilakukan menggunakan 13 titik perlakuan dengan kombinasi suhu dan waktu yang berbeda. Hasil penelitian menunjukkan bahwa titik optimum rendemen ekstraksi akar E.longifolia sebesar 4,07% diperoleh pada suhu 51,8oC dan waktu 12,13 jam dengan nilai D (desirability) sebesar 0,92. Uji validasi model RSM menunjukkan keakuratan sebesar 97,76%. Model persamaan regresi yang menggambarkan pengaruh suhu dan waktu ekstraksi terhadap rendemen akar E. longifolia adalah Y = - 70,1 + 2,536X1 + 1,387X2 – 0,02389X12 – 0,0464X22 – 0,00500X1X2. Kata Kunci: Eurycoma longifolia Jack., Suhu dan Waktu Ekstraksi, Metode RSM, Etanol 70%The root of the pasak bumi (Eurycoma longifolia Jack.) has long been used as a traditional medicine by the Indonesian people as an aphrodisiac. Extraction of plant roots is carried out with various solvents, one of which uses ethanol 70%. The selection of this solvent was carried out to obtain the maximum possible active metabolite content which is characterized by high yield. This study aims to determine the optimum extraction temperature and time in the root extraction process of E. longifolia with 70% ethanol as solvent. The OFAT (One Factor at The Time) method was used in the preliminary test and the RSM (Response Surface Methodology) method was used in the experimental design with the help of MINITAB 17 software. The study was conducted using 13 treatment points with different combinations of temperature and time. The results showed that the optimum yield point of E. longifolia root extraction was 4.07% at a temperature of 51.8°C and extraction time of 12.13 hours with D (desirability) value of 0.92. The validation test of the RSM model shows an accuracy of 97.76%. The regression equation model that describes the effect of temperature and extraction time on the root yield of E. longifolia is Y = - 70.1 + 2.536X1 + 1.387X2 – 0.02389X12 – 0.0464X22 – 0.00500X1X2.
SPF Test from Baccaurea lanceolata Muell.Arg Fruit Isolates Samsul Hadi; Subagus Wahyuono; Ag. Yuswanto; Endang Lukitaningsih
Indonesian Journal of Cancer Chemoprevention Vol 8, No 1 (2017)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev8iss1pp38-41

Abstract

Not many researches on a fruit of limpasu (Baccaurea lanceolata Muell. Arg ) were found, while the use by tribal hamlets in Kalimantan already became a daily routine before they went into the field with the way made powder and smeared on the face. Therefore, the research on active substances needs to be done. For this study, we prepared two isolates which coded as K2 and CE, K2 from qualitative test negative isolates phenolic groups was identified by spray FeCl3, whereas qualitative test positive isolates were coded as CE and detected by a nitrogen-containing reagents dragendorf spray. The K2 isolate from SPF test resulted an SPF value of 3.2 at a concentration of 0.2 mg/ml, while CE isolate was given a value of SPF 5.0 at a concentration of 0.2 mg/ml. According to sensitivity skin test on rabbit skin, both K2 and CE isolated were given the value below 1, indicated the isolates were found to not irritate. This study proposes the potential from Baccaurea lanceolata Muell.Arg fruit isolates to be developed as a sunscreen for UV-protection.Keywords : Baccaurea lanceolata Muell.Arg, SPF test, sensitivity skin test
SKRINING SENYAWA INHIBITOR H2 DARI KAYU MANIS (Cinnamomum verum J.Presl) Samsul Hadi; Diah Aulia Rosanti; Desiya Ramayanti Azhara; Kunti Nastiti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (291.519 KB) | DOI: 10.36387/jiis.v6i2.663

