Article Per Year (5 Year)
p-Index From 2021 - 2026
7.176
P-Index
This Author published in this journals
All Journal Journal of Food and Pharmaceutical Science Jurnal Ilmiah Farmasi Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Cancer Chemoprevention Pharmacon Berkala Kedokteran Jurnal Surya Medika PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Indonesian Journal of Chemical Analysis (IJCA) Journal of Midwifery and Nursing Jurnal Jamu Indonesia Fullerene Journal of Chemistry CERATA Jurnal Ilmu Farmasi JURNAL PENDIDIKAN MIPA Pharmacoscript Jurnal Farmamedika (Pharmamedica Journal) Jurnal Jejaring Matematika dan Sains Science Midwifery International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi Jurnal Ilmiah Medicamento Indonesia Berdaya Hydrogen: Jurnal Kependidikan Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pijar MIPA Jurnal Ilmiah Berkala Sains dan Terapan Kimia Journal of Pharmaceutical Care and Sciences Jurnal Farmasi Sains dan Praktis Jurnal Bakti Untuk Negeri Gunung Djati Conference Series Jurnal Pengabdian Masyarakat Indonesia Sejahtera Jurnal Farmasi SYIFA Journal of Food and Pharmaceutical Sciences CERATA Jurnal Pengabdian Masyarakat Panacea Jurnal Sains dan Kesehatan Journal of Pharmascience
Samsul Hadi
ULM
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 55 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 55 Documents
Search

 2   3   4   5   6 
Screening of Rhodomyrtus tomentosa (Aiton) Wight (Karamunting) Compounds that Have the Potential for Breast Cancer Samsul Hadi; Kunti Nastiti
Hydrogen: Jurnal Kependidikan Kimia Vol 11, No 2 (2023): April 2023
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v11i2.7189

Abstract

Breast cancer is the highest disease in the world beating lung cancer, so various alternatives are needed to find a treatment. Screening drug discovery against breast cancer by targeting BCL-2 occupies the main position and is the goal of this study. The method used is insilico. the material used is 10 compounds from R. tomentose, 2w3l protein from RCSB, PLANT docking software, the docking coordinate used is X: 39.8057 Y: 26.9355 Z: -12.4145 with a radius of 11.1871, then to find out the type of bond and residue involved using discovery studio. The results of this study were docking scores from -91.3871(5'-Desgalloylstachyurin) to -65.4754 (Afrormosin), activity predictions from PASS online from 0.174 (Rhodomyrtosone C) to 0.799 (Lupeol). Based on the docking score, three compounds that have the potential to inhibit the work of BCL-2 were obtained namely 5'-Desgalloylstachyurin, Rhodomyrtosone B and Rhodomyrtosone D.
AUTENTIKASI KULIT BUAH G. FORBESII KING DARI RISIKO ADULTERASI G. MANGOSTANA L MENGGUNAKAN KOMBINASI KEMOMETRIK-SPEKTROFOTOMETRI UV-VIS Samsul Hadi; Kunti Nastiti
Jurnal Farmamedika (Pharmamedika Journal) Vol 8 No 1 (2023): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v8i1.171

Abstract

Garcinia forbesii King adalah anggota genus Garcinia. Tanaman ini adalah tanaman endemik pulau Sumatera dan Kalimantan di Indonesia. Uji aktivitas dan isolasi senyawa aktif sudah dilakukan oleh para peneliti diantaranya bagian pericarp dari G. forbesii sudah terbukti memiliki kemampuan antioksidan, antiplasmodial dan antidiabetes secara invitro. Oleh karena itu untuk menjaga kualiatas bahan mentah dari G. forbesii diperlukan uji autentikasi. Metode yang dipergunakan dalam uji autentikasi ini menggunakan kemometrik dikombinasi oleh spektrofotometri UV-vis, komposisi bahan yang dipergunakan adalah G.forbesii: G.mangostana; 0;15;45;55;80 dan 100%.. Analisis data yang digunaka menggunakan PLSR. Hasil yang diperoleh dalam uji ini adalah pada daerah lamda 248.92-224.66 nm model derivatisasi kedua RMSEC 4.79; R2 0,9901; RMSEP 5,01; R2;0,9909; RMSECV 12,6; R2 0,9308. Pada lamda 292.37- 256.16 nm model derivatisasi pertama RMSEC 6,1; R2 0,9839; RMSEP 6,19; R2 6,19; RMSECV 18,6; R2 0,8642. Kesimpulannya adalah Lamda berkisar 248.92-224.66 nm model derivatisasi kedua merupakan model yang terbaik untuk autentikasi Garcinia forbesii.
Activity predication of rhodomyrtus tomentosa (Aiton) hassk against ace1 inhibitors Samsul Hadi; Kunti Nastiti
Science Midwifery Vol 11 No 2 (2023): June: Midwifery and Health Sciences
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v11i2.1271

