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All Journal Journal of Food and Pharmaceutical Science Jurnal Penelitian Farmasi Indonesia Majalah Obat Tradisional CHEMPUBLISH JOURNAL Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Farmasi Indonesia JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON JFL : Jurnal Farmasi Lampung PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Ensiklopedia of Journal Jurnal Ilmu Kefarmasian Indonesia INDRA: Jurnal Pengabdian kepada Masyarakat COVIT Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE Journal of Artificial Intelligence and Digital Business Jurnal Katalisator Jurnal Farmasi Indonesia Journal of Food and Pharmaceutical Sciences Jurnal Pengabdian Masyarakat Jurnal Garuda Pengabdian Kepada Masyarakat Jurnal Bakti Nusantara Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Armon Fernando
Sekolah Tinggi Ilmu Farmasi Riau
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UJI INHIBITOR ENZIM TIROSINASE EKSTRAK DAN FRAKSI DAUN KEDABU (Sonneratia ovata Backer) SECARA IN-VITRO Mustika Furi; Ainun Alfatma; Rahma Dona; Armon Fernando; Fina Aryani; Rahayu Utami; Septi Muharni; Husnawati; Wira Noviana Suhery; Melzi Octaviani
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 2 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i2.529

Abstract

Kedabu leaves (Sonneratia ovata Backer) are known contain secondary metabolites, one of which is phenolic, flavonoid and antioxidant activity. Phenolic, flavonoids and antioxidant are known to inhibit the tyrosinase enzyme. The tyrosinase enzyme is involved in the process of melanogenesis which produces melanin. Melanin can cause hyperpigmentation. To prevent hyperpigmentation, tyrosinase inhibitors are needed. This study aimed to test the tyrosinase enzyme inhibitor in ethanol extract, n-butanol fraction, ethyl acetate fraction, n-hexane fraction of kedabu leaf (Sonneratia ovatta Backer) using L-tyrosine as a substrate. The method used to get ethanol extract using ethanol maceration, while some fractions are obtained using the fractionation method. The test was carried out using L-tyrosine and kojic acid as a positive control with absorption measurements using microplate reader at a wavelength of 492 nm. The results showed that the best tyrosinase inhibitory activity was produced by the ethyl acetate fraction with an IC50 value of 18,82 g/mL, followed by the n-butanol fraction with an IC50 value of 24,42 g/mL, and the n-hexane fraction with an IC50 value. 28,77 g/mL, ethanol extract with an IC50 value of 99,09 with a strong category for all samples compared with kojic acid as a positive control with an IC50 value of 30,09 g/mL.
In Vitro Evaluation of Sunscreen Activity of Extract and Fraction of Kedabu Fruit (Sonneratia ovata Backer) : Uji Aktivitas Tabir Surya Ekstrak dan Fraksi Buah Kedabu (Sonneratia ovata Backer) Secara In Vitro Lestari, Putri; Furi, Mustika; Fernando, Armon; Amin, Syahrul; Irfan, Nawwar
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 1 (2025): (March 2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i1.17347

Abstract

The Kedabu fruit, scientifically known as Sonneratia ovata Backer, is a mangrove plant commonly found in Indonesia. This fruit is valued for its antioxidant properties and shows potential as a natural sunscreen. This study was conducted to determine the in-vitro activity of the extract and fractions of Kedabu fruit (Sonneratia ovata Backer) as a sunscreen, with the potential for development into a natural sunscreen preparation. Experiments were conducted on extracts and various fractions, including n-hexane, ethyl acetate, n-butanol, and water. The extracts and fractions of Kedabu fruit were prepared at concentrations of 200, 400, 600, 800, and 1000 µg/mL. Their absorbance was then measured in the UV A (320-375 nm) and UV B (290-320 nm) wavelength ranges. The n-butanol fraction, at a concentration of 1000 µg/mL, appears to be the most effective sunscreen, demonstrating a %Te value of 8.369% and %Tp of 50.345%. This performance places it in the standard Suntan range for UV B protection. Additionally, it has an SPF value of 10.58, categorizing it within the highest level of sun protection.
Cytotoxic activity of isolate compounds from derendan (Lansium parasiticum (Osbeck) K.C. Sahni & Bennet) fruit peel Fadhli, Haiyul; Rahmayanı, Wıky; Allaya, Regina; Jumadila, Ikhsal Mukri; Fernando, Armon; Utami, Rahayu
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1309

