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All Journal Jurnal Gizi dan Pangan Jurnal Ilmu Pertanian Indonesia Jurnal Silvikultur Tropika (JST) JURNAL KIMIA SAINS DAN APLIKASI Prosiding Seminar Biologi Biogenesis: Jurnal Ilmiah Biologi Jurnal Tanaman Industri dan Penyegar Current Biochemistry SC (Savana Cendana) : Jurnal Pertanian Konservasi Lahan Kering JURNAL PENGABDIAN KEPADA MASYARAKAT Menara Perkebunan Jurnal Ilmu dan Teknologi Kayu Tropis Jurnal Ilmu Kefarmasian Indonesia JTRM (Jurnal Teknologi dan Rekayasa Manufaktur) Wood Research Journal : Journal of Indonesian Wood Research Society Al-Ahwal Al-Syakhsiyyah: Jurnal Hukum Keluarga dan Peradilan Islam Wood Research Journal : Journal of Indonesian Wood Research Society Al-Muamalat : Jurnal Ekonomi Syariah Jurnal Informatika Teknologi dan Sains (Jinteks) Journal of Law, Poliitic and Humanities Innovative: Journal Of Social Science Research Jurnal Penelitian Kehutanan Wallacea Molekul: Jurnal Ilmiah Kimia La-Tahzan: Jurnal Pendidikan Islam Jurnal Medika: Medika IEMJ: Islamic Education and Management Journal

Syamsul Falah

Departemen Biokimia, Fakultas Matematika Dan IPA, IPB

Author-ID : 2677226

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Influence of Culture Medium and Mahogany Seed Extract on The Growth of Botryodiplodia sp. Isolate Causing Dieback on Jabon Seedling PENGARUH MEDIA KULTUR DAN EKSTRAK BIJI MAHONI TERHADAP PERTUMBUHAN ISOLAT Botryodiplodia sp. PENYEBAB MATI PUCUK Aji Winara; Achmad .; Syamsul Falah
Jurnal Silvikultur Tropika Vol. 5 No. 3 (2014): Jurnal Silvikultur Tropika
Publisher : Departemen Silvikultur, Fakultas Kehutanan dan Lingkungan, Institut Pertanian Bogor (IPB)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/j-siltrop.5.3.%p

Dieback on jabon seedling caused by fungi Botryodiplodia sp. decreased seedlings’ quality and nurseries economic benefits. Less studies on the control of dieback pathogen on jabon seedling used biofungicide from plant extract have been reported nowadays. Mahogany is one of the promising medicinal plants in Indonesia and has potential as an biofungicide. This research aimed to estimate the growth of Botryodiplodia sp. isolate on some culture medium and inhibitation by mahogany seed extract. The poisoned food technique was used to test the efficacy of mahogany seed extract on the isolate growth. The result showed that potatoes sucrose and potatoes dextrose medium most suitable for mycelium growth of the Botryodiplodia sp. isolate. The mahogany seed hot water extract inhibited the growth of Botryodiplodia sp. isolate with the highest growth inhibition was 41.85-59.90% at 50% extract. Microscopical examinaton showed the inhibition of mycelium growth was caused by the changes on hyphae morphology and growth direction which were shrinking and curling due to the cell wall degradation.Keywords : Botryodiplodia sp., inhibitation, mahogany seed extract, medium.

AKTIVITAS ANTIFUNGI EKSTRAK DAUN PICUNG TERHADAP CENDAWAN Botryodiplodia theobromae PENYEBAB MATI PUCUK BIBIT JABON MERAH Antifungal Activity of Picung Leaf Extracts Against Botryodiplodia theobromae A Dieback Fungus of Jabon Merah Seedling L M. Alfin Agushara Bena; Achmad .; Syamsul Falah
Jurnal Silvikultur Tropika Vol. 8 No. 2 (2017): Jurnal Silvikultur Tropika
Publisher : Departemen Silvikultur, Fakultas Kehutanan dan Lingkungan, Institut Pertanian Bogor (IPB)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/j-siltrop.8.2.110-115

