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The potential of Myricitrin, a Flavonoid Compound in Eugenia polyantha from Indonesia, as an Antiviral Drug for SARS-Cov-2 through the Molecular Docking Analysis Syamsul Falah; Laksmi Ambarsari; Dimas Andrianto; Rini Kurniasih; Sanro Tachibana
Jurnal Kimia Sains dan Aplikasi Vol 26, No 5 (2023): Volume 26 Issue 5 Year 2023
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.26.5.166-177

Abstract

A Flavonoid glycoside compound, isolated and identified from E. polyantha as myricitrin, was analyzed as a ligand for its molecular binding activity against SARS-CoV-2 protein (receptor binding domain on Spike/RBD, main protease/nsp5, EndoRNAse, RNA-dependent-RNA-polymerase/RdRp), and its receptor, ACE2, and computationally assessed via molecular docking method. This study aims to determine the potential of myricitrin in E. polyantha from Indonesia as an antiviral drug for SARS-CoV-2 through molecular docking and molecular dynamic simulation analysis. The results showed that the myricitrin had the strongest binding affinity energy towards the three important SARS-CoV-2 proteins, namely endoRNAse, main protease (3CLpro), and RdRp with ∆G values of −9.60 kcal/mol, −8.40 kcal/mol, and −8.30 kcal/mol, respectively. These values are stronger than the comparator ligands of favipiravir (−5.60 kcal/mol), atazanavir (−7.20 kcal/mol), and remdesivir (−7.70 kcal/mol). This indicated that the compound has the potential as an inhibitor against 3CLpro, endoRNAse, and RdRp of SARS-CoV-2 proteins. This result was supported by the prediction made according to the Molprobity and PASS Online web servers, which showed that myricitrin has high bioactivity potential as an enzyme inhibitor (with a score of 0.38) and antiviral (with a score of 0.704).
PELAKSANAAN SIDANG ITSBAT NIKAH TERPADU PENGADILAN AGAMA CIBADAK KABUPATEN SUKABUMI TERHADAP KESADARAN HUKUM MASYARAKAT Falah, Syamsul; Pelita, Bobang Noorisnan; Najmudin, Nandang
Al-Ahwal Al-Syakhsiyyah: Jurnal Hukum Keluarga dan Peradilan Islam Vol 4, No 2 (2023): Al-Ahwal Al-Syakhsiyyah: Jurnal Hukum Keluarga dan Peradilan Islam
Publisher : Fakultas Syariah dan Hukum UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/as.v4i2.29535

Abstract

AbstrakDampak yang terjadi terhadap masyarakat yang belum mempunyai buku nikah ialah mereka akan mengalami kesulitan mendapatkan akta kelahiran dan kartu keluarga. Untuk membantu masyarakat yang belum mempunyai buku nikah atau pernikahannya tidak tercatat, Mahkamah Agung Republik Indonesia mengeluarkan peraturan, yang termuat dalam Peraturan Mahkamah Agung nomor 1 tahun 2015, tentang pelayanan terpadu sidang keliling Pengadilan Negeri dan Pengadilan Agama/Mahkamah Syar‟iyah dalam rangka menerbitkan akta perkawinan, buku nikah dan akta kelahiran. Pengadilan Agama Cibadak menjadi salah satu pengadilan yang melaksanakan mandat dari Peratyran Mahkamah Agung. 47 kecamatan menjadi wilayah kerja Pengadilan Agama Cibadak untuk menjalankan fungsinya, dengan luas wilayah 4.146 KM2 tidak dapat dipungkiri bahwa kesulitan informasi atau jarak tempuh menjadi kendala dalam melaksanakannya pelayanan terpadu. Salah satu solusinya adalah menjalankan sidang isbat nikah terpadu untuk membantu masyarakat yang belum mempunyai buku nikah. 
Sistem Identifikasi Jumlah Produk Berbasis Pengolahan Citra dengan Algoritma YOLO pada Proses Pengepakan Industri Manufaktur Bhaskoro, Susetyo Bagas; Supriyanto, Hadi; Falah, Syamsul
JTRM (Jurnal Teknologi dan Rekayasa Manufaktur) Vol 6 No 1 (2024): Volume: 6 | Nomor: 1 | April 2024
Publisher : Pusat Penelitian, Pengembangan, dan Pemberdayaan Masyarakat (P4M) Politeknik Manufaktur Bandung (Polman Bandung)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48182/jtrm.v6i1.114

