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All Journal Journal of Food and Pharmaceutical Science Jurnal Ilmiah Farmasi Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Cancer Chemoprevention Pharmacon Pharmascience Berkala Kedokteran Jurnal Surya Medika PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Indonesian Journal of Chemical Analysis (IJCA) Journal of Midwifery and Nursing Jurnal Jamu Indonesia Fullerene Journal of Chemistry CERATA Jurnal Ilmu Farmasi JURNAL PENDIDIKAN MIPA Pharmacoscript Jurnal Farmamedika (Pharmamedica Journal) Jurnal Jejaring Matematika dan Sains Science Midwifery International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi Indonesia Berdaya Hydrogen: Jurnal Kependidikan Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pijar MIPA Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Journal of Pharmaceutical Care and Sciences Jurnal Farmasi Sains dan Praktis Jurnal Bakti Untuk Negeri Gunung Djati Conference Series Jurnal Nusantara Berbakti Jurnal Pengabdian Masyarakat Indonesia Sejahtera Jurnal Farmasi SYIFA Journal of Food and Pharmaceutical Sciences CERATA Jurnal Pengabdian Masyarakat Panacea Jurnal Sains dan Kesehatan
Samsul Hadi
ULM
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Interaksi Asam Galat dan Metil Galat dari Tumbuhan Kasturi (Mangifera casturi) sebagai Inhibitor Protein Human Epidermal Growth Factor 2 (HER2): Evaluasi Molekular Docking NOER KOMARI; ROBIATUL ADAWIYAH; SAMSUL HADI; EKO SUHARTONO
Gunung Djati Conference Series Vol. 15 (2022): Prosiding Seminar Nasional Kimia Tahun 2022
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (293.647 KB)

Abstract

Kasturi (Mangifera casturi) is a endemic plant of Borneo. The polyphenol content of M. casturi leaves has antioxidant properties, including gallic acid and methyl gallic. The antioxidant potential of gallic acid and methyl gallate of M. casturi leaves is thought to inhibit the growth of breast cancer cells. Human Epidermal Growth Factor 2 (HER-2) protein is an important factor in the epidermal growth of breast cells and is also a target for breast cancer treatment. This study aims to investigate the potential of gallic acid and methyl gallic compounds from M. casturi as inhibitors of HER-2 protein. Molecular docking parameters in Gibbs free energy, interaction of gallic acid and methyl gallic ligands with HER-2 protein residues Kasturi (Mangifera casturi) is a endemic plant of Borneo. The polyphenol content of M. casturi leaves has antioxidant properties, including gallic acid and methyl gallic. The antioxidant potential of gallic acid and methyl gallate of M. casturi leaves is thought to inhibit the growth of breast cancer cells. Human Epidermal Growth Factor 2 (HER-2) protein is an important factor in the epidermal growth of breast cells and is also a target for breast cancer treatment. This study aims to investigate the potential of gallic acid and methyl gallic compounds from M. casturi as inhibitors of HER-2 protein. Molecular docking parameters in Gibbs free energy, interaction of gallic acid and methyl gallic ligands with HER-2 protein residues
Antioxidant Test and Flavonoids Determination of Tuber Pakis Kinca (Nephrolepis cordifolia (L) C. Presl) Samsul Hadi; Arif Subekti; Amalia Khairunnisa
Indonesian Journal of Chemical Analysis (IJCA) Vol. 6 No. 1 (2023): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol6.iss1.art1

Abstract

One of the things that causes cell damage in the body is the formation of unpaired electrons, also known as free radicals, which can cause oxidative stress. Excessive oxidative stress is not maintained by the body's natural antioxidants, so natural antioxidants are needed from outside. One of the plants suspected of having antioxidant abilities is Pakis kinca. So, the aim of this study was to determine the levels of flavonoids and antioxidant abilities in the tuber of N. cordifoli. Therefore, the method used to determine flavonoids is by reacting with AlCl3 and reading by UV-vis spectrophotometry, while reacting antioxidants with DPPH using spectrophotometry. The results of the flavonoid test were 3.119 ± 0.09 w/w equivalent to quercetin, from this equation the flavonoid content in the range of the equation was obtained. The results of the antioxidant test obtained the mean value of antioxidants was 93.898 ± 0.923. The conclusion obtained is that the antioxidant IC50 value of tuber extract N. cordifolia is a strong category with a total flavonoid content of 3.119 ± 0.091 w/w equivalent to quercetin.
- Identifikasi daun Ceguk dengan Spektroskopi UV-VIS Samsul Hadi
Jurnal Kimia Fullerene Vol 7 No 2 (2022): Fullerene Journal of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v7i2.451