Invasion of Botryodiplodia theobromae as a dieback fungus on jabon merah (Anthocephalus macrophyllus) seedlings is a crucial issues. This pathogenic fungus needs to be controlled precisely. Phytochemical compounds of plant material is one alternative fungicides. Crude extracts of picung (Pangium edule) leaf in water and methanol solvent known to have antifungal potential. However, its activity against B. theobromae need to be revealed. In vitro assay aimed to measuring antifungal activity of water and methanol extracts of picung leaf on controlling growth of B. theobromae pathogenic fungus. Hot water extraction and maceration in methanol was conducted to obtain crude extract materials. In-vitro antifungal assay of water and methanol extracts of picung leaf was conducted by food poisoning method on Potato Dextrose Agar media. The results showed that water and methanol extracts of pangi leaf be able to suppress the growth of B. theobromae on the first day of observation, with the highest antifungal index reached 100% at concentration of 25mg/mL and 50mg/mL, respectively. This indicates that water and methanol extracts of picung leaf have antifungal activity. Generally, there was a trend of decrease in antifungal index over time.Key words: antifungal activity, Botryodiplodia theobromae, jabon merah, picung

KEEFEKTIFAN KITOSAN DALAM MENGENDALIKAN Botryodiplodia theobromae Pat. PENYEBAB MATI PUCUK PADA BIBIT JABON (Anthocephalus cadamba (Roxb.) Miq) Chitosan’s Effectiveness in Controlling Dieback by Botryodiplodia theobromae Pat on Jabon Seeding Desi Nurafida; Achmad .; Syamsul Falah
Jurnal Silvikultur Tropika Vol. 8 No. 3 (2017): Jurnal Silvikultur Tropika
Publisher : Departemen Silvikultur, Fakultas Kehutanan dan Lingkungan, Institut Pertanian Bogor (IPB)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/j-siltrop.8.3.170-176

Dieback disease by the fungus Botryodiplodia theobromae in Jabon seedlings (Anthocephalus cadamba) inhibits the regeneration of Jabon plant. Synthetic fungicides utilization to several problems such as residue on the environment and pathogen resistance. Chitosan is a potential natural compound used as an alternative to control plant disease.This research aims to examine the effectiveness of chitosan to control B. theobromae as causal agent of dieback on Jabon seedlings and to examine the effect of chitosan to control the viscosity of dieback disease on Jabon seedlings. The results showed that the chitosan solution can decrease the severity of disease in Jabon seedlings. However, it was different with the disease incidence rate parameter. Chitosan solution was not significantly affecting the disease because B. theobromae caused dieback symptoms on Jabon seedlings. The most effective treatment was chitosan solution with a concentration of 0.1% before inoculation with the severity of the disease by 25%. Chitosan solution viscosity was responsible in affecting the percentage of dieback disease in Jabon seeds. The higher the viscosity of chitosan, the higher the percentage of dieback disease attacks. The best viscosity to suppress the development of dieback disease on Jabon seedlings was 8.80 with 7.90% attack.Key words: Anthocephalus cadamba , Botryodiplodia theobromae, chitosan, dieback.

Aktivitas Antioksidan Teh Varietas GMB 7 Pada Beberapa Ketinggian Tempat Budi Martono; Syamsul Falah; Eneng Nurlaela
Jurnal Tanaman Industri dan Penyegar Vol 3, No 1 (2016): Jurnal Tanaman Industri dan Penyegar
Publisher : Pusat Penelitian dan Pengembangan Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/jtidp.v3n1.2016.p53-60

GMB 7 merupakan varietas unggul teh yang mempunyai produktivitas tinggi dan berpotensi sebagai sumber antioksidan alami, dapat tumbuh dengan baik di dataran rendah, sedang, dan tinggi. Tujuan penelitian adalah menganalisis pengaruh ketinggian tempat terhadap aktivitas antioksidan, kandungan fenolik, dan flavonoid pada teh varietas GMB 7. Penelitian dilakukan di Laboratorium Biofarmaka Institut Pertanian Bogor, mulai November 2014 sampai Februari 2015. Perlakuan yang diuji adalah ekstrak pucuk teh yang diambil dari tiga ketinggian tempat di perkebunan teh PT Tambi, Wonosobo, yaitu 690, 1280, dan 1890 m dpl. Serbuk pucuk teh sebanyak 100 g ditambahkan akuades dengan perbandingan 1:10, diekstraksi dengan air panas (90°C; 30 menit). Ekstrak disaring dan filtratnya dikeringkan menggunakan rotary vacuum evaporator (50 rpm; 60°C) sampai diperoleh ekstrak kasar kering. Fenolik total diuji dengan metode Follin-Ciocalteu pada panjang gelombang 765 nm, sedangkan flavonoid total diuji menggunakan metode AlCl3 pada panjang gelombang 510 nm. Aktivitas antioksidan ditentukan dengan metode diphenylpicrylhydrazyl (DPPH) pada panjang gelombang 517 nm. Hasil penelitian menunjukkan nilai fenolik dan flavonoid total, serta nilai IC50 GMB 7 pada ketinggian 690 m dpl lebih tinggi dibandingkan pada ketinggian 1.280 dan 1.890 m dpl, masing-masing sebesar 290,62 GAE mg/g ekstrak, 125 CE mg/gekstrak, dan 5,48 ppm. Kandungan fenolik dan flavonoid total berkorelasi sangat nyata dengan aktivitas antioksidan (IC50).

