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All Journal Biospecies CHEMISTRY PROGRESS Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Komunikasi Fisika Indonesia Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Jurnal Geosaintek CHEMPUBLISH JOURNAL JOURNAL ONLINE OF PHYSICS Jurnal Geocelebes Eksakta : Berkala Ilmiah Bidang MIPA JURNAL METEOROLOGI DAN GEOFISIKA Jurnal Abdimas Mahakam Jurnal Bio-Geo Material Dan Energi Jurnal Riset Teknik Pertambangan Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Jurnal Karya Abdi Masyarakat Jurnal Indonesia Sosial Teknologi Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Journal of The Indonesian Society of Integrated Chemistry Prosiding Seminar Nasional Unimus Jurnal Meteorologi dan Geofisika al Kimiya : Jurnal Ilmu Kimia dan Terapan Jurnal Geosaintek
Faizar Farid
Program Studi Kimia, Fakultas Sains Dan Teknologi , Universitas Jambi, Jl. Jambi – Muara Bulian Km. 15 36361, Jambi
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Nursing Physics Public Health Social Sciences Other

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In Silico Study of Bioactive Compounds of Putat Leaf Extract (Planchonia valida) as Anti-Cancer Against the VEGFR2 Receptor Bela, Anisa; Farid, Faizar; Nelson; Dewi, Tribuana Tungga; Prabawa, Satria; Khatib, Alfi; Yusnaidar, Yusnaidar; Latief, Madyawati; Tarigan, Indra Lasmana
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.32049

Abstract

Cancer is the process of forming new tissue that is abnormal and malignant. Efforts to discover anti-cancer drug compounds continue to be made to minimize the toxic effects of chemotherapy, so it is necessary to look for other alternatives to treat cancer. This research aims to determine the anti-cancer activity of putat plant bioactive compounds through identification of receptor targets and interaction studies using the molecular docking method against the VEGFR2 (Vascular endothelial growth factor receptor-2) receptor. The results showed that in the test of eight putat plant bioactive compounds the best results were obtained for the compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with a binding free energy value of -9.86 kcal-mol-1 with an inhibition constant value of 1.47 Micromolar. The best docking result has an inhibition constant value that is higher than the native ligand and has a binding free energy that is almost close to the binding free energy of the native ligand with an inhibition constant value of 42.38 Micromolar and a binding free energy value of 10.06 kcal-mol-1. Therefore, the results of the docking of the bioactive compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with the VEGFR-2 receptor are considered capable of being an alternative as a candidate for anti-cancer drugs.
UJI KERENTANAN BANGUNAN RUSUNAWA BERDASARKAN HVSR (HORIZONTAL TO SPECTRAL RATIO) DAN FSR (FLOOR SPECTRAL RATIO) Larasati, Nurrani; Farid, Faizar; Juventa, Juventa
Jurnal Geosaintek Vol. 8 No. 1 (2022)
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Lokasi penelitian terletak di gedung Rusunawa (asrama mahasiswa) yang termasuk ke dalam wilayah administratif Universitas Jambi. Penelitian ini dilakukan untuk mengetahui nilai frekuensi alami tanah (ft), nilai frekuensi alami bangunan (fb), nilai amplitudo (A0), nilai resonansi (%) dan nilai indeks kerentanan bangunan (K) berdasarkan HVSR (Horizontal to Vertikal Spectral Ratio) dan FSR (Floor Spectral Ratio). Secara geologi, gedung Rusunawa berada pada Formasi Muaraenim yang tersusun batupasir tufan dan batulempung tufan, batupasir kuarsa dan batulempung kuarsa, sisipan batubara dan oksida besi. Data penelitian diperoleh dari 36 titik perekaman data mikrotremor. Hasil nilai resonansi pada komponen East – West (EW) dengan rata-rata 330.296%, sedangkan komponen North – South (NS) dengan nilai rata-rata 249.305%. Nilai tersebut memiliki resonansi > 25% dengan klasifikasi rendah berdasarkan klasifikasi kerentanan resonansi. Hasil nilai indeks kerentanan bangunan (K) gedung Rusunawa Universitas Jambi komponen East – West (EW) dengan rata-rata 32.86813 cm/s2, komponen North – South (NS) dengan rata-rata 59.59811 cm/s2 memiliki nilai indeks kerentanan bangunan yang rendah. Nilai indeks kerentanan dibawah dari 1/100 gedung Rusunawa aman terhadap kerusakan.
Antioxidant Activity of Bioactive Compounds in the Ethyl Acetate Extract of Putat Leaves (Planchonia valida) Nelson; Silaban, Desy Vania; Farid, Faizar; Puspitasari, Ratih Dyah; Tarigan, Indra Lasmana; Ramadhan, Ilham Ifandi; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41632