Abstract

Ceguk have two different varieties seen in the shape of the flowers, some are elongated and rounded. Based on this varietal difference, it is likely that it will affect the activity produced by the leaves. The purpose of this study was to identify the typical spectra of these two varieties using a finger print approach using UV-vis combined multivariate spectroscopy. The results of the PLSR Combretum indicum Varr analysis. B against Combretum indicum Varr. M at a wavelength of 248.53-221.00 nm, the second derivative obtained an RMSEC value of 1.65; R2 0.9988; RMSEP 5.05; R2 0.9925, and RMSECV 8; R2 0.9804. While at a wavelength of 296.09-261.64 nm, the normal model obtained an RMSEC value of 0.647; R2 0.9998; RMSEP 0.868; R2 0.9997, and RMSECV 4.71; R2 0.9923. So it can be concluded that UV-VIS spectroscopic fingerprint analysis with a combination of chemometrics can distinguish Combretum indicum Varr leaves. B against the occurrence of leaf adulteration of Combretum indicum Varr. M in the normal model with a wavelength of 296.09-261.64 nm.
Inovasi Produk dan Pendampingan Ijin Produk pada Kelompok Masyarakat Guna Meningkatkan Perekonomian Kunti Nastiti; Setia Budi; Melviani Melviani; Samsul Hadi
Indonesia Berdaya Vol 4, No 3 (2023)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.2023502

Abstract

The Covid-19 pandemic has caused small businesses throughout Indonesia to experience an economic decline. People are psychologically afraid of contracting the virus, so they limit going out of the house. Indirectly causing a decrease in income because people limit spending and consumption patterns. This community service aims to help community small businesses located in Banjarbaru, South Kalimantan in managing their business. The survey results stated that there was a decline in sales, especially in the food, salon, cosmetic product, stalls and other clothing sales. The obstacle faced by this business unit is the absence of product innovation that adapts to pandemic conditions. Another thing in marketing products is that many people do not know about strategies regarding promotion, branding, product advertising, product legalization and other strategies. The forms and methods that are the solution to this activity are product innovation related to herbal products and providing knowledge about the legality of products, both herbal products and food products that have been produced so that they are expected to be widely marketed. Apart from that, providing knowledge about product marketing strategies through online promotion and branding as well as providing knowledge on how to have a good managerial system. Herbal product innovation has increased during the Covid-19 pandemic because several herbs are believed to help the body's resistance to disease.
Screening of Rhodomyrtus tomentosa (Aiton) Wight (Karamunting) Compounds that Have the Potential for Breast Cancer Samsul Hadi; Kunti Nastiti
Hydrogen: Jurnal Kependidikan Kimia Vol 11, No 2 (2023): April 2023
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v11i2.7189

Abstract

Breast cancer is the highest disease in the world beating lung cancer, so various alternatives are needed to find a treatment. Screening drug discovery against breast cancer by targeting BCL-2 occupies the main position and is the goal of this study. The method used is insilico. the material used is 10 compounds from R. tomentose, 2w3l protein from RCSB, PLANT docking software, the docking coordinate used is X: 39.8057 Y: 26.9355 Z: -12.4145 with a radius of 11.1871, then to find out the type of bond and residue involved using discovery studio. The results of this study were docking scores from -91.3871(5'-Desgalloylstachyurin) to -65.4754 (Afrormosin), activity predictions from PASS online from 0.174 (Rhodomyrtosone C) to 0.799 (Lupeol). Based on the docking score, three compounds that have the potential to inhibit the work of BCL-2 were obtained namely 5'-Desgalloylstachyurin, Rhodomyrtosone B and Rhodomyrtosone D.
AUTENTIKASI KULIT BUAH G. FORBESII KING DARI RISIKO ADULTERASI G. MANGOSTANA L MENGGUNAKAN KOMBINASI KEMOMETRIK-SPEKTROFOTOMETRI UV-VIS Samsul Hadi; Kunti Nastiti
Jurnal Farmamedika (Pharmamedika Journal) Vol 8 No 1 (2023): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v8i1.171