Abstract

Derendan (Lansium parasiticum (Osbeck) K.C. Sahni & Bennet) is a plant from the Meliaceae family that grows in the tropics, especially in Sumatra (Indonesia). It was reported that this plant has antimalarial, antimutagenic, and anticancer properties. This study aims to determine the cytotoxic activity of compounds isolated from the methanol extract of Lansium parasiticum bark. Extraction using maceration method with methanol solvent. Vacuum Liquid Chromatography (KVC) with 21 different eluent ratios (n-hexane : ethyl acetate and ethyl acetate ; methanol) was utilized for the fractionation. The result was 21 fractions. The washing technique was used to purify fraction 17. The obtained compound LPR17 with a melting point of 239-241ᵒC. Based on the UV spectrum, the wavelengths of the LPR17 compound were 277.0 nm and 205.0 nm. The FT-IR spectrum shows aliphatic OH, CH, C=O, C-H, and C-C functional groups. This compound reacts positively with the Liebermann-Burchard reagent. The compound obtained is a triterpenoid group. Cytotoxic test using BSLT method. LPR17 compounds provide very strong cytotoxic activity (LC50 = 67.15 g/mL).
Optimalisasi Edukasi Pengobatan Dalam Peningkatan Pengetahuan Masyarakat Terkait Penyakit Kronis di Wilayah Kota Pekanbaru Firmansyah, Ferdy; Fernando, Armon; Lestari, Putri; Hasti, Syilfia; Maryunita, Dinda; Hefriza Putri; Rahma, Indah Lutfianti; Rahma, Rizqia I’zza; Husein, Sadam; Alpatiqa, Silviana Lufti, Siti Hizra; Hariyani, Widya; Sari, Winda; Safira, Yola
Jurnal Bakti Nusantara Vol. 2 No. 3 (2025): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v2i3.93

Abstract

Penyakit kronis merupakan penyebab utama morbiditas dan mortalitas di seluruh dunia, termasuk di Indonesia. Penyakit seperti diabetes mellitus, hipertensi, penyakit jantung, dan penyakit paru obstruktif kronik (PPOK) tidak hanya berdampak pada kualitas hidup individu, tetapi juga memberikan beban ekonomi dan sosial yang signifikan bagi keluarga dan sistem pelayanan kesehatan. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kualitas kesehatan masyarakat melalui pemberian edukasi mengenai penyakit kronis, meliputi pemahaman tentang gejala, faktor risiko, serta strategi pencegahannya. Edukasi diikuti oleh 50 orang masyarakat yang menghadiri Car Free Day Jalan Sudirman, Pekanbaru, Provinsi Riau. Metode yang digunakan adalah edukasi secara langsung menggunakan media leafleat dan diskusi tanya jawab. Materi edukasi adalah penyakit kronis seperti hipertensi, diabetes dan asam urat, dengan tema CERIA (Cegah Hipertensi Diabetes dan Asam Urat), mulai dari cara pencegahan, mengetahui gejala dan faktor risiko penyebab penyakit kronis tersebut. Untuk mengetahui tingkat pengetahuan masyarakat maka dilakukan pemberian lembar ceklis tes awal dan tes akhir. Hasil dari analisis tes awal dan tes akhir menggunakan uji Wilcoxon. Hasil uji Wilcoxon menunjukkan p value sebesar 0,000 dimana nilai tersebut lebih kecil dari 0,05 sehingga dapat ditarik kesimpulan bahwa ada pengaruh yang signifikan antara tes awal dan tes akhir pengetahuan responden. Kegiatan pengabdian ini telah berhasil meningkatkan pemahaman masyarakat tentang penyakit kronis. Diharapkan dengan adanya program pengabdian masyarakat ini dapat mencegah tejadinya hipertensi, diabetes dan asam urat serta dapat meningkatkan derajat kesehatan masyarakat.
EDUKASI PANDUAN MINUM OBAT BAGI PENDERITA PENYAKIT DIABETES SAAT BERPUASA Susanty, Adriani; Fernando, Armon; Octavia, Rickha; Arief, Encik Juliansyah; Putri, Dhini Fahira; Safitri, Fasri Dian; Aprilia, Indri; Syafutri, Lidiyah; Aulia, Nada Aqilah; Farisa, Nayla Al; Jannati, Nisa; Ramona, Paula; Mayrade, Salma Yudhistira
BESIRU : Jurnal Pengabdian Masyarakat Vol. 2 No. 8 (2025): BESIRU : Jurnal Pengabdian Masyarakat, Agustus 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v2i8.1769