Abstract

ACE is a peptidyl-dipeptidase enzyme that catalyzes the conversion of substrates from angiotensin I to angiotensin II. These changes cause constriction of blood vessels so that blood pressure increases (hypertension), so This study aims to find compounds that have the potential to reduce blood pressure through the pathway of ACE1 enzyme inhibition. The method used is docking, the material used is a compound contained from Rhodomyrtus tomentosa and. The ACE1 protein was obtained from RCSB with the code 1UZF. The equipment used was an online pass webserver, PLNTS software and discovery studio. This research was started by redocking the native ligand to determine the coordinates and radius, followed by validating the docking results. The results of the early stage screening obtained 4 compounds with a threshold value above 0.3, these four compounds were continued with the docking test. The docking scores obtained were Afrormosin (-59.620); Pedunculagin (-45.205); Tomentosine (-70.986); Desgalloylstachyurin (-54.374). The conclusion obtained is that the Tomentosine compound binds most easily to ACE1
POTENTIAL PLANTS BALIK ANGIN (Alphitonia excels (Fenzl) Benth.) AS ANTI TUMOR samsul Hadi
Jurnal Sabdariffarma Vol 10, No 2 (2022): SABDARIFFARMA
Publisher : Prodi Farmasi - Universitas Al Ghifari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53675/jsfar.v10i2.162

Abstract

Cancer is a disease characterized by uncontrolled cell duplication and the ability of cells to invade other biological tissues. Thus treatment of this disease needs to be done. However, treatment of this disease poses a relatively high risk. So that research is needed to find compounds that have the potential to overcome cancer. By looking at the stability of the ligand interacting with the BCl2 receptor. One of the plants that has the potential as an alternative cancer treatment is Alphitonia excels and one of the methods that can be used to see stability is docking. This docking process begins with protein preparation with Yasara and ligand preparation with Marvinbean. Docking software used is PLANT and visualization of interactions with Discovery studio. The results of the docking score are Batulinic acid :-75,487; Alphitonin :-81,143; Alphitolic acid :-78,293; Ceanothic acid :-73,27. So it can be concluded that the most stable ligand interacting is Alphitonin. 
Development of QSAR Model of Caffeic Acid Phenethyl Ester as Anti-Cancer HT-29 Uripto Trisno Santoso
Jurnal Sains dan Terapan Kimia Vol 16, No 2 (2022)
Publisher : Program Studi Kimia, Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jstk.v16i2.12632

Abstract

Caffeic Acid Phenethyl Ester (CAPE) compounds are potentially colorectal anticancer drugs. QSAR (Quantitative Structure-Activity Relationship) research on the CAPE compound class has been carried out, but the model in the previous study did not meet the goodness of fit criteria. The development of the CAPE compound QSAR model as a colorectal anticancer was carried out to obtain a model that meets the goodness of fit criteria and is valid. Eighteen CAPE compounds were used to build the QSAR model using the Multiple Linear Regression (MLR) technique. The descriptor selection was carried out using the backward elimination method and the validation test using the internal leave one out (LOO) cross-validation. The results showed that the QSAR model with four descriptors, namely MDEC22, MDEC23, JGI1, and molecular weight (BM), met the goodness of fit and Q2(LOO) criteria. The development of the QSAR model by adding the LogP descriptor resulted in the QSAR 5 descriptor model with higher goodness of fit level than the QSAR model without the LogP descriptor. Both of these QSAR models have the potential to be used as predictors in the development of a new class of CAPE compounds as anticancer agents against HT-29 cells.
Autentikasi Bunga R.tomentosa dari Resiko Adulterasi M. Candidum dengan Metode Spektrofotometri UV-VIS Kombinasi Khemmometrik: Authentication of R.tomentosa Flowers From the Risk of M. Candidum Adulteration Using Chemometric Combination UV-VIS Spectrophotometry Method Samsul Hadi; Kunti Nastiti
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5140