Abstract

The Putat leaf (Planchonia valida) is a plant traditionally used by the community in the Tanjung Lanjut area, Jambi, both as a salad ingredient and as a traditional medicine to treat skin diseases and promote health. This identifies that the putat plant contains chemical compounds that potentially have antioxidant activity. In this study, putat leaf samples (Planchonia valida) that potentially have antioxidant activity. In this study, Planchonia valida (P. valida) leaf samples using n-hexane and ethyl acetate solvents through a multistep maceration process. Subsequently, phytochemical screening and antioxidant activity tests were conducted to obtain information about fractions that have the potential to be further isolated. The extraction percentage with a yield value of 1,28% was obtained in the maceration process. Further isolation was carried out using isolate liquid chromatography and FT-IR instruments. The obtained isolate was in the form of a wet solid, and through characterization, it was classified as a steroid compound suspected to be ergosterol. Free radicals or oxidants have reactive effects on the human body and can trigger various types of diseases. Antioxidants are known to have the ability to inhibit or neutralize free radicals in the human body. This study tested antioxidant activity using the DPPH (1,1-diphenyl-1,1-picrylhydrazyl) method on isolating F1. Isolate F1 was found to have antioxidant activity with a value of 714.637 ppm, falling into the range of weak antioxidant activity
Isolasi Proses Bioaktif Ekstrak Metanol Daun Putat (Planchonia valida) sebagai Antioksidan Farid, Faizar; Br Sembiring, Vera Lorensya; Nelson, Nelson; Saputra, Muhammad Furqon Novryan; Putri, Silvi Ayudiah; Tarigan, Indra Lasmana; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41634

Abstract

Putat leaves (Planchonia valida) are a plant that is traditionally used by people in the Tanjung Lanjut areas, Jambi as fresh vegetables, and as a traditional medicine to treat skin diseases and restore health. This identifies that the putat plant contains chemical compounds that have the potential to have antioxidant activity. Extraction was carried out using n-hexane and ethyl acetate solvents using multistage maceration. Next, phytochemical screening and antioxidant activity tests are carried out to obtain information about fractions that can potentially proceed to the isolation stage. In the maceration process, an extract percentage was obtained with a yield value of 1.39%. Next, isolation was carried out using vacuum liquid chromatography. The isolates obtained were then characterized using UV-Vis and FT-IR spectrophotometer instruments. The isolate obtained was in the form of a wet solid, and if seen through characterization, it belonged to the class of steroid compounds; it was suspected to be an ergosterol compound. Antioxidants are known to have the ability to inhibit and reduce the presence of free radicals in the human body. In this study, antioxidant activity was tested using the DPPH (2,2-diphenyl-1-picrihidazil) method on F1 isolates. The F1 isolate obtained was proven to have antioxidant activity with a value of 99.2265 ppm, which is classified in the strong antioxidant activity range.
Irritation Test and Effectiveness of Facial Humidity Skin from Peel Off Gel Mask Based of Date Palm Seeds Powder (Phoenix dactylifera) Lestari, Uce; Farid, Faizar; Yuliawati, Yuliawati; Pratama, Septa
Jurnal Bio-Geo Material Dan Energi Vol. 1 No. 2 (2021): Journal of Bio-Geo Material and Energy (BiGME), September 2021
Publisher : PUI BiGME Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/bigme.v1i2.15318