Abstract

Diabetes mellitus is a chronic disease that poses challenges during Ramadan fasting due to changes in dietary patterns and mediacation schedules. These conditions may increase the risk of hypoglycemia and hyperglycemia, thus requiring proper health education. This community service aimed to improve diabetic patients knowledge regarding medication use during fasting. The methods included lectures, distribution of leaflets, and evaluation using pre-test and post-test questionnaires. The activity was carried  out at Raudhatul Jannah Mosque Pekanbaru, on March 16, 2025, involving 30 participants. The results showed an improvement in participants knowledge, where the “very good” category increased from 13,3% to 40% after the intervention, Statistical analysis using a T-test obtained a p-value of 0,014  indicating a significant difference. This program demonstrated that simple education through counseling and leaflet distribution is effective in enhancing public understanding of proper medication use for diabetic patients during fasting.
Molecular docking, prediction of drug-likeness properties, and toxicity risk assessment of compounds from Cinnamomum zeylanicum as inhibitors of Dengue DEN2 NS2B/NS3. Frimayanti, Neni; Fernando, Armon; Rahmah, Rizka I’zaa; Iskandar, Benni
Chempublish Journal Vol. 9 No. 2 (2025): Chempublish Journal (July - December)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i2.43598

Abstract

Dengue hemorrhagic fever (DHF) is a serious mosquito-borne disease caused by the dengue virus, most often transmitted by the bite of female Aedes aegypti mosquitoes. In Indonesia, the number of DHF cases has steadily increased since the disease was first reported, underscoring the urgent need for effective treatments. This study used in silico methods to explore the potential of three bioactive compounds from Cinnamomum zeylanicum i.e. cinnamaldehyde, α-terpineol, and chavicol as inhibitors of the dengue virus NS2B/NS3 protease and evaluated their drug-likeness and potential toxicity. The compounds sourced from the NADI database were compared with panduratin A as a positive control. Molecular docking was performed using the Molecular Operating Environment (MOE) 2023.0901 software, and drug-likeness and toxicity predictions were performed using SwissADME and Protox-II. Among the tested compounds, α-terpineol exhibited the strongest potential to inhibit NS2B/NS3, while all three met the standard drug-likeness criteria. Notably, α-terpineol demonstrated the most favorable safety profile compared to cinnamaldehyde, chavicol, and panduratin A.
Increased Dissolution Rate of Solid Dispersion Fenofibric Acid PEG 6000 and In Vivo Study Anggraini, Deni; Agistia, Nesa; Fernando, Armon; Yulia, Amanda; Repuja, Dira
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26376

Abstract

Fenofibrate acid is a fibrate drug with high permeability but low water solubility, resulting in limited bioavailability. Solid dispersion using hydrophilic carriers is one strategy to increase solubility. The objective of this study was to improve the solubility of fenofibric acid by converting it into a solid dispersion system using PEG 6000 as a carrier. Preparation of solid dispersion systems by the melting method. The fenofibric acid PEG 6000 weight ratios were F1 (1:1), F2 (1:3), and F5 (1:5). Physicochemical characterization of the solid dispersions included DSC, PXRD, FTIR, and SEM tests, as well as dissolution and bioavailability tests with the determination of pharmacokinetic parameters. Characterization results show that fenofibric acid with PEG 6000 as a carrier still exhibits a crystalline phase but with reduced intensity, resulting in increased solubility and dissolution rate. Dissolution test show that solid dispersion F3 (1:5) dissolves faster (78.7%) than pure fenofibric acid (53.2%). after 60 minutes. Pharmacokinetic parameter determination tests showed no significant difference between pure fenofibric acid and solid dispersion. Solid dispersion of fenofibric acid with PEG 6000 as a carrier can improve the physicochemical performance and dissolution rate of fenofibric acid but pharmacokinetic parameters did not differ significantly.
Gambaran Penyimpanan Obat di Apotek ”X” Kota Pekanbaru Tahun 2026 Meyrika Putri Wandala; Suci Bettiza Oktarisma; Armon Fernando
RIGGS: Journal of Artificial Intelligence and Digital Business Vol. 5 No. 2 (2026): Mei-Juli
Publisher : Prodi Bisnis Digital Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/riggs.v5i2.8830

