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Siti Nurhajjah
Bagian Anatomi Fakultas Kedokteran Universitas Andalas
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EKSFRESI GEN SUPEROXIDE DISMUTASE 1 SERTA I{UBUNGANNYA DENGAN FUNGSI TIMUS PENDERITA SINDROMA DOWN Siti Nurhajjah; Rinang Mariko; Raysa Ramayumi
Majalah Kedokteran Andalas Vol 37 (2014): Supplement 2 | Published in December 2014
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3403.28 KB)

Abstract

lnfeksi merupakan masalah kesehatan pada penderita sindroma Down (SD), sehingga tinggiangka kesakitan dan kematian. Peningkatan ekspresi SOD1 1,5 kali pada penderita SDyang berefek terhadap peningkatan peroksidasi (Hr0r), sehingga diperkirakan sebagai faktorpenyebab apoptosis timus. Tujuan penelitian ini untuk mengetahui ekspresi gen SOD1 danhubungannya dengan sel timus pada penderita SD. Penelitian ini nnengunakan desain crosssectionalcomparative sfudydengan jumlah sampelsebanyak 50 orang (25 orang penderita SDdan 25 orang kontrol). Darah vena diambil sebanyak 5 cc setiap sampel untuk isolasi RNAdanDNA, ekspresi gen SODl dengan teknik Real Time PCR, sedangkan fungsi timus dilihat dariprensentas TREC. Analisis statistik untuk ekspresi gen dan hubungan antar variabel denganmengunakan uji t. Penelitian ini ditemukan log copy nurnber SOD 1 pada kelompok penderita$D adalah 11,10T t0,44lng cDNA, sedangkan pada kontrol 10,501 t 0,48/ng cDNA,secarastatistik terdapat perbedaan bermakna (P=0,000). Presentase TREC adalah 44,7 + 7,4o/opada kelompok penderita SD dan 57,9t5,4% pada kelompok kontrol. secara st-atistik terdapatperbedaan bermakna p<0,05. Penelitian ini dapat disimpulkan bahwa terdapat peningkatanekspresi gen SOD 1 pada penderita SD dibandingkan kontrol dan rendahnya prensentasiTREC pada penderita SD dibandingkan kontrol, hal ini mungkin disebabkan terjadi penurunanfungsi timus akibat peningkatan ekspresi gen SOD1.Kata Kunci: sindrom Down, ekspresi gen SOD 1, prensentasi TREC
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN ASCARIASIS PADA MURID SEKOLAH DASAR Atikah Mardhika Ihsan; Selfi Renita Rusjdi; Siti Nurhajjah
Majalah Kedokteran Andalas Vol 38, No 2 (2015): Published in September 2015
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (414.683 KB) | DOI: 10.22338/mka.v38.i2.p80-88.2015

Abstract

AbstrakKejadian Ascariasis masih tinggi di Kota Padang, terutama pada anak usia sekolah dasar. Banyak faktor yang mempengaruhi tingginya kejadian Ascariasis ini. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang berhubungan dengan kejadian Ascariasis pada murid Sekolah Dasar. Penelitian ini merupakan penelitian analitik dengan metode cross sectional study yang dilakukan pada 122 murid SDN 25 dan 28 Purus, Kota Padang pada bulan Desember 2013. Faktor-faktor yang diteliti antara lain higienitas perorangan, tingkat pengetahuan ibu, sanitasi lingkungan, tempat tinggal, dan tingkat penghasilan orang tua. Hubungan antar variabel dianalisis dengan uji chi-square. Hasil penelitian menunjukkan bahwa murid yang positif Ascariasis sebesar 34,4%. Kejadian Ascariasis ditemukan pada murid yang higienitas perorangan kurang baik sebesar 52%, tingkat pengetahuan ibu yang rendah sebesar 34,9%, sanitasi lingkungan yang kurang baik sebesar 29,3%, dan tingkat penghasilan orang tua yang rendah sebesar 37%. Analisis statistik menunjukkan tidak terdapat hubungan bermakna antara higienitas perorangan (p=0.06), pengetahuan ibu (p=1), sanitasi lingkungan (p=0,35), dan tingkat penghasilan orang tua (p=0,59) dengan kejadian Ascariasis. Kesimpulan: Kejadian Ascariasis pada pada murid SDN 25 dan 28 Purus, Kota Padang tahun 2013 tidak berkaitan dengan higienitas perorangan, pengetahuan ibu, sanitasi lingkungan, dan tingkat penghasilan orang tua.AbstractThe prevalence of Ascariasis is still high in Padang, especially at primary school age children. There are many factors contribute to the high incidence of this Ascariasis. The purpose of this study was to know the factors that associated with the incidence of Ascariasis in primary school. This study uses an analytical design method of cross -sectional study on 122 students in 25 and 28 primary school Purus, Padang in December 2013. The factors studied include personal hygiene, level of maternal knowledge, sanitary living environment, and the level of parental income. The relationship between all variables was analyzed by Chi-Square test. The results showed that students were positive Ascariasis was 34.4%. Ascariasis incidence in poor individual hygiene students was 52%, a low level of maternal knowledge was 34,9%, poor environmental sanitation was 29,3%, and a low level of parental income was 37%. Statistical analysis showed there was not significant relationship between the individual hygiene (p=0.06), the level of maternal knowledge (p=1), environmental sanitation (p=0,35), and the parental income (p=0,59) with Ascariasis. Conclusion: Ascariasis incidence in 25 and 28 primary school Purus, Padang in 2013 was not associated with individual hygiene, the level of maternal knowledge, environmental sanitation, and the parental income.
Hubungan Status Gizi, Umur, dan Jenis Kelamin dengan Derajat Pneumonia pada Balita di RSUP Dr. M. Djamil Padang Periode Januari 2018 – Desember 2018 Faris Saadi Firdaus; Eva Chundrayetti; Siti Nurhajjah
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1416.744 KB) | DOI: 10.25077/jikesi.v2i1.418