Aktivitas Antifungi Ekstrak Akar Mahoni terhadap Isolat Botryodiplodia theobromae Pat. Penyebab Mati Pucuk pada Bibit Jabon (Antifungal Activity of Mahogany Root Extracts against Botryodiplodia theobromae Pat. Isolate Causing Dieback on Jabon Seedling) Syamsul Falah; Achmad Achmad; Aji Winara
Jurnal Ilmu dan Teknologi Kayu Tropis Vol 13, No 1 (2015): Jurnal Ilmu dan Teknologi Kayu Tropis
Publisher : Masyarakat Peneliti Kayu Indonesia

Dieback on jabon (Anthocephalus cadamba (Roxb.) Miq.) seedling caused by fungi Botryodiplodia theobromae Pat. decreased seedling’s quality and nurseries economic benefits. The control of dieback pathogen on jabon seedling used biofungicide from plant extract have not been studied intensively nowadays. Mahogany (Swietenia macrophylla King.) is one of the promising medicinal plants in Indonesia but its utilization as a biofungicide specially for controlling the dieback on jabon seedling has not been reported. This research aimed to examine the antifungal activities of mahogany root extracts against B.theobromae isolate causing dieback on jabon seedling in vitro. The poisoned food technique was used in assay of the antifungal activities of mahogany root extract. The result showed that mahogany root extract has antifungal activities against B.theobromae with the highest efective growth inhibition was the metanol solvent on 50% concentration level. Microscopical examination showed the inhibition of mycelium growth was caused by the changes on hyphae morphology and growth direction which were beads formation and curling.Keywords: antifungal, Botryodiplodia theobromae, jabon, mahogany root

Potensi Ekstrak Tanin Daun dan Kulit Batang Surian sebagai Penghambat α-Glukosidase (Tannin Extract Potential of Surian Leafand Bark as α-Glucosidase Inhibitor) Fitriana S Monisa; Maria Bintang; Mega Safithri; Syamsul Falah
Jurnal Ilmu dan Teknologi Kayu Tropis Vol 14, No 2 (2016): Jurnal Ilmu dan Teknologi Kayu Tropis
Publisher : Masyarakat Peneliti Kayu Indonesia

The purpose of the study was to know the inhibition activity surian leaves and bark tannin to α-glucosidase by in vitro method. Leaves and bark of surian was extracted with water and ethanol 70% solvent using infundation and maceration methods. Tannin was tested with phytochemical analysis and activity of inhibition to α-glucosidase with a microplate reader at a wavelength of 410 nm. The yield of tannins extract from leaves sample were 65.46% and 66.12% by water and ethanol 70% solvents, respectively, as well as 83.34% and 90.29% were obtained from bark sample. Water and ethanol extract of surian leaves and bark contain flavonoids, triterpenoids, tannins and saponins. Leaves tannin consist mainly hydrolyzable tannin, i.e. galat and gallotanin/ellagotanin, however, bark tannin consist of condensed tannin (catechol). Total tannin content of ethanol and water extract were 9.35 and 7.61 mg g-1 for bark sample, and 6.24 and 5.20 mg g-1 for leaves sample. Inhibition activity test showed that ethanol extract of leaves sample exhibited the highest inhibition activity (IC50=50.44 μg ml-1) and water extract of leaves sample was smallest (IC50=183.22 μg ml-1).