Abstract

Penyimpanan obat merupakan salah satu bagian penting dalam pengelolaan perbekalan farmasi yang bertujuan menjaga mutu, keamanan, serta ketersediaan obat agar tetap layak digunakan. Penyimpanan yang baik juga berperan dalam mencegah kerusakan, kehilangan, penyalahgunaan, dan memudahkan proses pencarian maupun pengawasan sediaan farmasi. Penelitian ini bertujuan untuk mengetahui gambaran penyimpanan obat di Apotek “X” Kota Pekanbaru Tahun 2026 berdasarkan Petunjuk Teknis Standar Pelayanan Kefarmasian di Apotek. Metode penelitian yang digunakan adalah observasional dengan pendekatan deskriptif. Pengumpulan data dilakukan melalui wawancara dan observasi langsung terhadap sistem penyimpanan obat di apotek. Data yang diperoleh dianalisis secara deskriptif dan disajikan dalam bentuk tabel. Hasil penelitian menunjukkan bahwa penyimpanan obat di Apotek “X” telah menggunakan rak atau etalase sebagai tempat penyimpanan. Penataan obat dilakukan berdasarkan urutan alfabetis, bentuk sediaan, dan indikasi obat. Obat yang mengandung prekursor disimpan secara terpisah dari golongan obat lainnya. Suhu penyimpanan obat disesuaikan dengan ketentuan yang tertera pada kemasan, sedangkan obat dengan penyimpanan khusus ditempatkan di dalam kulkas. Sistem pengeluaran obat menggunakan metode First Expired First Out (FEFO). Namun, masih ditemukan ketidaksesuaian pada penyimpanan obat Look Alike Sound Alike (LASA) dan high alert yang masih disimpan berdekatan dengan obat lain serta belum seluruhnya diberi label khusus. Penyimpanan obat kedaluwarsa telah dilakukan secara terpisah sebelum dimusnahkan.
ISOLASI, IDENTIFIKASI DAN UJI AKTIVITAS ANTIBAKTERI ISOLAT JAMUR ENDOFIT DAUN KENIKIR (Cosmos caudatus Kunth.) Melzi Octaviani; Kolista Sisilawati; Elsa Safitri; Haiyul Fadhli; Emma Susanti; Armon Fernando
Jurnal Penelitian Farmasi Indonesia Vol 15 No 1 (2026): Jurnal Penelitian Farmasi Indonesia (JPFI)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (P3M) Sekolah Tinggi Ilmu Farmasi Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kenikir (Cosmos caudatus Kunth.) is a plant used by the community as a traditional medicine and has antibacterial activity. Kenikir leaves contain secondary metabolite compounds such as alkaloids, flavonoids, phenolics and saponins. This plant has endophytic fungi that can produce the same bioactive compounds as its host. This study aims to isolate endophytic fungi from kenikir leaves, identify and test the antibacterial activity of endophytic fungi isolates from kenikir leaves against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Pseudomonas aeruginosa and Salmonella typhi) bacteria. Endophytic fungi were isolated from kenikir leaves, then purified to obtain a pure culture of endophytic fungi. Endophytic fungal isolates were then identified macroscopically and microscopically. Fermentation was carried out on endophytic fungal isolates to obtain supernatants, then tested for antibacterial activity using the disc diffusion method. The results of endophytic fungal isolation obtained 4 isolates, namely FECC-D1 (Alternaria sp.), FECC-D2 (Lichtheimia sp.), FECC-D3 (Canidiobolus sp.), FECC-D4 (Aspergillus sp.). The results of the antibacterial activity test of the supernatants of the four endophytic fungal isolates showed antibacterial activity. The results of data analysis using the One Way ANOVA test showed a significant difference in the diameter of the inhibition zone between the positive control and the supernatants of the endophytic fungal isolates. The supernatants of the 4 endophytic fungal isolates of kenikir leaves have activity in inhibiting the growth of pathogenic bacteria.
Pengembangan Permen Jelly Rempah sebagai Produk Farmasi yang Inovatif dan Berkhasiat Armon Fernando; M. Almurdani; Ihsan Ikhtiarudin; Tengku Yuni Atika S; Tiara Salsabila P.A; Tita Adhaha F; Venny Wulandari; Victriani Sitohang; Winda Windiati; Yeni Karlina; Yulius Mubharroq; Zakiyah Manaf
Jurnal Garuda Pengabdian Kepada Masyarakat Vol 4 No 1 (2026)
Publisher : Ali Institute of Research and Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55537/gabdimas.v4i1.1394