Abstract

Garcinia forbesii King adalah anggota genus Garcinia. Tanaman ini adalah tanaman endemik pulau Sumatera dan Kalimantan di Indonesia. Uji aktivitas dan isolasi senyawa aktif sudah dilakukan oleh para peneliti diantaranya bagian pericarp dari G. forbesii sudah terbukti memiliki kemampuan antioksidan, antiplasmodial dan antidiabetes secara invitro. Oleh karena itu untuk menjaga kualiatas bahan mentah dari G. forbesii diperlukan uji autentikasi. Metode yang dipergunakan dalam uji autentikasi ini menggunakan kemometrik dikombinasi oleh spektrofotometri UV-vis, komposisi bahan yang dipergunakan adalah G.forbesii: G.mangostana; 0;15;45;55;80 dan 100%.. Analisis data yang digunaka menggunakan PLSR. Hasil yang diperoleh dalam uji ini adalah pada daerah lamda 248.92-224.66 nm model derivatisasi kedua RMSEC 4.79; R2 0,9901; RMSEP 5,01; R2;0,9909; RMSECV 12,6; R2 0,9308. Pada lamda 292.37- 256.16 nm model derivatisasi pertama RMSEC 6,1; R2 0,9839; RMSEP 6,19; R2 6,19; RMSECV 18,6; R2 0,8642. Kesimpulannya adalah Lamda berkisar 248.92-224.66 nm model derivatisasi kedua merupakan model yang terbaik untuk autentikasi Garcinia forbesii.
Activity predication of rhodomyrtus tomentosa (Aiton) hassk against ace1 inhibitors Samsul Hadi; Kunti Nastiti
Science Midwifery Vol 11 No 2 (2023): June: Midwifery and Health Sciences
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v11i2.1271

Abstract

ACE is a peptidyl-dipeptidase enzyme that catalyzes the conversion of substrates from angiotensin I to angiotensin II. These changes cause constriction of blood vessels so that blood pressure increases (hypertension), so This study aims to find compounds that have the potential to reduce blood pressure through the pathway of ACE1 enzyme inhibition. The method used is docking, the material used is a compound contained from Rhodomyrtus tomentosa and. The ACE1 protein was obtained from RCSB with the code 1UZF. The equipment used was an online pass webserver, PLNTS software and discovery studio. This research was started by redocking the native ligand to determine the coordinates and radius, followed by validating the docking results. The results of the early stage screening obtained 4 compounds with a threshold value above 0.3, these four compounds were continued with the docking test. The docking scores obtained were Afrormosin (-59.620); Pedunculagin (-45.205); Tomentosine (-70.986); Desgalloylstachyurin (-54.374). The conclusion obtained is that the Tomentosine compound binds most easily to ACE1
POTENTIAL PLANTS BALIK ANGIN (Alphitonia excels (Fenzl) Benth.) AS ANTI TUMOR samsul Hadi
Jurnal Sabdariffarma Vol 10, No 2 (2022): SABDARIFFARMA
Publisher : Prodi Farmasi - Universitas Al Ghifari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53675/jsfar.v10i2.162

Abstract

Cancer is a disease characterized by uncontrolled cell duplication and the ability of cells to invade other biological tissues. Thus treatment of this disease needs to be done. However, treatment of this disease poses a relatively high risk. So that research is needed to find compounds that have the potential to overcome cancer. By looking at the stability of the ligand interacting with the BCl2 receptor. One of the plants that has the potential as an alternative cancer treatment is Alphitonia excels and one of the methods that can be used to see stability is docking. This docking process begins with protein preparation with Yasara and ligand preparation with Marvinbean. Docking software used is PLANT and visualization of interactions with Discovery studio. The results of the docking score are Batulinic acid :-75,487; Alphitonin :-81,143; Alphitolic acid :-78,293; Ceanothic acid :-73,27. So it can be concluded that the most stable ligand interacting is Alphitonin. 
Development of QSAR Model of Caffeic Acid Phenethyl Ester as Anti-Cancer HT-29 Uripto Trisno Santoso
Jurnal Sains dan Terapan Kimia Vol 16, No 2 (2022)
Publisher : Program Studi Kimia, Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jstk.v16i2.12632

