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All Journal Jurnal Gizi dan Pangan Jurnal Ilmu Pertanian Indonesia Jurnal Silvikultur Tropika (JST) JURNAL KIMIA SAINS DAN APLIKASI Biogenesis: Jurnal Ilmiah Biologi Jurnal Tanaman Industri dan Penyegar Current Biochemistry SC (Savana Cendana) : Jurnal Pertanian Konservasi Lahan Kering Indonesian Journal of Chemistry JURNAL PENGABDIAN KEPADA MASYARAKAT QARDHUL HASAN: MEDIA PENGABDIAN KEPADA MASYARAKAT Menara Perkebunan Jurnal Ilmu dan Teknologi Kayu Tropis Jurnal Ilmu Kefarmasian Indonesia Wood Research Journal : Journal of Indonesian Wood Research Society Al-Ahwal Al-Syakhsiyyah: Jurnal Hukum Keluarga dan Peradilan Islam Wood Research Journal : Journal of Indonesian Wood Research Society Al-Muamalat : Jurnal Ekonomi Syariah Jurnal Informatika Teknologi dan Sains (Jinteks) Journal of Law, Poliitic and Humanities Jurnal Pengabdian Masyarakat Dharma Andalas Innovative: Journal Of Social Science Research Jurnal Penelitian Kehutanan Wallacea Molekul: Jurnal Ilmiah Kimia La-Tahzan: Jurnal Pendidikan Islam Annales Bogorienses IEMJ: Islamic Education and Management Journal Biodiversitas Journal of Biological Diversity Nusantara Bioscience
Syamsul Falah
Departement Of Biochemistry, Faculty Of Mathematics And Natural Sciences, Institut Pertanian Bogor. Jl. Meranti, Kampus IPB Dramaga, Bogor 16680, West Java, Indonesia
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Effectiveness of gel formulation of mahogany (Swietenia macrophylla) bark extract and its potential as an anti-inflammatory in white male rats (Rattus norvegicus) SHAFA GEULISTIA NURANI; NAFASYA NEGIY DELUNA; PUTRI NABILA; SYAMSUL FALAH
Nusantara Bioscience Vol. 14 No. 1 (2022)
Publisher : Smujo International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/nusbiosci/n140114

Abstract

Abstract. Nurani SG, Deluna NN, Nabila P, Falah S. 2022. Effectiveness of gel formulation of mahogany (Swietenia macrophylla) bark extract and its potential as an anti-inflammatory in white male rats (Rattus norvegicus). Nusantara Bioscience 14: 117-121. Mahogany bark contains phytochemical compounds that have anti-inflammatory activity. This study aims to determine the anti-inflammatory activity of mahogany-bark extract gel formulation in-vivo. Gel formulations of 96% ethanol extract of mahogany bark at different concentrations were tested for anti-inflammatory activity on the paws of rats induced by 1% carrageenan. The data observed were the thickness of the foot edema of rats. Positive control was anti-inflammatory drugs (Desoximetasone), and negative control was the gel formulation without extract. Data on the thickness of rat paw edema were analyzed using the ANOVA test. The results of the anti-inflammatory test showed that gel formulation 2 with an extract concentration of 10% had a thickness reduction value of 41.83%, which was not significantly different from the positive control treatment of 44.38%. The results of the dispersion test showed that formulation 2 and formulation 3 had good dispersibility, as suggested in SNI, and all gel formulations had good adhesion. Based on these results, it was concluded that formulation 2 was the most effective in reducing rat paw edema.
Optimization of Growth Media, Antibiofilm Evaluation and Taxonomic Identification of Symbiotic Bacteria from the Sea Anemone Heteractis magnifica Ela Novianti; Syamsul Falah; Kania Salsabila
Annales Bogorienses Vol. 29 No. 1 (2025): Annales Bogorienses
Publisher : National Research and Innovation Agency (BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/ann.bogor.2025.v29.n1.19-28