Abstract

Dry skin is the main problem of skin damage such as scaly, peeling, cracked and itchy skin, this is because the skin loses fluids due to weather changes and as we age we experience a decrease in the amount of oil and water on the skin. Facial skin care is done, one of which is by using a peel off gel mask of dates palm powder. The fat content is useful as a facial skin moisturizer. This study aims to determine the formula of the peel off gel mask which has determine its safety and effectiveness in moisturizing facial skin. The peel off gel mask was made into 3 formulas with the concentration of date palm seeds powder 1% (FI), 2% (FII) and 3% (FIII).  Procedures in this study include irritation test, hedonic test and facial skin moisture test using a skin analyzer compared before and after use. Peel off gel mask choco milk as a positive control. The results showed that FII ( 2%) corresponding the requirements of no irritation occurs compared to other formulas. Testing the effectiveness of facial skin moisture showed that FII (2%) was able to increase the water content after use and the water content was higher than the positive control. Results it can be concluded that the FII has safe for use and effective in moisturizing facial skin.
Analisis ground vibration pada kegiatan peledakan batuan gamping menggunakan pendekatan PPV di wilayah eksisting 206 PT. Semen Padang Karang Putih Sumatra Barat Daryati, Daryati; Novianti, Novianti; Farid, Faizar; Denny Prabawa, Aditya
Jurnal Indonesia Sosial Teknologi Vol. 2 No. 07 (2021): Jurnal Indonesia Sosial Teknologi
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5002.239 KB) | DOI: 10.59141/jist.v2i07.187

Abstract

PT. Semen Padang merupakan salah satu perusahaan tambang batu gamping yang wilayah penambangannya terletak di Bukit Karang Putih, Kelurahan Indarung, Kecamatan Lubuk Kilangan, Sumatera Barat. Sistem penambangan yang diterapkan adalah quarry. Perusahaan ini melakukan pembongkaran batuan gamping di wilayah eksisting 206 menggunakan metode peledakan. Hal ini dilakukan karena batuan gamping memiliki kekerasan 3,5 skala mohs. Peledakan batuan menimbulkan getaran tanah yang apabila melebihi batas aman menyebabkan kerusakan retakan bangunan dan perkantoran. Tahapan yang digunakan pada penelitian ini yaitu pengambilan data dilapangan berupa jumlah lubang ledak, jarak lokasi peledakan, isian perdelay dan nilai PPV aktual. Penelitian ini dilakukan untuk menganalisis dan memberi kontrol getaran dampak ground vibration akibat peledakan, membatasi penggunaan jumlah bahan peledak dengan melakukan analisis dengan metode regresi power. Analisis dilakukan dengan memperhatikan nilai PPV dan SD yang didapatkan secara aktual. Analisis regresi power menghasilkan sebuah persamaan untuk memprediksi nilai PPV yaitu PPV= 13,261 (SD)−0,603. Pengamatan dilakukan dengan menggunakan hasil regresi power yang hasilnya antara prediksi dengan aktual tidak jauh berbeda. Setelah itu, dilakukan rekomendasi untuk membatasi penggunaan jumlah bahan peledak dari hasil regresi power.
Kajian Senyawa Bioaktif Dari Tumbuhan Obat Tradisional Kulit Akar Tumpunik (Artocarpus rigida BI) Farid, Faizar
Biospecies Vol. 3 No. 2 (2010): Februari 2010
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/biospecies.v3i2.241

Abstract

This study aims to isolate and identify bioactive compounds contained in the root of tumpunik (Artocarpus rigida BI). The root was firstly extracted using ethanol and then continued with fractionation process using a solvent combination of hexane, chloroform, ethyl acetate, and methanol. The obtained fractionate then was tested its toxicity towards shrimp A Salina larvae. The results show that soxhletation with methanol solvent could produce 36.5 grams of concentrated extract (7.30% of sample weight). Meanwhile, soxhletation using hexane fractionates, chloroform, ethyl acetate, and methanol produces 3.4 grams, 6.9 grams, 9.3 grams, and 16 grams of concentrated extract respectively. The LC50 (ppm) after three-hour toxicity test are 780, 367, 136, and 845 respectively.
Adsorption of Remazol Brilliant Blue Dye Using Palm Oil Shell Fly Ash HCl Activated Lestari, Intan; Azira, Ayu; Farid, Faizar
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 10 No. 2 (2023): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v10i2.29420