Abstract

Machine vision is a technology commonly used in modern industry for image-based autonomous analysis and inspection. Machine vision helps the process of product analysis and inspection in the industry faster than manual analysis and inspection. This study applies machine vision to an image processing-based product number identification system in the manufacturing industry packing process using the YOLOv4 algorithm and evaluation of the confusion matrix system. The results of the identification are stored in a database and displayed on the website to facilitate the monitoring process. This system has carried out several tests, especially testing the main function of the system, namely product calculations, carried out 10x experiments. Then, testing variations in light intensity with a range of 20 – 225 lux and variations in height with a range of 48 – 68 cm with 10 trials each. From the tests that have been carried out, an evaluation of the confusion matrix is ​​applied and produces an accuracy and precision of 100% and an error of 0%. The average computing speed of this system is 6.95 FPS with the help of CUDA.
Implementasi Penggunaan Media Big Book Berbasis Dongeng dalam Meningkatkan Kemampuan Membaca Interaktif Siswa Kelas II MI Islamiyah Jatimulya Syamsul Falah; Khalimatus Sadiah; Muhammad Duror An Nashich
La-Tahzan: Jurnal Pendidikan Islam Vol. 16 No. 1 (2024): La-Tahzan: Jurnal Pendidikan Islam
Publisher : Fakultas Ilmu Tarbiyah dan Keguruan, Institut Agama Islam Bakti Negara Tegal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62490/latahzan.v16i1.734

Abstract

This thesis is the result of research regarding the Implementation of the Use of Fairy Tale-Based Big Book Media in Improving the Interactive Reading Ability of Class II Students at MI Islamiyah Jatimulya. As for the background of this research, the researcher found indications of the problem of students' lack of concentration in learning and the low reading ability of class II students, monotonous teacher learning methods and the absence of use of interesting learning media which had an impact on students' lack of learning motivation and enthusiasm in learning. so that the teaching and learning process tends to be passive. This type of research is field research. The method used in this research is a qualitative method. To analyze the problems above, researchers used the interactive data analysis model from Miles and Huberman which involves four stages of data analysis, namely data collection, data reduction, data presentation, and data verification. This research aims to improve the interactive reading skills of class II students at MI Islamiyah Jatimulya. The subjects of this research were 20 class II students consisting of 10 male students and 10 female students. Data collection techniques in this research are observation and interviews. Interviews were used to see the use of fairy tale-based big book media. Meanwhile, observation is used to see student activities in the application of fairy tale-based big book media in classroom learning. The results of the research show that there is an increase in student learning activities when implementing fairy tale-based big book media. A total of 14 students obtained a score percentage of 88% in the "good" category. A total of 4 students obtained a percentage score of 92% in the "very good" category and there were only 2 students who obtained a low percentage score, namely 76% in the "not good" category. The indicators of reading difficulties experienced by these students are not being able to pronounce vowel diphthong letter combinations (nya, nyi, nga, ngi...) and having help to read and spell syllables
Utilization of Medicinal Plants by the Tapos Village Community, Cijeruk District, Bogor Regency Ni’mah, Naily Fitrotun; Safira Purwanto, Ukhradiya Magharaniq; Syamsul Falah
Jurnal Ilmu Pertanian Indonesia Vol. 30 No. 2 (2025): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.30.2.251

Abstract

The diversity of medicinal plant species in Tapos Village has the potential to be developed. However, studies on medicinal plants are still limited. This study aimed to inventory the types of ethnophytomedica, their efficacy, and their utilization by residents of Tapos Village, Cijeruk District, Bogor Regency. This research is expected to provide a reference for further research and efforts to increase public understanding of medicinal plants. Data were collected through several stages: literature study, observation, unstructured interviews, and documentation. The results of this study showed that as many as 39% of the 99 types of medicinal plants were dominated by herbal habitus. The most widely used parts are the leaves (60 %) and cultivated medicinal plants (59 %). Most types of plants are used to cure a group of gastrointestinal diseases, with as many as 23 types of plants. The people of this village maintain local wisdom in utilizing medicinal plants. Keywords: Ethnophytopharmaca, medicinal plants, Tapos Village
Aktivitas antihiperglikemia ekstrak kulit dan daun surian (Toona sinensis) pada tikus diabetes (Sprague-dawley) yang diinduksi streptozotocin Theresia, Rori; Falah, Syamsul; Safithri, Mega
Jurnal Gizi dan Pangan Vol. 12 No. 3 (2017)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (531.996 KB) | DOI: 10.25182/jgp.2017.12.3.187-194