Abstract

R. tomentosa flowers have various activities and these activities are different from M. candidum flowers, but have similar flowers so the risk of mixing is very high. Therefore, this study aims to prevent the occurrence of mixtures using UV-VIS spectrophotometry method combined with chemometrics. The method used in this study was the extracts of the two species were dissolved with methanol p.a and scanned the spectra at a wavelength of 200-400 nm, data analysis using partial least squares. The results obtained in the authentication of Bunga R.tomentosa produced various models, at 248.14-222.5 nm scanning resulted in data RMSEC: 2.61, R2: 0.9971, RMSEP:5.78, R2: 0.9951 and RMSECV:9.19, R2: 0.9655, On scanning 298.43- 56.36nm produces data RMSEC:0.929, R2: 0.9996, RMSEP:3.54, R2: 0.9956 and RMSECV:10.5,R2:0.9591, by looking at the two data, the lowest RMSE value and the highest R2 value are selected. The conclusion in this study is that the best model for R.tomentosa authentication is the second derivatization with a wavelength of 298.43-256.36nm.
Cox2 Inhibitor Test Of Limpasu (Baccaurea Lanceolata) Using Computation Method Samsul Hadi; Nashrul Wathan; Deni Setiawan; Pratika Viogenta; Kunti Nastiti
Journal of Midwifery and Nursing Vol. 5 No. 3 (2023): September: Health Science
Publisher : Institute Of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/jmn.v5i3.4104

Abstract

The use of anti-inflammatory drugs with the COX-2 method is starting to develop tolerance, so that drugs circulating in the community now cause various kinds of complaints, namely inhibition of blood clotting and stomach ulcers. Therefore, the purpose of this study was to screen natural product compounds that have potential as COX-2 inhibitors. The materials used are compounds contained in B.lanceolata and COX-2 enzymes with code 3ln1 obtained from the RCSB database, the equipment used is a windows laptop with PLANT and discover studio software, the method used in this study is a computational study using docking software . The results in this study were that the docking score of B. lanceolata was higher than the native ligand, so the effectiveness was weaker than the native ligand, the docking scores obtained were as follows: Epidihydrotutin (-50.243); Sapidolide A (-51052); Melatonin (-53039); 6'-O-Vanilloylisotachioside (-60.910) and 6'-O-Vanilloyltachioside (-61.131). In conclusion, 6'-O-Vanilloyltachioside is a potential compound as a COX-2 inhibitor from B.lanceolata.
Skrining Inhibitor Antihistamin Secara In Silico dari Senyawa Melati Belanda (Quisqualis indica L.) Nashrul Wathan; Samsul Hadi; Rizki Swastika Puri
JURNAL PENDIDIKAN MIPA Vol 13 No 3 (2023): JURNAL PENDIDIKAN MIPA
Publisher : Pusat Publikasi Ilmiah, STKIP Taman Siswa Bima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37630/jpm.v13i3.1164

Abstract

Gejala gatal-gatal, ruam kulit, hidung tersumbat, bersin-bersin, mata merah, dan anafilaksis merupakan tanda dari alergi. Penanganan penyakit alergi dilakukan dengan pemberian terapi glukokortikoid, antileukotrien dan antihistamin H1. Sehingga tujuan dari penelitian ini adalah skrening bahan alam dengan metode Insilico. Alur cara kerja dimulai dengan mencari senyawa dari melati belanda, kemudian dipreparasi di chem axon, tahap selanjutnya adalah docking PLANT dan yang terakhir Visualisasi dengan menggunakan Discovery studio. Hasil dari peneltian ini adalah skordocking dari masing masing ligand yaitu: asquisqualic acid (-67,0166); arachidonic acid (-114,165); linoleic acid(-109,504); rutin ( -29,15); Quisqualic acid (-69,3609); Trigonelline (-65,1792); quinoline-4-carbonitrile (-76,9548); gallic acid (-70,2333); ellagic acid (-67,0591); flavogallonic acid (-30,9294); brevifolin carboxylic acid (-74,2838); quercetin(-82.544); β-sitosterol (-67,9037); lupeol (-30,033); linalool (-75,1704). Kesimpulannya yang memiliki energi terendah yang berpotensi sebagai inhibitor antihistamin adalah asam arachidonat.
Analisis Antioksidan Ekstrak Etanol Daun Ceguk (Combretum indicum L.) varr.M dengan Berbagai Lokasi Kalimantan Selatan, Indonesia Samsul Hadi; Umi Nur Hapifah; Amalia Khairunnisa
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5427