Abstract

Remazol Brilliant blue is an azo dye that is widely used in textile dyeing. The most appropriate handling method to be used in overcoming problems caused by textile dye waste is adsorption. Fly ash is an adsorbent that can be used to overcome this problem. Chemical activation was carried out using 1 M HCl solution. Besides that, physical activation was also carried out at 500°C for 1 hour. Research is needed to determine the optimum conditions for fly ash in dye adsorption to produce high adsorption efficiency. XRF characterization showed that palm shell fly ash was dominated by CaO of 71.064% and SiO2 of 15.734%. Characterization using FTIR shows the presence of Si-O groups in Fly ash. To analyze the surface morphology of the fly ash adsorbent, an SEM test was carried out and it was known that the surface morphology of the fly ash adsorbent after chemical and physical activation showed pore formation. Characterization using Surface Area Analyzer showed a surface area of 13.6153 m2/g. optimum absorption conditions at pH 6 with an adsorption capacity of 15.84 mg/g. optimum contact time of 60 minutes with an adsorption capacity of 15.54 mg/g. The optimum adsorbent mass is 0.5 g with an adsorption capacity of 9.54 mg/g and the optimum adsorbent concentration is at 200 ppm with an adsorption capacity of 69.08 mg/g. In this study the adsorption model used is the Freundlich isotherm. Based on the research result, it is known that fly ash is a suitable adsorbent for dye adsorption which is characterized by high color removal efficiency. Further characterization regarding the initial conditions of fly ash is needed as a comparison for fly ash after activation
Co-Authors -, Maison Afrianto, Muhammad Ficky Agnes Vionita Yohana Agus Syarif Alfi Khatib, Alfi Ali Nurdin Hidayat Arsa, Daniel Azira, Ayu Azril Bela, Anisa Br Sembiring, Vera Lorensya Daryati, Daryati Defia Indah Permatasari Denny Prabawa, Aditya Dewi, Tribuana Tungga Dhian Eka Wijaya Diah Riski Gusti Dwi Tata Damayanti Edwin Permana Edwin Permana Eka Nurshafni Erna Yustika Hutasoit Fandi Oktasendra Gusti, Diah Rizki Havizur Rahman Helga Dwi Fahyuan Helga Dwi Fahyuan Heriyanti Heriyanti Iful Amri Indra Lasmana Tarigan Intan Lestari Intan Lestari ira kusuma dewi Istiqomah Malinda Jesi Pebralia Juventa, Juventa Larasati, Nurrani Linda Handayani Madyawati Latief Mahraja, Mahra Mardian Peslinof Megakusuma, Yosha Mia Aina Muhammad Ikhsan Muhammad Ikrar Lagowa Nadea Arie Saragih Nelson Nelson Nelson Ngatijo Ngatijo Novianti Novianti Nurhidayah Nurhidayah Nurrani Larasati Oky Dwi Syaputra Prabawa, Satria Puspitasari, Ratih Dyah Putri Maya Sari Putri Maya Sari Putri, Silvi Ayudiah Rahman, Havizur Rahmat Basuki Ramadhan, Ilham Ifandi Resta, Ichy Lucya Restina Bemis Revis Asra Revis Asra Rikaldo Pratama Rikaldo Pratama Rustan Sampe Napitupulu Sampe Napitupulu Sampe Napitupulu, Sampe Samsidar Samsidar Samsidar Saputra, Muhammad Furqon Novryan Sarinah Pakpahan Silaban, Desy Vania Sukor, Mohd Zaki Suwarni Suwarni Suwarni Suwarni Uce Lestari Uce Lestari Usna, Sri Rahayu Alfitri Wahyudi, Abdi Wahyudi, Lutfi Wibowo, Yudha Gusti Wiratama, Jarot Wiwid Joni Yohana, Agnes Vionita Yoza Fendriani Yuliawati Yusnaidar, Yusnaidar Zahar, Wahyudi