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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Kesehatan Andalas Jurnal Penelitian Kesehatan Suara Forikes AcTion: Aceh Nutrition Journal Acta Biochimica Indonesiana Majalah Kedokteran Andalas Contagion: Scientific Periodical Journal of Public Health and Coastal Health Science Midwifery Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Archives Pharmacia Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Pharmaceutical and Sciences. Jurnal Riset Ilmiah Proceeding International Health Conference
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Journal : JURNAL KIMIA SAINS DAN APLIKASI

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Antibacterial Activity of Endophytic Bacterial Isolates from Kaempferia galanga Leaves Rafifa Ridha; Dira Hefni; Zetryana Puteri Tachrim; Gian Primahana; Jepri Agung Priyanto; Linosefa Linosefa; Adrial Adrial; Endrinaldi Endrinaldi; Muhammad Eka Prastya
Jurnal Kimia Sains dan Aplikasi Vol 27, No 11 (2024): Volume 27 Issue 11 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.11.538-548

Abstract

Indonesia has a high biodiversity, which can be relied upon as a potential source of medicinal materials. One of the medicinal plants in Indonesia is Kaempferia galanga, which demonstrates various pharmacological properties, including antibacterial, anti-inflammatory, antioxidant, anticancer, and antiangiogenic effects. However, directly extracting active compounds from plants requires a considerable amount of biomass. To address this challenge, utilizing endophytic bacteria associated with these plants presents a promising alternative. Consequently, the antibacterial activity of endophytic bacterial isolates from K. galanga leaves needs to be investigated. This study is an experimental laboratory investigation conducted in vitro. Two isolates demonstrated antibacterial activity: isolate code DR4 inhibited the growth of Escherichia coli (3 ± 0.5 mm), while isolate DR10 inhibited the growth of four bacteria: Bacillus subtilis (5 ± 0 mm), Staphylococcus aureus (1.5 ± 0.5 mm), Escherichia coli (1 ± 0 mm), and Pseudomonas aeruginosa (1 ± 0 mm). Disc diffusion tests using ethyl acetate extracts of isolate DR10 showed the highest antibacterial activity at a concentration of 10,000 ppm. The Minimum Inhibitory Concentration (MIC) was determined to be 156.2 ppm against B. subtilis, while the Minimum Bactericidal Concentration (MBC) was >625 ppm. Molecular identification showed that isolate DR 10 had 100% similarity to Bacillus sp. TS8. The active compound suspected to have antibacterial properties is pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, with the highest abundance.
Co-Authors Adrial Adrial Afriani, Nita Afriwardi Afriwardi Almurdi Almurdi Alvin Muhammad Arni Amir Asrawati Nurdin Asterina Asterina Aswiyanti Asri Aswiyanti Asri Bobby Indra Utama Delmi Sulastri Desmiwati Desmiwati2 Dessy Arisanti Dessy Arisanty Dia Rofinda, Zelly Dia Dian Pertiwi Dira Hefni Dira, Atshyfa Zsazsa Djosan, Al Hafiz Dwi Yulia Effy Huriyati Efrida Efrida Eldi Sauma Elmatris Sy Ennesta Asri Erlina Rustam Erly Erly Ervan Arditya Kusuma Fadil Oenzil Fathoni Afif Feby Febriatama Fitria Ramanda Fortuna, Fory Gardenia Akhyar Gian Primahana Gita Rahmadani Gusti Revilla Hasmiwati Husna Yetti Husnil Kadri Ibrahim Ibrahim Ilham, Nur Muhammad Intan, Shinta Ayu Irrahmah, Miftah Jepri Agung Priyanto Julizar Nazar Linosefa Linosefa Lisma Evareny Magza, Dekasih Tria Mahata, Liganda Endo Masrul Mayetti Mayetti Miftah Irramah Mohamad Reza Muchtar, Masrul Muhammad Eka Prastya Nadhira Isza Qushoyyi Nadia Oktarina Nailatul Fadhila Novita Sari Nur Afrainin Syah Nur Indrawaty Lipoeto Nurhayati Nurhayati Nurul Fadila Oea Khairsyaf P, Anastasya Inayah Nabila Putri, Biomechy Oktomalio Rafifa Ridha Rahmani Welan Raisa Hussein Ramadhani, Dhea Amaliya Rani Afrisetiawati Rauza Sukma Rita Rikarni Rikarni Rizki Amelia Roslaili Rasyid Saptino Miro Saptino Miro, Saptino Sari Handayani Utami Setiawan, Mentari Adinda Sisca Dwi Yarni Siti Utari Agustina Sri Wahyuni Suci Aulia Yude Tofrizal Triyunita, Rian Ulya Uti Fasrini Vitresia, Havriza Yarni, Sisca Dwi Yaumil Fauziah Yerizel , Eti Yuniar Lestari Yusticia Katar Yustini Alioes Zelly Dia Rofinda Zetryana Puteri Tachrim Zulkarnain Edward