Phytochemical Compounds and Cytotoxicity Screening of Suren (Toona sinensis) Leaves Extracts against Vero and MCF-7 Cells SYAMSUL FALAH; DIDIT HARYADI; POPI ASRI KURNIATIN; SYAEFUDIN SYAEFUDIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1276.603 KB)

Daun suren diindikasikan memiliki beragam aktivitas farmakologi seperti antioksidan, antidiabetes, antihiperlipidemia, dan antikanker. Penelitian ini bertujuan menganalisis komponen-komponen fitokimia daun suren secara kualitatif dan kuantitatif, serta menguji aktivitas sitotoksisitasnya terhadap sel vero dan sel kanker payudara MCF-7. Pelarut yang digunakan untuk mengekstraksi daun suren adalah air, etanol 70%, etil asetat, dan n-heksana. Rendemen yang diperoleh untuk pelarut air, etanol 70%, etil asetat, dan n-heksana secara berurutan sebesar 33,54; 34,85; 6,38; dan 1,31%. Komponen fitokimia dalam daun suren meliputi alkaloid, triterpenoid, flavonoid, tanin, fenol, dan steroid. Total fenolik ekuivalen asam galat (GAE) tertinggi terdapat pada ekstrak etanol 70% diikuti oleh ekstrak air, etil asetat, dan n-heksana masing-masing sebesar 101,78; 97,84; 33,24; dan 14,81 mg/g GAE. Total flavonoid ekuivalen kuersetin (QE) ekstrak air, etanol 70%, etil asetat, dan n-heksana masing-masing sebesar 81,14; 53,72; 17,58; dan 6,46 mg/g QE. Uji sitotoksisitas menunjukkan bahwa semua ekstrak daun suren tidak toksik terhadap sel vero dengan nilai IC50 sebesar 463,03 (ekstrak air), 197,88 (ekstrak etanol 70%), 121,09 (ekstrak etil asetat), dan 217,43 μg/ml (ekstrak n-heksana). Nilai IC50 semua ekstrak daun suren terhadap sel kanker payudara MCF-7 >100 μg/ml. Berdasarkan Natianal Cancer Institute (NCI), nilai ini menunjukkan aktivitas antikanker ekstrak daun suren yang sangat lemah terhadap sel MCF-7.

The Inhibitory Activity and Kinetics of α-Glucosidase by Toona sinensis Stem Bark Extracts Melati Devina Gustini Wirastuti; Syamsul Falah; Syaefudin
Current Biochemistry Vol. 9 No. 1 (2022)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.9.1.2

Research on the potential of the Surian tree (Toona sinensis) for medicine has been carried out, especially for the leaves. However, the bark section has not been done much. This study aimed to determine the inhibitory activity of -glucosidase and IC50 extract as well as the fraction of surian bark as antidiabetic in vitro. The reflux method with water at 90oC and maceration using 70% ethanol at room temperature was carried out to obtain aqueous and ethanol extracts. Furthermore, the ethanol extract was fractionated successively using n-hexane, diethyl ether, and ethyl acetate. Phytochemical screening test showed that the aqueous extract contained flavonoids, saponins, and tannins. Meanwhile, the 70% ethanol extract and its fraction showed terpenoid content, in addition to flavonoid compounds, saponins, and tannins. The best -glucosidase inhibition was shown by 70% ethanol extract, which was 70.45 ppm followed by ethyl acetate fraction, n-hexane fraction, diethyl ether fraction, and water extract of surian bark with values of 81.96 g/mL, 98.76 g/mL, respectively. , 140.25 g/mL, and 242.85 g/mL. Kinetics of -glucosidase inhibition showed that 70% ethanol extract of surian bark inhibited through a non-competitive inhibition mechanism, characterized by a decrease in Vmax from 8.29x10-3 mM/min to 1.65x10-3 mM/min and a decrease in Km from 0.17 mM to 0.03 mM.

In Vitro Antibakteri Ekstrak Etanol Puni (Zingiber zerumbet) Asal Pulau Timor Origenes Boy Kapitan; Laksmi Ambarsari; Syamsul Falah
Savana Cendana Vol 2 No 02 (2017): Savana Cendana (SC) - April 2017
Publisher : Fakultas Pertanian, Universitas Timor

Puni (Zingiber zerumbet) is a wildly grown plant that used by Timorese people to treat ulcerative lesions in Timor Island. This study aims to determine the antibacterial activity of plants extracts and know the content of active compounds on the most active extracts of plants. Extraction of active compounds was carried out using four solvent ie n-hexane, ethyl acetate, ethanol, and aqueous solvent. Antibacterial activity test was done using the diffusion method of the four crude extract and extract with the highest activity was then used to find MIC value. Analyzed the content of the active compounds using LC-MS. It was found that ethanol extract had the highest antibacterial activity compared to other extracts. The MIC value of ethanol extract against S. aureus, B. Subtilis, E. coli, and P. aeruginosa were respectively determined to be 50, 100, 150, 250 mg mL-1. The result of LC-MS analysis showed that the ethanol extract contained zerumbone and gingerglycolipid B.

