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All Journal Journal of Food and Pharmaceutical Science Jurnal Penelitian Farmasi Indonesia Majalah Obat Tradisional CHEMPUBLISH JOURNAL Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Farmasi Indonesia JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON JFL : Jurnal Farmasi Lampung PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Ensiklopedia of Journal Jurnal Ilmu Kefarmasian Indonesia INDRA: Jurnal Pengabdian kepada Masyarakat COVIT Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE Journal of Artificial Intelligence and Digital Business Jurnal Katalisator Jurnal Farmasi Indonesia Journal of Food and Pharmaceutical Sciences Jurnal Pengabdian Masyarakat Jurnal Bakti Nusantara
Armon Fernando
Sekolah Tinggi Ilmu Famasi Riau
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Molecular docking, prediction of drug-likeness properties, and toxicity risk assessment of compounds from Cinnamomum zeylanicum as inhibitors of Dengue DEN2 NS2B/NS3. Frimayanti, Neni; Fernando, Armon; Rahmah, Rizka I’zaa; Iskandar, Benni
Chempublish Journal Vol. 9 No. 2 (2025): Chempublish Journal (July - December)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i2.43598

Abstract

Dengue hemorrhagic fever (DHF) is a serious mosquito-borne disease caused by the dengue virus, most often transmitted by the bite of female Aedes aegypti mosquitoes. In Indonesia, the number of DHF cases has steadily increased since the disease was first reported, underscoring the urgent need for effective treatments. This study used in silico methods to explore the potential of three bioactive compounds from Cinnamomum zeylanicum i.e. cinnamaldehyde, α-terpineol, and chavicol as inhibitors of the dengue virus NS2B/NS3 protease and evaluated their drug-likeness and potential toxicity. The compounds sourced from the NADI database were compared with panduratin A as a positive control. Molecular docking was performed using the Molecular Operating Environment (MOE) 2023.0901 software, and drug-likeness and toxicity predictions were performed using SwissADME and Protox-II. Among the tested compounds, α-terpineol exhibited the strongest potential to inhibit NS2B/NS3, while all three met the standard drug-likeness criteria. Notably, α-terpineol demonstrated the most favorable safety profile compared to cinnamaldehyde, chavicol, and panduratin A.
Increased Dissolution Rate of Solid Dispersion Fenofibric Acid PEG 6000 and In Vivo Study Anggraini, Deni; Agistia, Nesa; Fernando, Armon; Yulia, Amanda; Repuja, Dira
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26376

Abstract

Fenofibrate acid is a fibrate drug with high permeability but low water solubility, resulting in limited bioavailability. Solid dispersion using hydrophilic carriers is one strategy to increase solubility. The objective of this study was to improve the solubility of fenofibric acid by converting it into a solid dispersion system using PEG 6000 as a carrier. Preparation of solid dispersion systems by the melting method. The fenofibric acid PEG 6000 weight ratios were F1 (1:1), F2 (1:3), and F5 (1:5). Physicochemical characterization of the solid dispersions included DSC, PXRD, FTIR, and SEM tests, as well as dissolution and bioavailability tests with the determination of pharmacokinetic parameters. Characterization results show that fenofibric acid with PEG 6000 as a carrier still exhibits a crystalline phase but with reduced intensity, resulting in increased solubility and dissolution rate. Dissolution test show that solid dispersion F3 (1:5) dissolves faster (78.7%) than pure fenofibric acid (53.2%). after 60 minutes. Pharmacokinetic parameter determination tests showed no significant difference between pure fenofibric acid and solid dispersion. Solid dispersion of fenofibric acid with PEG 6000 as a carrier can improve the physicochemical performance and dissolution rate of fenofibric acid but pharmacokinetic parameters did not differ significantly.
Increased Dissolution Rate of Solid Dispersion Fenofibric Acid PEG 6000 and In Vivo Study Anggraini, Deni; Agistia, Nesa; Fernando, Armon; Yulia, Amanda; Repuja, Dira
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26376