Abstract

Antibiotic resistance and biofilm-associated infections remain critical global health challenges. Its responsible for up to 65% of infections in humans and have adaptive resistance 10–1000 times higher against conventional antibiotics. Thus, development and finding of new antibiofilm agent is needed. Marine bacteria, particularly symbion of anemone Heteractis magnifica, offer promising yet underexplored sources of bioactive componds as antibiofilm agents. This research aimed to optimize the growth condition, assess the antibiofilm activities and identify potential strain of symbiotic bacteria from H. magnifica in Samalona Island, Indonesia. The growth of two bacterial isolates (CM01 and CM03) were optimized, revealing that CM01 grew best in TSB with 2%NaCl and 2% peptone at 37°C for 48 h incubation, while CM03 exhibited optimal growth in Zobell medium with 2% peptone at 28°C for 48 h. Secondary metabolites produced under these conditions were tested against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus epidermidis, and Staphylococcus aureus. The 50-hour metabolite of CM03 demonstrated the strongest and broadest antibiofilm activity. Due to its antibiofilm potential, strain CM03 was subjected to genomic characterization using 16S rRNA PCR method. Phylogenetic analysis identified the isolate as Halalkalibacter okhensis. These findings indicate that symbiotic bacteria of H. magnifica, particularly H. okhensis CM03, represent promising candidates for the discovery of new antibiofilm agent.
Co-Authors Achmad . Achmad Achmad Agnia Nurul Jannati Agus Setiawan Aji Winara Aji Winara Anggita Aziz Pratiwi Ani Sulistiyani Apri Heri Iswanto ASEP HIDAYAT ASEP HIDAYAT Ayu Lestari Azmi Azhari Azmi Azhari, Azmi Brilyan Yudha Pratama Budi Martono Desi Nurafida Desi Sommaliagustina Desriani Desriani DIMAS ANDRIANTO Dwi Endah Kusumawati Ekajayanti Kining Ela Novianti Eneng Nurlaela ERISA FEBRIYANI Faizal, Enceng Arif Fitriana S Monisa Gumelar, Dian Rachmat Hasana, Nurul Hasim Hasim I Gusti Agung Komang Diafari Djuni Hartawan I MADE ARTIKA Jaka, Aris Tri Kania Salsabila Kapitan, Origenes Boy Khalimatus Sadiah L M. Alfin Agushara Bena Laita Nurjanah Laita Nurjanah, Laita Laita Nurjannah Laita Nurjannah, Laita LAKSMI AMBARSARI Latifah K Darusman Lia Kusuma Dewi Livia Rhea Alvita Maheswari Alfira Dwicesaria MARIA BINTANG Martini Hudayanti Marwanto, Yoga Dwi Maulana Hasanudin Mega Safithri Melati Devina Gustini Wirastuti Moh. Wifaqul Idaini Muhammad Assyar Muhammad Duror An Nashich Mustopa Mustopa NAFASYA NEGIY DELUNA Naily Fitrotun Ni’mah Nandang Najmudin Neneng Hasanah Noora Qotrun Nada, Noora Qotrun Novik Nurhidayat Novik Nurhidayat Novilia Eka Syafitri Nuur’Alimah, Shobiroh NUZULIA MUTIKA SARI Padma, Zahara Dwi Pelita, Bobang Noorisnan Perkasa Arian Popi Asri Kurniatin Pratama, Arkan Nandia Purwanto, Ukhradiya Magharaniq Safira Putra, Nauval Dwi Anugrah PUTRI NABILA Rahmadhani Ambarsavitri Rahmania, Fitriani Jati Rara Annisaur Rosyidah Resti Wahyuni Resti Wahyuni Rini Kurniasih, Rini Rini Novita Riska Ariyanti, Riska RIZKI RABECA ELFIRTA Robiatul Adawiyah Rori Theresia Saebani, Beni Ahmad Sanro Tachibana SARAH ASIH FAULINA Setriani, Sofia SHAFA GEULISTIA NURANI Shobiroh Nuur'Alimah Siagian, Amita Stefani Dhale Rale Sulistiyani Sulistiyani Suryani Suryani Suryani Suryani Suryani Suryani Syabilla Aulia Rahman Syaefudin Syaripudin, Dadang Takeshi Katayama Theresia, Rori Tien Lastini TIEN LASTINI TIEN LASTINI Toshisada Suzuki Triadiati Triadiati Tusadiah, Alima Umul Karimah Waras Nurcholis Wiwit Amrinola Yogi Nur Anggowo Zuraida Zuraida