Abstract

This study aimed to examine the antihyperglycemia activity of ethanol extract of 70% on surian bark and leaves on diabetic rats induced with streptozotocin based on body weight, and fasting blood glucose level. Consist of 28 rats are grouped into 7 groups namely normal, negative control, positive control which given glybenclamide with a dose of 3.22 mg/kg bw, bark extract with dose of 150 mg/kg bw, bark extract with a dose of 300 mg/kg bw, leaf extract with dose 150 mg/kg bw and leaf extract with dose 300 mg/kg bw. Diabetogenic mechanisms was conducted with intraperitoneal injection of streptozotocin at  dose of 50 mg / kg bw. This research was conducted experimentally using complete randomized design (RAL) to analyze the results obtained. Bark extract with a dose of 150 mg/kg bw had a better antihyperglycemia activity compared to the other groups which was showed by the decrease of blood glucose level percentage of 72.83% and this group also had ability to maintain body weight was better than the other groups as well as stable feed consumption during research process.
The Views of Scholars of The Islamic Union of Subang And Sumedang On Contemporary Issues Of Family Law (Juridical Analysis of the Granting of Compulsory Wills for Heirs of Different Religions and its Contribution to the National Legal System) Beni Ahmad Saebani; Syamsul Falah; Maulana Hasanudin; Brilyan Yudha Pratama
Journal of Law, Politic and Humanities Vol. 5 No. 4 (2025): (JLPH) Journal of Law, Politic and Humanities
Publisher : Dinasti Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/jlph.v5i4.1398

Abstract

Mandatory wills regulated in Article 209 of the Compilation of Islamic Law are only for adoptive parents and adopted children, there are no mandatory wills for heirs of different religions. However, the Supreme Court Decision stipulates the right to non-Muslim inheritance with a mandatory will, so it requires in-depth study. The purpose of this study is to analyze the thoughts of the scholars of the Subang and Sumedang Islamic Union regarding the obligatory will for the heirs of different religions. The framework of thinking in this study is (1) Grand Theory: The Theory of Maqasid Shari'ah by Muhammad al-Syathibi in his book al-Muwafaqot, which emphasizes that maqashid shari'ah is one of the important concepts in the study of Islamic law. The essence of the theory of maqashid shari'ah is to attract benefits and reject madharat; Middle ranges theory is Gustav Radbruch's theory of legal justice, certainty, and the usefulness of huku as the three legal principles. The applied theory is a progressive legal theory from Satjipto Rahardjo which states that progressive law is responsive and can contextualize the application of law with the basis of the development of human life. The research method used is descriptive analysis with a normative juridical approach. This research is classified as a type of qualitative research, therefore the type of data is related to the purpose of the research in question. The primary data source is taken from the views of the Islamic Union of Subang and Sumedang scholars about the inheritance of different religions. Data collection techniques with interviews and literature studies. The data is analyzed by collecting, classifying, and interpreting it with the content analysis method and then inferred. This study concludes: (1) The views of the scholars of the Subang and Sumedang Islamic Union regarding the share of inheritance for heirs of different religions depend on the content of the heirs' wills and the agreements of other Muslim heirs. Philosophically, the name heir is not the essential meaning of heir, but because there is a postulate of the Quran and al-Hadith that states that "Muslims do not inherit to the infidels", then the heirs of different religions, who accept by way of a will with the principle of effort to give their rights as worship.
Akibat Hukum Perjanjian Penyelesaian Sengketa Perbankan Syariah (Kajian Terhadap Klausula Pilihan Forum Penyelesaian Sengketa Di Pengadilan Negeri): Legal Effects of Sharia Banking Dispute Settlement Agreements (A Study of the Choice of Dispute Resolution Forum Clause in the District Court) Hasana, Nurul; Mustopa, Mustopa; Faizal, Enceng Arif; Falah, Syamsul; Syaripudin, Dadang
Al-Muamalat: Jurnal Ekonomi Syariah Vol. 10 No. 2 (2023): July
Publisher : Department of Sharia Economic Law, Faculty Sharia and Law, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/am.v10i2.29594