Abstract

Background. Pneumonia is an acute infection of lower respiratory tract. Pneumonia in under 5-year-old children is a health problem in developing countries, including Indonesia. Nutritional status, age, and sex are risk factors that increase the severity of pneumonia. Objective.The study aims to determine the relationship of nutritional status, age, and sex to severity of pneumonia in under 5-year-old children at Dr. M. Djamil General Hospital Padang in the period from January to December 2018. Methods.The study is of analytical cross-sectional design.The data is collected from the hospitals’s medical records department. The sample is 57 under 5-year-old children diagnosed with pneumonia at Dr. M. Djamil General Hospital Padang in the period from January to December 2018. Simple random sampling is used to select the sample. Chi-square tests are applied in data analysis. Results.The highest incidence of pneumonia is found in the category of severe pneumonia (64,9%), the age group of 2-24 months (73,7%), among males (52,6%), and nutritional status of normal and overnutrition (64,9%). The results of the chi-square test used to determine the relationship of nutritional status, age, and sex to severity of pneumonia are respectively p = 0,015, p = 0,033 and p = 0,532. Conclusion.There are relationships of nutritional status and age to severity of pneumonia, but no relationship of sex to severity of pneumonia
Hubungan Faktor Risiko dengan Kejadian Infeksi Saluran Kemih pada Anak di RSUP Dr. M. Djamil Padang Sherly Vanessa Putri Hadiyanto; Amirah Zatil Izzah; Siti Nurhajjah
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 2 (2023): Juni 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i2.1059

Abstract

Latar Belakang: Penyakit infeksi saluran kemih pada anak masih menjadi masalah kesehatan karena tingginya angka kesakitan dan kematian pada anak di negara berkembang, termasuk Indonesia. Penyakit ini menempati urutan kedua penyakit infeksi tersering pada anak setelah infeksi saluran nafas atas. Kejadian ISK dapat dipengaruhi oleh berbagai macam faktor risiko, seperti sirkumsisi, konstipasi kronis, status gizi, dan cara membersihkan genitalia. Objektif: Mengetahui hubungan faktor risiko dengan kejadian ISK pada anak di RSUP Dr. M. Djamil Padang. Metode: Jenis penelitian ini adalah analitik dengan rancangan penelitian case control. Jumlah sampel pada penelitian ini adalah 120 orang, yang terdiri dari 60 orang pasien anak dengan infeksi saluran kemih pada kelompok kasus dan 60 orang pasien anak tanpa infeksi saluran kemih pada kelompok kontrol di RSUP Dr. M. Djamil Padang periode Januari 2018 – Desember 2021. Analisis data dilakukan dengan menggunakan chi square. Hasil: Hasil penelitian didapatkan karakteristik pasien infeksi saluran kemih pada anak yang terbanyak yaitu usia <1 tahun (43,3%), laki-laki (51,7%), belum sirkumsisi (77,4%), tidak ada konstipasi kronis (63,3%), gizi kurang (53,3%), dan cara membersihkan genitalia dari arah depan ke belakang (62,1%). Secara statistik ditemukan hubungan yang bermakna antara konstipasi kronis (p=0,006), status gizi (p=0,005) dengan kejadian infeksi saluran kemih pada anak, sedangkan sirkumsisi (p=0,569), cara membersihkan genitalia (p=0,395) tidak memiliki hubungan yang bermakna dengan kejadian infeksi saluran kemih pada anak. Kesimpulan: Konstipasi kronis dan status gizi merupakan faktor risiko kejadian infeksi saluran kemih pada anak sedangkan sirkumsisi dan cara membersihkan genitalia tidak memiliki hubungan yang bermakna dengan kejadian infeksi saluran kemih pada anak.
Pengaruh Ekstrak Daun Kemangi (Ocimum Basilicum) terhadap Ekspresi TNF-Α pada Tikus Diabetes Melitus Gestasional Muhammad Faisal Rachman; Hirowati Ali; Siti Nurhajjah
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 3 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i3.762