Abstract

Indicum has 2 variations, especially in terms of flowers, namely elongated and rounded types with antioxidant effects. So the aim of this research is to know the antioxidant of C. Indicum leaves, one of the varieties in Banjar, Banjarbaru and Tanah Laut areas, that variety is C. indicum varr.M. Antioxidant testing using TLC and quantitative using UV-Vis spectrophotometer. The antioxidant results qualitatively have antioxidant activity marked by a yellowish white stain. The quantitative test results of Banjar, Banjarbaru and Tanah Laut have 97.2219±0.263 ppm, 50.0832±0.078 ppm and 56.2046±0.185 ppm IC50 values. The results of One Way Anova analysis on the ethanol extract of elongated C. indicum leaves from Banjar, Banjarbaru and Tanah Laut had significant differences between each location and other locations. Based on these results Banjarbaru has the best antioxidants.
Penetapan Kadar Air Dan Kadar Protein Pada Biskuit Yang Beredar Di Pasar Banjarbaru Normilawati; Fadlilaturrahmah; Samsul Hadi; Normaidah
CERATA Jurnal Ilmu Farmasi Vol 10 No 2 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v10i2.77

Abstract

Many biscuits circulating in the community are not labeled and do not include the value of water and protein content in accordance with SNI. Therefore, it is necessary to determine the water content and protein content in the biscuits. Determination of water content and protein content in biscuits was carried out on 2 biscuit samples taken at the Banjarbaru Market. The water content test on the sample was carried out by the gravimetric method and the protein content test was carried out by the Kjeldahl method. The results obtained were the test of water content of 2 biscuit samples respectively at 4.43% and 3.84%. While the results of the protein content test from 2 samples are 5.31% and 6.89%, respectively. According to SNI 01-2973-2011 the water content limit does not exceed 5% while the protein content limit is a minimum of 5%. The results of 2 samples showed the water content and protein content in accordance with SNI.
Co-Authors Ag. Yuswanto Ag. Yuswanto Agustina, Ni Kadek Ayu Amalia Khairunnisa Amalia Khairunnisa Amalia Khairunnisa Ana Maulana Ana Muliana Arif Subekti Arif Subekti Bawaihi Bawaihi Buih, Putri Helena Junjung Deni Setiawan Desiya Ramayanti Azhara Desiya Ramayanti Azhara Diah Aulia Rosanti Diah Aulia Rosanti Dian Ekowati Dian Ekowati Dian Kusuma Putra Eko Suhartono Elvina Astria Agustin Endang Lukitaningsih Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah Fanli Yudi Anwar Farida Istiqamah Fathul Jannah, Fathul Febriani, Noor Rahmi Fery Ramadhan Gunawan Gunawan Gunawan Gunawan Indriani, Erika Irawati Irawati Izma, Hayatun Khadijah, Nor Khoerul Anwar Kunti Nastiti Kunti Nastiti Kunti Nastiti Kunti Nastiti Kunti Nastiti Kunti Pelita Kuranji Blok Nastiti Liling Triyasmono Liling Triyasmono Liling tryasmono Linda Wahyuni Ludowika Adonita Tarong Lutfi Chabib, Lutfi Malahayati, Siti Melviani Melviani Mirza Maulana Ahmad Muhammad Firman Akbar Muhammad Ikhwan Rizki Muhammad Luthfi Firdaus Muhammad Syihab Setia Budi Nashrul Wathan Nastiti, Kunti Noer Komari Normaidah, Normaidah Normilawati Noval Noval Noval Noval Noval Noval Nugi Maulana Nur Mahdi Nurul Mardiati Okta Muthia Sari Pertiwi Awilda Rafiah Anggianingrum Rahmadina, Nazwa Rahmawati, Nanda Hesti Ramadani, Rizka aulia Ratnapuri, Prima Happy Rezka Fajar Ramadhan Rinda, Ririn Purnama Risye Hendry Rizki Swastika Puri ROBIATUL ADAWIYAH RR. Endang Lukitaningsih Rufi'i Salma Salma Sefa Nur Khalifah Setia Budi Sheila Nurrahmah Shindi, Muhammad Riki Sintya Oktaviani Sri Oktaviana Sari Sri Oktaviana Sari Subagus Wahyuono Subagus Wahyuono Suci Kamelia Sukmana, M. Laily Qadry Tazkia Safarina Ulfah, Nahdiati Umi Nur Hapifah Umi Nur Hapifah Uripto Trisno Santoso Viogenta, Pratika Wijaya, Eka Setya Yusri Yusri Yusri Yusri