Abstract

This research examines the legal consequences of the choice of forum clause for resolving Sharia banking disputes in the general court in the agreement made by the parties. Prior to the issuance of Constitutional Court Decision Number 93/PUU-X/2012, the parties could determine the clause of choice of forum for resolving banking disputes by litigation through the district court. The research objectives examine 1) the authority of religious courts in adjudicating and resolving Sharia banking disputes before the issuance of Constitutional Court Decision Number 93/PUU-X/2012; and 2) the legal consequences of the choice of forum for resolving Sharia banking disputes in the district court in the agreement before the issuance of Constitutional Court Decision Number 93/PUU-X/2012. This type of doctrinal research uses a conceptual approach and legislation. The technique of analyzing research materials uses a prescriptive approach with the aim of providing arguments for the results of research that has been done. This research concludes that: 1) the choice of forum clause for resolving Sharia banking disputes before the issuance of Constitutional Court Decision Number 93/PUU-X/2012, cannot override the legal provisions related to the absolute competence of religious courts; 2) the legal consequences of the lawsuit for Sharia banking disputes through the district court, either before or after the issuance of Constitutional Court Decision Number 93/PUU-X/2012, the decision on the case must be declared unacceptable (niet ontvankelijke verklaard).     Penelitian ini mengkaji akibat hukum klausula pilihan forum penyelesaian sengketa perbankan syariah di peradilan umum dalam perjanjian yang dibuat para pihak. Sebelum keluarnya putusan MK Nomor 93/PUU-X/2012, para pihak dapat menentukan klausula pilihan forum penyelesaian sengketa perbankan secara litigasi melalui pengadilan negeri. Tujuan penelitian mengkaji: 1) kewenangan pengadilan agama dalam mengadili dan menyelesaikan sengketa perbankan syariah sebelum keluarnya putusan MK Nomor 93/PUU-X/2012; dan 2) akibat hukum pilihan forum penyelesaian sengketa perbankan syariah di pengadilan negeri dalam perjanjian sebelum adanya putusan MK Nomor 93/PUU-X/2012. Jenis penelitian doktrinal dengan menggunakan pendekatan konseptual, dan peraturan perundang-undangan. Teknik analisis bahan penelitian menggunakan pendekatan preskriptif dengan tujuan untuk memberikan argumentasi terhadap hasil penelitian yang telah dilakukan. Penelitian ini menyimpulkan bahwa: 1) klausula pilihan forum penyelesaian sengketa perbankan syariah sebelum keluarnya putusan MK Nomor 93/PUU-X/2012, tidak dapat mengesampingkan ketentuan hukum terkait dengan kompetensi absolut pengadilan agama; 2) akibat hukum gugatan sengketa perbankan syariah melalui pengadilan negeri, baik sebelum atau setelah keluarnya putusan MK Nomor 93/PUU-X/2012, maka putusan atas perkara tersebut harus dinyatakan tidak dapat diterima (niet ontvankelijke verklaard).
In silico study: molecular docking of SARS-Cov-2 endoribonuclease on active compounds of Gmelina arborea Roxb. bark Shobiroh Nuur'Alimah; Agnia Nurul Jannati; Laksmi Ambarsari; Syamsul Falah
Menara Perkebunan Vol. 92 No. 1 (2024): 92(1), 2024
Publisher : INDONESIAN OIL PALM RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/iribb.jur.mp.v92i1.561

Abstract

Infection by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) triggers COVID-19 disease of the respiratory tract similar to pneumonia. The virus encodes four structural proteins and 16 non-structural proteins (nsp), one of which includes nsp15 or endoribonuclease (NendoU). NendoU plays an important role in viral replication and transcription and reduces the stimulation of immune cell responses. Active compounds in Gmelina arborea Roxb. bark have antioxidant properties that can inhibit the NendoU activity of SARS-CoV-2. This study aims to analyze the potential of compounds from Gmelina arborea Roxb. bark in inhibiting SARS-CoV-2 NendoU within in silico using the YASARA structure application. Balnophonin is the best test ligand based on binding ΔG value, dissociation constant (Kd), prediction of physicochemical characteristics, pharmacokinetics, and toxicity. Therefore, balanophonin can be developed as an effective alternative drug to inhibit SARS CoV-2 NendoU.
Penguatan Kebijakan Riset Daerah Berbasis Kearifan Lokal Melalui Naskah Akademik di Kabupaten Tegal Rakhman, Itmam Aulia; Mubarok, Zaki; Falah, Syamsul; Wibowo, Agus; Rakhman, Arif; Khodijah, Khodijah; Dewi, Ria Candra
Jurnal Medika: Medika Vol. 4 No. 3 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/y03b5r46