Abstract

Fenofibrate acid is a fibrate drug with high permeability but low water solubility, resulting in limited bioavailability. Solid dispersion using hydrophilic carriers is one strategy to increase solubility. The objective of this study was to improve the solubility of fenofibric acid by converting it into a solid dispersion system using PEG 6000 as a carrier. Preparation of solid dispersion systems by the melting method. The fenofibric acid PEG 6000 weight ratios were F1 (1:1), F2 (1:3), and F5 (1:5). Physicochemical characterization of the solid dispersions included DSC, PXRD, FTIR, and SEM tests, as well as dissolution and bioavailability tests with the determination of pharmacokinetic parameters. Characterization results show that fenofibric acid with PEG 6000 as a carrier still exhibits a crystalline phase but with reduced intensity, resulting in increased solubility and dissolution rate. Dissolution test show that solid dispersion F3 (1:5) dissolves faster (78.7%) than pure fenofibric acid (53.2%). after 60 minutes. Pharmacokinetic parameter determination tests showed no significant difference between pure fenofibric acid and solid dispersion. Solid dispersion of fenofibric acid with PEG 6000 as a carrier can improve the physicochemical performance and dissolution rate of fenofibric acid but pharmacokinetic parameters did not differ significantly.
Gambaran Penyimpanan Obat di Apotek ”X” Kota Pekanbaru Tahun 2026 Meyrika Putri Wandala; Suci Bettiza Oktarisma; Armon Fernando
RIGGS: Journal of Artificial Intelligence and Digital Business Vol. 5 No. 2 (2026): Mei-Juli
Publisher : Prodi Bisnis Digital Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/riggs.v5i2.8830

Abstract

Penyimpanan obat merupakan salah satu bagian penting dalam pengelolaan perbekalan farmasi yang bertujuan menjaga mutu, keamanan, serta ketersediaan obat agar tetap layak digunakan. Penyimpanan yang baik juga berperan dalam mencegah kerusakan, kehilangan, penyalahgunaan, dan memudahkan proses pencarian maupun pengawasan sediaan farmasi. Penelitian ini bertujuan untuk mengetahui gambaran penyimpanan obat di Apotek “X” Kota Pekanbaru Tahun 2026 berdasarkan Petunjuk Teknis Standar Pelayanan Kefarmasian di Apotek. Metode penelitian yang digunakan adalah observasional dengan pendekatan deskriptif. Pengumpulan data dilakukan melalui wawancara dan observasi langsung terhadap sistem penyimpanan obat di apotek. Data yang diperoleh dianalisis secara deskriptif dan disajikan dalam bentuk tabel. Hasil penelitian menunjukkan bahwa penyimpanan obat di Apotek “X” telah menggunakan rak atau etalase sebagai tempat penyimpanan. Penataan obat dilakukan berdasarkan urutan alfabetis, bentuk sediaan, dan indikasi obat. Obat yang mengandung prekursor disimpan secara terpisah dari golongan obat lainnya. Suhu penyimpanan obat disesuaikan dengan ketentuan yang tertera pada kemasan, sedangkan obat dengan penyimpanan khusus ditempatkan di dalam kulkas. Sistem pengeluaran obat menggunakan metode First Expired First Out (FEFO). Namun, masih ditemukan ketidaksesuaian pada penyimpanan obat Look Alike Sound Alike (LASA) dan high alert yang masih disimpan berdekatan dengan obat lain serta belum seluruhnya diberi label khusus. Penyimpanan obat kedaluwarsa telah dilakukan secara terpisah sebelum dimusnahkan.
Co-Authors Adriani Susanty Agistia, Nesa Agustini, Tiara Tri Allaya, Regina Alpatiqa, Silviana Lufti, Siti Hizra Amin, Syahrul Anita Lukman Arief, Encik Juliansyah Aulia, Nada Aqilah Azkia Wanudya Rahmadhani BENNI ISKANDAR Buddy Giovanni DAYAR ARBAIN Deni Anggraini Deni Anggraini Dwi Winarsih Enda Mora Fadhilatun Khoiriyah Farediah Ahmad Farisa, Nayla Al Ferdy Firmansyah Fina Aryani, Fina Fitri Suryani Furi, Mustika Gressy Novita Haiyul Fadhli Hariyani, Widya Hasnah M. Sirat Hayu Lestari Hefriza Putri Indah Puspita Sari Indri Aprilia, Indri Irfan, Nawwar Ivona Adelin Jannati, Nisa Jumadila, Ikhsal Mukri Maryunita, Dinda Mayrade, Salma Yudhistira Meyrika Putri Wandala Milianty, Jesy Muhtadi, Wildan Khairi Musyirna Rahmah Nst Neni Frimayanti Netralis Has Ningrum, Tilar Eka Widia Nofri Hendri Sandi Putri Lestari Putri Lestari, Putri Putri, Dhini Fahira Rahayu Utami Rahayu Utami Rahma Dona Rahma, Indah Lutfianti Rahma, Rizqia I’zza Rahmah, Rizka I’zaa Rahmayanı, Wıky Rajeb Fadillah Ramona, Paula Repuja, Dira Rickha Octavia Ronapadua Musyirna Rahmah Nasution Sahara dan Emma Susanti Rusnedy, Rahmayati Sadam Husein Safira, Yola Safitri, Fasri Dian Suci Bettiza Oktarisma Suhelmi - Syafutri, Lidiyah Syahbandi, Ilham Syilfia Hasti Winda Sari Wira Noviana, Wira Noviana Yulia, Amanda