Abstract

Indonesia memiliki kekayaan biodiversitas rempah-rempah seperti jahe, kunyit, dan sereh yang secara empiris terbukti memiliki aktivitas antioksidan dan imunomodulator. Namun, pemanfaatan rempah tersebut masih terbatas pada pengolahan tradisional yang kurang praktis dan memiliki profil rasa yang kurang diminati oleh masyarakat modern, sehingga potensi manfaat kesehatannya belum teroptimalisasi. Penelitian ini bertujuan untuk melakukan diversifikasi produk herbal melalui pengembangan permen jelly berbasis rempah sebagai sediaan farmasi inovatif yang praktis, memiliki cita rasa menarik, dan bermanfaat bagi kesehatan. Metode pelaksanaan dilakukan melalui kegiatan sosialisasi dan pelatihan pembuatan produk secara langsung kepada masyarakat di kawasan Stadion Utama Riau. Evaluasi keberhasilan kegiatan diukur melalui instrumen pre-test dan post-test untuk menilai pemahaman peserta. Hasil pengabdian menunjukkan adanya peningkatan signifikan pada tingkat pengetahuan masyarakat. Rata-rata nilai pre-test yang semula berada pada kategori rendah (40–57%) meningkat menjadi 73–84% (post-test) yang dikategorikan dalam rentang cukup hingga baik. Dapat disimpulkan bahwa edukasi yang disertai inovasi formulasi bahan alam efektif dalam meningkatkan kesadaran dan keterampilan masyarakat dalam mengonsumsi herbal dalam bentuk sediaan yang lebih modern dan akseptabel.
Co-Authors Adriani Susanty agistia, nesa Agistia, Nesa Agustini, Tiara Tri Ainun Alfatma Allaya, Regina Alpatiqa, Silviana Lufti, Siti Hizra Amanda Yulia Amin, Syahrul Anita Lukman Annisa Safitri Arief, Encik Juliansyah Aulia, Nada Aqilah Azkia Wanudya Rahmadhani Benni Iskandar Buddy Giovanni DAYAR ARBAIN Deni Anggraini Dira Repuja Dwi Winarsih Elsa Safitri Enda Mora Fadhilatun Khoiriyah Farediah Ahmad Farisa, Nayla Al Ferdy Firmansyah Fina Aryani, Fina Fitri Suryani Furi, Mustika Gressy Novita Haiyul Fadhli Hariyani, Widya Hasnah M. Sirat Hayu Lestari Hefriza Putri Husnawati Ihsan Ikhtiarudin Indah Puspita Sari Indri Aprilia, Indri Irfan, Nawwar Ivona Adelin Jannati, Nisa Jumadila, Ikhsal Mukri Kolista Sisilawati M. Almurdani Maryunita, Dinda Mayrade, Salma Yudhistira Meiriza Djohari, Meiriza Melzi Octaviani Meyrika Putri Wandala Milianty, Jesy Muhtadi, Wildan Khairi Musyirna Rahmah Nst Neni Frimayanti Netralis Has Ningrum, Tilar Eka Widia Nofri Hendri Sandi Nurul Elisa Putri Lestari Putri Lestari, Putri Putri, Dhini Fahira Rahayu Utami Rahayu Utami Rahma Dona Rahma, Indah Lutfianti Rahma, Rizqia I’zza Rahmah, Rizka I’zaa Rahmayanı, Wıky Rajeb Fadillah Ramona, Paula Repuja, Dira Rickha Octavia Rusnedy, Rahmayati Sadam Husein Safira, Yola Safitri, Fasri Dian Septi Muharni Suci Bettiza Oktarisma Suhelmi - Suhelmi - Syafutri, Lidiyah Syahbandi, Ilham Syilfia Hasti Tengku Yuni Atika S Tiara Salsabila P.A Tita Adhaha F Venny Wulandari Victriani Sitohang Winda Sari Winda Windiati Wira Noviana, Wira Noviana Yeni Karlina Yulia, Amanda Yulius Mubharroq Zakiyah Manaf