Abstract

Penguatan kebijakan riset daerah berbasis kearifan lokal merupakan langkah strategis untuk mendorong pembangunan berkelanjutan di Kabupaten Tegal. Penelitian ini bertujuan untuk menyusun Naskah Akademik dan Rancangan Peraturan Bupati (Raperbup) sebagai landasan hukum yang mengintegrasikan nilai-nilai lokal dalam tata kelola riset daerah. Metode yang digunakan meliputi studi literatur, analisis kebijakan, serta Focus Group Discussion (FGD) dengan melibatkan pemangku kepentingan, termasuk akademisi, pemerintah daerah, dan masyarakat. Hasil penelitian menunjukkan tiga temuan utama: (1) perlunya penguatan regulasi yang memadukan kearifan lokal dalam perencanaan riset, (2) pentingnya mekanisme pendanaan berkelanjutan yang melibatkan partisipasi masyarakat, dan (3) sinergi antarlembaga untuk optimalisasi pemanfaatan hasil riset. Naskah akademik yang dihasilkan menjadi dasar penyusunan Raperbup dengan pendekatan berbasis bukti dan berorientasi pada potensi lokal. Kegiatan ini membuktikan bahwa kolaborasi antara perguruan tinggi, pemerintah daerah, dan komunitas lokal mampu menciptakan kebijakan riset yang inklusif dan berkelanjutan. Dampak jangka panjangnya adalah terwujudnya ekosistem riset yang tidak hanya mendukung pembangunan daerah, tetapi juga melestarikan nilai-nilai kearifan lokal Kabupaten Tegal.
Co-Authors , Triadiati Achmad . Achmad Achmad Agnia Nurul Jannati Agus Setiawan Agus Wibowo Aji Winara Aji Winara Ani Sulistiyani Arif Rakhman Azmi Azhari Azmi Azhari, Azmi Brilyan Yudha Pratama Budi Martono Desi Nurafida Desriani Desriani Dewi, Ria Candra DIMAS ANDRIANTO Dwi Endah Kusumawati Ekajayanti Kining Eneng Nurlaela Faizal, Enceng Arif Fitriana S Monisa Gumelar, Dian Rachmat Hasana, Nurul Hasim Hasim I Gusti Agung Komang Diafari Djuni Hartawan I MADE ARTIKA Jaka, Aris Tri Kapitan, Origenes Boy Khalimatus Sadiah Khodijah Khodijah L M. Alfin Agushara Bena Laita Nurjanah Laita Nurjanah, Laita Laita Nurjannah Laita Nurjannah, Laita LAKSMI AMBARSARI Latifah K Darusman Lia Kusuma Dewi Livia Rhea Alvita MARIA BINTANG Maulana Hasanudin Mega Safithri Melati Devina Gustini Wirastuti Moh. Wifaqul Idaini Muhammad Assyar Muhammad Duror An Nashich Mustopa Mustopa Nandang Najmudin Neneng Hasanah Ni’mah, Naily Fitrotun Noora Qotrun Nada, Noora Qotrun Novik Nurhidayat Novik Nurhidayat Novilia Eka Syafitri Nuur’Alimah, Shobiroh Pelita, Bobang Noorisnan Perkasa Arian Rakhman, Itmam Aulia Resti Wahyuni Resti Wahyuni Rini Kurniasih, Rini Rini Novita Rori Theresia Saebani, Beni Ahmad Safira Purwanto, Ukhradiya Magharaniq Sanro Tachibana Shobiroh Nuur'Alimah Stefani Dhale Rale Sulistiyani Sulistiyani Supriyanto, Hadi Suryani Suryani Suryani Suryani Suryani Suryani Susetyo Bagas Bhaskoro Syaefudin Syaripudin, Dadang Takeshi Katayama Theresia, Rori Toshisada Suzuki Umul Karimah Waras Nurcholis Wiwit Amrinola Yogi Nur Anggowo Zaki Mubarok, Zaki