Abstract

Latar Belakang: Jumlah penderita diabetes melitus gestasional terus meningkat di seluruh dunia. Kondisi hiperglikemia yang terjadi pada masa kehamilan dapat memicu terjadinya stress oksidatif yang dapat menstimulasi peningkatan ekspresi Tumor Necrosis Factor-α (TNF-α). Ekstrak daun kemangi (Ocimum basilicum) mengandung zat antidiabetes dan antioksidan. Penelitian ini bertujuan untuk melihat efektifitas ekstrak daun kemangi (Ocimum basilicum) terhadap ekspresi TNF-α pada tikus model diabetes melitus gestasional. Objektif: Untuk mengetahui pengaruh pemberian ektrak daun kemangi (Ocimum basilicum) terhadap ekspresi TNF-α pada tikus model diabetes melitus gestasional. Metode: Penelitian ini merupakan penelitian eksperimental dengan menggunakan metode post test only control group design. Sampel penelitian menggunakan bahan biologis tersimpan dari RNA tikus yang telah diinduksi streptozotocin 40 mg/KgBB sebagai animal model DMG pada manusia yang disimpan di Lab Biomedik FK Unand. Hasil: Ekspresi TNF-α pada kontrol negatif, kontrol positif, perlakuan satu dan perlakuan dua berturut-turut adalah 1,01, 1,06, 0,95, dan 0,61. Kesimpulan: Menunjukkan adanya pengaruh pemberian ekstrak daun kemangi (Ocimum basilicum) terhadap ekspresi TNF-α pada tikus model diabetes melitus gestasional.
SKRINING PENYAKIT KECACINGAN DAN GANGGUAN VISUS PADA SISWA SD DI KELURAHAN SUNGAI PISANG KECAMATAN BUNGUS TELUK KABUNG KOTA PADANG Cimi Ilmiawati; Siti Nurhajjah; Nur Afrainin Syah; Mohamad Reza; Efrida Efrida; Eka Nofita; Hasmiwati Hasmiwati; Selfi Renita Rusjdi; Nuzulia Irawati; Sukri Rahman; Elmatris Elmatris; Desmawati Desmawati; Nur Indrawaty Lipoeto; Afriwardi Afriwardi
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 2 No. 4 (2019)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v2i4.114

Abstract

Sungai Pisang Village is a village that has only been accessible by smooth road roads in the past year in Padang City. Previously this village was only accessible by sea and by lousy road. This condition causes the Pisang River community to lag in socio-economic and health aspects. This activity aims to screen for worms in elementary school students in Sungai Pisang village because worms are closely related to environmental health and affect the quality of human resources experiencing growth and development. Screening for worms is carried out by examining fecal preparations. This activity also aims to check visual acuity in elementary students and make references for sharp vision correction to learn well. Visual acuity checks were carried out using a Snellen card. The results of the examination showed that 3/143 students had worms and 3/273 students had visual disturbances. Students with worms are recommended to go to the Puskesmas to be given deworming medicine, and students with visual impairments are facilitated for examination by an ophthalmologist and given glasses if needed.
UPAYA PENINGKATAN PENGETAHUAN ORANG TUA TERHADAP ZINC DAN PEMBERIAN ZINC KEPADA SISWA SD BUSTANUL ULUM PADANG Siti Nurhajjah; Nur Afrinin Syah; Afdal Afdal; Dewi Rusnita; Tofrizal Tofrizal; Dwisari Dillasamola; Desmawati Desmawati
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 4 No. 1 (2021)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v4i1.288