Abstract

Digestive tract disorders, especially gastric disorders, are often experienced by people. One drug to treat this disorder has a mechanism of blocking the H2 receptor. This research was conducted to find compounds from C.verum which have the stability of bind to H2 receptors. The method used is protein modeling with swiss-model, docking with PLANTS (CHEMPLP) and activity prediction. The test results obtained that the docking score was ?- amorphene (-65,79), ?-bergamotene (-65,48), ?-copaene (-66,62), ?-cubebene (-66,46), Cadinene (-64 , 79), Camphor (-52.15), Caryophyllene (-62.61), Cinnamaldehyde (-68.17), Epicatechin (-80.43), Ergosterol (-85.24), Eugenol (-67.35), Hydrocinnamaldehyde (-65,53), Quercetin (-74,38), Protocatechuic acid (-71,49), Stigmasterol (-88,88), 4- (2,3-dihydro-3- (hydroxymethyl) - 5- (3-hydroxypropyl) -7- (methoxy) benzofuranyl] -2-methoxyphenyl (-85,29). Combined with the probability activity of compounds that have the potential to be further developed are Epicatechin and urolignoside.
POTENSI DARI EKSTRAK DAN FRAKSI KULIT BUAH MUNDAR (Garcinia forbesii) SEBAGAI TABIR SURYA BERDASARKAN NILAI SUN PROTECTION FACTOR (SPF) Muhammad Ikhwan Rizki; Samsul Hadi; Lutfi Chabib
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.827 KB) | DOI: 10.36387/jiis.v6i2.716

Abstract

UV rays cause skin damage such as loss of skin elasticity, wrinkles, sagging, and skin cancer. South Kalimantan is a wetland area with more than 4,000 species of medicinal plants. Mundar (Garcinia forbesii) is one of the plants in South Kalimantan. Mundar pericarp is empirically used for cosmetics which is believed to protect the skin from ultraviolet rays. The purpose of the study was to determine the sunscreen potency of the extract and fraction from pericarp of mundar (Garcinia forbesii) based on the Sun Protection Factor (SPF) parameter. The research started from material drying, making simplicia powder, extraction, and fractions. The extracts and fractions were measured for SPF values ??using a UV-Vis Spectrophotometer. The results showed that the ethanol extract and ethyl acetate fraction had weak protection, while the n-hexane fraction had extreme protective power with SPF values ??in the range of 6.51 – 30.00
Co-Authors Ag. Yuswanto Ag. Yuswanto Agustina, Ni Kadek Ayu Amalia Khairunnisa Amalia Khairunnisa Amalia Khairunnisa Ana Maulana Ana Muliana Arif Subekti Arif Subekti Bawaihi Bawaihi Buih, Putri Helena Junjung DENI SETIAWAN Deni Setiawan Desiya Ramayanti Azhara Desiya Ramayanti Azhara Diah Aulia Rosanti Diah Aulia Rosanti Dian Ekowati Dian Ekowati Dian Kusuma Putra Eko Suhartono Elvina Astria Agustin Endang Lukitaningsih Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah Fanli Yudi Anwar Farida Istiqamah Fathul Jannah, Fathul Febriani, Noor Rahmi Fery Ramadhan Fitri Puspitasari Gunawan Gunawan Gunawan Gunawan Indriani, Erika Irawati Irawati Izma, Hayatun Khadijah, Nor Khoerul Anwar Kunti Nastiti Kunti Nastiti Kunti Nastiti Kunti Nastiti Kunti Nastiti Kunti Pelita Kuranji Blok Nastiti Liling Triyasmono Liling Triyasmono Liling tryasmono Linda Wahyuni Ludowika Adonita Tarong Lutfi Chabib, Lutfi Malahayati, Siti Melviani Melviani Mirza Maulana Ahmad Muhammad Firman Akbar Muhammad Ikhwan Rizki Muhammad Luthfi Firdaus Muhammad Syihab Setia Budi Nashrul Wathan Nastiti, Kunti Noer Komari Normaidah, Normaidah Normilawati Noval Noval Noval Noval Nugi Maulana Nur Mahdi Nurul Mardiati Nurul Mardiati Okta Muthia Sari Pertiwi Awilda Rafiah Anggianingrum Rahmadina, Nazwa Rahmawati, Nanda Hesti Ramadani, Rizka aulia Ratnapuri, Prima Happy Rezka Fajar Ramadhan Rinda, Ririn Purnama Riswandayani Savitri Risye Hendry Rizki Swastika Puri ROBIATUL ADAWIYAH RR. Endang Lukitaningsih Salma Salma Sefa Nur Khalifah Setia Budi Sheila Nurrahmah Shindi, Muhammad Riki Sintya Oktaviani Sri Oktaviana Sari Sri Oktaviana Sari Subagus Wahyuono Subagus Wahyuono Suci Kamelia Sukmana, M. Laily Qadry Tazkia Safarina Ulfah, Nahdiati Umi Nur Hapifah Umi Nur Hapifah Uripto Trisno Santoso Viogenta, Pratika Wijaya, Eka Setya Yusri Yusri Yusri Yusri