Abstract

Caffeic Acid Phenethyl Ester (CAPE) compounds are potentially colorectal anticancer drugs. QSAR (Quantitative Structure-Activity Relationship) research on the CAPE compound class has been carried out, but the model in the previous study did not meet the goodness of fit criteria. The development of the CAPE compound QSAR model as a colorectal anticancer was carried out to obtain a model that meets the goodness of fit criteria and is valid. Eighteen CAPE compounds were used to build the QSAR model using the Multiple Linear Regression (MLR) technique. The descriptor selection was carried out using the backward elimination method and the validation test using the internal leave one out (LOO) cross-validation. The results showed that the QSAR model with four descriptors, namely MDEC22, MDEC23, JGI1, and molecular weight (BM), met the goodness of fit and Q2(LOO) criteria. The development of the QSAR model by adding the LogP descriptor resulted in the QSAR 5 descriptor model with higher goodness of fit level than the QSAR model without the LogP descriptor. Both of these QSAR models have the potential to be used as predictors in the development of a new class of CAPE compounds as anticancer agents against HT-29 cells.
Autentikasi Bunga R.tomentosa dari Resiko Adulterasi M. Candidum dengan Metode Spektrofotometri UV-VIS Kombinasi Khemmometrik: Authentication of R.tomentosa Flowers From the Risk of M. Candidum Adulteration Using Chemometric Combination UV-VIS Spectrophotometry Method Samsul Hadi; Kunti Nastiti
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5140

Abstract

R. tomentosa flowers have various activities and these activities are different from M. candidum flowers, but have similar flowers so the risk of mixing is very high. Therefore, this study aims to prevent the occurrence of mixtures using UV-VIS spectrophotometry method combined with chemometrics. The method used in this study was the extracts of the two species were dissolved with methanol p.a and scanned the spectra at a wavelength of 200-400 nm, data analysis using partial least squares. The results obtained in the authentication of Bunga R.tomentosa produced various models, at 248.14-222.5 nm scanning resulted in data RMSEC: 2.61, R2: 0.9971, RMSEP:5.78, R2: 0.9951 and RMSECV:9.19, R2: 0.9655, On scanning 298.43- 56.36nm produces data RMSEC:0.929, R2: 0.9996, RMSEP:3.54, R2: 0.9956 and RMSECV:10.5,R2:0.9591, by looking at the two data, the lowest RMSE value and the highest R2 value are selected. The conclusion in this study is that the best model for R.tomentosa authentication is the second derivatization with a wavelength of 298.43-256.36nm.
Co-Authors Ag. Yuswanto Ag. Yuswanto Agustina, Ni Kadek Ayu Amalia Khairunnisa Amalia Khairunnisa Amalia Khairunnisa Ana Maulana Ana Muliana Arif Subekti Arif Subekti Bawaihi Bawaihi Buih, Putri Helena Junjung DENI SETIAWAN Deni Setiawan Desiya Ramayanti Azhara Desiya Ramayanti Azhara Diah Aulia Rosanti Diah Aulia Rosanti Dian Ekowati Dian Ekowati Dian Kusuma Putra Eko Suhartono Elvina Astria Agustin Endang Lukitaningsih Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah Fanli Yudi Anwar Farida Istiqamah Fathul Jannah, Fathul Febriani, Noor Rahmi Fery Ramadhan Fitri Puspitasari Gunawan Gunawan Gunawan Gunawan Indriani, Erika Irawati Irawati Izma, Hayatun Khadijah, Nor Khoerul Anwar Kunti Nastiti Kunti Nastiti Kunti Nastiti Kunti Nastiti Kunti Nastiti Kunti Pelita Kuranji Blok Nastiti Liling Triyasmono Liling Triyasmono Liling tryasmono Linda Wahyuni Ludowika Adonita Tarong Lutfi Chabib, Lutfi Malahayati, Siti Melviani Melviani Mirza Maulana Ahmad Muhammad Firman Akbar Muhammad Ikhwan Rizki Muhammad Luthfi Firdaus Muhammad Syihab Setia Budi Nashrul Wathan Nastiti, Kunti Noer Komari Normaidah, Normaidah Normilawati Noval Noval Noval Noval Nugi Maulana Nur Mahdi Nurul Mardiati Nurul Mardiati Okta Muthia Sari Pertiwi Awilda Rafiah Anggianingrum Rahmadina, Nazwa Rahmawati, Nanda Hesti Ramadani, Rizka aulia Ratnapuri, Prima Happy Rezka Fajar Ramadhan Rinda, Ririn Purnama Riswandayani Savitri Risye Hendry Rizki Swastika Puri ROBIATUL ADAWIYAH RR. Endang Lukitaningsih Salma Salma Sefa Nur Khalifah Setia Budi Sheila Nurrahmah Shindi, Muhammad Riki Sintya Oktaviani Sri Oktaviana Sari Sri Oktaviana Sari Subagus Wahyuono Subagus Wahyuono Suci Kamelia Sukmana, M. Laily Qadry Tazkia Safarina Ulfah, Nahdiati Umi Nur Hapifah Umi Nur Hapifah Uripto Trisno Santoso Viogenta, Pratika Wijaya, Eka Setya Yusri Yusri Yusri Yusri