Abstract

Zinc is an essential micronutrient in the human body as a cofactor of about 300 enzymes. Zinc is very instrumental in the growth process, including maintaining the thymus so that atrophy is not fast. Zinc deficiency can affect the immune system. Zinc deficiency can be caused due to a lack of zinc intake. In theory, many factors affect zinc intake, among others, community knowledge, education, economy, diet, habits, and customs. Lambung Bukit Village is a fostered village of Andalas University. Most people in this village are classified as economically deficient because the community generally farms. The level of public knowledge about zinc is still lacking. This service aims to increase public knowledge of the importance of zinc on body health and the provision of zinc supplements to prevent zinc deficiency and is expected to reduce morbidity and mortality due to infection in children. This activity has been carried out at Bustanul Ulum Elementary School in Batu Busuk Village, Lambung Bukit Village, Pauh District, Padang City. Counseling conducted to 48 people (parents of students and teachers). Almost all parents' knowledge is lacking about zinc, the role, source of zinc, and its relation to several diseases. We hope this counseling can increase public knowledge about the importance of zinc on the body, mainly to prevent susceptibility to infections and any food sources that contain zinc. The results of a health examination by pediatricians found two students suffering from Congenital Heart Disease (CHD), poor oral hygiene, and many teeth carious students. Giving zinc syrup to children aged 7-10 years is expected to prevent zinc deficiency in children.
Hubungan Kualitas Hidup dengan Gejala Depresi pada Pasien Artritis Reumatoid di RSUP Dr. M. Djamil Padang Gina Matahati; Siti Nurhajjah; Arina Widya Murni
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.5877

Abstract

Rheumatoid arthritis (RA), as an autoimmune disease with a chronic inflammatory nature, can decrease quality of life, with depression in RA patients being one of the factors influencing the determination of quality of life. The purpose of this study was to determine the relationship between depression and the quality of life of RA patients at RSUP Dr. M. Djamil Padang. The type of research used is analytical case-control study. There were 60 samples consisting of 20 people with depressive symptoms in the case group and 40 people without depressive symptoms in the control group. The data analysis used was the Chi-Square correlation test. The results of this study showed female respondents, late adult age, and duration of illness less than five years were characteristics of most of the respondents of this study. Analysis with  the Chi-Square test  showed an association (p<0.05) between the quality of life of the emotion domain (p=0.000) and depressive symptoms in RA patients. Meanwhile, there was no association (p>0.05) between the quality of life of patients in the domains of physical function (p=1.000), physical role (p=0.208), pain (p=0.151), general health (p=0.308), social function (p=0.195), vitality (p=0.389), and mental health (p=0.255) with depressive symptoms in RA patients. To sum up, there is a correlation between depression and the emotion domain of QoL of RA patients but there is no correlation between depression and the physical function, physical role, pain, general health, social function, vitality, and mental health domain of QoL of RA patients.
Co-Authors Adnil Edwin Nurdin Afdal Afdal Afdal Afdal Afriwardi Afriwardi Aisyah Elliyanti Amirah Zatil Izzah Arina Widya Murni Athika Rahmawati Atikah Mardhika Ihsan Desmawati Desmawati Dewi Rusnita Dia Rofinda, Zelly Dia Dian Pertiwi Dwisari Dillasamola Dwitya Elvira, Dwitya Efrida Efrida Eka Nofita Elizabeth Bahar Elmatris Sy Eti Yerizel Eva Chundrayetti Faris Muhammad Faris Saadi Firdaus Farmaditya EP Mundhofir Gina Matahati Gusti Revilla Hasmiwati Hirowati Ali Ikky Nabila Nandinanti Ilmiawati, Ilmiawati M. Randi Sakti Pratama Mohamad Reza Muhammad Faisal Rachman Nur Afrainin Syah Nur Afrinin Syah Nur Afrinin Syah Nur Indrawaty Lipoeto Nurhayati Nurhayati Nuzulia Irawati RAVEINAL RAVEINAL Raysa Ramayumi Rinang Mariko Rusnita, Dewi Safrina D Ratnaningrum Selfi Renita Rusjdi Sherly Vanessa Putri Hadiyanto Suci Maulida Sukri Rahman Sultana MH Faradz Tofrizal Tofrizal Tofrizal Yaslinda Yaunin Yenita Yenita Yulistini, Yulistini