Induction of Agarwood in Aquilaria malaccensis Using Nitrogen Fertilizer and Fusarium solani) Resti Wahyuni; Triadiati Triadiati; Syamsul Falah
Jurnal Penelitian Kehutanan Wallacea Vol. 7 No. 2 (2018)
Publisher : Foresty Faculty of Hasanuddin University

Aquilaria malaccensis is agarwood producing species in Indonesia. Agarwood compounds are formed as a chemical response of Aquliaria malaccensis tree to various physical damages, phatogen infection, or chemical treatment. Factors influencing agarwood formation are age of the tree, season, geographical location, environment, and treatment period. Agarwood induction may be done in tree or sapling. Agarwood induction in saplings need more effort than in trees. Combination of fungi (Fusarium solani) and nutrient (Nitrogen fertilizer) treatment may be one way to induce agarwood in A. malaccensis saplings. This study aims to produce A. malaccensis agarwood (aromatic compounds and colour) by induction of F. solani and nitrogen fertilizer, and analyse the agarwood chemical content. The agarwood chemical content was investigated by Gas Chromatography Mass Spectrometry (GCMS) analysis. Results indicated that agarwood had a different colour for every treatment. The darkest brown and most fragrant agarwood were produced by A. malaccensis treated by a combination of nitrogen fertilizer (4 gr/sapling) and F. solani inoculation. Three chemical compounds were identified i.e. silanediol dimethyl, 4-ethyl benzoic acid and 1,4,7,10,13,16- hexaoxacyclooctadecane with percentages of 25.7, 17.62, and 3.56 respectively. A. malaccensis treated by nitrogen fertilizer and F. solani for 3 months is able to induce aromatic compounds formation, but the colour still dark brown. Biosynthesis of aromatic compounds in agarwood occurs first before changes in the colour of the wood.

Co-Authors , Triadiati Achmad . Achmad Achmad Agnia Nurul Jannati Agus Setiawan Agus Wibowo Aji Winara Aji Winara Ani Sulistiyani Arif Rakhman Azmi Azhari Azmi Azhari, Azmi Brilyan Yudha Pratama Budi Martono Desi Nurafida Desriani Desriani Dewi, Ria Candra DIMAS ANDRIANTO Dwi Endah Kusumawati Ekajayanti Kining Eneng Nurlaela Faizal, Enceng Arif Fitriana S Monisa Gumelar, Dian Rachmat Hasana, Nurul Hasim Hasim I Gusti Agung Komang Diafari Djuni Hartawan I MADE ARTIKA Jaka, Aris Tri Kapitan, Origenes Boy Khalimatus Sadiah Khodijah Khodijah L M. Alfin Agushara Bena Laita Nurjanah Laita Nurjanah, Laita Laita Nurjannah Laita Nurjannah, Laita LAKSMI AMBARSARI Latifah K Darusman Lia Kusuma Dewi Livia Rhea Alvita MARIA BINTANG Maulana Hasanudin Mega Safithri Melati Devina Gustini Wirastuti Moh. Wifaqul Idaini Muhammad Assyar Muhammad Duror An Nashich Mustopa Mustopa Nandang Najmudin Neneng Hasanah Ni’mah, Naily Fitrotun Noora Qotrun Nada, Noora Qotrun Novik Nurhidayat Novik Nurhidayat Novilia Eka Syafitri Nuur’Alimah, Shobiroh Pelita, Bobang Noorisnan Perkasa Arian Rakhman, Itmam Aulia Resti Wahyuni Resti Wahyuni Rini Kurniasih, Rini Rini Novita Rori Theresia Saebani, Beni Ahmad Safira Purwanto, Ukhradiya Magharaniq Sanro Tachibana Shobiroh Nuur'Alimah Stefani Dhale Rale Sulistiyani Sulistiyani Supriyanto, Hadi Suryani Suryani Suryani Suryani Suryani Suryani Susetyo Bagas Bhaskoro Syaefudin Syaripudin, Dadang Takeshi Katayama Theresia, Rori Toshisada Suzuki Umul Karimah Waras Nurcholis Wiwit Amrinola Yogi Nur Anggowo Zaki Mubarok, Zaki

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